desmopressin / Generic mfg. - LARVOL DELTA

Glycolysis-dependent reactive oxygen species mediate desmopressin acetate-induced rescue of platelet dysfunction caused by antiplatelet therapy. (PubMed, Med Gas Res) - "Desmopressin acetate rescued platelet dysfunction induced by antiplatelet therapy through a glycolysis-reactive oxygen species-proteomic profiling identified peroxiredoxin-5 axis, in which glycolysis-driven reactive oxygen species generation plays a central regulatory role. These findings indicate redox modulation as a critical mechanism underlying desmopressin acetate-mediated platelet rescue and suggest a potential therapeutic strategy for managing severe bleeding associated with antiplatelet therapy."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Vascular Neurology

Epidemiology, clinical characteristics, and treatment patterns in patients with Von Willebrand disease: retrospective data from an Austrian tertiary care center (OeGHO-AHOP 2026) - "On-demand hemostatic therapy was given in 76.9%: desmopressin (33.0%), tranexamic acid (22.9%), and VWF concentrates (27.0%). VWD patients treated at our center were predominantly female and of blood group O. Bleeding was more frequent in type 2 VWD. Prophylactic therapy significantly reduced postoperative bleeding, underscoring the benefit of targeted hemostatic management in clinical practice."

Retrospective data • Hematological Disorders • Hemophilia

TRANSCRIPTIONAL MACHINERY OF RNA POLYMERASE II PAUSING AND RELEASE REGULATES VASOPRESSIN-RESPONSIVE AQP2 TRANSCRIPTION (ISN-WCN 2026) - "ChIP-qPCR demonstrated that Trim28 knockdown markedly reduced Pol II occupancy at the Aqp2 promoter in response to dDAVP stimulation. Furthermore, immunofluorescence staining revealed that TRIM28 formed dynamic nuclear condensates whose number per nucleus increased upon dDAVP treatment, suggesting phase separation-mediated transcriptional regulation.Conclusion These findings establish TRIM28 as a critical component of a transcriptional scaffold that modulates Pol II recruitment, stabilization, and elongation at the Aqp2 gene, thereby enhancing vasopressin-responsive water reabsorption in the kidney collecting duct."

BRD4 • CDK9 • PARP1 • TRIM28

EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS FOLLOWING CENTRAL DIABETES INSIPIDUS: A RARE CASE REPORT AND LITERATURE REVIEW (ISN-WCN 2026) - "EGPA was diagnosed and treated with steroids, rituximab, and plasma exchange...Furthermore, desmopressin discontinuation was successfully achieved...Although the precise mechanism remains unclear, the absence of eosinophilia and pituitary enlargement at CDI onset, along with the subsequent response to immunosuppression, suggests that vasculitic ischemia, rather than eosinophilic infiltration, may have contributed to CDI. A direct pathological link could not be confirmed, and idiopathic CDI cannot be excluded; however, the clinical course raises the possibility that CDI may reflect early central involvement of EGPA.Conclusion Clinicians should suspect EGPA when CDI occurs in patients with asthma or sinusitis, as this may indicate early vasculitic involvement."

Case report • Clinical • Review • Allergic Rhinitis • Asthma • Cardiovascular • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Immunology • Inflammation • Langerhans Cell Histiocytosis • Metabolic Disorders • Otorhinolaryngology • Rare Diseases • Renal Disease • Respiratory Diseases • Sinusitis • Vasculitis

A SALT-SENSITIVE GENETIC BACKGROUND STRONGLY SUPPRESSES MEDULLARY CYST FORMATION IN ARPKD RAT MODEL (ISN-WCN 2026) - "Furthermore, SS-PCK rats were subjected to either high salt loading, or treated with desmopressin, a synthetic vasopressin analog.Results SS-PCK rats fed a standard salt diet exhibited significantly elevated blood pressure and serum creatinine levels...We plan to further explore this mechanism by inhibiting epithelial sodium channel (ENaC) activity, which was upregulated in the collecting ducts of SS-PCK rats. Given that ENaC activation has been implicated in medullary cyst formation in PCK rats, this approach may provide key insights into the mechanisms underlying cyst suppression in SS-PCK rats."

Preclinical • Cardiovascular • Hypertension • Nephrology • Polycystic Kidney Disease • Renal Disease • PKHD1

DEVELOPMENT OF DIRECT AQUAPORIN-2 (AQP2) WATER CHANNEL INHIBITORS: ESTABLISHMENT OF A HIGH-THROUGHPUT CELL- BASED SCREENING SYSTEM (ISN-WCN 2026) - "Dysregulation of the AVP–V2R–AQP2 axis contributes to disorders of water balance: loss of AQP2 function causes nephrogenic diabetes insipidus, whereas excessive AQP2 activation results in water retention in conditions such as heart failure, liver cirrhosis, and SIADH.Although the V2R antagonist tolvaptan induces aquaresis and is used clinically, it has not demonstrated significant survival benefits...Phosphorylated AQP2 at Ser269 appeared only with dDAVP stimulation, indicating functional activation and apical membrane accumulation.For water transport assays, mpkCCD cells were cultured on permeable membranes in Transwell plates (ultimately 96-well format)...This 96-well, absorbance-based platform enables efficient high-throughput screening for AQP2 modulators.Future Perspectives:Screening of compound libraries will be initiated to identify selective direct inhibitors of AQP2. Such compounds may provide novel "pure aquaretic" therapies—inducing water diuresis..."

Cardiovascular • Congestive Heart Failure • Fibrosis • Gastroenterology • Heart Failure • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Metabolic Disorders

DESMOPRESSIN AS A PROMISING THERAPEUTIC APPROACH FOR THE POLYURIC PHENOTYPE IN PATIENTS WITH LRBA DEFICIENCY (ISN-WCN 2026) - "In HEK293T cells, overexpressed murine LRBA-R1442Q (corresponding to human LRBA p.R1445Q) was markedly degraded in lysosomes, and this degradation was rescued by chloroquine treatment. As a result, urine osmolality rapidly increased within 1 hour after desmopressin administration in these mice, leading to a significant amelioration of polyuria.Conclusion LRBA deficiency impairs urinary concentration in both mice and humans. The LRBA-R1442Q mutant retains its function as a scaffold protein for PKA in IMCDs, and LrbaR1442Q/R1442Q knock-in mice—serving as a model of human LRBA deficiency—remain responsive to desmopressin."

Clinical • IO biomarker • Genetic Disorders • CTLA4 • LAMP1 • LAMP2

VASOPRESSIN-DEPENDENT Β-CATENIN PHOSPHORYLATION AT SER552 REGULATES GENE EXPRESSION AND BRANCHING STRUCTURE OF MOUSE COLLECTING DUCT SYSTEM (ISN-WCN 2026) - "Experiments were done in both wild type (WT) mice and Mut mice undergoing administration of vehicle or the vasopressin analog, desmopressin (dDAVP) by osmotic minipumps (2 ng/hour, 5days) without water restriction (n=4 mice for each group)...The repression is associated with decreasing chromatin accessibility in the promoter-TSS regions of target genes. The observed structural changes in the collecting duct system of adult mice point to a role of vasopressin-mediated post-translational modification of β-catenin at Ser552 in collecting duct development, presumably PKA-mediated Ser552 phosphorylation."

Preclinical • CTNNB1

REGULATION OF NKCC2 PHOSPHORYLATION BY HYPOKALEMIA THROUGH THE PKA–DARPP-32–PP1 PATHWAY IN THE RENAL MEDULLA (ISN-WCN 2026) - "NKCC2 activity was confirmed by furosemide response test following thiazide pretreatment, and medullary expression of osmoregulatory genes was analyzed. Ex vivo kidney slices were treated with DDAVP, forskolin, or calyculin A to assess V2R–cAMP–PKA-PP1 pathway effects on NKCC2 phosphorylation...In LK mice, DARPP-32 phosphorylation shifted from T34 to T75, then pT34 DARPP-32 was diminished along the apical membrane of medullary TALs, together with pPP1A, highlighting the importance of PKA-DARPP-32-PP1 pathway in regulating NKCC2.Conclusion Hypokalemia reduces ADH-PKA signaling and shifts DARPP-32 phosphorylation from T34 to T75, thereby promoting NKCC2 dephosphorylation via the PKA-DARPP-32-PP1 axis, which may underlie impaired urinary concentrating ability. This abstract was also submitted for the Kidney Week 2025 congress."

TNS1

A CASE OF FLUCONAZOLE-INDUCED ARGININE VASOPRESSIN RESISTANCE (ISN-WCN 2026) - "Acquired AVP-R includes drug-induced AVP-R, and typical causative drugs are lithium, demeclocycline, amphotericin B, and rifampicin.Methods We report a rare case of fluconazole drug-induced AVP-R.Results A 52-year-old woman with type I diabetes was admitted to our hospital because of impaired consciousness. The patient had been in her usual state of health until 2 days before the admission, and her diabetic medications included dapagliflozin, insulin, and metformin...Broad spectrum antibiotics, meropenem and daptomycin, were introduced and continued to control the infection...Initially, micafungin 150 mg q12hr was introduced and then stopped due to liver dysfunction...Desmopressin administration did not increase urine osmolality or reduce urine volume, which demonstrated renal unresponsiveness...FCZ has been rarely reported to cause AVP-R, and its mechanistic is unclear. Careful continuous observation of urinary concentration and serum sodium level are important to..."

Clinical • Atherosclerosis • CNS Disorders • Dermatitis • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Obesity • Ocular Infections • Ocular Inflammation • Ophthalmology • Type 1 Diabetes Mellitus

International Delphi consensus on acute kidney injury: Foundations for AI-driven digital twin development in critical care nephrology. (PubMed, PLoS One) - "This Delphi study established a clinically grounded framework for AKI in critical care while highlighting areas of practice variability. The resulting causal structure provides a transparent foundation for future AI-driven digital twin development and prospective validation."

Biomarker • Journal • Acute Kidney Injury • Critical care • Nephrology • Renal Disease

Reduction of hemorrhagic complications after non-focal renal biopsy with pre-procedure desmopressin administration. (PubMed, Diagn Interv Radiol) - "Routine DDAVP administration before NRFB significantly reduces clinically significant bleeding, supporting its potential role as a simple prophylactic strategy."

Journal • Cardiovascular • Heart Failure • Hematological Disorders

Desmopressin for antiplatelet-associated traumatic intracranial hemorrhage: A systematic review. (PubMed, Clin Neurol Neurosurg) - "Eligible studies enrolled adults with TBI and acute tICH on aspirin and/or a P2Y12 inhibitor who received DDAVP and reported clinical outcomes. Reviewed studies showed no clear advantage in platelets transfusion. Our review mostly found that TBI-specific randomized trials with standardized hematoma expansion definitions, prespecified repeat-CT windows, and safety monitoring are needed to definitively clarify the role of DDAVP in antiplatelet-associated tICH and to guide evidence-based clinical practice."

Journal • Review • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Vascular Neurology

Haemostatic effectiveness of intranasal desmopressin for tunnelled dialysis catheter placement: a pilot randomised controlled trial. (PubMed, Int Urol Nephrol) - "There was a statistically insignificant reduction in exit-site bleeding with intranasal desmopressin."

Journal • Hematological Disorders • Nephrology

Long-Term Safety of Desmopressin Orally Disintegrating Tablets in Men With Nocturia due to Nocturnal Polyuria: Final Results of a Specified Drug Use-Results Survey in Japan. (PubMed, Low Urin Tract Symptoms) - "The survey provides insights into the safety profile of desmopressin ODT in real-clinical practice in Japan. Patients aged ≥ 75 years, those with underlying medical conditions, and those with abnormal clinical laboratory values, such as reduced renal function or a baseline serum sodium level of < 140 mmol/L, should be closely monitored for the development of hyponatremia during desmopressin treatment for nocturia due to NP."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure

Comparing Treatment Strategies for the Overcorrection of Hyponatremia (SCCM 2026) - "DDAVP given as the initial agent for the overcorrection of hyponatremia is associated with fewer episodes of overcorrection. This may be due to the longer duration of effect compared to hypotonic fluids and the variation in dosing of hypotonic fluids. Providers should consider the use of DDAVP for the initial treatment of overcorrection."

Cardiovascular • Heart Failure

An Evaluation of a Proactive Versus Reactive Desmopressin Dosing Strategy for Sodium Overcorrection (SCCM 2026) - "In this study, proactive desmopressin dosing resulted in a lower 24-hour sodium correction rate and faster time to hyponatremia resolution compared to reactive dosing."

Cardiovascular • Heart Failure • Nephrology

Battle at the Nephron: A Case of Metastatic Small Cell Lung Cancer Complicated by AVP-D and SIADH (SCCM 2026) - "Oncology was consulted and she started carboplatin and etoposide, and had palliative radiation to the brain and lung...Nephrology was consulted for management of AVP-D and the patient was started on ddAVP...Presentations vary based on lesion size/location, magnitude of trauma, and degree of neurohypophysial destruction.This case illustrates a rare but clinically significant scenario in which a patient with metastatic SCLC developed both AVP-D due to pituitary metastasis and SIADH, a frequent paraneoplastic complication of SCLC. It provides a valuable opportunity to review the pathophysiology of sodium and fluid balance as well as highlights the importance of involving specialists to aid in the diagnosis and management strategies for complex cases."

Clinical • Metastases • Cardiovascular • Chronic Obstructive Pulmonary Disease • Endocrine Disorders • Heart Failure • Immunology • Infectious Disease • Lung Cancer • Mood Disorders • Nephrology • Oncology • Pneumonia • Respiratory Diseases • Small Cell Lung Cancer • Solid Tumor

Perceived Role of Platelets and DDAVP in Antiplatelet-Associated Traumatic Intracranial Hemorrhage (SCCM 2026) - "Of those, 34% never administer platelets to those on aspirin, and 18% never administer platelets to those on P2Y12 inhibitors (with the remainder always, usually, or sometimes administering platelet transfusions). Academic neurosurgeons expressed significant uncertainty on the utility of platelet transfusion and DDAVP for tICH, they describe significant practice variation, and many disagree with national clinical practice guideline recommendations. These data support the importance of a future clinical trial to determine definitively the utility of platelet transfusion in these patients."

Cerebral Hemorrhage • CNS Disorders • Hematological Disorders

Sodium 101: Profound Symptomatic Hyponatremia Case Induced by Beer Potomania (SCCM 2026) - "Sodium level increased to 116 mmol/L over 24 hours which raised concerns for overcorrection, as a result desmopressin (DDAVP) and D5W were started to safely re-correct serum sodium over several days to prevent osmotic demyelination...A systemic review of published case reports showed that serum sodium values between 105 and 115 mmol/L in beer potomania, with rare cases reporting values as low as 101 mmol/L or below. The treatment of severe hyponatremia requires extreme caution to the rate of the sodium correction ( between 4–6 mmol/L in 24 hours) to prevent osmotic demyelination syndrome (ODS)."

Clinical • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure • Metabolic Disorders • Nephrology

Dialysis Catheter Placement in Patients With Severe Refractory Thrombocytopenia Transfusion Practice (SCCM 2026) - "While there was some variability in practice, most providers chose to transfuse one unit of platelets during HDC placement, consistently used ultrasound guidance, and preferred the internal jugular vein insertion site."

Clinical • Hematological Malignancies • Myelodysplastic Syndrome • Thrombocytopenia

Impact of Pharmacy Response to Hemorrhagic Emergencies on Time to Antithrombotic Reversal (SCCM 2026) - "Available reversal agents were four-factor prothrombin complex concentrate, phytonadione, protamine, idarucizumab, and desmopressin. Pharmacy response to ICH emergencies significantly reduced time from order entry to antithrombotic reversal agent administration."

Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage

Desmopressin for Prevention of Overcorrection of Hyponatremia Among Patients With Renal Dysfunction (SCCM 2026) - "This study was the first of its kind to assess desmopressin efficacy and safety in the setting of renal dysfunction and did not show a significant difference in sodium overcorrection after desmopressin in those with renal dysfunction. Further studies assessing the impact of renal dysfunction on desmopressin safety and efficacy are needed."

Clinical • Cardiovascular • Heart Failure • Nephrology • Renal Disease

Evaluation of Severe Hyponatremia Management Care Pathway in Critically Ill Patients (SCCM 2026) - "While this study has several limitations and barriers, the results suggest that utilizing a health system-based Care Pathway may be associated with optimized pharmacologic treatment, lower in-hospital mortality rates, and shorter hospital and ICU LOS in patients with severe hyponatremia."

Clinical • Cardiovascular • Heart Failure

Sex and age-based evaluation of a newly formulated intranasal DDAVP compared with intranasal DDAVP and subcutaneous DDAVP in type 1 von Willebrand disease (THSNA 2026) - "In 2020, production of intranasal desmopressin acetate (Stimate®) was discontinued and ongoing shortages of all DDAVP formulations have further limited global access. No clinically-relevant sex- or age-dependent differences in DDAVP responsiveness between newly formulated IN DDAVP, IN DDAVP, and SC DDAVP were observed. These results support the use of newly formulated DDAVP for treatment of bleeding in responsive patients with type 1 VWD. Improved availability and full regulatory approval of newly formulated IN DDAVP will broaden global access to effective and safe treatment."

Cardiovascular • Hematological Disorders • Hemophilia • Rare Diseases • Thrombosis