furosemide / Generic mfg. - LARVOL DELTA

Restoring autophagy flux by rolipram attenuates ototoxicity in Hearing loss. (PubMed, Eur J Pharmacol) - "In this study we investigated whether enhancing autophagy can mitigate kanamycin and furosemide induced cytotoxicity by using rolipram to restore the autophagy flux...Consistent with an autophagy dependent mechanism, the protective effect of rolipram was abolished by chloroquine or Atg7 knockdown, confirming that intact autophagy flux is required for cellular protection...Notably, ribbon synapses of inner hair cells were also maintained, indicating that autophagy enhancement protected both cellular integrity and synaptic function. These findings demonstrate that restoring autophagy flux represents a viable therapeutic strategy against ototoxic injury, and identify rolipram as a potential pharmacological agent for protecting auditory cells and hearing function."

Journal • Otorhinolaryngology • ATG7

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: University of Delaware | Phase classification: P=N/A ➔ P4

Phase classification • Cardiovascular • Hypertension

Effect of Vericiguat on Pulmonary Artery Pressures in Heart Failure Patients: Real-World Insights from Pressure Sensor Monitoring. (PubMed, J Cardiovasc Pharmacol) - "At 90 days the median loop diuretic dose (Furosemide equivalent) was 40mg [0-160], compared to 42mg [0-240] prior to vericiguat. In conclusion, vericiguat was well tolerated in stable HF patients with mild pulmonary hypertension, but no significant effect on PAP was observed. Larger studies, including patients with higher PAP, are needed to clarify its impact."

Journal • Real-world evidence • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia. (PubMed, Res Sq) - "Adjusted mean changes were similar across routes: IV, -25.3 (-35.8, -14.7), gastric, -25.8 (-32.2, -19.4), and duodenal, -25.8 (-34.2, -17.4). Conclusions : Our data suggest a 1:2 IV-to-enteralconversion leads to comparable diuretic effects in infants with established BPD, supporting this common clinical practice."

Journal • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

Vasopressin role in hypertrophic obstructive cardiomyopathy post-cardiac surgery: A case report. (PubMed, World J Crit Care Med) - "Vasopressin seems to be the preferred vasopressor for managing LVOTO and SAM post-cardiac surgery, because of its absence of inotropic effects. Echocardiography is crucial for early diagnosis and therapeutic management."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Hypertrophic Cardiomyopathy • Hypotension • Obstructive Hypertrophic Cardiomyopathy • Respiratory Diseases

Management of Neonatal Severe Hyperparathyroidism due to Homozygous CASR Mutation: Challenges and Literature Insights. (PubMed, Mol Syndromol) - "Despite initial treatment with hydration and furosemide, her hypercalcemia persisted. Cinacalcet was started but failed to control calcium levels, leading to the need for a subtotal parathyroidectomy at 2.5 months of age...Postoperatively, the patient developed hypocalcemia due to hungry bone syndrome and later experienced recurrent hypercalcemia, which was managed with pamidronate followed by calcitriol...Subtotal parathyroidectomy proved essential for controlling hypercalcemia. Continued documentation of NSHPT cases will help improve treatment strategies and outcomes for this rare condition."

Journal • Endocrine Disorders • Metabolic Disorders • CASR

Retrospective Evaluation of Acute Postoperative Complications Occurring in the ICU Following Canine Mitral Valve Repair Surgery Under Cardiopulmonary Bypass (2019-2020): 41 Cases. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Postoperative abnormalities are common in dogs undergoing mitral valve repair, with many expected given the nature of surgery performed. Many dogs experienced complications requiring deviation from standard protocol. This study provides the first exploratory analysis of dogs undergoing mitral valve repair at a single center."

Journal • Retrospective data • Cardiovascular • Critical care • Hematological Disorders • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • CRP

Comparison of Planar and 3-Dimensional Methods for Quantification of Differential Renal Function Using 99mTc-DMSA and 99mTc-Glucoheptonate Renal Scintigraphy. (PubMed, J Nucl Med Technol) - "Forty-five patients were injected with 99mTc-dimercaptosuccinic acid (DMSA), and 63 patients were injected with 99mTc-glucoheptonate and furosemide, depending on which radiotracer was available at the time of the examination... The SPECT quantification method for the evaluation of DRF is reliable because of high intraobserver and interobserver agreement. Furthermore, it differs significantly from the planar quantification method, with more pronounced differences observed with 99mTc-glucoheptonate compared with 99mTc-DMSA."

Journal

Renography: Methods and Pitfalls. (PubMed, Semin Nucl Med) - "Renography is routinely performed under furosemide challenge, administered 15 min before, at the same time as or 20 min after tracer administration...Tc-99m-MAG3 secretion into tubular lumen is mediated by multidrug resistance (MDR) transporters so the renogram is exposed to the effects of MDR inhibitors such as chemotherapeutics. Ga-68-has great potential as renographic agent, especially in renal transplant management."

Journal • Review • Renal Disease • Transplantation

99mTc EC Renal Scintigraphy in a Rare Case of Retrovesical Kidney: Insights Into Protocol Considerations and Diagnosis. (PubMed, Clin Nucl Med) - "A 28-year-old man presenting with swollen feet underwent a 99mTechnetium Ethylene-Dicysteine (EC) renal diuretic scintigraphy to evaluate the renal function, which demonstrated a zone of increased tracer uptake in the retrovesical space, indicative of an ectopic kidney with tracer accumulation in the dilated pyelocalyceal system and good excretion following Lasix administration. SPECT/CT imaging further confirmed the presence of the ectopic kidney, which was positioned horizontally just posterior to the bladder, exhibiting normal cortical thickness with a dilated pyelocalyceal system in its upper portion. This case highlights the consideration of ectopic kidney in the retrovesical masses and emphasizes the critical role of urinary catheterization and performing SPECT/CT imaging for accurately evaluating kidney function in such cases."

Journal

Central Sodium Sensing: Implications for Blood Pressure Regulation (clinicaltrials.gov) - P=N/A | N=29 | Completed | Sponsor: University of Delaware | Recruiting ➔ Completed

Trial completion

SQI-01-03: Study to Compare Bioavailability and Pharmacokinetics of a Novel Furosemide Regimen Administered Subcutaneously Versus the Same Dose (80 mg) Administered Intravenously in Healthy Volunteers (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: SQ Innovation, Inc.

New P1 trial

Case Report: Concurrent atrial and ventricular septal defect in a young Sphynx cat. (PubMed, Front Vet Sci) - "Initial treatment with furosemide and supplemental oxygen led to clinical improvement...Medical management with phlebotomy, sildenafil, clopidogrel, and oxygen supplementation provided temporary stabilization; however, the cat eventually died approximately 1 year after diagnosis, likely due to disease progression and inconsistent therapeutic compliance...Histopathological examination revealed pulmonary vascular remodeling and myocardial fibrosis, indicative of chronic pulmonary hypertension. This report represents the first documented case of concurrent ASD and VSD with Eisenmenger physiology in a cat, with long-term clinical follow-up and postmortem confirmation."

Journal • Cardiovascular • Fibrosis • Heart Failure • Hematological Disorders • Hypertension • Immunology • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Point-of-Care Agitated Saline Contrast Echocardiography in the Diagnosis of Respiratory Failure: A Case of Hepatopulmonary Syndrome With Decompensated Heart Failure. (PubMed, Cureus) - "Past medical history was notable for dilated alcoholic cardiomyopathy, heart failure with reduced ejection fraction (New York Heart Association (NYHA) class II, left ventricle ejection fraction (LVEF) 30%), permanent atrial fibrillation (AF) (on bisoprolol and anticoagulation with acenocoumarol), and a prior mitral valve prosthesis...However, despite high-flow nasal oxygen therapy, subsequent noninvasive ventilation(NIV) (fraction of inspired oxygen (FiO₂) 1.0), and pharmacologic therapy with furosemide resulting in satisfactory diuresis (250 mL/h) and reduced pulmonary congestion on lung ultrasound, oxygenation improved only minimally (PaO₂ up to 40 mmHg), and dyspnea persisted.  Given the presence of cirrhosis with portal hypertension and refractory hypoxemia, and that a workup for HPS had not yet been performed, a bedside agitated-saline contrast echocardiography was performed at the point of care. Microbubbles appeared in the left atrium (LA) and..."

Journal • Addiction (Opioid and Alcohol) • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Gastroenterology • Heart Failure • Hepatology • Hypertension • Immunology • Liver Cirrhosis • Portal Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Transplantation

Urine Olfactomedin 4 Predicts Furosemide Response and Kidney Replacement Therapy in Critically Ill Children. (PubMed, Crit Care Explor) - "In critically ill children at high risk for AKI, both uOLFM4 and uNGAL have moderate discriminatory ability to predict furosemide responsiveness and KRT receipt on the first day of PICU stay. The NPV greater than or equal to 95% for uOLFM4 for both outcomes make it a promising candidate for implementation into clinical decision support to facilitate early KRT initiation decision-making."

Biomarker • Journal • Observational data • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease • LCN2 • OLFM • OLFM4

Copper uptake in blue crabs is independent of sodium transport under hyposaline conditions. (PubMed, Comp Biochem Physiol C Toxicol Pharmacol) - "Specific inhibitors targeting Na+/H+ exchangers (amiloride, 100 μM) and Na+, K+, 2 Cl- cotransporters (NKCC) (furosemide, 120 μM) were used. The 64Cu accumulated mainly in the carapace (49 %) and posterior gills (22 %), regardless of Na+ availability. The findings clearly demonstrate that Cu uptake, irrespective of the uptake pathway, proceeds independently of Na."

Journal

Anti-nephrin antibodies in minimal change disease: Case report series. (PubMed, Clin Nephrol) - "Anti-nephrin autoantibodies have been detected in a subgroup of patients with MCD supporting the autoimmune etiology of the disease. Targeted anti-B-cell therapy with rituximab is an additional therapeutic option in patients with relapsing or treatment-resistant disease, or drug-related adverse effects to standard therapy."

Journal • Acute Kidney Injury • Glomerulonephritis • Immunology • Nephrology • Renal Disease

A Case of TAFRO Syndrome Complicated by Alveolar Hemorrhage during Disease Exacerbation (APSR 2025) - "He was managed on outpatient basis with oral prednisolone and cyclosporine; however, cyclosporine was discontinued six months before admission due to worsening renal function...The patient was admitted and treated with ceftriaxone and furosemide without the use of anticoagulant/antiplatelet medications...Rituximab was added on hospital day 9...Discussion : This case represents a rare instance of alveolar hemorrhage complicating TAFRO syndrome. During disease exacerbations, clinicians should consider alveolar hemorrhage in the differential diagnosis of new pulmonary infiltrates, alongside bacterial pneumonia and pulmonary congestion."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Infectious Disease • Inflammation • Myelofibrosis • Nephrology • Pneumonia • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Thrombocytopenia • IL6

Isolated trigeminal sensory neuropathy in a patient with mixed connective tissue disease: A diagnostic challenge (EHF-EHC 2025) - "Chronic medication included gabapentin 100mg three times daily, prednisolone 10mg, hydroxychloroquine 400mg, aspirin 150mg, pentoxifylline 400mg, nifedipine 20mg, furosemide, tadalafil and ambrisentan. This case highlights the importance of considering autoimmune mechanisms in isolated trigeminal neuropathies, especially in patients with systemic connective tissue disease. EMG may assist in detecting trigeminal dysfunction, and intrathecal autoantibodies, even without structural lesions, support an immune-mediated process and underscore the value of CSF analysis in atypical neurological presentations."

Clinical • Cardiovascular • Immunology • Melanoma • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Rheumatology • Solid Tumor

Octreotide in the management of pharmacoresistant idiopathic intracranial hypertension: A case report (EHF-EHC 2025) - "First-line pharmacological treatment includes acetazolamide, a carbonic anhydrase inhibitor that reduces CSF production, along with topiramate or diuretics...We present the case of a 34-year-old obese woman diagnosed with IIH, treated with furosemide and topiramate, with poor response and limiting side effects...Treatment-refractory IIH presents a therapeutic challenge. Octreotide is a promising alternative with favorable outcomes, expanding therapeutic options for this condition."

Case report • Clinical • Cardiovascular • CNS Disorders • Genetic Disorders • Hypertension • Obesity • IGF1 • SSTR

Computed Tomography Coronary Angiogram as a First-Line Diagnostic Tool in Pregnancy-Associated Spontaneous Coronary Artery Dissection: A Case Report of Left Main Stem and Left Anterior Descending Artery Dissection at 35 Weeks' Gestation. (PubMed, Cureus) - "She experienced a brief episode of pulmonary edema that responded well to furosemide and subsequently remained hemodynamically stable. The patient was monitored in the hospital and later delivered uneventfully about four weeks after the event. This case highlights the value of CT coronary angiogram as a non-invasive diagnostic option in hemodynamically stable antepartum patients with suspected SCAD, providing a safe alternative to invasive angiography in selected cases."

Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Myocardial Infarction • Pain • Respiratory Diseases

MannKind Announces U.S. FDA Accepts for Review its Supplemental New Drug Application (sNDA) of FUROSCIX ReadyFlow Autoinjector for the Treatment of Edema in Adults with Chronic Heart Failure or Chronic Kidney Disease (GlobeNewswire) - "The application has been assigned a Prescription Drug User Fee Act (PDUFA) target action date of July 26, 2026."

FDA filing • PDUFA • Chronic Kidney Disease • Heart Failure

REDUCE 2: a randomised feasibility study comparing recurrent therapeutic thoracentesis to indwelling pleural catheter insertion, daily drainage and talc instillation for the management of medically-resistant cardiogenic pleural effusions (BTS WM 2025) - "Furosemide up titration and SGLT2i addition were the most common changes in the 47 patients deemed ineligible due to medical optimisation...Advances in medical HF management may have reduced the incidence of symptomatic HF effusions requiring recurrent drainage - a notable proportion of screened patients in this study were managed successfully with medical approaches. In persistently symptomatic patients, IPC/talc was a potentially beneficial management strategy; however, medical management with TT remains standard care."

Clinical • Pleural effusion • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Disease • Respiratory Diseases

Predicting Pharmacokinetics of Drugs in Patients with Heart Failure and Optimizing Their Dosing Strategies Using a Physiologically Based Pharmacokinetic Model. (PubMed, Pharmaceutics) - "Eight commonly used drugs (digoxin, furosemide, bumetanide, torasemide, captopril, valsartan, felodipine and midazolam) for treating HF and its comorbidities were selected. A PBPK model was successfully developed to predict the plasma concentration-time profiles of the eight tested drugs in both healthy subjects and HF patients. Furthermore, this model may also be applied to guide digoxin dose optimization for HF patients."

Journal • PK/PD data • Cardiovascular • Congestive Heart Failure • Heart Failure