ebastine / Generic mfg. - LARVOL DELTA

Ebastine Versus Mebeverine in IBS Patients (clinicaltrials.gov) - P3 | N=200 | Active, not recruiting | Sponsor: Guy Boeckxstaens | Recruiting ➔ Active, not recruiting

Enrollment closed • Gastrointestinal Disorder

Development of Lyophilized Ebastine-Loaded Novasome Tablets: Comprehensive Physicochemical Characterization and In Vitro/In Vivo Release Evaluation. (PubMed, Recent Adv Drug Deliv Formul) - "The lyophilized Ebastine-loaded novasome tablet constitutes a stable, effective, and pharmacokinetically superior oral dosage form, offering significant potential for enhance the oral bioavailability of poorly water-soluble drugs."

Journal • Preclinical

Second-generation H1 antihistamines for the treatment of chronic urticaria: a network meta-analysis. (PubMed, Front Med (Lausanne)) - "To evaluate the efficacy and safety of 10 commonly used second-generation H1 antihistamines (cetirizine, levocetirizine, loratadine, desloratadine, ebastine, bilastine, olopatadine, rupatadine, fexofenadine, and mizolastine) at licensed doses in treating chronic urticaria using network meta-analysis. In addition, fexofenadine had the lowest incidence of adverse reactions. However, the conclusions of this study still need to be validated by further high-quality randomized controlled trials."

Journal • Retrospective data • Review • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Ebastine for Adjuvant Treatment of Tumor Budding-Positive Liver Cancer After Surgery (clinicaltrials.gov) - P4 | N=45 | Not yet recruiting | Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

New P4 trial • Hepatocellular Cancer • HER2 Positive Breast Cancer • Liver Cancer • Oncology • Solid Tumor

Blood–brain barrier permeability of antihistamines and risk of depression in children and adolescents: a real-world cohort study (CINP 2026) - "Exposure groups were defined by antihistamine BBB permeability: the low-BBB cohort (fexofenadine, bilastine, ebastine, olopatadine, acrivastine) and the high-BBB cohort (diphenhydramine, chlorpheniramine, hydroxyzine, promethazine, doxylamine, triprolidine, pheniramine). This large-scale, real-world analysis suggests that high-BBB-penetrant antihistamines may confer an elevated risk of depression in children and adolescents with allergic rhinitis. The absence of associations for negative-control outcomes supports the internal validity of this finding and implicates BBB permeability as a plausible factor influencing psychiatric vulnerability. Clinically, these results highlight the importance of considering BBB penetrability when selecting antihistamines for pediatric patients, particularly those with emotional or behavioral risk factors."

Clinical • Real-world • Real-world evidence • Acne Vulgaris • Allergic Rhinitis • CNS Disorders • Depression • Immunology • Inflammation • Mental Retardation • Mood Disorders • Psychiatry

Ebastine mitigates cisplatin-induced pulmonary injury associated with alterations in the miR-101/PI3K/mTOR/ULK1 signaling axis. (PubMed, Mol Biol Rep) - "EBT effectively attenuated cisplatin-induced pulmonary injury in rats, and these protective effects were associated with modulation of oxidative stress, inflammatory responses, and alterations in the miR-101/PI3K/mTOR/ULK1 signaling axis. Further mechanistic and clinical investigations are warranted to confirm these molecular interactions and evaluate therapeutic applicability in patients."

IO biomarker • Journal • Inflammation • Respiratory Diseases • AMPK • BCL2 • CASP3 • CD36 • IGF1 • SCARB1 • TSC1 • TSC2 • ULK1

Risk of drug-related aggression in pediatric populations: a pharmacovigilance analysis using the FAERS database. (PubMed, Front Pediatr) - "Signals for tezacaftor, elexacaftor, macrogol, desloratadine, and ebastine were identified despite absent FDA label warnings. The strongest signals were for ebastine (ROR: 23.40) and perampanel (17.41), while montelukast had the highest case volume (N = 1,392). Most drugs showed the highest aRORs in early childhood, except levetiracetam, which peaked in adolescence...This study identifies robust signals linking multiple drugs to pediatric aggression, with elevated risks observed particularly in younger children and females. These findings underscore the need for heightened clinical vigilance, consideration of demographic-specific risks, and updated regulatory labeling to improve pediatric drug safety."

Adverse events • Journal • Pediatrics

CHRONIC KIDNEY DISEASE AND ACUPUNCTURE: AN UNEXPECTED TURNAROUND (ERA 2026) - "The patient was able to discontinue all home medications (sodium bicarbonate, ebastine, pantoprazole, famotidine, macrogol, treoli, rizmoic, trimebutine, pyridostigmine, rifaximin/VSL, normast, bisacodyl, glycerin, senna, buprenorphine) retaining only clonazepam. Why this case is exeptional In summary, this case demonstrates that acupuncture may provide meaningful clinical benefits in patients with CKD who experience refractory symptoms, supporting its consideration as a complementary approach in nephrology care. Table Laboratory Parameters and Medications Changes in a patient treated with Acupuncture Baseline (March 2025) Session VII (July 2025) Follow-up (Jan 2026) sCreat (mg/dL) 2.19 1.68 1.96 Urea (mg/dL) 74 64 79 eGFR (mL/min) 25 35 28 Total sProtein (g/dL) 7.3 7.1 6.9 Uprot (mg/day) 675 693 800 UUrea (g/die) 10 14.4 13.2 Hb (g/dL) 13.4 13.6 13.1 HCO3 (mmol/L) 21 28 21 Total N. Medications 16 1 3 Image TE6 point needling for treating constipation"

Cardiovascular • Chronic Kidney Disease • Constipation • Endometriosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Inflammation • Metabolic Disorders • Movement Disorders • Musculoskeletal Pain • Nephrology • Renal Disease

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2. (PubMed, Protein Sci) - "Lipid composition was found to have no effect on substrate (ebastine) binding affinities...Fluorescence anisotropy measurements with DPH (1,6-Diphenyl-1,3,5-hexatriene) were also used to characterize the membrane fluidity of cholesterol- and sphingomyelin-containing nanodiscs. Together, the results show that lipid composition directly modulates the thermal stability and functional properties of CYP2J2 in nanodiscs and underscore the importance of the charge of the lipid headgroup and membrane fluidity in our understanding of the mechanism by which lipid composition exerts these effects."

Journal

Chinese herbal formulas as adjuncts to antihistamines in chronic spontaneous urticaria: a network meta-analysis of efficacy, recurrence, and safety. (PubMed, Front Pharmacol) - "Among these regimens, loratadine or ebastine combined with Danggui Yinzi demonstrated the most pronounced reduction in recurrence risk, with the effect being more evident in the long-course subgroup (>12 weeks). Certain combination regimens, such as cetirizine combined with Danggui Yinzi and loratadine combined with Guizhi decoction, were associated with a reduced risk of AEs...Further high-quality head-to-head trials are needed to confirm these findings. https://www.crd.york.ac.uk/PROSPERO, identifier CRD420251022634."

Journal • Retrospective data • Review • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria • IL4

TREATMENT PATTERNS, HEALTHCARE RESOURCE UTILIZATION, AND DIRECT MEDICAL COSTS OF CHRONIC URTICARIA IN CHINA: A REAL-WORLD STUDY (ISPOR 2026) - "Over 90% received second-generation antihistamines, mainly ebastine, levocetirizine, and cetirizine. Omalizumab was used by 573 (Tianjin) and 399 (Xiamen) patients, primarily at 300 mg... This real-world study provides comprehensive insights into CU treatment patterns, healthcare resource utilization, and economic burden in China, informing decision-making for CU management and healthcare resource allocation."

Clinical • HEOR • Real-world • Real-world evidence • CNS Disorders • Dermatology • Dermatopathology • Immunology • Infectious Disease • Respiratory Diseases • Sleep Disorder • Urticaria

Effect of cationic amphiphilic drugs on mRNA lipoplex-induced protein expression. (PubMed, J Liposome Res) - "The mRNA lipoplexes were formulated using a modified ethanol injection method and applied to human hepatoma HuH-7 cells, human prostate cancer PC-3 cells, and DC2.4 mouse dendritic cells in the presence of various CADs: ebastine (EBS), loperamide (LPM), carvedilol (CVD), nortriptyline (NRT), desloratadine (DSL), and chloroquine (CQ). However, EBS also diminishes antibody responses triggered by mRNA lipoplexes. Accordingly, caution is warranted when administering lipid-based mRNA vaccines to patients taking CADs, as these drugs may influence vaccine efficacy and safety."

Journal • Genito-urinary Cancer • Hepatocellular Cancer • Liver Cancer • Oncology • Prostate Cancer • Solid Tumor • TNFA

Exploratory Study on the Adjunctive Therapy of Nano-Selenium Capsules in Patients with Chronic Urticaria (ChiCTR) - P=N/A | N=60 | Sponsor: Dematology Hospital of Southern Medical University; Dematology Hospital of Southern Medical University

New trial • Dermatology • Immunology • Urticaria

Molecular and pharmacological impacts of phytochemicals on the enoyl-acyl carrier protein reductase: potential therapeutic implications in tuberculosis. (PubMed, Integr Biol (Camb)) - "Among 42 screened phytocompounds, the top five (Ebastine, 2-Phenylaminoadenosine, Gosogliptin, Lorcainide, and Levomefolic acid) showed promising binding affinities towards InhA (PDB: 2X22), with binding free energy ranging from -9.6 to -10.9 kcal/mol. Computational tools such as molecular docking, molecular dynamics simulations, and predictive toxicology models, provides a rational framework for selecting promising leads for further experimental validation. This integrated approach not only facilitates the translation of traditional medicinal plant knowledge into evidence-based drug discovery but also maximizes the efficiency of the drug development pipeline."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Repositioning of Nonsedating Antihistamine Ebastine for Anti-lung Adenocarcinoma Based on EGFR/ERBB2 Dual-targeting Strategy. (PubMed, Eur J Pharmacol) - "Notably, Ebastine promoted macrophage infiltration and M1 polarization both in vivo and in vitro. Our findings establish Ebastine as a promising therapeutic candidate for EGFR/ERBB2-mutant lung adenocarcinoma through a unique dual-targeting approach that combines direct tumor cell inhibition with enhancement of anti-tumor immunity."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR • HER-2

BREAKING THE CYCLE: EBASTINE INHIBITS PDAC TUMOR PROGRESSION BY DISRUPTING THE CHRONIC STRESS-INDUCED HISTAMINERGIC-NEUROTROPHIN LOOP AND Β-CATENIN SIGNALING. (DDW 2026) - No abstract available

Oncology

Efficacy and safety of oral antihistamines for allergic rhinitis: Network meta-analysis. (PubMed, J Allergy Clin Immunol Pract) - "Although some OAH seem to be more efficacious than others, most differences between individual second-generation medications are trivial or small. In addition, we did not find relevant differences in the safety profiles of second-generation OAH."

Journal • Retrospective data • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report. (PubMed, Medicine (Baltimore)) - "The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly."

Journal • Castration-Resistant Prostate Cancer • Dermatitis • Dermatology • Genito-urinary Cancer • Hormone Sensitive Prostate Cancer • Immunology • Oncology • Prostate Cancer • Skin Cancer • Solid Tumor

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer. (PubMed, Int J Mol Med) - "These findings demonstrated that ebastine effectively disrupts key pathways involved in CSC‑like traits and HER2 activity, even under trastuzumab‑resistant conditions. Its multifaceted inhibitory effects support the repositioning of ebastine as a promising therapeutic strategy for treating refractory HER2‑positive breast cancer."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • ALDH1A1 • EGFR • ERBB3 • VIM

Clinical Observation of Nerve Block Therapy in the Treatment of Refractory Neurodermatitis: A Single-Center Randomized Controlled Trial (ChiCTR) - P=N/A | N=129 | Not yet recruiting | Sponsor: The Seventh Affiliated Hospital Sun Yat-sen University; The?Seventh?Affiliated?Hospital?Sun?Yat-sen?University

New trial • Dermatitis • Dermatology • Immunology • IL13 • IL4

Dose-Dependent Effect of the Histamine 1 Receptor Antagonist Ebastine in Patients With Non-Constipated Irritable Bowel Syndrome. (PubMed, Neurogastroenterol Motil) - "Our study shows that ebastine 40 mg is more effective than 20 mg, resulting in increased symptom control, in particular reduction in abdominal pain, and supports further evaluation of ebastine as treatment of non-constipated IBS."

Journal • Constipation • Dermatology • Gastrointestinal Disorder • Immunology • Pain • Urticaria

Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation. (PubMed, Xenobiotica) - "The deduced amino acid sequences (500-502 residues) were highly homologous (79-87%) to human CYP2J2 and were closely related to human CYP2J2 in a phylogenetic tree.All five novel tree shrew CYP2J genes contained nine coding exons and formed a gene cluster at a genomic region corresponding to human CYP2J2. Except for CYP2J104 mRNA, expression of all tree shrew CYP2J2 mRNAs was detected in liver.All five tree shrew CYP2Js metabolised ebastine and astemizole, typical substrates of human CYP2J2, and thus were functional enzymes with characteristics similar to human CYP2J2."

Journal • CYP2C19 • CYP2E1

Evaluation of photochemical behavior of ebastine and elucidation of its photoproducts. (PubMed, J Pharm Biomed Anal) - "Finally, in silico toxicity prediction was performed for the estimation of toxicological potencies of EB photoproducts, suggesting the nature of EB might be changed by the photodegradation. In conclusion, two novel EB photoproducts were clarified and their formation mechanisms were proposed, which might make it possible to the better understanding of EB photodegradability."

Journal • Allergy • Immunology

Case Report: Delayed-type hypersensitivity reaction to meropenem in an elderly patient-successful management with imipenem-cilastatin. (PubMed, Front Med (Lausanne)) - "This allergic reaction was immediately managed with calcium gluconate, dexamethasone sodium phosphate, and ebastine...Following a 14-day antimicrobial therapy, initially with imipenem-cilastatin and subsequently with amoxicillin-clavulanate potassium tablets, the patient's skin rashes gradually subsided and the infection was successfully controlled. This case highlights the risk of DTH reaction induced by meropenem in clinical settings. Clinicians should remain vigilant for DTH reactions during meropenem therapy and cautiously consider alternative carbapenems such as imipenem-cilastatin."

Journal • Allergy • Dermatology • Immunology • Infectious Disease

A STRANGE CASE OF HYPOKALAEMIA IN A TEENAGER WITH EBASTINE TREATMENT (ESPN 2025) - "We reported the case of a 13 years-old boy with severe and symptomatic hypokalaemia three days after an ebastine initiation treatment with a normal dose. Preliminary plasma and urinary tests suggested a renal waste of potassium without any other electrolytes disorder. Metabolic disorders were corrected with only potassium supplementation and discontinuation of ebastine treatment witch suggested an iatrogenic cause of hypokalaemia."

Clinical • Asthma • Cardiovascular • Hypertension • Immunology • Metabolic Disorders • Pediatrics • Respiratory Diseases