beta-lapachone (HK-660S)
/ Curome Biosci
- LARVOL DELTA
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July 29, 2025
Correspondence to editorials (CMH-2025-0699) on "Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial".
(PubMed, Clin Mol Hepatol)
- No abstract available
Journal • P2a data
July 15, 2025
Letter to the editor on" Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial. ".
(PubMed, Clin Mol Hepatol)
- No abstract available
Journal • P2a data
May 17, 2025
Efficacy and Safety of HK-660S in the Treatment of Primary Sclerosing Cholangitis
(clinicaltrials.gov)
- P2 | N=105 | Not yet recruiting | Sponsor: CuromeBiosciences
New P2 trial
March 17, 2025
Critical Considerations in Evaluating the Therapeutic Potential of HK-660S for Primary Sclerosing Cholangitis.
(PubMed, Clin Mol Hepatol)
- No abstract available
Journal • Hepatology
November 16, 2024
Correspondence to editorials on "Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial".
(PubMed, Clin Mol Hepatol)
- No abstract available
Journal • P2a data • Hepatology
November 04, 2024
Challenges and Innovations in PSC Clinical Trials: Evaluating HK-660S and the Path Forward.
(PubMed, Clin Mol Hepatol)
- No abstract available
Journal
October 15, 2024
SAFETY AND EFFICACY OF HK-660S VERSUS PLACEBO IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2A TRIAL
(AASLD 2024)
- "This study aimed to assess the clinical feasibility of HK-660S (beta-lapachone) in PSC... This 12-week proof-of-concept trial demonstrated that HK-660S is well-tolerated among PSC patients and may improve bile duct strictures and decrease serum ALP levels. Further randomised trials with long-term follow-up are necessary to confirm these promising results."
Clinical • P2a data • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • Primary Biliary Cholangitis
September 24, 2024
Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial.
(PubMed, Clin Mol Hepatol)
- "This study aimed to assess the clinical feasibility of HK-660S (beta-lapachone) in PSC...HK-660S is well-tolerated among patients with PSC and may improve bile duct strictures, decrease serum ALP levels, and reduce liver fibrosis. (cris.nih.go.kr, Number KCT0006590)."
Clinical • Journal • P2a data • Fibrosis • Hepatology • Immunology • Liver Cirrhosis
April 02, 2024
A randomized phase II proof-of-concept study of beta-lapachone in patients with primary sclerosing cholangitis
(EASL-ILC 2024)
- P2 | "This 12-week proof-of-concept clinical trial demonstrated that HK-660S was well- tolerated in PSC patients and had the potential to decrease serum ALP levels. Further phase 3 randomized trials with long-term follow-up are warranted to validate these promising results. (ClinicalTrials.gov NCT05866809)"
Clinical • P2 data • Cholestasis • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • Primary Biliary Cholangitis
December 14, 2023
Beta-lapachone ameliorates the progression of primary sclerosing cholangitis pathogenesis in rodent models.
(PubMed, Life Sci)
- "This study provided a new concept for PSC treatment, suggesting that pharmacological stimulation of the NAD synthetic pathway and Abcb4 via βL ameliorates PSC pathogenesis."
Journal • Preclinical • Cholestasis • Fibrosis • Hepatology • Immunology • Inflammation • ABCB4 • SIRT1
July 27, 2023
Evaluation of the Safety and Efficacy of HK-660S in Patients With Primary Sclerosing Cholangitis
(clinicaltrials.gov)
- P2 | N=23 | Completed | Sponsor: CuromeBiosciences | Active, not recruiting ➔ Completed
Trial completion • Hepatology
May 19, 2023
Evaluation of the Safety and Efficacy of HK-660S in Patients With Primary Sclerosing Cholangitis
(clinicaltrials.gov)
- P2 | N=23 | Active, not recruiting | Sponsor: CuromeBiosciences
New P2 trial • Hepatology
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