ceftaroline fosamil / Generic mfg. - LARVOL DELTA

Stewardship Challenges, PK/PD Evidence, and Prescribing Appropriateness for Recently Approved Antibiotics in Pediatric Practice. (PubMed, Antibiotics (Basel)) - "This review explores the landscape of the most recent antibiotics, including advanced cephalosporins (ceftaroline, cefiderocol, and ceftobiprole), novel beta-lactam/beta-lactamase inhibitor combinations (e.g., ceftazidime/avibactam, meropenem/vaborbactam), and long-acting lipoglycopeptides. Furthermore, we emphasize the role of antimicrobial stewardship through the "3 D's" rule and the evolution of Therapeutic Drug Monitoring (TDM) from reactive safety controls to proactive, model-informed precision dosing (MIPD). Finally, we advocate for a multidisciplinary synergy between pediatricians and pharmacologists as the cornerstone for optimizing outcomes and preserving the efficacy of the future antibiotic pipeline."

Journal • PK/PD data • Review • Pediatrics

Reserve antibiotics in paediatrics: single-centre clinical experience and antimicrobial stewardship implementation. (PubMed, Eur J Pediatr) - " Reserve antibiotic use in complex paediatric populations highlights the importance of characterizing our clinical experience of prescribing in real-world practice. In this context, the development and implementation of a structured institutional antimicrobial stewardship program represents a pragmatic strategy to improve clinical governance and guide the appropriate positioning of these last-resort agents."

Journal • Observational data • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pediatrics

Ceftaroline Diffusion into Cerebrospinal Fluid of Children with Ventriculitis due to Ventriculoperitoneal Shunt Infection (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Pharmacodynamic Optimization of Ceftaroline Fosamil Dosing in Patients Undergoing Intermittent Hemodialysis: a Monte Carlo Simulation Analysis (IDWeek 2026) - No abstract available

Clinical • PK/PD data • Infectious Disease

Mano-a-Mano (IDWeek 2026) - "Organized by Co-Organizing Groups: NA Learning Objectives: At the conclusion of this session, participants will be able to:Discuss factors to consider when recommending antimicrobial lock therapyDescribe evidence-based data to inform decisions regarding the use of ceftaroline, linezolid, daptomycin, and other agents for severe MRSA infectionsDescribe available data to inform whether gowns and gloves are useful in preventing nosocomial transmission of respiratory viruses"

Infectious Disease

Advances in the diagnosis and management of skin and soft tissue infections. (PubMed, BMJ) - "Management of SSTI includes antibiotics such as penicillin VK, dicloxacillin, or a cephalosporin, while treatment for skin abscess includes incision and drainage, with antibiotics recommended in select patients. While most patients with cellulitis or skin abscess are appropriate for discharge with follow-up, patients with sepsis and those with challenges adhering to therapy, immunosuppression, or failed outpatient therapy should be referred to the emergency department. Novel antibiotics such as tedizolid, delafloxacin, omadacycline, and ceftaroline may be considered in select cases."

Journal • Review • Dermatology • Infectious Disease • Inflammation • Pain • Septic Shock

Antimicrobial Resistance in Major Gram-Positive Pathogens: Beyond the Vancomycin Border. (PubMed, Antibiotics (Basel)) - "The increasing prevalence of multidrug-resistant (MDR) Gram-positive infections has led to the widespread use of vancomycin and other next-line agents including linezolid, daptomycin, ceftaroline and dalbavancin. Additionally, resistance surveillance, antimicrobial stewardship and the development of novel antimicrobials are warranted to address the rising threat of resistant Gram-positive infections. This review aims to provide an overview of resistance mechanisms in major Gram-positive pathogens and discuss existing and emerging approaches to overcome resistance to agents beyond vancomycin, incorporating recent evidence on combination therapies and providing a practical treatment algorithm."

Journal • Review • Infectious Disease

Methicillin resistant staphylococcus aureus treatment and control in neonates: lessons learned - a Vietnam perspective. (PubMed, Expert Rev Anti Infect Ther) - "Vancomycin remains the first-line therapy for severe MRSA infections. Alternative agents - including linezolid, daptomycin, ceftaroline, clindamycin, and adjunctive rifampin - have limited roles, underscoring the importance of local antibiogram-guided therapy...Effective strategies to reduce MRSA burden include infection prevention bundles, surveillance cultures, targeted decolonization, and antimicrobial stewardship programs. These interventions must be tailored to Vietnam's healthcare."

Journal • Review • Critical care • Infectious Disease • Pediatrics

In vitro activity of ceftaroline against clinical isolates of Gram-positive bacteria in paediatric patients: ATLAS programme 2018-2023. (PubMed, JAC Antimicrob Resist) - "High susceptibility to daptomycin, linezolid, teicoplanin, tigecycline (from the FDA), trimethoprim/sulfamethoxazole and vancomycin was demonstrated against these isolates for both breakpoints...High susceptibility to linezolid, levofloxacin, tigecycline and vancomycin was demonstrated against these isolates across regions from both breakpoints, whereas, for ceftriaxone, higher susceptibility following the CLSI than EUCAST was observed...Ceftaroline demonstrated potent activity against key GPB. This study significantly contributes to the limited current information on paediatric antimicrobial resistance patterns across AfME, APAC, Europe and LATAM."

Journal • Preclinical • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Assessment of Susceptibility of Methicillin-Resistant Staphylococcus aureus Isolates to Ceftaroline and Other Antistaphylococcal Agents. (PubMed, Cureus) - "Vancomycin showed 100% susceptibility, whereas linezolid showed 98.8% susceptibility. Conclusion Ceftaroline demonstrated substantial in vitro activity against clinical MRSA isolates, and remained effective across diverse demographic and clinical subgroups. These findings support its potential role as an additional therapeutic option for MRSA infections and highlight the importance of continued antimicrobial surveillance and susceptibility-guided therapy to monitor the emerging resistance patterns."

Journal • Infectious Disease

Pharmacokinetic and pharmacokinetic/pharmacodynamic (PK/PD) considerations of ceftaroline and ceftobiprole for the treatment of Staphylococcus aureus infections: a systematic review. (PubMed, Int J Antimicrob Agents) - "Ceftaroline and ceftobiprole pharmacokinetics are highly variable in hospitalized patients, potentially compromising attainment of stringent pharmacokinetic/pharmacodynamic targets for S. aureus infections. Intensified doses and prolonged infusions may therefore be necessary to ensure adequate drug exposure."

Journal • PK/PD data • Review • Infectious Disease

Antibiotic-associated adverse events in bone and joint infections: a FAERS pharmacovigilance study. (PubMed, Front Med (Lausanne)) - "Indication-supported signals included vancomycin-nephrotoxicity (within-cohort ROR 3.30, 95% CI 2.95-3.70), linezolid-hematologic toxicity (3.65, 3.21-4.16), ceftaroline-hematologic toxicity (4.81, 3.42-6.77), and ertapenem-neurotoxicity (4.76, 3.50-6.47). Findings are hypothesis-generating and require validation in controlled observational studies. They prioritize safety signals rather than providing estimates of incidence, absolute risk, causality, dose-response, or renal-function effects."

Adverse events • Journal • Hematological Disorders • Infectious Disease

Trends in Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) infections in Hospitalized Children. (PubMed, J Pediatric Infect Dis Soc) - "The rate of MRSA cases per 1000 hospitalizations decreased over time, while the rate of MRSA cases requiring ICU care remained constant. There was a marked inter-hospital variability in anti-MRSA antibiotic prescribing."

Journal • Infectious Disease

ZINVAN-Trial: Comparing Ceftaroline and Vancomycin for severe infections in the Intensive Care Unit. (ANZCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Hanoi Medical University

New P4 trial • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock

Susceptibility of Staphylococcus aureus Strains Isolated from Blood Cultures Between 2024 and 2025: A Single-Center Study. (PubMed, Antibiotics (Basel)) - "In this single-center cohort, S. aureus bacteremia was associated with high mortality and a substantial burden of MRSA and MDR phenotypes, although preserved activity of key anti-staphylococcal agents was observed. These findings support the need for continuous local resistance surveillance, rapid microbiological diagnosis, and stewardship-guided treatment strategies."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease

Ceftaroline and ceftobiprole monotherapy for the treatment of Staphylococcus aureus infections: a systematic review and Bayesian meta-analysis. (PubMed, J Antimicrob Chemother) - "Current evidence does not demonstrate superiority of ceftaroline or ceftobiprole over standard-of-care therapy for clinical cure in non-urinary S. aureus infections. Estimates remain imprecise and are largely driven by registrational trials and subgroup data. These findings support cautious, indication-specific interpretation rather than routine preference of these agents over established therapies."

Clinical • Journal • Monotherapy • Retrospective data • Review • Infectious Disease

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus to Ceftaroline: A Prospective Observational Study From a Tertiary Care Hospital in North India. (PubMed, Cureus) - "Tetracycline, vancomycin, linezolid, and daptomycin also demonstrated sensitivity rates above 80%. Conclusions These findings demonstrate excellent in vitro susceptibility of MRSA isolates to ceftaroline and support further multicenter studies incorporating clinical outcome data to evaluate its therapeutic role in tertiary care settings. Its clinical use should, however, be reserved for MRSA infections resistant to other antimicrobials."

Journal • Observational data • Preclinical • Infectious Disease

Impact of early vs delayed initiation of dual antimicrobial salvage therapy on clinical outcomes in MRSA bacteremia. (PubMed, Microbiol Spectr) - "Our retrospective observational cohort study investigated the effect of the timing of escalation to dual salvage therapy utilizing ceftaroline with vancomycin or daptomycin for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia on patient outcomes. We sought to address this knowledge gap with our retrospective review of patient outcomes at our hospital system who received ceftaroline for this indication. Overall, earlier initiation of ceftaroline-based dual therapy was beneficial, as evidenced by reduced microbiologic recurrence, shorter duration of bacteremia, reduced metastatic disease, and subsequent shorter duration of therapy if patients were escalated to dual salvage therapy with ceftaroline within 5 days of the index culture."

Clinical data • Journal • Diabetes • Infectious Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

Impact on daptomycin resistance using combination of daptomycin plus ceftaroline in daptomycin-susceptible and -resistant Staphylococcus aureus. (PubMed, FEMS Microbes) - "In addition, coverage profiling detected a large, combination-associated mobile-element/prophage gene-content event in the 703 background affecting an immune-evasion/β-hemolysin-converting region, highlighting that antibiotic pressure can couple resistance dynamics with pathogenesis-relevant genome remodeling. Together, these data show that DAP+CPT provides potent activity beyond synergistic killing-improving clearance while constraining or reshaping resistance evolution-and they define genomic signatures that help explain divergent evolutionary trajectories under DAP alone versus DAP+CPT."

Journal • Cardiovascular • Infectious Disease

Ceftaroline pharmacokinetics on ECMO, a pediatric case report. (PubMed, Int J Antimicrob Agents) - "This case report demonstrates that achieving therapeutic ceftaroline concentrations for patients on ECMO may be feasible using current oxygenators. Clinicians could consider continuing ceftaroline therapy following ECMO cannulation for patients achieving good microbiologic response."

Journal • PK/PD data • Infectious Disease • Influenza • Pediatrics • Pneumonia • Respiratory Diseases

Virulence determinants and toxin profile of methicillin resistant Staphylococcus aureus from commercial cheese in Bangladesh: A public health risk. (PubMed, PLoS One) - "All the isolates showed resistance against penicillin, tetracycline, doxycycline, trimethoprim-sulfamethoxazole and azithromycin, whereas ceftaroline, norfloxacin, and levofloxacin exhibited intermediate level of sensitivity. The substantial prevalence of blaCTX-M-2a (88.46%) and blaTEM (25.64%) highlights the significant public health risks associated with MRSA contamination in cheese. The high occurrence of S. aureus and the detection of multiple toxin-encoding genes further emphasize the need for strengthened monitoring and stricter control measures across the production and distribution chain to reduce contamination and ensure product safety."

Journal • Infectious Disease

Molecular Diversity and Comparison of Staphylococcal Cassette Chromosome mec Element in Hospital- and Community-Associated Methicillin-Resistant Staphylococcus aureus From Pakistan. (PubMed, Int J Microbiol) - "Antibiotic resistance profiles revealed the highest resistance towards ciprofloxacin (78.62%), while high susceptibility rates were recorded for ceftaroline (95.17%), quinupristin/dalfopristin (93.79%), and linezolid (91.03%). Because of the high prevalence of multiresistant type III cassettes, antibiotic resistance is also increasing. The high occurrence of community-specific SCCmec in hospital settings suggests implementing infection control practices to prevent severe MRSA infection and the rise in antibiotic resistance."

Journal • Infectious Disease • CAT

CLINDAMYCIN RESISTANCE OF MSSA AND MRSA IN A REGIONAL HOSPITAL IN CENTRAL GREECE AND THE IMPORTANCE OF LOCAL RESISTANCE RATES FOR APPROPRIATE ANTIBIOTIC SELECTION (ESPID 2026) - "Beta-lactam antibiotics are considered safe to treat methicillin-sensitive Staphylococcus aureus (MSSA), while vancomycin has long been the standard therapy for MRSA; alternative options include clindamycin, daptomycin, ceftaroline, and linezolid...The MRSA rate was 32.4%, while resistance rates to clindamycin, vancomycin, and daptomycin were 18%, 1.8%, and 0.9% respectively, with complete susceptibility to linezolid and rifampicin...Due to clindamycin resistance exceeding 15%, empirical clindamycin treatment is not recommended in severe infections – alternatives include antibiotics with full or near-full susceptibility in the region, such as vancomycin and linezolid. Larger studies are needed to confirm the resistance rates in the region."

Clinical • Infectious Disease

STUDY OF ANTIMICROBIAL RESISTANCE OF STAPHYLOCOCCUS AUREUS STRAINS IN PEDIATRIC PATIENTS OVER A THREE-YEAR PERIOD (2022–2024) (ESPID 2026) - "MRSA strains accounted for 16% of all isolates, while high resistance rates were observed for fucidic acid (50%) and mupirocin (33.3%). Susceptibility to glycopeptides, ceftaroline and linezolid was 100%...MRSA prevalence was highest in surgical departments (31.1%), followed by pediatric wards (12.4%) and the intensive care unit (7.1%). Conclusions/Learning Points In conclusion, the observed seasonal variation of SA infections and high antimicrobial resistance rates to commonly used antibiotics, underscore the importance of susceptibility testing and continuous surveillance to guide appropriate antimicrobial therapy."

Clinical • Infectious Disease

SUCCESSFUL NON-OPERATIVE MANAGEMENT OF MRSA PYOMYOSITIS AND OSTEOMYELITIS IN A PEDIATRIC ATHLETE PRESENTING WITH A PAINFUL LIMP: A CASE REPORT (ESPID 2026) - "The patient was started on a continuous infusion of vancomycin and MRSA decolonization protocols...Due to persistent fever, ceftaroline was added to the daptomycin regimen, leading to marked improvement. After 15-day intravenous treatment, she was successfully transitioned to oral trimethoprim/sulfamethoxazole...Learning Points/Discussion This case underscores the importance of maintaining a high index of suspicion for deep-seated musculoskeletal infections in children presenting with fever and pain, even with unremarkable initial imaging and normal procalcitonin levels. The role of MRI is critical in defining the extent of the disease; this case highlights that a complex MRSA infection can be managed successfully without surgical drainage through an aggressive and staged antimicrobial strategy."

Case report • Clinical • Infectious Disease • CRP