ultra-rapid acting insulin (AT247) / Arecor - LARVOL DELTA

Examining Silybum marianum as a natural countermeasure to 1,4-dioxane induced hemato-, hepato- and nephrotoxicity in male Sprague-Dawley rats. (PubMed, Pak J Pharm Sci) - "While 1,4-dioxane at 3000 ppm severely altered the selected parameters in SD rats. Conclusively, S. marianum, due to its therapeutic potential at 247 mg/kg, countermeasured the 1,4-dioxane induced hemato-, hepato- and nephrotoxicity in male SD rats."

Journal • Preclinical

Life cycle analysis of ammonia-driven calcium looping processes for post-combustion CO2 capture in NGCC power plants. (PubMed, J Environ Manage) - "Economically, based on an annual operation time of 4000 h of NGCC, the solar-driven CaL system has the lowest Life Cycle Cost of GHG Removed (LCOR) at 247.7 $/t CO2. With anticipated reductions in ammonia prices to 240 $/t in 2050, the NH3-driven CaL system is expected to gain a significant advantage in economic at 46.5 $/t CO2 when natural gas price is 0.6 $/Nm3. And it is important to pay attention the clean production process of ammonia to reduce its impact on the environment."

Journal

Characteristics of Maturity-Onset Diabetes of the Young: A Single-Center Experience from a Tertiary Referral Hospital (ESPE-ESE 2025) - "Treatment regimens varied: 58.1% were on metformin, 4.7% on GLP-1 analogues, 14.7% on gliclazide, 18.6% on SGLT2 inhibitors, 21.7% on DPP-4 inhibitors, and 52.7% on insulin...At admission, mean HbA1c was 8.93±3.81%, with fasting plasma glucose at 213.7±88.5 mg/dL, creatinine at 0.74±0.18 mg/dL, and triglycerides at 247.7±232.3 mg/dL... Selecting appropriate patients for MODY genetic testing is crucial for avoiding unnecessary tests and ensuring effective diabetes management. Given ethnic differences in MODY types, large-scale national studies could contribute significantly to understanding its genetic and clinical variability."

Clinical • Diabetes • Hypoglycemia • Metabolic Disorders • Nephrology • Pain • Renal Disease • Retinal Disorders • Type 2 Diabetes Mellitus • HNF1A

INCIDENCE OF BRUTON TYROSINE KINASE INHIBITOR ASSOCIATED ARRHYTHMIAS: A PROSPECTIVE ANALYSIS USING CONTINUOUS INSERTABLE CARDIAC MONITORS - Jason Ng (ACC 2025) - "We report observations from the initial patients enrolled in this single center, prospective, pilot study. 12 patients enrolled from January 1 2023 to August 31 2024 included 6 on acalabrutinib, 5 on zanubrutinib, and 1 on ibrutinib...Non-sustained ventricular tachycardia (NSVT) occurred in 1 patient on acalabrutinib at 247 days and 1 on zanubrutinib at 78 days... This is the first prospective study utilizing continuous rhythm monitoring via ICM to enable early detection of asymptomatic arrhythmia in patients initiating BTKis. VA occurred in 2/12 patients (16.7 %) after initiating BTKis during median 9.5 months of follow up. This study will provide valuable data on the true incidence and patterns of BTKi-associated arrhythmias."

Clinical • Atrial Fibrillation • Cardiovascular • Hematological Malignancies • Oncology • Ventricular Tachycardia

Biogenic Nickel Oxide Nanoparticles: Synthesis, Characterization and Biomedical Potential. (PubMed, Mol Biotechnol) - "Synthesized NPs were characterization by UV, XRD, FTIR, SEM, and TEM revealed spherical, well-dispersed particles (17-168 nm) with a UV-Visible absorption peak at 247 nm...Zebrafish embryo assays demonstrated dose-dependent toxicity, influencing body length, heart rate, hatchability, and survival rates, confirming the nanoparticles' biosafety. These results highlight FV-NiO NPs as promising candidates for biomedical and environmental applications."

Journal • Lung Cancer • Oncology • Solid Tumor

Apixaban versus aspirin for stroke prevention in people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack: subgroup analysis of the ARTESiA randomised controlled trial. (PubMed, Lancet Neurol) - P4 | "Treatment with the direct-acting oral anticoagulant apixaban in people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack led to a 7% absolute risk reduction in stroke or systemic embolism over 3·5 years, compared with a 1% absolute risk reduction for individuals without a previous history of stroke or transient ischaemic attack. The corresponding absolute increase in major bleeding was 3% and 1%, respectively. Apixaban could be considered for secondary stroke prevention in people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack."

Clinical • Journal • Atrial Fibrillation • Cardiovascular

Fungal disease incidence and prevalence in Iraq - Preliminary estimates. (PubMed, J Mycol Med) - "Recurrent Candida vaginitis, fungal rhinosinusitis, and tinea capitis are considered to be the most frequent fungal diseases present in Iraq."

Journal • Allergic Bronchopulmonary Aspergillosis • Asthma • Candidiasis • Dermatology • Gynecology • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Sinusitis • Vaginitis

A single phosphorylatable amino acid residue is essential for the recognition of multiple potyviral HCPro effectors by potato Nytbr. (PubMed, Mol Plant Pathol) - "We found that substituting the serine at 247 in the HCPro of PVYO (HCProO) with an alanine as in PVYN HCPro (HCProN) disrupts Nytbr recognition...Extending beyond PVY, we establish that the same response elicited by the PVYO HCPro is also induced by HCPro proteins from other members of the Potyviridae family that have a serine at position 247, but not by those with an alanine. Together, our results provide further insights in the strain-specific PVY resistance in potato and infer a broad-spectrum detection mechanism of plant potyvirus effectors contingent on a single amino acid residue."

Journal

Optimizing the green synthesis of antibacterial TiO2 - anatase phase nanoparticles derived from spinach leaf extract. (PubMed, Sci Rep) - "The change in the color of the extract, absorption at 247 nm, change and increase of the peak at 800 - 400 wavelengths, and the maximum intensity of X-ray diffraction at the angle of 25.367 with the crystal plane 101 were indications of the synthesis of these nanoparticles. Notably, the synthesized nanoparticles exhibited antibacterial activity with MIC values of 0.5 mg/ml against E. coli and 2 mg/ml against S. aureus. This research presents a novel, eco-friendly approach to synthesizing titanium dioxide nanoparticles with promising antibacterial properties."

Journal

Extraction and characterization of novel alternative cellulosic fiber for sustainable textiles from Aloe barbadensis Miller stems (agricultural waste). (PubMed, Heliyon) - "The UV-Visible spectrum exhibited a distinct λ max at 247 nm in ethanol, while FT-IR analysis provided characteristic peaks at 3759, 1590, 1750, 1663, 1250, 564, SEM images displayed the smooth surface morphology of the fibers, and X-ray diffraction analysis indicated a high degree of crystallinity (78.67 %), suggesting a well-structured and crystalline nature. Energy dispersive X-ray (EDX) analysis was conducted to determine the elemental composition of the fibers, revealing the presence of carbon, oxygen, calcium, and copper, with carbon being the predominant element in cellulose. These results showed promising properties suggesting potential applications in textile industry as an alternative sustainable natural cellulosic fiber."

Journal

Kinetics and mechanism of the (silver nanoparticle) SNaP assay for quantitative determination of antioxidant capacity (ACS-Fall 2024) - "Subsequently, we explored the mechanism of the assay by determining concentration of Ag+ ion (by Ag+ selective electrode) and gallic acid and ascorbic acid (by UV/Vis at 247 nm) before and after assay reagent incubation using a Discover SP laboratory microwave. We show that concentrations of Ag+ and antioxidant (as gallic acid or ascorbic acid) decrease over time while LSPR of the AgNPs increases to a certain limit, indicating that the AgNPs grow to a certain size before they are growth-limited by the presence of stabilizing antioxidants. These data are useful for understanding how this assay works to produce enhanced LSPR in the presence of antioxidants from foods and beverages."

Rapid, Simple and Low-Cost Analytical Method Development for Quantification of Eltrombopag Olamine in Tablet Dosage by UV Spectroscopy Method. (PubMed, Drug Metab Bioanal Lett) - "The developed method is simple, economical, accurate and selective. The developed method was adaptable for the estimation of Eltrombopag Olamine analysis in pharmaceutical dosage form and routine quality control laboratory."

Journal • Aplastic Anemia • Hematological Disorders • Thrombocytopenia • Thrombocytopenic Purpura

A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma. (PubMed, Luminescence) - "The newly synthesized reagent exhibited a satisfactory level of fluorescence emission at 365 nm after excitation at 247 nm. The concentration range was shown to be linear between 0.1 and 1.5 μg/mL. The technique was effectively utilized for sofosbuvir analysis in both its tablet dosage form and spiked human plasma, with mean percentage recoveries of 100.13 ± 0.35 and 94.26 ± 1.69, respectively."

Journal • Hepatitis C • Hepatology • Infectious Disease • Inflammation

Comparison of 3-year local control using DAHANCA radiotherapy guidelines before and after implementation of five millimetres geometrical GTV to high-dose CTV margin. (PubMed, Radiother Oncol) - "DAHANCA radiotherapy guidelines based on a geometrically generated isotropic CTV1 margin led to less variation in treatment volumes and between centres than previous guidelines. The transition towards consensus GTV-CTV1 margins did not influence local tumour control. The majority of local recurrences were inside CTV1 and covered by the prescription dose."

Journal • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Designing dynamic coordination bonds in polar hybrid crystals for a high-temperature ferroelastic transition. (PubMed, Chem Sci) - "In detail, the strongly coordinative A'-site Me3SO+ cations prevent 1 from a structural phase transition, while coordinatively free A'-site Me4N+ cations trigger a conventional order-disorder ferroelastic transition at 247 K in 2, accompanied by a latent heat of 0.63 J g-1 and a usual "high → low" second-harmonic-generation (SHG) switch. Interestingly, the A'-site Me3NNH2+ cations in 3 reveal unusual dynamic coordination bonds, driving a high-temperature ferroelastic transition at 369 K with a large latent heat of 18.34 J g-1 and an unusual "low → high" SHG-switching behaviour. This work provides an effective molecular assembly strategy to establish dynamic coordination bonds in a new type of host-guest model and opens an avenue for designing advanced ferroelastic multifunctional materials."

Journal

Efficacy of combined HBsAg, anti-HBc and anti-HBs screening in minimizing transfusion transmission risk of hepatitis B infection in low resource setting. (PubMed, Heliyon) - "Out of 547 samples, 16 (2.92%) were positive for HBV DNA with median level at 247.89 IU/mL (IQR: 126.05-666.67 IU/mL)...A combined HBsAg, anti-HBc and anti-HBs screening for donor samples could be an alternative achievable strategy to minimize the HBV transmission as well as financial burden. In resource limited setup, the proposed combined strategy could be helpful in minimizing the risk of OBI transmission."

Journal • Hepatitis B • Hepatology • Infectious Disease • Inflammation

Influence of certified perioperative nurses on the establishment of preoperative outpatient clinic and rate of preoperative assessment in Japan. (PubMed, Sci Rep) - "The study was conducted from February 2021 to September 2022; data were collected and analyzed using a questionnaire at 247 hospitals in Japan...Facilities with certified perioperative nurses have a significantly higher prevalence of preoperative outpatient clinic and significantly higher rates of preoperative assessments than facilities without certified perioperative nurses. Enrollment of certified perioperative nurses may lead to the improvement of the quality of preoperative nursing interventions."

Journal

Tropical Red Macroalgae Cultivation with a Focus on Compositional Analysis. (PubMed, Plants (Basel)) - "Highest productivity in small-scale cultivation was demonstrated with A. subulata in the 10% deep seawater (64.7 µg N L) treatment, growing at up to 26% specific growth rate day with highest yields observed at 247.5 g m day fresh weight...The compositional fingerprint of the high carbohydrate content of both Agardhiella and Halymenia makes for an attractive feedstock for downstream biorefinery applications. By focusing on scaling and optimizing seaweed farming technologies for large-scale onshore farms, the opportunities for yield potential, adaptability to cultivation conditions, and meeting global sustainability goals through novel, carbon-negative biomass sources such as seaweed can be realized."

Journal

Hyperammonemia Not Just From Cirrhosis: A Case of Late Onset Urea Cycle Disorder (ACG 2023) - "She was discharged with lactulose and prednisone with regular outpatient follow-up...She was initially treated with lactulose and rifaximin for presumed hepatic encephalopathy, with clinical deterioration requiring intubation...An ammonia level was obtained in the ICU at 247 mcmol/L, elevated from 87 mcmol/L on admission...Alternatively, it is possible another mutation resulted in underlying chronic liver disease. This case highlights how hyperammonemia is not always sorely from hepatic encephalopathy and to consider genetics and metabolic disorders in the workup, especially if the patient does not improve."

Clinical • CNS Disorders • Fibrosis • Genetic Disorders • Hepatic Encephalopathy • Hepatitis C • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Liver Failure • Metabolic Disorders • Obesity

The quality monitoring of paracetamol medicament using a noninvasive microwave sensor. (PubMed, Sci Rep) - "The experiments show the presence of optimal wavelength values for carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) at 247.92 nm, 656.49 nm, 244.23 nm, and 777.48 nm, respectively...Meanwhile, the LIBS measurement shows a remarkable shift in terms of intensity of approximately 8884 and 812 for carbon and hydrogen, respectively. Understanding how paracetamol dries under high temperatures and improving the process settings of the microwave sensor are investigated and assessed in this work."

Journal

Comparative Study of Impact of Gamma and MeV Ion Irradiations on Electrical and Optical Properties Polystyrene/EuO Nanocomposites. (PubMed, J Fluoresc) - "The photoluminescence emission spectra show three characteristic peaks of Eu ions, when excited at 247 nm wavelength...There appears a significant improvement in the dielectric response as a result of structural changes in both types of irradiations. AFM images show that the film becomes smoother upon both types of irradiations."

Journal

Double-Blind Crossover Study of Ultra-Rapid AT247 Compared with NovoLog and Fiasp during Continuous Subcutaneous Infusion (CSII) Assessed by a Hyperinsulinemic Euglycemic Clamp (ADA 2023) - "The faster absorption of AT247 resulted in higher early insulin exposure than for F or N following bolus dose delivery during CSII. The demonstrated PK profile of AT247 supports further investigation into its potential to further improve automated insulin delivery."

Clinical • Metabolic Disorders • Type 1 Diabetes Mellitus

Development and antibacterial investigation of Linezolid loaded SPIONs and HPLC method development for quantitative analysis of Linezolid. (PubMed, J AOAC Int) - "Successfully reduction of dose of LNZ was established with the aid of biocompatible MNPs to attain the equivalent antibacterial activity."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Using high-density perimetry to explore new approaches for characterizing visual field defects. (PubMed, Vision Res) - "Contrast thresholds for a Goldmann size III stimulus were measured at 247 locations of a 13°×19° rectangular grid, with separation 0.5°, extending from 11° to 17° horizontally and -3° to +6° vertically, covering a portion of the optic nerve head and several major blood vessels...Such alternatives to conventional threshold perimetry have the potential to map the shape of defects without the extensive time demands of high-density threshold perimetry. Simulations illustrate how such an algorithm could operate."

Journal • Ophthalmology

Numerical Optimization on Char Conversion and NOx Emission under Various Operating Conditions in a Retrofit Biomass Boiler. (PubMed, ACS Omega) - "The adjustment of the secondary air ratio from 30 to 50% of the total air and the mass ash at the hopper significantly decreased to a low value at 247 kg/h and a high value of char conversion at 97.33% in case R (SA40%)...Comparative analysis of the burner standby conditions showed that the NOx emission was similar at the boiler outlet (approximately 94-116 ppm). Burner A on standby, with a secondary air ratio of 40%, was used as the optimal case with the highest value of char conversion at 98.43%, the lowest bottom ash release of 204 kg/h, and a low-NOx emission of 106 ppm."

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