ceftaroline fosamil / Generic mfg. - LARVOL DELTA

Methicillin-Resistant Staphylococcus aureus (MRSA) Strikes Deep: Infected Femoral Aneurysm in a Patient With Deep Vein Thrombosis. (PubMed, Cureus) - "Despite vancomycin, he had persistent bacteremia, and antibiotics were escalated to ceftaroline and daptomycin. In patients with bacteremia and DVT who deteriorate despite treatment, infectious aneurysm should be considered. Early imaging and multidisciplinary care are crucial in preventing rupture and limb loss."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Thrombosis • Venous Thromboembolism • CRP

Use of Daptomycin to Manage Severe MRSA Infections in Humans. (PubMed, Antibiotics (Basel)) - "The data suggest that treatment with high-dose (8-10 mg kg⁻1) DAP shortened the time to blood-culture sterilisation by a median of 2 days compared with standard-dose vancomycin without increasing toxicity when model-informed area-under-the-curve monitoring was employed. Particular attention is given to the synergistic effects of DAP combined with fosfomycin or β-lactams, especially ceftaroline and ceftobiprole, in overcoming persistent and refractory MRSA infections; this approach results in a reduction in microbiological failure relative to monotherapy...Despite promising preclinical and clinical evidence supporting combination strategies, further randomized controlled trials are necessary to establish their definitive role in clinical practice, as are head-to-head cost-effectiveness evaluations. DAP remains a critical option in the evolving landscape of MRSA management, provided its use is integrated with precision dosing, resistance surveillance, and..."

Journal • Review • Infectious Disease

In Vitro Activity of Novel Antibiotics Against Corynebacterium spp. Clinical Isolates Responsible for Difficult-to-Treat Infections. (PubMed, Microb Drug Resist) - "The activity of ceftaroline (MIC90 >2 mg/L), ceftobiprole (MIC90 >8 mg/L), and delafloxacin (MIC90 >1 mg/L) was limited. By contrast, other molecules tested showed higher activity with low MIC90 values: linezolid (MIC90 ≤0.5 mg/L), tedizolid (MIC90 = 0.12 mg/L), dalbavancin (MIC90 = 0.12 mg/L), tigecycline (MIC90 = 0.12 mg/L), eravacycline (MIC90 = 0.06 mg/L), and omadacycline (MIC90 = 0.5 mg/L). One C. striatum strain exhibited a high level of daptomycin resistance after antibiotic exposure (MIC >16 mg/L). The in vitro activity of most of these novel antibiotics is excellent against Corynebacterium clinical isolates. They could represent a real alternative for treating DTT infections due to Corynebacterium spp."

Journal • Preclinical • Infectious Disease

Clinical Impact of Methicillin-Resistant Staphylococcus aureus (MRSA) Misidentification by PCR Due to Polymicrobial Gram-Positive Cocci Bloodstream Infection (ASM Microbe 2025) - "Ceftaroline was initiated for MRSA coverage...He was initially started on vancomycin and piperacillin-tazobactam...After the MRSA was identified as a false positive, the patient was switched to daptomycin and oxacillin prior to vascular surgery... The Cepheid Xpert MRSA/SA Blood Culture test performs well overall. Out of 814 tests, only 0.25% produced incorrect results due to the presence of mixed GPC. While extremely rare, these incorrect results may impact therapy and infection control practices."

Clinical • Gram positive • Infectious Disease • Pneumonia • Respiratory Diseases

What is the Best Synergistic Combination Against Enterococcus faecalis? In-Vitro Synergy Activity of Ampicillin in Combination with Cephalosporins and Carbapenems for Determining Synergy, Addition, and Antagonism (ASM Microbe 2025) - "In this study we compared the activity and potential synergy between ampicillin (AMP) with cephalosporins (ceftaroline-CPT or ceftriaxone-CRO) and carbapenems (ertapenem-ERTP or imipenem-IMI) in vancomycin susceptible E. faecalis. The combination AMP with cephalosporins demonstrated the most synergy/additive effect with AMP + CPT at 67% (n=16), followed by the combination of AMP and CRO at 37.5% (n=9). AMP and carbapenem combination yielded the least effects with AMP and IMI being the lowest with no synergy observed."

Combination therapy • Preclinical • Cardiovascular • Gastrointestinal Disorder • Infectious Disease • Nephrology

Adjunctive β-lactams for Staphylococcus aureus bacteremia: a narrative review. (PubMed, Ther Adv Infect Dis) - "Approaches such as the Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR) enable holistic evaluations of treatment efficacy and safety, accounting for the overall patient experience. Future research should prioritize individualized treatment strategies, leveraging biomarkers and refined risk stratification to identify patients most likely to benefit from adjunct β-lactam therapy while minimizing adverse events."

Journal • Review • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease

Ceftaroline Exhibits Promising In Vitro Activity Against Methicillin-Resistant Staphylococcus aureus Clinical Isolates From Alexandria, Egypt. (PubMed, Int J Microbiol) - "Of the five SDD isolates, three were identified as spa type t037, corresponding to ST-239, ST-240, or ST-241 by multilocus sequence type (MLST), whereas the two remaining isolates were untypeable. From various clinical samples, ceftaroline demonstrated excellent in vitro activity against MRSA strains, positioning it as a promising therapeutic option for managing MRSA infections in Egypt."

Journal • Preclinical • Infectious Disease

An Unexpected Culprit: Sympathetic Pleural Effusion as a Rare Manifestation of Pyogenic Spondylodiscitis (ATS 2025) - "Patient's dialysis catheter was removed and he was initially treated with cefepime and vancomycin, narrowed to vancomycin once blood cultures confirmed MRSA. The patient was anticoagulated with intravenous heparin for the PE, and a new Quinton catheter was placed. Despite appropriate antibiotic therapy, the patient remained persistently MRSA positive, leading to escalation of antibiotics to ceftaroline and daptomycin, and subsequent salvage therapy with linezolid added for 14 days due to prolonged bacteremia...These sympathetic pleural effusions are usually sterile but may mimic infectious or malignant effusions due to their exudative nature. As initial investigations for pleural effusions often focuses on pulmonary pathology, diagnosis of non-pulmonary causes like spondylodiscitis may be delayed leading to potential adverse outcomes like poor neurological recovery."

Pleural effusion • Back Pain • Cardiovascular • Chronic Kidney Disease • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Nephrology • Oncology • Pain • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Tuberculosis

Balancing Infection and Inflammation Control: A Case of Burkholderia Multivorans Pneumonia in Chronic Granulomatous Disease (ATS 2025) - "Initial blood cultures grew Staphylococcus hominis, and the patient was treated with Ceftaroline and Isavuconazole. As the patient's condition worsened, he was admitted to the ICU, requiring vasopressor support, mechanical ventilation, and broad-spectrum antimicrobials, including Meropenem, Linezolid, and Amphotericin B. Bronchoalveolar lavage (BAL) cultures later identified Burkholderia multivorans, prompting the addition of Bactrim... This case highlights the critical importance of balancing infection management and inflammation control in CGD patients. The judicious use of corticosteroids, in combination with appropriate antimicrobial therapy, may be effective in managing refractory infections complicated by granulomatous inflammation. However, further research is essential to establish the safety and efficacy of corticosteroid use in CGD-related infections."

Clinical • Cough • Immunology • Infectious Disease • Inflammation • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • CAT • IFNG

Management of Status Asthmaticus Requiring Intubation and VV-ECMO Secondary to S. Pneumoniae Pneumonia, Bacteremia, and Rhinovirus Infection (ATS 2025) - "The next day, blood and ventilator cultures identified S. pneumoniae, and the respiratory viral panel tested positive for Rhinovirus; she had initially been placed on empiric vancomycin and piperacillin-tazobactam, but later transitioned to ceftaroline with clinical improvement. Our patient, a 29-year-old immunocompetent woman vaccinated with PPSV23 and with asthma as her only preexisting condition, highlights the need for careful evaluation and management of S. pneumoniae in younger patients with underlying pulmonary issues. This case also demonstrates the ability to successfully bridge refractory asthma exacerbation to recovery with the V-V ECMO."

Intubation • Asthma • Cardiovascular • Immunology • Infectious Disease • Metabolic Disorders • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Daptomycin Dilemma: Navigating Dosing in a Critically Ill Post-LVAD, Post-xenothymokidney Transplant Patient (ATS 2025) - "The patient was empirically started on daptomycin (10 mg/kg daily) and ceftaroline (600 mg every 8 h)...After 2 doses of linezolid combined with sertraline, the patient developed myoclonus secondary to serotonin syndrome, leading to linezolid discontinuation...Abscess development on POD 31 likely reflects bacterial proliferation in a protected space (hematoma) rather than antimicrobial failure. Pharmacokinetic studies in porcine xenothymokidneys are essential to determine optimal doses."

Clinical • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Infectious Disease • Movement Disorders • Transplantation

EVALUATING THE USE OF CEFTAROLINE: A THIRD-LEVEL CENTRE CASE SERIES (ESPID 2025) - "Further research is needed to explore additional therapeutic indications, optimize dosing strategies, and assess its role in managing complex infections. Although therapeutic drug monitoring is not routinely required, it may be beneficial in critically ill patients to optimize dosing."

Clinical • Infectious Disease • Pneumococcal Infections

USE OF NEW ANTIBIOTICS IN PEDIATRIC CARE: INSIGHTS FROM THE BREF STUDY ON RELEVANCE AND PRESCRIBING PRACTICES (ESPID 2025) - "In group B, 18 children received the association of ceftazidime/avibactam (n=10 in association with aztreonam), 10 fidaxomicin, 10 dalbavancin, 3 ceftaroline, 3 meropenem/vaborbactam, 3 colymicin, 1 cefiderocol, 1 ceftolozane/tazocillin, 1 imipenem/relebactam, 1 tigecycline. Conclusions/Learning Points These preliminary findings highlight a high rate of probabilistic treatment with daptomycin, while other molecules appear to be used more judiciously. The results suggest that daptomycin has found a role in routine pediatric ATB prescriptions, whereas other "new ATBs" are reserved for the optimal management of complex or resistant infections."

Clinical • Infectious Disease

Drug-Induced Leukocytoclastic Vasculitis From an Unreported Source: Daptomycin. (PubMed, Cureus) - "At the time of the biopsy, warfarin and daptomycin were discontinued, and the patient was transitioned to heparin and ceftaroline. This case is clinically significant as it represents the first reported case of LCV associated with daptomycin use. It underscores the importance of considering the patient's history, clinical presentation, and histopathological findings to ensure prompt recognition and management of this rare drug reaction, allowing for the resolution of LCV."

Journal • Cardiovascular • Immunology • Infectious Disease • Oncology • Pain • Vasculitis

Comparison of ceftriaxone versus ceftaroline in combination with ampicillin or penicillin against Enterococcus faecalis. (PubMed, Microbiol Spectr) - "Ceftaroline is an alternative cephalosporin that has been explored as it does not carry the risks ceftriaxone has to increase vancomycin resistance and Clostridoides difficile infection. The activity of ceftaroline-based combinations against borderline-PRASEF is unknown. This study demonstrates the ability of ampicillin or penicillin plus ceftaroline to maintain activity against borderline-PRASEF where ampicillin or penicillin plus ceftriaxone combination activity is limited."

Journal • Cardiovascular • Infectious Disease

Global patterns of antibiotic resistance in group B Streptococcus: a systematic review and meta-analysis. (PubMed, Front Microbiol) - "The highest resistance rates were observed for tetracycline (80.1, 95% CI: 77.1-82.8%), while tedizolid (0.1, 95% CI: 0.0-0.8%) showed the lowest resistance rates. Significant heterogeneity in resistance rates was observed, particularly for antibiotics such as azithromycin and gentamicin (I 2 = 97.29%), variability across studies. On the other hand, tigecycline and ceftaroline exhibited no heterogeneity (I 2 = 0%), suggesting consistent resistance patterns...Significant increase in resistance rates for several antibiotics over time, including clindamycin, erythromycin, ceftriaxone, cefuroxime, ciprofloxacin, levofloxacin, moxifloxacin, chloramphenicol, and ofloxacin...Rising resistance trends for multiple antibiotics underscore the urgent need for global surveillance and improved antibiotic stewardship. https://www.crd.york.ac.uk/PROSPERO/view/CRD42024566269, CRD42024566269."

Journal • Retrospective data • Review • CNS Disorders • Infectious Disease • Septic Shock

Time to reappraise the antibiotic treatment for methicillin-susceptible Staphylococcus aureus infective endocarditis: data from the experimental model. (PubMed, J Infect Dis) - "In the MSSA experimental endocarditis model, daptomycin combinations with beta-lactams had significantly better activity than either their monotherapies in sterilizing valve vegetations and preventing DNS development. These findings support their use in clinical practice and to perform clinical trials."

Journal • Cardiovascular • Infectious Disease

Do Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Require Ceftaroline Dosage Adjustments? Ceftaroline PopPK Model and Dosage Simulations with the Probability of Target Attainment Analysis Based on Retrospective Data. (PubMed, Antibiotics (Basel)) - " Our successfully developed model allows flexible PK simulations of ceftaroline, including real-time changes in settings and even temporary or permanent cessation of CRRT. However, the results of our study warrant clinical validation and should be used with caution primarily due to the limited CRRT patient number included in the analysis."

Journal • Retrospective data • Critical care • Infectious Disease • Pneumonia

Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in Dogs from Cape Verde and São Tomé and Príncipe: Implications for Public Health. (PubMed, Antibiotics (Basel)) - "Antimicrobial susceptibility testing showed 100% resistance to aztreonam, cefotaxime, cefpodoxime, and ceftaroline, and high resistance to cefepime (93.8%), ciprofloxacin (93.8%), and trimethoprim/sulfamethoxazole (90.6%). All isolates were considered multidrug-resistant but remained susceptible to cefoxitin, imipenem, and meropenem...DNA fingerprinting revealed seven clusters, suggesting genetic diversity and strain dissemination across locations. These findings highlight the role of dogs as vectors for antimicrobial resistance dissemination, underscoring the need for continuous surveillance in both veterinary and human medicine."

Journal • Infectious Disease • Pneumonia

Uvarinol and Dichamanetin Derived from Uvaria chamae as Potential Dual-Site Inhibitors Against PBP2a in Methicillin Resistant Staphylococcus aureus: An In Silico Study. (PubMed, Pharmaceuticals (Basel)) - " Among the evaluated compounds, Uvarinol and Dichamanetin demonstrated high binding affinities compared to the co-crystallized ligand and standard antibiotics like ceftaroline... Uvarinol and Dichamanetin show promise as dual-site PBP2a inhibitors, offering a novel strategy to combat MRSA resistance. Their structural and pharmacokinetic properties make them viable candidates for further development, though experimental validation and formulation optimization are necessary to overcome bioavailability challenges."

Journal • Gastrointestinal Disorder • Infectious Disease

In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication. (PubMed, Viruses) - "CF inhibited viral replication in the human Calu-3 cell model at submicromolar concentrations when added to cell culture medium at 12 h. Our results suggest that CF should be evaluated as a potential repurposing agent for COVID-19, considering not only viral proteases but also other viral targets and relevant cellular pathways. Additionally, the reactivity of sulfur in the 1,2,4-thiadiazole moiety warrants further exploration for the development of viral protease inhibitors."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CTSS

Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: pharmacokinetics and probability of target attainment. (PubMed, Int J Antimicrob Agents) - "In healthy subjects, ceftaroline, ceftazidime and avibactam poorly distribute to CSF. Nonetheless, CSF exposure of both cephalosporins might be sufficient to cover certain, but not all, pathogens causative of CNS infections."

Journal • PK/PD data • Infectious Disease

Stability of the antibiotic ceftaroline fosamil with focus on degradation products and decomposition pathways - Integrative analysis by LC-DAD, ESI-QTOF and in silico prediction. (PubMed, J Pharm Biomed Anal) - "Through mass spectrometry analysis by ESI-QTOF, the degradation products m/z 303, m/z 337, m/z 442, m/z 483, and m/z 543 and their degradation pathways were proposed. It was possible to partially relate the results of mass spectrometry and in silico experimental model for predicting degradation products."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

METHICILLIN-RESISTANTSTAPHYLOCOCCUS AUREUSPURULENT PERICARDITIS WITH CARDIAC TAMPONADE FOLLOWING PERCUTANEOUS INTERVENTION - Bahjat Ghazzal (ACC 2025) - "Despite vancomycin therapy, the patient continued to deteriorate with persistent bacteremia and continuous pericardial drainage. Three days later, antibiotics were escalated to daptomycin and ceftaroline, and subtotal pericardiectomy was planned... Early recognition and aggressive management of purulent pericarditis are critical. Surgical intervention may be necessary for refractory cases."

Cardiovascular • Infectious Disease • Pain

PATENT FORAMEN OVALE CLOSURE DEVICE ENDOCARDITIS - Berniece Johnson (ACC 2025) - "He was discharged on vancomycin and ceftaroline for total of 6 weeks. Endocarditis of occluding devices is well-known, but rare phenomenon and occurs usually before complete endothelization. Endocarditis of occluding devices is well-known, but rare phenomenon and occurs usually before complete endothelization. TEE is warranted in patients with clinical suspicion of endocarditis when a prosthetic heart valve or an intracardiac device is present. Prolonged antibiotic management could be crucial in these patients."

Cardiovascular • Immunology • Infectious Disease • Pain • Rheumatology