furosemide / Generic mfg. - LARVOL DELTA

Eosinophilic-Rich Linear Immunoglobulin A Bullous Dermatosis (AAD 2026) - "The drug-induced variant is most commonly linked to vancomycin, though other implicated agents include trimethoprim-sulfamethoxazole, amoxicillin, nonsteroidal anti-inflammatory drugs, simvastatin, cyclosporine, furosemide, lithium, and various additional medications...Treatments—including metronidazole gel, prednisone, triamcinolone, mupirocin, and doxycycline—provided minimal relief...Eosinophil-rich LABD has been infrequently reported in both adult and pediatric patients. Known associations include COVID-19 vaccination, parvovirus B19 infection, hematologic malignancies, and certain medications."

Alopecia • Cough • Dermatology • Hematological Malignancies • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Novel Coronavirus Disease • Orthopedics • Pruritus • Respiratory Diseases

Assessment of Antimicrobial Stewardship during Dinutuximab Therapy in a Single Pediatric Institution (HOPA 2026) - "Capillary leak syndrome occurred in 42 encounters (53%) and required treatment with albumin, furosemide, or both in all cases. Ceftriaxone was the most frequently initiated antimicrobial and used in 34 encounters (90%)... In patients with HR NB, dinutuximab was associated with a high incidence of fever and capillary leak syndrome without any documented bloodstream infections, despite frequent sepsis mimicking clinical features. Antipseudomonal antibiotics were infrequently used and appeared appropriate, as patients were not neutropenic."

Clinical • Hypotension • Infectious Disease • Neuroblastoma • Pediatrics • Septic Shock • Solid Tumor • CSF2

Early Prediction of Acute Kidney Injury Using the Furosemide Stress Test in Pediatric Cardiac Surgery Patients. (PubMed, Children (Basel)) - "The findings support the potential clinical utility of the furosemide stress test in the early stages after pediatric cardiac surgery to predict acute kidney injury."

Journal • Acute Kidney Injury • Cardiovascular • Critical care • Heart Failure • Nephrology • Pediatrics • Renal Disease

Comparative Effects of Mineralocorticoid Receptor Antagonism on Organ Dysfunction in COVID-19-Associated ARDS. (PubMed, Biomedicines) - " Spironolactone use was associated with a more favorable trajectory of organ dysfunction and improved volume, electrolyte, and cardiac stress marker dynamics compared with furosemide in patients with COVID-19-associated ARDS. Although confirmation in larger prospective studies is needed, spironolactone may be considered a reasonable diuretic alternative in selected patients, particularly when potassium preservation and avoidance of hypernatremia are clinical priorities."

Journal • Acute Respiratory Distress Syndrome • Critical care • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases

Epidemiology, pharmacological treatment and invasive management of idiopathic intracranial hypertension in Austria: a nationwide, hospital-based, controlled analysis of insurance data. (PubMed, J Headache Pain) - "The estimated prevalence falls within reported ranges for Central Europe while likely underestimating the prevalence due to reliance on hospital discharge data. Treatment patterns generally reflect guideline-based management, although invasive procedures appear overrepresented because hospital data skew towards severe cases. Bariatric surgery is underutilized in patients with IIH compared to those with obesity alone."

Journal • Reimbursement • US reimbursement • Cardiovascular • CNS Disorders • Genetic Disorders • Hypertension • Obesity • Pain • Rare Diseases

Evaluation of Urinary Tubular Biomarkers in Dogs with Myxomatous Mitral Valve Disease Across ACVIM Stages. (PubMed, Vet Sci) - "No urinary biomarker was associated with daily furosemide dose. Urinary tubular biomarkers, particularly uALPc and uGGTc, detect early CvRD in dogs with MMVD and complement traditional serum markers."

Biomarker • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Renal Disease • CST3

Contribution of murine strain background to Na + reabsorption in the kidney. (PubMed, bioRxiv) - "We found that the kidney expression of NHE3, NKCC2, and NCC are strain dependent. Additionally, murine strain significantly contributes to the diuretic responses induced by hydrochlorothiazide, amiloride, and furosemide."

Journal • Preclinical

A Clinical Study of the Effect of MK-2828 on Rosuvastatin or Furosemide in Healthy People (MK-2828-005) (clinicaltrials.gov) - P1 | N=39 | Recruiting | Sponsor: Merck Sharp & Dohme LLC | Not yet recruiting ➔ Recruiting

Enrollment open • Congestive Heart Failure

SGLT2 INHIBITOR PREVENTS LOOP DIURETIC–INDUCED PLASMA VOLUME LOSS THROUGH A VASOPRESSIN-INDEPENDENT THIRSTSTIMULATING MECHANISM (ISN-WCN 2026) - "We recently reported that SGLT2 inhibitor–loop diuretic combination therapy preserves body fluid balance in chronic kidney disease (Front Med 2023, Diagnostics 2024), but the underlying mechanism remains unclear.Methods Non-diabetic male Sprague–Dawley rats were divided into four groups: vehicle (Veh), SGLT2 inhibitor ipragliflozin (Ipra; 5 mg/kg), loop diuretic furosemide (Furo; 50 mg/kg), and combination. Plasma renin activity and aldosterone were markedly increased in the combination group.Conclusion SGLT2 inhibitor–loop diuretic coadministration prevents diuretic-induced plasma volume contraction by stimulating thirst and fluid intake despite reduced AVP activity. This indicates a novel vasopressin-independent thirst mechanism contributing to maintenance of plasma volume during combined diuretic therapy.I have potential conflict of interest to disclose.Astellas Pharma provided ipragliflozin for this project.I did not use generative AI and AI-assisted technologies in..."

Chronic Kidney Disease • Nephrology • Renal Disease

POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME IN A PERITONEAL DIALYSIS PATIENT: A CASE REPORT (ISN-WCN 2026) - "Despite high-dose furosemide, residual urine was only 300 – 400 mL/day, so PD prescription was tailored...To our knowledge, this is the first reported PD case of PRES in which icodextrin was deliberately used to achieve controlled, sustained ultrafiltration during recovery.Download: Download high-res image (214KB)Download: Download full-size imageDownload: Download high-res image (88KB)Download: Download full-size imageDownload: Download high-res image (461KB)Download: Download full-size imageConclusion PRES may occur in PD after interruption of dialysis and antihypertensives. In this first reported PD-PRES case deliberately using icodextrin, pairing targeted blood-pressure control with an osmotically steady PD program enabled controlled ultrafiltration without steep osmotic shifts and resulted in full neurologic recovery."

Case report • Clinical • Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Hypertension • Infectious Disease • Ischemic stroke • Nephrology • Ophthalmology • Renal Disease • Respiratory Diseases

DIURETIC-RESISTANT CONGESTIVE NEPHROPATHY WITHOUT HEART FAILURE: BENEFIT OF SMALL-VOLUME HYPERTONIC SALINE—A CASE REPORT (ISN-WCN 2026) - "A continuous furosemide infusion, even with additional diuretics, did not achieve adequate urine output...HTS likely attenuated maladaptive tubuloglomerular feedback at the macula densa, thereby increasing delivery of sodium chloride to the distal tubule.Conclusion In congestive nephropathy without heart failure, adjunct low-volume HTS may restore diuretic responsiveness and promote decongestion with renal recovery. Prospective work is warranted to establish indications, dosing strategies, and safety profile."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Infectious Disease • Myasthenia Gravis • Nephrology • Renal Disease • Respiratory Diseases • Solid Tumor • Thymic Carcinoma • Thymus Cancer

ASSOCIATION BETWEEN URINARY BIOMARKERS AND DIURETIC RESPONSE IN ACUTE HEART FAILURE: A COHORT ANALYSIS (ISN-WCN 2026) - "Dose conversion was standardized: azosemide 60 mg = furosemide 40 mg, torasemide 8 mg = furosemide 40 mg; oral doses were adjusted using a bioavailability factor 0.5.Urinary biomarkers (L-FABP, NGAL, and tAM) were collected within 3 days of admission, normalized to urinary creatinine, log10-transformed, and standardized (z-scores) using JMP software. Spearman correlation coefficients were weak: L-FABP (r = −0.0142, p = 0.8796), NGAL (r = 0.0203, p = 0.8703), tAM (r = −0.0189, p = 0.8395).Multivariable regression results were as follows:Model 1: L-FABP = 0.044 (95% CI −0.256 to 0.344), NGAL = −0.005 (−0.303 to 0.292), tAM = 0.057 (−0.206 to 0.319)Model 2: L-FABP = 0.054 (−0.274 to 0.381), NGAL = −0.036 (−0.360 to 0.288), tAM = 0.105 (−0.195 to 0.405), LVEF = 0.074 (−0.235 to 0.382), TRPG = 0.179 (−0.179 to 0.537)Model 3: L-FABP = 0.135 (−0.224 to 0.494), NGAL = 0.026 (−0.303 to 0.356), tAM = −0.109 (−0.491 to 0.409), TRPG = 0.247 (−0.115 to 0.609), BNP = −0.183 (−0.570 to..."

Biomarker • Cardiovascular • Congestive Heart Failure • Heart Failure • ADM • FABP1

INTEGRATING MULTIPARAMETRIC KIDNEY MRI TO TRACK STAGE DEPENDENT HEMODYNAMICS, OXYGENATION, AND SGLT2 INHIBITOR RESPONSE IN OBESITY AND TYPE 2 DIABETES (ISN-WCN 2026) - "Assessments included iohexol-measured glomerular filtration rate (GFR) and estimated GFR, p-aminohippurate (PAH) clearance to estimate renal plasma flow (RPF), urinary albumin-to-creatinine ratio (UACR), and kidney MRI metrics: total kidney volume (TKV), apparent transverse relaxation rate (R2*), and medullary furosemide-suppressible oxygen consumption (FSOC) derived from blood oxygenation level dependent (BOLD) MRI...SGLT2 inhibition demonstrates reversal of abnormal renal oxygenation, evidenced by favorable changes in medullary FSOC. These findings support multiparametric MRI as a non-invasive biomarker suite to track progression and therapeutic response in early diabetic kidney disease."

Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Genetic Disorders • Metabolic Disorders • Nephrology • Obesity • Renal Disease • Type 2 Diabetes Mellitus

REGULATION OF NKCC2 PHOSPHORYLATION BY HYPOKALEMIA THROUGH THE PKA–DARPP-32–PP1 PATHWAY IN THE RENAL MEDULLA (ISN-WCN 2026) - "NKCC2 activity was confirmed by furosemide response test following thiazide pretreatment, and medullary expression of osmoregulatory genes was analyzed. Ex vivo kidney slices were treated with DDAVP, forskolin, or calyculin A to assess V2R–cAMP–PKA-PP1 pathway effects on NKCC2 phosphorylation...In LK mice, DARPP-32 phosphorylation shifted from T34 to T75, then pT34 DARPP-32 was diminished along the apical membrane of medullary TALs, together with pPP1A, highlighting the importance of PKA-DARPP-32-PP1 pathway in regulating NKCC2.Conclusion Hypokalemia reduces ADH-PKA signaling and shifts DARPP-32 phosphorylation from T34 to T75, thereby promoting NKCC2 dephosphorylation via the PKA-DARPP-32-PP1 axis, which may underlie impaired urinary concentrating ability. This abstract was also submitted for the Kidney Week 2025 congress."

TNS1

Impact of thiamin supplementation on thiamin pyrophosphate effect and cardiac function in pediatric heart disease patients on diuretics: a randomized controlled trial. (PubMed, Sci Rep) - P3 | "Multiple linear regression showed that furosemide dosage was independently associated with TPPE changes (β: +0.36, p = 0.015), indicating a dose-dependent association with thiamin status...For those with TD, doses exceeding 50 mg/day may be necessary.Trial registration NCT03989700 (ClinicalTrials.gov). Date of registration: 18/06/2019."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Pediatrics

Onset of furosemide-triggered bullous pemphigoid, possibly induced by CD8-positive T cell-mediated hypersensitivity reactions to drug and ultraviolet exposure. (PubMed, Eur J Dermatol) - No abstract available

Journal • Bullous Pemphigoid • Dermatology • Dermatopathology • Immunology • CD8

Prevalence of Missed Medication Doses and Outcomes of Hospitalized Patients Living with HIV in Uganda. (PubMed, Drug Healthc Patient Saf) - "Missed doses were common across nearly all medications, with omission rates exceeding 80% for ceftriaxone, paracetamol, metronidazole, omeprazole, metoclopramide, and levofloxacin, and approaching 100% for furosemide, co-amoxiclav, ondansetron, enoxaparin, albumin, and artesunate. Missed parenteral medication doses are highly prevalent among hospitalized PLHIV in Uganda. Strengthening medication administration and documentation systems is urgently needed to improve patient safety and outcomes."

Journal • Human Immunodeficiency Virus • Infectious Disease

Polysaccharide-based suspensions: A novel pediatric-friendly formulation for administering furosemide through nasogastric tubes. (PubMed, Drug Dev Ind Pharm) - "Oral furosemide suspensions prepared with xanthan gum exhibited satisfactory physicochemical and microbiological stability. These neonatal formulations show potential for the safe management of pediatric cardiovascular disorders."

Journal • Cardiovascular • Pediatrics

PAUSE-CRRT: A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy (clinicaltrials.gov) - P4 | N=80 | Recruiting | Sponsor: Chiang Mai University | N=40 ➔ 80 | Trial completion date: Jun 2024 ➔ Dec 2028 | Trial primary completion date: Jun 2024 ➔ Dec 2028

Enrollment change • Trial completion date • Trial primary completion date • Acute Kidney Injury • Nephrology • Renal Disease

What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia? (PubMed, Curr Treat Options Pediatr) - "This review critically examines the role of furosemide and chlorothiazide in the prevention and management of bronchopulmonary dysplasia (BPD)...In the absence of robust evidence-based guidance, minimizing routine diuretic use and considering short-term, selective treatment with measurable individualized goals is prudent. Addressing the disconnect between widespread use and limited supporting evidence will require well-designed studies that consider optimal patient selection, timing, dosing and duration in the context of current diuretic practice patterns."

Journal • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

Adverse events associated with drug-related thiamine deficiency: A pharmacovigilance study. (PubMed, JPEN J Parenter Enteral Nutr) - "This pharmacovigilance analysis identifies safety signals linking specific medications with thiamine deficiency, potentially mediated by mechanisms such as transport inhibition and metabolic interference. These findings highlight the importance of clinical vigilance and the consideration of thiamine monitoring in high-risk patients to mitigate the risk of neurological complications."

Adverse events • Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Treatment of glomerular and tubular proteinuria in the nephrotic range in a female cat: case report. (PubMed, Braz J Vet Med) - "Treatment included furosemide, dexamethasone, benazepril, omega-3 fatty acid, mirtazapine and renal diet, in addition to procedures such as paracentesis for drainage. The patient remained stable, with no recurrence of symptoms. The therapeutic conclusions are limited by the single-case design, although continuous clinical and laboratory monitoring was implemented, aiming to adjust therapeutic management."

Journal • Glomerulonephritis • Nephrology • Pulmonary Disease • Renal Disease

Evaluation of Albumin Plus Furosemide Versus Furosemide Alone in Pediatric Critical Illness (PAS 2026) - No abstract available

Clinical • Pediatrics

Neonatal Sustained Furosemide Exposure Alters KCC2/NKCC1 Expression and Causes Behavioral Abnormalities during Immature Brain Development (PAS 2026) - No abstract available

Brain Development • SLC12A2

Furosemide pharmacokinetics in infants with established bronchopulmonary dysplasia using whole blood microsampling (PAS 2026) - No abstract available

PK/PD data • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases