NN1953 / Merrion, Novo Nordisk - LARVOL DELTA

Predicting human half-life for insulin analogs: An inter-drug approach. (PubMed, Eur J Pharm Biopharm) - "The requirements for the inter-drug approach were shown to be a span of at least 2 orders of magnitude in half-life for the included drugs and a shared clearance mechanism. The insulin analogs in this study were the five fatty acid protracted analogs: Insulin degludec, insulin icodec, insulin 320, insulin 338 and insulin 362, as well as the non-acylated analog insulin aspart."

Journal • IR

Democrats have a plan to cap insulin at $35 a month. Republicans won't say if they'll block it (The Week) - '"As I researched this topic, I found that 25 to 30 percent of Americans ration their insulin because of high cost,' S. Vincent Rajkumar, a Mayo Clinic physician, tells the Post. 'The ability to keep increasing the price every year on the same product happens only when there is no market force' to keep drugmakers in check."

Media quote

First report of Mycoleptodiscus terrestris causing root rot of soybean in Indiana. (PubMed, Plant Dis) - "The morphological characters matched with the description of Mycoleptodiscus terrestris (Gerd.) Ostaz (Gerdemann 1953)...terrestris has been proposed as a biological control agent against multiple aquatic weeds (Verma and Charudattan 1993; Shearer and Jackson 2006). Introduction of this fungus into soybean production regions should be avoided."

Journal • Gastroesophageal Reflux Disease

The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects. (PubMed, Clin Pharmacokinet) - P1 | "Oral insulin 338 pharmacokinetics are not affected by food intake from 30 min after dosing, implying that patients with diabetes mellitus do not need to wait more than 30 min after a morning dose of oral insulin 338 before having their breakfast. This is considered important for convenience and treatment compliance. CLINICALTRIALS."

Clinical • Journal • PK/PD data • Diabetes • Metabolic Disorders

First Report of Mycoleptodiscus terrestris Causing Crown and Root Rot of Alfalfa (Medicago sativa) in Minnesota. (PubMed, Plant Dis) - "However, it is also a pathogen on many legumes including alfalfa (Gerdemann 1953; Smith et al...Samples were air-dried and placed on water agar (WA) amended with 25 µg/ml rifampicin...The pathogen was re-isolated from all infected alfalfa cultivars and had the same morphology as isolates DAZ5 and DAZ9, fulfilling Koch's postulates. To our knowledge, this is the first report of M. terrestris causing crown and root rot disease of alfalfa in Minnesota."

Journal • Gastroesophageal Reflux Disease

Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial. (PubMed, Lancet Diabetes Endocrinol) - P2 | "I338 can safely improve glycaemic control in insulin-naive patients with type 2 diabetes with no evidence of a difference compared with insulin glargine, a widely used subcutaneously administered basal insulin. Further development of this particular oral insulin project was discontinued because I338 doses were high and, therefore, production of the required quantities of I338 for wide public use was deemed not commercially viable. Improvement of technologies involved in the product's development is the focus of ongoing research."

Clinical • Journal • P2 data • Diabetes • Hypoglycemia • Immunology • Metabolic Disorders • Type 2 Diabetes Mellitus

Drug added to the pipeline for the indication type 1 and 2 diabetes (Novo Nordisk) - NN1953/Novonordisk

Corporate Pipeline Update