desmopressin / Generic mfg. - LARVOL DELTA

Prophylactic Desmopressin Before Native Kidney Biopsy in Severe Renal Impairment (clinicaltrials.gov) - P=N/A | N=250 | Completed | Sponsor: Sindh Institute of Urology and Transplantation

New trial • Renal Disease

A Case of Potential Oral Desmopressin Malabsorption Secondary to Concurrent Tube Feed Administration in a Patient With Arginine Vasopressin Deficiency. (PubMed, Cureus) - "However, it reportedly does not affect pharmacodynamics; therefore, no precautions are currently advised regarding food intake or tube feeding (TF). We present a case in which severe polyuria and hypernatremia developed after TF was initiated in a patient receiving oral DDAVP for AVP-D, which was corrected upon switching to subcutaneous DDAVP, suggesting TF-induced enteral DDAVP malabsorption."

Journal • Endocrine Disorders

Treatment of Antithrombotic-Associated Intracranial Hemorrhage in Adults: A Focused Guideline Update from the Neurocritical Care Society and the Society of Critical Care Medicine. (PubMed, Neurocrit Care) - "The guideline writing panel provided new conditional recommendations for the treatment of antithrombotic-associated acute ICH. These recommendations are intended for consideration along with the patient's clinical status and patient-specific factors."

Journal • Cerebral Hemorrhage • CNS Disorders • Critical care • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Pituitary Stalk Enlargement With Panhypopituitarism and Arginine Vasopressin Deficiency in Lung Adenocarcinoma: Metastatic Infundibular Disease or Paraneoplastic Hypophysitis? (PubMed, Cureus) - "The patient was initiated on hydrocortisone and levothyroxine replacement therapy...The patient showed subsequent clinical improvement with desmopressin. Serum prolactin was mildly elevated, likely reflecting both pituitary stalk infiltration and concomitant metoclopramide therapy. This case discusses an exceptionally rare presentation of lung adenocarcinoma with isolated pituitary stalk infiltration, panhypopituitarism, and AVP-D before exposure to immune checkpoint inhibitors. Clinicians should be aware of this unusual manifestation, as prompt hormone replacement can significantly reduce morbidity and improve patient outcomes."

Journal • Endocrine Disorders • Growth Hormone Deficiency • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • PRL

The effect of F8 missense variants on desmopressin response in people with nonsevere hemophilia A investigated using machine learning. (PubMed, Res Pract Thromb Haemost) - "This population pharmacokinetic study, using machine learning, enabled a comprehensive analysis of the effect of F8 variants on FVIII peak levels in response to desmopressin, accounting for other covariates and illustrating the complexity of interindividual variability. These findings provide insights into the underlying molecular mechanisms that influence FVIII peak levels in response to desmopressin."

Journal • Hematological Disorders • Hemophilia • Hemophilia A • Rare Diseases • F8

Pregnancy-unmasked latent autoimmune arginine vasopressin deficiency with anti-rabphilin-3a antibody positivity. (PubMed, JCEM Case Rep) - "AVP-D was suspected; desmopressin promptly relieved her symptoms...This case raises the possibility that pregnancy may unmask latent autoimmune AVP-D through a vasopressinase-independent mechanism. In patients who develop AVP-D during pregnancy, anti-rabphilin-3A antibody positivity and persistent loss of the posterior pituitary bright spot on MRI may offer crucial diagnostic clues, supporting the significance of long-term endocrine follow-up."

Journal • Immunology • RPH3A

Case Report: Pediatric Erdheim-Chester disease with cerebral ventricular system infiltration and epiphyseal involvement. (PubMed, Front Pediatr) - "The patient received dabrafenib (a BRAF inhibitor), interferon alpha-2b, and desmopressin. Importantly, this case illustrates that continuous administration of dabrafenib is crucial for disease management in children with BRAF V600E-mutated ECD, as even a brief interruption in therapy can result in rapid and severe deterioration. Our findings highlight the necessity of multimodal imaging and molecular analysis for accurate diagnosis and targeted therapeutic strategies in pediatric ECD."

Journal • Hematological Disorders • Langerhans Cell Histiocytosis • Musculoskeletal Pain • Pain • Pediatrics • Rare Diseases • CD163 • CD1a • CD68

Central Diabetes Insipidus as a Rare Presentation of Small Cell Lung Cancer: A Case Report. (PubMed, Cureus) - "A marked concentrating response following desmopressin administration supported the diagnosis of CDI, while MRI of the brain demonstrated a sellar-suprasellar mass with laboratory findings concerning for central hypothyroidism, indicating hypothalamic-pituitary axis disruption...This case highlights a rare presentation of SCLC with CDI likely due to pituitary metastasis. New-onset polyuria and hypernatremia in patients with advanced malignancy should prompt evaluation for CDI to allow timely diagnosis and management, even in the setting of poor overall prognosis."

Journal • Endocrine Disorders • Hepatology • Lung Cancer • Metabolic Disorders • Oncology • Pain • Small Cell Lung Cancer • Solid Tumor

DDAVP Effect by TEG6 in Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2027 ➔ Dec 2028 | Trial primary completion date: Dec 2027 ➔ Dec 2028

Enrollment open • Trial completion date • Trial primary completion date • Cardiovascular

The "DDAVP Clamp" for Severe Hyponatremia: Is It Time to Change the Standard of Care? (KIDNEY WEEK 2026) - No abstract available

Cardiovascular • Heart Failure

Evidence-Based Updates in the Diagnosis and Management of Dysnatremia (KIDNEY WEEK 2026) - "Experts debate the utility of the "DDAVP (desmopressin) clamp" strategy, present new paradigms for diagnosing diabetes insipidus (arginine vasopressin [AVP] deficiency) using copeptin, evaluate effective therapies for chronic hyponatremia, and discuss the latest mechanisms of drug-induced hyponatremia. Learning Objective(s) Evaluate the safety and efficacy of emerging therapeutic strategies for severe hyponatremia to optimize correction rates, specifically comparing the "DDAVP clamp" method with intermittent bolus therapy Discuss the novel copeptin-based diagnostic algorithm for accurately differentiating between AVP deficiency, AVP resistance, and primary polydipsia in patients presenting with polyuria and hypernatremia Identify the most effective treatment for significant chronic hyponatremia Describe the pathogenesis of drug-induced hyponatremia, such as thiazide-induced hyponatremia"

Cardiovascular • Heart Failure • Metabolic Disorders

Post-tonsillectomy Bleeding in Pediatric Hemophilia Patients (AAO-HNSF 2026) - "Hemophilia patients more often received hemostatic agents (aminocaproic acid 32.4%, N=81 vs 0.18%, N=588; factor VIII 17.6%, N=44 vs 0.04, N=140; tranexamic acid 10.4%, N=26 vs 0.23%, N=744; desmopressin 4.8%, N=12 vs 0.13%, N=436) and received less NSAID prescriptions (12.4%, N=31 vs 56.5%, N=186,947) (all p<.0001). These findings suggest that current perioperative management of children with hemophilia undergoing TA can result in postoperative bleeding outcomes comparable to unaffected peers. Further work incorporating medication dose/timing may refine best practices for this high-risk population."

Clinical • Hematological Disorders • Hemophilia • Pediatrics • Rare Diseases

DDAVP Challenges in 170 Children With von Willebrand Disease: Response Classification Varies According to Criteria Used. (PubMed, Haemophilia) - "Inconsistent DDAVP response criteria between classification systems may lead to inconsistent use of DDAVP. As the Castaman system does not require a >2-fold increase in VWF:Act, it may be more realistic in children who may already have a stress-induced increase in levels at time 0-h of the challenge."

Journal • Hemophilia • Pediatrics

PERIPROCEDURAL DESMOPRESSIN-INDUCED HYPONATREMIA REQUIRING HOSPITALIZATION IN A LUNG TRANSPLANT RECIPIENT (CHEST 2026) - No abstract available

Clinical • Cardiovascular • Heart Failure • Transplantation

A case report on the co-presentation of pituitary abscess and POEMS-like syndrome. (PubMed, Medicine (Baltimore)) - "The diagnosis of complex comorbidities is based on the combination of clinical manifestations and laboratory tests, multidisciplinary and comprehensive assessment are of great significance for this disease."

Journal • CNS Disorders • Endocrine Disorders • Metabolic Disorders • Monoclonal Gammopathy • Oncology • Pain • Rare Diseases

Severe recurrent hypernatremia and probable lithium-associated nephrogenic diabetes insipidus following pancreatectomy in a patient with schizophrenia: a case report. (PubMed, Front Med (Lausanne)) - "Because urine osmolality and a standardized desmopressin response test were unavailable, NDI could not be biochemically confirmed and central diabetes insipidus could not be definitively excluded...Lithium was discontinued after psychiatric and multidisciplinary consultation, and hydrochlorothiazide was initiated...In patients receiving long-term lithium, postoperative polyuria, recurrent hypernatremia, and low urine specific gravity should prompt consideration of lithium-associated urinary concentrating dysfunction while other causes of water loss are assessed. Careful perioperative medication review, sodium and fluid-balance monitoring, individualized fluid management, and multidisciplinary collaboration are essential."

Journal • CNS Disorders • Metabolic Disorders • Nephrology • Psychiatry • Renal Disease • Schizophrenia • Type 2 Diabetes Mellitus

Acute Aortic Dissection Surgery Complicated by Nephrogenic Diabetes Insipidus (PubMed, Kyobu Geka) - "We first assumed vasopressin deficiency due to cardiopulmonary bypass, and desmopressin nasal spray was somewhat effective...Neither a vasopressin challenge test on post operative day 16 nor a water restriction test on post operative day 48 demonstrated an increase in urine osmolality, leading to a diagnosis of nephrogenic diabetes insipidus. This case highlighted the complexity of fluid management when nephrogenic diabetes insipidus complicates postoperative course after surgery using cardiopulmonary bypass."

Journal • Cardiovascular • Critical care • Metabolic Disorders

Efficacy of desmopressin in reducing post-procedural bleeding among chronic kidney disease patients: a systematic review and meta-analysis. (PubMed, Front Med (Lausanne)) - "However, subgroup analyses restricted to RCTs, and the intranasal administration route suggest a reduction in bleeding complications. PROSPERO ID: CRD420251118342, URL: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251118342."

Journal • Retrospective data • Review • Cardiovascular • Chronic Kidney Disease • Heart Failure • Nephrology • Renal Disease

Risk of Postpartum Hemorrhage in Women With Von Willebrand Disease: A Real-World Data Analysis. (PubMed, Haemophilia) - "Von Willebrand disease is the most common inherited bleeding disorder. For many women, it can cause heavy periods and can also increase the risk of heavy bleeding after delivery, called postpartum haemorrhage. Even though this risk is well recognised, there is still limited information about what happens in real-world delivery care across the United States. In this study, we looked at a large national insurance claims database that included almost 1.5 million delivery encounters from 2011 to 2021. Of these, 1,514 were among women with von Willebrand disease. Compared with women without von Willebrand disease, women with von Willebrand disease had higher odds of postpartum haemorrhage, longer hospital stays, and emergency department visits or readmissions within 30 days of delivery. We also looked at outcomes among women with von Willebrand disease based on whether treatment was documented in the claims data. Women who had claims for von Willebrand factor concentrate or..."

Journal • Real-world evidence • Hematological Disorders • Hemophilia • Postpartum Hemorrhage

Spontaneous remission of Cushing disease after clinically silent pituitary apoplexy with persistent positive desmopressin stimulation. (PubMed, Pol Arch Intern Med) - No abstract available

Journal • Cushing’s Disease

From syndrome of inappropriate antidiuretic hormone secretion deficiency to excess - Challenges and solutions in a unique case (PubMed, Nutr Hosp) - "this case highlights the rare sequential transition from ADH deficiency to ADH excess caused by the same hypothalamic-pituitary disease and supports oral urea as an effective, safe, and cost-effective therapeutic option for chronic SIADH."

Journal • Burkitt Lymphoma • Cardiovascular • Endocrine Disorders • Heart Failure • Hematological Malignancies • Lymphoma • Metabolic Disorders • Nephrology • Oncology • Renal Disease

ARGININE VASOPRESSIN DEFICIENCY: TOWARDS A BETTER CHARACTERIZATION. (PubMed, Endocr Relat Cancer) - "In patients with apparently idiopathic AVP deficiency, a careful longitudinal follow-up is warranted, since it may represent the first manifestation of an underlying pathology. Treatment of AVP deficiency consists of desmopressin replacement combined with etiology-specific management."

Journal • Cardiovascular • Heart Failure • Immunology • Infectious Disease • Metabolic Disorders

Platelet Type Von Willebrand Disease - Diagnostic and Therapeutic Challenges. (PubMed, Hamostaseologie) - "In the course of the disease, the patient developed recurrent mucosal bleeding and a hypersensitivity reaction to tranexamic acid. According to the literature, platelet transfusions were most effective (in case of major hemorrhage or surgical setting); VWF concentrates or desmopressin showed variable efficacy and occasional transient thrombocytopenia. These data demonstrate the diagnostic challenges of PT-VWD and emphasize the importance of clinical case collection to improve therapeutical management."

Journal • Hematological Disorders • Hemophilia • Immunology • Thrombocytopenia

Short-Term Association of Add-On Gosha-Jinki-Gan with Sleep and Nocturia Outcomes in Patients with Persistent Nocturia Despite Desmopressin: A Real-World Study. (PubMed, Medicina (Kaunas)) - "These findings should be considered preliminary and hypothesis-generating. Prospective controlled studies are required to determine whether add-on Gosha-jinki-gan provides benefits beyond desmopressin alone."

Journal • Real-world evidence • Retrospective data • CNS Disorders • Insomnia • Overactive Bladder • Sleep Disorder

PRONATREOUS: International Multi-center Retrospective Study of Patients With Serum Sodium ?110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia (clinicaltrials.gov) - P=N/A | N=800 | Enrolling by invitation | Sponsor: Rochester General Hospital | Trial completion date: Jun 2026 ➔ Sep 2026 | Trial primary completion date: Jun 2026 ➔ Sep 2026

Trial completion date • Trial primary completion date • Cardiovascular • Heart Failure