trimethobenzamide/diphenhydramine / MultiCorp - LARVOL DELTA

Dystonia in a Dose: Recognizing a Class Effect in Susceptible Patients (ACG 2025) - "This case report describes a young patient who has extrapyramidal side effects to multiple anti-emetics (metoclopramide, promethazine, and prochlorperazine), all of which triggered dystonic reactions, rendering only trimethobenzamide and ondansetron as viable treatment options.Case Description/ A 32-year-old male was admitted to hospital with viral gastroenteritis due to coronavirus infection...The healthcare team promptly responded, and given characteristic dystonic presentation, prior history of dystonia with other medications, and temporal relation with metoclopramide administration, the reaction was identified as a medication-induced extrapyramidal side effect and diphenhydramine was administered...This case emphasizes the need for healthcare providers to be vigilant and proactive when choosing antiemetic agents, particularly for patients with a history of extrapyramidal symptoms. Further research into strategies to prevent medication-related adverse effects,..."

Clinical • CNS Disorders • Dystonia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Movement Disorders • Novel Coronavirus Disease • Respiratory Diseases

Sublingual Film Well-Tolerated for Parkinson 'Off' Episodes (Medscape) - P3, N=176; "The apomorphine sublingual film has 'the advantage of ease of use compared to the injectable form,' Ondo said. 'I think the injectable form, purely based on anecdotal experience, might start to work a minute or two faster than the sublingual form, but overall I would say efficacy as far as potency of turning 'on' and consistency of turning 'on' is comparable.'"

P3 data

Episode 3: Apomorphine Subcutaneous Injection: Efficacy and Administration for Off-Episodes in Parkinson Disease (NeurologyLive) - "Rajeev Kumar, MD: When people would take something that they shouldn't have taken-for example, in the 1950s-apomorphine could be administered and they would vomit. If you have ever been exposed to it, it can make you puke pretty nicely. Daniel E. Kremens, MD, JD: Right. As you pointed out, for most people, when we're using apomorphine, we have them premedicate for 3 days before starting with Tigan [trimethobenzamide]. Then the majority of the patients after they've been exposed to Apokyn [apomorphine hydrochloride], even for a brief period-eg, a couple of weeks-are able to titrate off the Tigan [trimethobenzamide]. The studies went out to about 2 months, but in the real world, I often have patients on it for 2 weeks. Then, if they're using their Apokyn [apomorphine hydrochloride] regularly by that point, they no longer need their Tigan [trimethobenzamide]."

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