furosemide / Generic mfg. - LARVOL DELTA

Mineralocorticoid Receptor Blockade Mitigates Loop Diuretic-Exacerbated Plasma Volume Contraction and Target-Organ Fibrosis in Angiotensin II-Induced Hypertension. (PubMed, Int J Mol Sci) - "Male Sprague-Dawley rats were assigned to six groups (n = 6/group) receiving Sham or Ang II with or without furosemide and spironolactone. Spironolactone attenuated PV contraction, lowered blood pressure, preserved endothelial integrity, alleviated fibrosis, and partially normalized molecular alterations. MR blockade was associated with attenuation of PV contraction and target-organ injury, supporting a potential relationship between PV homeostasis and organ protection during chronic loop diuretic treatment."

Journal • Cardiovascular • Fibrosis • Hypertension • Immunology

A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder. (PubMed, J Clin Med) - "Treated with AVAPS, IV Zosyn, IV Lasix, steroids, bronchodilators, and diuretics. Its occurrence in this patient suggests an unrecognized gastrointestinal manifestation of TSD as the patient does not have known history of portal hypertension. This represents an potentially underreported manifestation of acquired TSD presenting with combined hepatic, pulmonary, hematologic, and gastrointestinal (GAVE) involvement."

Journal • Aplastic Anemia • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Diabetes • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Liver Cirrhosis • Metabolic Disorders • Oncology • Portal Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Thrombocytopenia • DKC1 • TERT • TINF2

Biological Activities and In Silico Molecular Docking of an Aqueous Extract of Nigella sativa L. Seeds: A Focus on Antioxidant, Cytotoxic, and Diuretic Effects. (PubMed, Pharmaceuticals (Basel)) - "We evaluated the diuretic effect in vivo in Wistar rats by measuring urinary concentrations of Na+, K+, Cl-, and creatinine, using furosemide as a reference drug... The aqueous extract of N. sativa demonstrated antioxidant and diuretic activities without significant cytotoxicity. These findings support its pharmacological potential and warrant further investigation of its mechanisms of action and therapeutic relevance."

Journal

Batch-to-Flow Translation of β-Cyclodextrin Polymer Adsorption for Emerging Contaminant Removal: Hydrodynamic and Operational Validation. (PubMed, Polymers (Basel)) - "Under these controlled high-loading conditions, removal was strongly contaminant-dependent: cyproconazole exceeded 90%, acetaminophen reached 72-77%, hydrochlorothiazide reached 40-65%, ciprofloxacin reached 24-50%, and furosemide remained below 30%. These preliminary conditions require confirmation through replicated adsorption-desorption cycles under continuous-flow operation. These results identify laboratory-scale hydrodynamic, adsorption, matrix, and regeneration considerations that require confirmation through fixed-condition, long-term testing during subsequent process development."

Journal

Decisions in Diuretic Resistance: Oral or Subcutaneous Furosemide in Advanced Ambulatory Heart Failure? (PubMed, Biomedicines) - " In this exploratory real-world cohort of patients with advanced HF and refractory congestion, both outpatient strategies were associated with short-term decongestion, with differences observed in symptomatic response. These findings are hypothesis-generating and warrant confirmation in prospective studies using comparable dosing strategies."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

In Vivo Diuretic Efficacy, Antioxidant Capacity, and Mineral Profiling of Tree Gum Exudates from Sour Cherry (Prunus cerasus), Mahaleb (Prunus mahaleb), and Cherry (Prunus avium). (PubMed, Pharmaceuticals (Basel)) - "Rats were assigned to five groups: Control (distilled water), Furosemide (standard drug), PCRWE (group treated with P. cerasus tree gum exudate), PMRWE (group treated with P. mahaleb tree gum exudate), and PARWE (group treated with P. avium tree gum exudate)...Specifically, sour cherry tree gum exudate displays significant diuretic and natriuretic potential, positioning it as a promising natural therapeutic agent for fluid balance management. Further research is required to isolate the active compounds and elucidate their specific mechanism on renal function."

Journal • Preclinical

Safety and Efficacy of Dapagliflozin in Ascites Management (ACG 2026) - "Standard management with spironolactone and furosemide is often limited by suboptimal efficacy and adverse effects. At 1 year, combination therapy was associated with lower all-cause mortality (13.8% vs. 17.9%; HR 0.72, 95% CI 0.60â0.85; p< 0.001) and hospitalization (18.3% vs. 22.6%; HR 0.73, 95% CI 0.63â0.86; p< 0.001), with no difference in paracentesis."

Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Diabetes • Fibrosis • Heart Failure • Hepatology • Hypotension • Immunology • Liver Cirrhosis • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Torsemide vs Furosemide in Cirrhosis and Ascites: A Propensity-Matched Analysis Stratified by Spironolactone Use (ACG 2026) - "The overall matched cohort included 1,666 patients per group. Torsemide was associated with lower all-cause mortality at 30 days (16.4% vs 27.3%; HR 0.53, 95% CI 0.46-0.62), 90 days (24.8% vs 33.2%; HR 0.63, 95% CI 0.55-0.72), and 1 year (31.9% vs 40.2%; HR 0.66, 95% CI 0.59-0.75). Torsemide was also associated with lower hospitalization, paracentesis, ICU admission, and decompensation across all follow-up intervals with similar renal composite outcomes and hyponatremia."

Cardiovascular • Chronic Kidney Disease • Fibrosis • Heart Failure • Hepatology • Immunology • Peritoneal Cancer • Renal Disease

Finerenone vs Spironolactone in MASH-Cirrhosis With CKD: A Propensity Score-Matched Real-World Study (ACG 2026) - "1:1 propensity score matching on demographics, heart failure, portal hypertension, varices, medications (ARBs, ACEi, furosemide, beta-blockers), and labs (potassium, bilirubin, eGFR, platelets, albumin, ALT, INR). Before matching, 207â227 finerenone and 26,400â29,701 spironolactone users were identified. Finerenone users had lower bilirubin (0.81 vs 2.21 mg/dL), higher albumin (3.89 vs 3.24 g/dL), and lower baseline eGFR (52.5 vs 71.9 mL/min/1.73m²). After PSM, 203, 224, and 210 pairs were analyzed at 1, 3, and 5 years."

Clinical • Real-world • Real-world evidence • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Diabetic Nephropathy • Fibrosis • Heart Failure • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Portal Hypertension • Renal Disease

An Unusual Presentation of Small Bowel Obstruction Following Liver Transplantation (ACG 2026) - "Complications include persistent ascites, treated with furosemide; acute kidney injury; and urinary retention...The patient receives a standard immunosuppressive regimen of tacrolimus following discontinuation of everolimus due to side effects...Nirogacestat, a ɣ-secretase inhibitor, targets aberrant Notch signaling in tumor proliferation. Radiation may offer a non-surgical alternative. Furthermore, an intestinal or multivisceral transplant may be considered, particularly when removal of desmoid tumors leads to short bowel syndrome."

Acute Kidney Injury • Desmoid Tumors • Fibrosis • Gastrointestinal Disorder • Hepatology • Immunology • Nephrology • Renal Disease • Sarcoma • Short Bowel Syndrome • Solid Tumor • Transplantation • CCND1 • NOTCH1

Harmless or Harmful? A Case Report on Pseudomelanosis Duodeni (ACG 2026) - "She reported adherence with her medications including carvedilol, hydralazine, torsemide, semaglutide, and ferrous sulfate...PD appears to occur predominantly in middle-age females and have a strong association with hypertension and diabetes mellitus and the use of certain medications such as hydralazine, ferrous sulfate, and sulfur-containing loop diuretics such as furosemide or torsemide...Therefore, the purpose of this case report is to bring awareness about PD and highlight the importance of distinguishing it from duodenal melanoma to avoid unnecessary work-up as it is benign and requires no further work-up or treatment. Figure: Abnormal mucosa in the duodenum"

Case report • Clinical • Cardiovascular • Congestive Heart Failure • Constipation • Diabetes • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hypertension • Melanoma • Metabolic Disorders • Solid Tumor

When Ascites Is at Breaking Point: A Rare Case of Flood Syndrome (ACG 2026) - "The patient was discharged on hospital Day 6 with midodrine, furosemide, and spironolactone, given strict return precautions, and scheduled outpatient biweekly paracenteses with interventional radiology. In clinical cases where liver transplantation or TIPS are not options, multidisciplinary management of ascites and surgical intervention should be considered. Figure: Ulcerated focus at the most protruding portion of umbilical hernia."

Clinical • Cardiovascular • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Septic Shock • Thrombosis

New-Onset Decompensated Cirrhosis Secondary to Congestive Hepatopathy Complicated by Spontaneous Bacterial Peritonitis: A Case Report (ACG 2026) - "Management and Outcome: The patient received ceftriaxone IV albumin and therapeutic paracenteses...Diuresis with furosemide and spironolactone sodium restriction lactulose and carvedilol were initiated...High SAAG with high ascitic protein strongly suggests congestive hepatopathy and should prompt cardiac evaluation and optimization. Recognition of this entity may prevent delayed diagnosis and guide appropriate multidisciplinary management."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Fibrosis • Heart Failure • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Cirrhosis • Liver Failure • Respiratory Diseases

Comparative Outcomes of Proton Pump Inhibitors and H2 Receptor Antagonists in Cirrhosis: A Propensity-Matched Cohort Study (ACG 2026) - "One-to-one propensity score matching was performed for age, sex, race, socioeconomic status, tobacco and alcohol use, comorbidities, cirrhosis etiology, prior decompensating events, MELD score, and concomitant medications (lactulose, rifaximin, furosemide, and spironolactone). Propensity matching yielded two well-balanced cohorts of 8,922 patients each. Over 5-year follow-up, overall patients on PPIs had a high risk of SBP than patients on H2RAs (HR: 1.760; 95% CI: 1.135 - 2.729), however there was no difference in the risk of HE, CDI, osteoporosis/fragility fractures between the 2 groups (Table 1). On sub analysis of the 2 most commonly prescribed PPIs, omeprazole and pantoprazole, there was a higher risk of HE and CDI in omeprazole users than patients on H2RAs, while there was a higher risk for HE in patients on pantoprazole than H2RAs (Tables 2 and 3)."

Biliary Cancer • Cholangiocarcinoma • CNS Disorders • Fibrosis • Gastroenterology • Hepatic Encephalopathy • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Failure • Musculoskeletal Diseases • Osteoporosis • Solid Tumor

Losing More Than Fluid: Diuretic-Associated Agranulocytosis (ACG 2026) - "Introduction: Management of ascites in decompensated cirrhosis includes routine diuretic therapy such as furosemide and spironolactone...The patient was maintained on an increased dose of filgrastim and diuresed with ethacrynic acid instead, with noted improvement in ANC (Table 1)...Figure: Figure 1: Bone marrow core biopsy (H&E, Ã400) showing hypercellular marrow with selective granulocytic aplasia and compensatory erythroid and megakaryocytic hyperplasia. Figure: Table 1: Time course of diuretic administration and filgrastim treatment, white blood cell count, and absolute neutrophil count, demonstrating recovery of agranulocytosis following diuretic discontinuation."

Agranulocytosis • Fibrosis • Granulocytopenia • Hepatology • Immunology • Infectious Disease • Neutropenia

Cytology-Positive Malignant Ascites With Concurrent High-SAAG Physiology: When Portal Hypertension Is Not the Whole Story (ACG 2026) - "All five met criteria for refractory ascites despite furosemide (5) and spironolactone (3), with ascitic fluid reaccumulation at a mean of 2.8 days. Baseline demographic and clinical characteristics at initial presentation in patients with cytology-confirmed malignant ascites and concurrent high SAAG physiology (N=5) Figure: Table 2. Comprehensive ascitic fluid analysis and serum laboratory profiles at time of diagnostic evaluation in patients with cytology-positive high-SAAG malignant ascites (N=5)"

Cytology • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Fibrosis • Gastroenterology • Heart Failure • Hepatitis B • Hepatitis C • Hepatocellular Cancer • Hepatology • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Portal Hypertension • Thrombosis

The 2,000 Club: High Triglycerides and a Tan-Yellow Drain: A Chylous Tale (ACG 2026) - "Following resolution of the chylous output, she was started on diuretics (furosemide/spironolactone) for portal hypertensive ascites and discharged in stable condition. Nutritional intervention is paramount: MCTs are absorbed directly into the portal venous system, bypassing the intestinal lymphatic vessels and allowing the leak to heal. Figure: CT of the abdomen and pelvis demonstrating trace fluid in the right upper quadrant [yellow arrow] which clinical and laboratory correlation later identified as chylous ascites."

Cardiovascular • Dyslipidemia • Fibrosis • Gastroenterology • Hepatology • Hypertension • Hypertriglyceridemia • Immunology • Mood Disorders • Portal Hypertension • Primary Biliary Cholangitis

When Laxatives Fail: A 14.6 cm Hepatic Cyst Presenting as Chronic Refractory Constipation (ACG 2026) - "He returned 4 months later with constipation refractory to polyethylene glycol, docusate, sennosides, lactulose, and fiber...Patient was on amlodipine, HCTZ, and furosemide...This case demonstrates the importance of widening the differentials in refractory constipation and a multidisciplinary approach. Figure: Initial CT scan with a 14.6 cm hepatic cyst Figure: Repeat CT scan with a smaller 7.7 cm cyst"

Constipation • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Obesity • AFP

SGLT-2 Inhibitors Are Associated With Reduced Hepatic Decompensation and Mortality in Patients With Cirrhosis and Type 2 Diabetes: A Propensity-Matched Real-World Analysis (ACG 2026) - "Adults with cirrhosis and T2DM receiving dapagliflozin, empagliflozin, or canagliflozin were compared with matched controls receiving furosemide and spironolactone without SGLT2 inhibitor exposure. : After PSM, SGLT2 inhibitor use was associated with a significantly lower risk of the composite hepatic decompensation outcome at 3 years (2.3% vs 3.6%; HR 0.58, 95% CI 0.49-0.69; p< 0.001). Individual analyses demonstrated lower risks of SBP (HR 0.43, 95% CI 0.31-0.58; p< 0.001) and peritoneal drainage/paracentesis-related procedures (HR 0.63, 95% CI 0.52-0.76; p< 0.001). Independent assessment of variceal bleeding was limited by low event counts."

Clinical • Real-world • Real-world evidence • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Fibrosis • Hepatocellular Cancer • Hepatology • Immunology • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease • Solid Tumor • Type 2 Diabetes Mellitus

Pseudomelanosis Duodeni: Endoscopic and Histopathologic Features in an Elderly Male With Comorbid Hypertension, Diabetes, and Chronic Kidney Disease (ACG 2026) - "His medication regimen included chlorthalidone and furosemide, both of which are potentially implicated in the pathogenesis of PD. B.) Esophagastroduodenoscopic image of Forest (III) duodenal ulcer within the duodenal bulb. Figure: Figure 2: (A-B) 20x and 40x image of duodenal bulb biopsy with H&E staining demonstrating multiple black-brown deposits within macrophages in the duodenal sub-epithelium."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Gastroenterology • Hematological Disorders • Hypertension • Melanoma • Metabolic Disorders • Mood Disorders • Nephrology • Peptic Ulcer • Renal Disease • Solid Tumor

Personalized Sequential Nephron Blockade for Diuretic Resistance in Acute Decompensated Heart Failure: A Narrative Review for the Cardiorenal Clinician. (PubMed, J Pers Med) - "We integrate contemporary randomized evidence with renal tubular physiology to propose a mechanism-based approach: acetazolamide for patients with hypochloremic metabolic alkalosis and enhanced proximal sodium reabsorption, thiazide-type diuretics when distal cotransporter escape predominates, vasopressin antagonists for dilutional hyponatremia complicating congestion, and sodium-glucose cotransporter 2 inhibitors as foundational therapy that combines modest acute natriuresis with durable cardiorenal protection...We propose a personalized, phenotype-driven framework in which early urinary sodium response, kidney function, serum chloride, acid-base status, serum sodium, background SGLT2 inhibitor therapy, and venous congestion imaging guide the selection, escalation, and de-escalation of adjunctive therapy, with the goal of more complete and safer decongestion in acute decompensated heart failure. Matching adjunct choice to a patient's individual biochemical..."

Journal • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Metabolic Disorders • Nephrology

Results of a Phase I/II Study of Tagraxofusp in Combination with Decitabine for Patients with Myelodysplastic/Myeloproliferative Neoplasms and Higher Risk Myelodysplastic Syndromes (ASH 2024) - "One patient (11%) had received prior allogeneic stem-cell transplantation and 1 (11%) had received prior HMA-venetoclax therapy...Both events occurred in patients >75 years of age during cycle 1 of therapy and reverted to baseline (< grade 1) with appropriate management including steroids, albumin and furosemide. One patient received a single dose of tocilizumab...Although TAG at low doses is associated with acceptable safety profile with no new safety signals, CLS and CRS can be observed in older patients. Further follow up and enrollment is ongoing in younger (<75 years of age) patients to confirm the long-term efficacy and safety of this combination."

Clinical • Combination therapy • P1/2 data • Atrial Fibrillation • Cardiovascular • Chronic Myelomonocytic Leukemia • Constipation • Cough • Febrile Neutropenia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Myelodysplastic Syndrome • Myeloproliferative Neoplasm • Neutropenia • Oncology • Pneumonia • Respiratory Diseases • CD123 • IL3RA • TP53

Pre‒Cardiopulmonary Bypass Furosemide Administration and Intraoperative Urinary Oxygen Tension During Coronary Artery Bypass Surgery: A Prospective Observational Study. (PubMed, J Cardiothorac Vasc Anesth) - "Pre-CPB furosemide administration was associated with a greater intraoperative reduction in PuO₂ during elective on-pump CABG, without significant differences in early postoperative renal outcomes. These findings suggest altered urine oxygen tension dynamics and should be considered hypothesis-generating."

Journal • Observational data • Acute Kidney Injury • Anesthesia • Cardiovascular • Critical care • Nephrology • Renal Disease

Thoracoscopic diaphragmatic plication technique in a patient with refractory hepatic hydrothorax (PubMed, Rev Med Inst Mex Seguro Soc) - "Diuretic therapy with propranolol, furosemide, and spironolactone was administered, along with sodium restriction (80-90 mEq/day) and fluid restriction (< 2 L/day), without improvement and with symptom progression. Chemical pleurodesis induces pleural adhesion and obliteration of the space. The combination of both techniques increases therapeutic effectiveness."

Journal • Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Pain • Portal Hypertension • Primary Biliary Cholangitis • Pulmonary Disease • Respiratory Diseases

Hypertonic saline and high-dose furosemide in very elderly patients hospitalized for acute heart failure: A real-world cohort study. (PubMed, Eur J Intern Med) - "In this real-world cohort of very elderly patients with AHF, HSS with high-dose intravenous furosemide, plus discretionary sequential diuretics, was feasible and had an acceptable short-term safety profile. Poor diuretic response identified a subgroup with very high early mortality, whereas mid-term outcomes related more to baseline characteristics. These hypothesis-generating findings describe a population common in internal medicine wards and seldom represented in published studies."

Journal • Real-world evidence • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease