ceftaroline fosamil / Generic mfg. - LARVOL DELTA

Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study. (PubMed, Infect Dis Ther) - "The recently reported ST105(CC5)-SCCmecII-t002 clone has disseminated in hospitals from different Brazilian regions, together with other lineages that have been previously associated with community-associated infections, composed a new molecular landscape of MRSA causing HA BSIs in Brazil."

Clinical • Journal • Infectious Disease

P012 Metastatic Staphylococcus aureus bacteraemia in atopic dermatitis: a case series. (PubMed, Br J Dermatol) - "IV, intravenousPatientClinical manifestationsComplications of SABTreatment of metastatic SABOutcome1Diaphoresis, rigors, nausea, fatigueMitral/aortic valve IE8 weeks IV flucloxacillinRecommenced on methotrexate; good control of AD2ErythrodermaMitral valve IE6 weeks IV flucloxacillinCommenced on dupilumab; excellent control of AD3Pyrexia and rigors following abscess development at footMitral/aortic valve IE6 weeks IV cefazolinMitral valve repair for mitral regurgitation. Recent commencement of dupilumab; AD improving4Erythroderma, subjective fevers, fatigueMRSA bacteraemia with mitral valve IETotal duration 6 weeks 6 days: IV vancomycin → IV daptomycin → IV ceftaroline + vancomycin → oral linezolidRecent recommencement of tralokinumab; AD improving5Right shoulder painSeptic arthritis of right shoulderIV flucloxacillin + vancomycin → 8 weeks daptomycin + rifampicin → 6 weeks doxycyclineCommenced on dupilumab; excellent control of ADAD, atopic dermatitis; IE, infective..."

Journal • Atopic Dermatitis • Cardiovascular • Cognitive Disorders • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain • Rheumatology

In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis. (PubMed, J Antimicrob Chemother) - "Exebacase activity was independent of methicillin resistance and consistently higher against S. aureus than S. epidermidis. Further research is warranted to explore lysins in combination against staphylococcal infections."

Journal • Preclinical • Cardiovascular • Infectious Disease

Correction for Funk et al., "Comparison of ceftriaxone versus ceftaroline in combination with ampicillin or penicillin against Enterococcus faecalis". (PubMed, Microbiol Spectr) - No abstract available

Journal

How to use novel antimicrobials beyond official indications: an expert consensus. (PubMed, JAC Antimicrob Resist) - "The process comprised three survey rounds evaluating off-label uses of eight drugs: ceftazidime-avibactam, ceftolozane-tazobactam, cefiderocol, ceftaroline, ceftobiprole, dalbavancin, tedizolid, and isavuconazole. The guidance prioritizes targeted treatment over empirical use, aligning with international ASP principles and WHO recommendations. These results provide a regional reference to optimize ASP initiatives focus on new antibiotic use while minimizing ecological impact and resistance development."

Journal • Cardiovascular • Critical care • Infectious Disease

Case report of peritoneal dialysis-associated peritonitis caused by Mycobacterium abscessus in a child, successfully treated with dual β-lactam combination therapy. (PubMed, ASM Case Rep) - "Many regimens use amikacin, which can worsen renal function and cause deafness...Based on predicted synergy testing, the patient was treated with a combination that included meropenem and ceftaroline for the initial intensified intravenous phase, followed by a regimen that included amoxicillin combined with cefdinir for step-down therapy...This case highlights the potential benefit of dual β-lactam therapy for the treatment of M. abscessus infection as a well-tolerated regimen for a difficult-to-treat infection. To our knowledge, this is the first report using this approach for the treatment of M. abscessus peritonitis."

Journal • Infectious Disease • Nephrology • Otorhinolaryngology • Renal Disease

A mixed methods approach (EXPANS) to assess current and future uses of antimicrobials: a case study of ceftaroline. (PubMed, Eur J Clin Microbiol Infect Dis) - "The components used in our EXPANS approach were complementary, gathering original data on clinical experiences with specific antimicrobials and identifying barriers to their use in practice. We recommend this systematic approach to explore untapped potential of existing antimicrobial agents and optimize their use."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Leukopenia

A SINGLE CENTER RETROSPECTIVE EXPERIENCE ABOUT INFECTIONS AND ANTIMICROBIALS USE DURING CAR T-CELLS HOSPITALISATION FOR RELAPSED/REFRACTORY LYMPHOMA (SIE 2025) - "Twenty-six lymphoma pts were treated from April 2021 to December 2024: 16 DLBCL, 5 PMBCL and 5 MCL received Axi-Cel (14 pts), Tisa-Cel (7 pts) and Brexu-Cel (5 pts)...Eighteen pts received Tocilizumab, 17 pts Dexamethasone, 10 pts received high dose Metilprednisolone, 4 pts had Anakinra...The most prescribed molecule was piperacilline-tazobactam in 1st line for 24 pts; follows meropenem used in 11 pts as 2nd line and vancomycin in 11 pts as 2nd antibiotic and in 8 pts as 3rd molecule. Three pts received Linezolid (as 2nd, 3rd and 4th molecule respectively), two pts fosfomycine (as 3rd and 4th molecule in association), one pt teicoplanine as 3rd molecule, 1 pt Ceftaroline as 5th antibiotic. Drugs like Cefiderocol and Vaborem were used 3 times: the latter was used as 4th and 5th molecule in 2 pts and Cefiderocol as 1st line in the context of known A.Baumannii and S. Maltophilia colonisation...For mold prophylaxis, 14 pts received Mycafungin, 6 pts Isavuconazole, 4 pts..."

CAR T-Cell Therapy • Retrospective data • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Lymphoma • Primary Mediastinal Large B-Cell Lymphoma • Respiratory Diseases

Ghost Catheter Fibrin Sheath Presenting with Septic Pulmonary Emboli (AHA 2025) - "It's typically detected incidentally on imaging like echocardiography or CT.Case33-year-old female with a history of polysubstance IV drug abuse, hepatitis C infection, multiple hip surgeries with abscess drainage, tricuspid valve endocarditis with MRSA bacteremia, treated with IV Ceftaroline and daptomycin for 6 weeks via left PICC line, which was removed 2 weeks before her hospital presentation...Patient was started on Anticoagulation with Eliquis and was evaluated by the Cardiothoracic surgery team for possible AngioVac, yet no good targets were found, and a decision was made to treat the patient medically without placing any further central lines...AngioVac has been used in some instances, but its clear benefits has not been established. Our case demonstrated complete resolution of the GFCS with anticoagulation despite not being compliant with antibiotics."

Cardiovascular • Hematological Disorders • Hepatitis C • Hepatology • Infectious Disease • Inflammation • Pneumonia • Pulmonary Embolism • Thrombosis

A TRIFECTA OF CHALLENGES: A CASE REPORT OF TRIPLE-VALVE ENDOCARDITIS (CHEST 2025) - "He was started on broad-spectrum antibiotics including vancomycin and was later adjusted to salvage therapy of daptomycin and ceftaroline due to persisting bacteremia. Triple Valve Endocarditis is a rare presentation and has a poor prognosis.Early diagnosis and treatment with surgery is crucial."

Case report • Clinical • Anemia • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Fibrosis • Gastroenterology • Heart Failure • Hematological Disorders • Hepatology • Hypotension • Immunology • Infectious Disease • Liver Cirrhosis • Respiratory Diseases • Septic Shock • Thrombocytopenia

A BRAIN TEASER: MRSA BRAIN ABSCESS PRESENTING AS BRAIN METASTASIS (CHEST 2025) - "Despite initial stabilization with benzodiazepines, he experienced another seizure and was treated with levetiracetam...A brain CT revealed a right parietal mass with vasogenic edema, for which dexamethasone and antiepileptics were started.CT imaging of the chest, abdomen, and pelvis revealed multiple pulmonary nodules and heterogeneous bone lesions, raising suspicion for metastatic disease...Vancomycin and ceftaroline were continued until blood cultures cleared, followed by a six-week course of daptomycin... This case illustrates the complexity of diagnosing and managing a brain abscess. The overlapping clinical and radiological features with other intracranial pathologies can delay diagnosis and treatment. Early recognition, advanced imaging, and tailored treatment with a multidisciplinary approach are crucial."

CNS Disorders • Epilepsy • Infectious Disease • Psychiatry • Schizophrenia • Solid Tumor

MANAGEMENT OF ELECTRODE LEAD ENDOCARDITIS IN A PATIENT WITH MRSA OSTEOMYELITIS AND AICD (CHEST 2025) - "Upon admission, he was treated with ceftaroline and daptomycin to cover the documented MRSA. This case underscores the importance of considering electrode lead endocarditis in any patient with bacteremia and an indwelling cardiac device. Early recognition and intervention, including laser-assisted lead extraction, can significantly improve clinical outcomes in these patients."

Clinical • Acute Respiratory Distress Syndrome • Anesthesia • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Hypertrophic Cardiomyopathy • Infectious Disease • Inflammation • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Ventricular Tachycardia

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SEPTIC EMBOLISM FROM PELVIC VEIN THROMBOPHLEBITIS: A CASE OF SUCCESSFUL MANAGEMENT WITH MECHANICAL THROMBECTOMY (CHEST 2025) - "Vancomycin and Ceftaroline were started...She went on to make a gradual recovery and completed a 6 week course of Daptomycin and Linezolid... Mechanical thrombectomy is a novel minimally invasive technique for source control that can be utilized for septic thrombophlebitis when traditional therapies of systemic antibiotics, anticoagulation and surgical intervention fail."

Clinical • Cardiovascular • CNS Disorders • Infectious Disease • Inflammation • Musculoskeletal Pain • Respiratory Diseases • Venous Thromboembolism

A RARE CASE OF RECURRENT BILATERAL PNEUMOTHORAX SECONDARY TO SEPTIC PULMONARY EMBOLI FROM TRISCUSPID VALVE ENDOCARDITIS IN AN INTRAVENOUS DRUG ABUSER (CHEST 2025) - "Persistent positive blood cultures led to a change in antibiotics to daptomycin and ceftaroline. Spontaneous bilateral pneumothorax is a rare but lethal complication of septic pulmonary embolism from endocarditis. Vigilant clinical monitoring, early identification of pneumothorax and rapid management are needed to prevent catastrophe. In intubated patients using lung protective strategies with low tidal volumes may reduce barotrauma, further decreasing the risk of pneumothorax and overall mortality."

Clinical • Cardiovascular • Infectious Disease • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Septic Shock

SPONTANEOUS BACTERIA EMPYEMA OF AN UNUSUAL PATHOGEN: MRSA (CHEST 2025) - "The patient was initially treated with IV Vancomycin and Zosyn...Antibiotics were switched to Daptomycin and Ceftaroline salvage therapy... SBEM is an infection of a hepatic hydrothorax, typically seen in patients with cirrhosis and ascites. SBEM associated with high mortality, making early and prompt antibiotic treatment crucial for improving patient outcomes."

Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Respiratory Diseases • Septic Shock

RAPIDLY PROGRESSIVE NECROTIZING MRSA PNEUMONIA WITH RECURRENT PNEUMOTHORACES: A FATAL CASE OF SUSPECTED PVL-POSITIVE INFECTION IN A POSTPARTUM PATIENT (CHEST 2025) - "Empiric therapy with vancomycin and oseltamivir was initiated, alongside high-flow oxygen and anticoagulation with therapeutic Lovenox...She progressed to severe acute respiratory distress syndrome (ARDS), necessitating neuromuscular blockade, prone positioning, lung-protective ventilation, and dexamethasone therapy. Concerns for infective endocarditis persisted due to persistent MRSA bacteremia over nine days despite escalation to ceftaroline and daptomycin... Final conclusions of this case are pending while awaiting the result of the bacterial typing wide genome sequencing lab test sent to Mayo Clinic Laboratories."

Clinical • Acute Respiratory Distress Syndrome • Cardiomyopathy • Cardiovascular • Dermatology • Gynecology • Hematological Disorders • Hypertension • Infectious Disease • Inflammation • Influenza • Pneumonia • Pulmonary Embolism • Respiratory Diseases

GHOST CATHETER FIBRIN SHEATH (GCFS) FORMATION AFTER PERIPHERALLY INSERTED CENTRAL CATHETER (PICC) LINE PLACEMENT, COMPLICATING INFECTIVE ENDOCARDITIS (CHEST 2025) - "She was recently discharged from the hospital after being diagnosed with Infective endocarditis, growing Methicillin-resistant Staphylococcus aureus, and had PICC line placed for completion of 6 weeks IV antibiotics wherein she completed treatment with Ceftaroline and Daptomycin infusion. GCFS is a rare sequelae of catheter removal which poses a challenge for clinicians as there has been no specific guidelines for its diagnosis and treatment. While its complications are rare, likelihood should not be disregarded."

Cardiovascular • Hematological Disorders • Hepatitis C • Hepatology • Infectious Disease • Inflammation • Pulmonary Embolism • Respiratory Diseases

A RARE CASE OF TAVR-IE WITH ATYPICAL PRESENTATION (CHEST 2025) - "CASE PRESENTATION: A 64-year-old male with a complex cardiovascular history, including non-rheumatic aortic stenosis and aortic insufficiency managed with transcatheter aortic valve replacement (TAVR), coronary artery disease (CAD) with prior stents, atrial fibrillation on anticoagulation who presented with epistaxis, black stools, and groin wound bleeding while on Brilinta and Eliquis...Vancomycin was initiated and later optimized for daptomycin and ceftaroline to target culture sensitivities and mitigate nephrotoxicity risks... We aim to raise clinical suspicion of the atypical presentations in patients with prior TAVR. With mortality rates as high as 40%, early recognition and intervention are paramount. Multi-center registries for TAVR-IE are urgently needed to refine diagnostic accuracy and improve outcomes."

Clinical • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Hematological Disorders • Infectious Disease • Ischemic stroke • Thrombocytopenic Purpura

DAPTOMYCIN-INDUCED HYPOXEMIA: MORE THAN JUST HEART FAILURE (CHEST 2025) - "INTRODUCTION: Daptomycin is a bactericidal antibiotic commonly given for methicillin-resistant staph aureus (MRSA) and vancomycin-resistant enterococcus (VRE) bacteremia...Initially he was suspected of heart failure exacerbation in the setting of sepsis, undergoing aggressive diuresis with continued daptomycin and added ceftaroline; however despite volume optimization, hypoxemia worsened to requiring high-flow nasal cannula a few days after admission... Despite an initial presentation of sepsis and heart failure exacerbation, worsening respiratory failure prompted consideration of secondary causes of acute hypoxemia, implicating daptomycin-induced eosinophilic pneumonia that quickly resolved with high-dose steroid therapy."

Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Cough • Eosinophilia • Heart Failure • Hypertension • Infectious Disease • Myositis • Nephrology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • CCL11 • IL5

Antimicrobial resistance among agents of community-associated lower respiratory tract infection in the UK and Ireland: trends from 1999/2000 to 2018/2019. (PubMed, J Antimicrob Chemother) - "CA-LRTI remains eminently treatable, yet shifts are occurring in the serotypes of S. pneumoniae most associated with resistance and in the nature of amoxicillin resistance in H. influenzae. β-Lactamase-related cephalosporin MIC differentials for M. catarrhalis are striking but their clinical significance remains uncertain."

Journal • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

A COMPLEX CASE OF RUPTURED LUNG ABSCESS IN A PATIENT WITH EPILEPSY (CHEST 2025) - "Empirical treatment with ceftriaxone and azithromycin was initiated for suspected aspiration pneumonia following a seizure.Given persistent fever and worsening hypoxemia, he was transferred to the ICU...Extensive infectious workup, including testing for Mycobacterium tuberculosis, Histoplasma and Aspergillus was negative.Given worsening hypoxemia, antimicrobials were escalated to linezolid, ceftaroline, cefepime and metronidazole, for dual MRSA and gram-negative organism coverage...After 7 days, antibiotics were narrowed to vancomycin and upon clinical stabilization, patient was discharged on a six-week course of linezolid... This case highlights the complexity of managing an evolving LA, BPF with subsequent rupture and associated polymicrobial infection. Early broad-spectrum antimicrobial therapy tailored to culture results, along with vigilant monitoring and supportive care, facilitated clinical stabilization. While most cases of LAs resolve with prolonged antibiotic..."

Clinical • Addiction (Opioid and Alcohol) • Bronchiectasis • Cardiovascular • CNS Disorders • Cough • Cystic Fibrosis • Epilepsy • Gastrointestinal Disorder • Genetic Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Antimicrobial Susceptibility Trends in E. coli Causing Pediatric Urinary Tract Infections in the United States (AAP-NCE 2025) - "UPEC susceptibility remained high (>95%) for ceftazidime–avibactam, ceftolozane–tazobactam, colistin, imipenem, meropenem, nitrofurantoin, piperacillin–tazobactam, and tigecycline, with ceftazidime–avibactam and meropenem exhibiting 100% susceptibility. Ampicillin–sulbactam, tetracycline, and trimethoprim–sulfamethoxazole displayed the lowest susceptibility rates ( < 80.0%). Age-related differences were notable, with infants and young (0-24 months) and preschool (3-5 years) children exhibiting lower susceptibility to ampicillin–sulbactam, cefepime, ceftaroline, and ceftriaxone (P < 0.05)... This study highlights substantial demographic variations in UPEC susceptibility and rising ESBL prevalence. Lower susceptibility rates ( < 80%) for certain antibiotics may warrant revised recommendations regarding agents that are used as first-line empiric treatment. Ongoing monitoring and adaptive treatment strategies are essential to address evolving resistance patterns."

Clinical • Infectious Disease • Nephrology • Pediatrics

Evaluation of Ceftaroline Use in Pediatric Patients: A Retrospective Case Series. (PubMed, Antibiotics (Basel)) - "These findings support its use as a therapeutic option when the alternatives are limited. Larger multicenter studies are needed to further evaluate the clinical outcomes and safety of CPT use in pediatric patients."

Journal • Retrospective data • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

SABEDTIO: Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes? (clinicaltrials.gov) - P4 | N=300 | Enrolling by invitation | Sponsor: West Virginia University | Not yet recruiting ➔ Enrolling by invitation

Enrollment open

Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease. (PubMed, IJTLD Open) - "Ceftaroline-avibactam administered twice a day would be an adequate replacement for the four-times-a-day cefoxitin treatments for MAB-LD."

Journal • PK/PD data • Pulmonary Disease • Respiratory Diseases