Omnicef (cefdinir) / Abbott - LARVOL DELTA

Adverse events of cephalosporins in the pediatric population: a comprehensive review. (PubMed, Expert Opin Drug Metab Toxicol) - "For oral administration, the most common AE of the GI SOC was diarrhea with an incidence rate varying between from 0.6% to 15.2% for which cefdinir was the most reported cephalosporin with AE...This narrative review provides a complete overview of reported AEs in literature caused by cephalosporins in pediatrics. In the future, cephalosporin therapeutic drug monitoring might provide insights in toxicity threshold concentrations."

Adverse events • Journal • Review • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pediatrics

Severe and Rapid Progression of Tropheryma whipplei-Related Pneumonia With Septic Shock: A Case Report. (PubMed, Respirol Case Rep) - "We treated him with mechanical ventilation, continuous renal replacement therapy (CRRT) for 3 days, and meropenem and trimethoprim/sulfamethoxazole (TMP/SMX), as well as other therapies for 12 days...During the follow-up period, the patient was given oral TMP/SMX and cefdinir for up to 33 days, and the chest CT scan showing almost complete absorption of lesions. Clinicians should strengthen the awareness of the presence of severe TW-related pneumonia in a patient without immunodeficiency diseases. Rapid detection characteristics of mNGS can guide us to diagnose rare pathogenic bacteria and improve survival for those severe pneumonia patients."

Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock

In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of Mycobacterium abscessus. (PubMed, Antibiotics (Basel)) - "These findings suggest that imipenem/relebactam may offer a significant advancement in the management of MABS infections in PwCF. The promising efficacy of multidrug regimens combining imipenem/relebactam with agents like cefoxitin, azithromycin, moxifloxacin, clofazimine, and rifabutin highlights potential therapeutic strategies."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Ocrelizumab-induced Cryptogenic Organizing Pneumonia in a Patient With Multiple Sclerosis (ATS 2025) - "Prior outpatient treatments included pseudoephedrine, benzonatate, inhaled albuterol, doxycycline, cefdinir, and prednisone, all without relief of symptoms. Our case represents an additional instance of organizing pneumonia induced by anti-CD20 agents. As our patient developed symptoms at 3.5 years after initiation, it provides additional data regarding the timing of organizing pneumonia presentation with anti-CD20 agents."

Clinical • CNS Disorders • Infectious Disease • Interstitial Lung Disease • Migraine • Multiple Sclerosis • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases

Severe Persistent COVID in Setting of Ocrelizumab-Induced Hypogammaglobulinemia (ATS 2025) - "She was treated with cefdinir and Molnupiravir; however, symptoms continued and she was readmitted 2 weeks later with persistent CT findings,acute pulmonary embolus (PE), and new 3 L/min oxygen requirement. Further research is required to establish standards related to monitoring and treatment of ocrelizumab-induced hypogammaglobulinemia. Providers should consider testing for and treating hypogammaglobulinemia in patients on ocrelizumab who develop severe respiratory infections."

CNS Disorders • Cough • Inflammation • Multiple Sclerosis • Novel Coronavirus Disease • Pneumonia • Pulmonary Embolism • Respiratory Diseases

Unraveling Kartagener's: The Triad of Mystery in Cilia Dysfunction (ATS 2025) - "Initially managed in an outpatient setting with a prednisone taper and cefdinir, her symptoms did not improve, leading to an ED visit for progressive dyspnea and hypoxia...In this case, the patient was on alternating tobramycin and azithromycin therapy, prescribed by her pulmonologist...Patients also require close monitoring of their respiratory function, with spirometry the mainstay of evaluation. For effective management of Kartagener's syndrome, collaboration among specialists, including pulmonology and ENT, along with coordinated care from primary care providers, is essential."

Bronchiectasis • Infectious Disease • Influenza • Otorhinolaryngology • Pneumococcal Infections • Pneumonia • Pulmonary Disease • Respiratory Diseases • Sinusitis

Evaluation of direct oral provocation test results in mild cutaneous reactions to cephalosporins in children. (PubMed, Allergy Asthma Proc) - "The most commonly suspected drugs were cefixime (45.3%), cefdinir (25.8%) and cefuroxime (18%). In our study, direct DPT ruled out suspected allergy in 96.1% of patients with a history of mild skin reactions to cephalosporins. In conclusion, direct oral DPT was found to be a safe and feasible approach for patients with isolated mild skin reactions, effectively bypassing the need for skin testing."

Journal • Allergy • Immunology • Pediatrics

DACAT: Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing (clinicaltrials.gov) - P2 | N=300 | Recruiting | Sponsor: Massachusetts General Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Allergy • Immunology

Cefdinir-Induced Liver Injury: A Case Report. (PubMed, Cureus) - "This case highlights the importance of obtaining a thorough medical history, including recent medication use, drug dose, and time of symptom onset, for a patient presenting with elevated liver enzymes. This case also emphasizes keeping a broad list of differential diagnoses when managing patients with elevated liver enzymes."

Journal • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Nephrology • Pain

Provider Report Cards as a Scalable Tool for Outpatient Antibiotic Stewardship: Insights from a Medicaid Claims-Based Approach (PAS 2025) - "The report cards assessed inappropriate prescriptions for diagnoses for which antibiotics weren’t indicated, guideline adherence rates, and cefdinir utilization... Fifty-six providers had at least one prescription in both periods and were included in the analysis. Guideline-concordant prescriptions significantly increased from 59% pre-intervention to 67.8% post-intervention (p < 0.0001). The proportion of prescriptions for appropriate diagnosis rose from 13.05% to 26.3% (p < 0.0001), while inappropriate prescriptions also increased from 3.98% to 6.91% (p < 0.0001)."

Clinical • Medicaid • Reimbursement • US reimbursement • Huntington's Disease • Movement Disorders • Pediatrics

Patient Age and Antibiotic Formulation Administration in the Pediatric Emergency Department. (PubMed, Pediatr Emerg Care) - "We identified age-related differences in antibiotic formulations in a pediatric ED. These findings can inform prescribing practices to optimize medication adherence and treatment effectiveness through clinical decision support and shared decision-making and may be especially useful during periods of formulation shortages or when planning for clinical research."

Journal • Dermatology • Otorhinolaryngology • Pediatrics

The 16p11.2 microdeletion influences how early-life microbiota perturbations affect hippocampal development and behavior throughout the lifespan. (PubMed, bioRxiv) - "The cephalosporin antibiotic, cefdinir, broadly altered the gut microbiome acutely, with persistent reductions in several Lachnospiraceae genera despite overall recovery...Taken together, this study highlights how early-life microbial alterations affect behavior and reveals that genetic predisposition influences antibiotic-induced changes in hippocampal development. Further, these insights identify metabolic mechanisms as potential targets for intervention and may raise concerns regarding antibiotic use during infancy."

Journal • CNS Disorders • Developmental Disorders • Gastrointestinal Disorder • Metabolic Disorders • Psychiatry

Trends in Extended Oral Antibiotic Prophylaxis After Primary Total Knee Arthroplasty (AAOS 2025) - "EOA was defined as a 7-14 day course of first-generation cephalosporins, cefdinir, clindamycin, doxycycline, or trimethoprim-sulfamethoxazole filled 5 days pre-op to 3 days post-op. From 2009 to 2022, rates of EOA prophylaxis dramatically increased. This trend could not be explained by changing patient characteristics, suggesting changes in prescribing practices are likely reflective of a relatively small number of recently-published cohort studies evaluating EOA. There is a need for further high-quality research on the criteria for and safety and efficacy of EOA prophylaxis."

Immunology • Infectious Disease • Orthopedics • Osteoarthritis • Pain • Rheumatology

PERINEAL BURNS FOLLOWING A PORTABLE CHARGER EXPLOSION (SCCM 2025) - "Medical history positive only for allergies to Ancef and Omnicef. Reconstructive surgery can be sought for aesthetic satisfaction. Outcomes are variable and data is limited due to the rarity of perineal burns."

Immunology • Thermal Injury

How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins? (PubMed, Antimicrob Agents Chemother) - "Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, or Proteus mirabilis isolates susceptible to ceftriaxone."

Journal • Infectious Disease • Pneumonia

An Assessment Of Subsequent Re-Exposure To Beta-Lactam Antibiotics Among Patients With A Prior Beta-Lactam Antibiotic-Induced Acute Interstitial Nephritis, USA 2003-2024: A Single Centre Retrospective Review (AAAAI-WAO 2025) - "First, we identified cases through MDE pathology codes for acute tubulointerstitial nephritis and cross-referenced with BLA allergy labels for penicillin, amoxicillin, piperacillin-tazobactam, nafcillin, cefazolin, cephalexin, ceftriaxone, and cefdinir from 2003-2024. Conclusions Approximately half of the patients with BLA-induced AIN were re-exposed to an alternative BLA, and none had a recurrence of AIN. Larger studies are needed to assess the safety of re-exposure in this population."

Retrospective data • Review • Immunology • Nephrology

Safety of Direct Cephalosporin Oral Challenges in Children (AAAAI-WAO 2025) - "There is much data regarding direct amoxicillin challenges; however, published reports of pediatric direct cephalosporin challenges are limited...Results A total of 194 oral challenges were completed - 146 cefdinir, 39 cephalexin, 5 cefprozil, 3 cefixime, and 1 cefuroxime...Conclusions Direct oral cephalosporin challenges can be safe to use in children without a history of anaphylaxis or SCAR. Oral challenges can be an excellent tool for those with CAL to delabel and allow for optimal care."

Clinical • Dermatology • Immunology • Pediatrics • Urticaria

Evaluation of Carboxymethyl Cellulose/Gelatin Hydrogel-Based Dressing Containing Cefdinir for Wound Healing Promotion in Animal Model. (PubMed, Gels) - "The percentage of wound healing on the ninth day of treatment for an untreated wound was 30%, while this percentage was 40% with a wound dressing without medicine and 60% with a wound dressing containing medicine, and on the fifteenth day of treatment, the wound treated with both wound dressings had more than 85% healing. As a result, it is possible to use CMC/Gel hydrogel polymeric wound dressing containing Cef as a wound dressing for wound healing, according to the desired physicochemical properties and biocompatibility."

Journal • Preclinical

Inhalation of multiple pen caps causing bronchial foreign bodies: a rare case in an older child. (PubMed, BMC Pediatr) - "This case highlights the critical need for clinicians to remain vigilant regarding bronchial foreign bodies in older children. The rare occurrence of multiple foreign bodies, particularly resulting from active inhalation, necessitates a comprehensive medical history during patient evaluation. Early recognition and intervention can lead to significant improvements in patient outcomes, underscoring the importance of thorough clinical assessment in similar cases."

Journal • Chronic Cough • Cough • Infectious Disease • Respiratory Diseases

FL058, a novel β-lactamase inhibitor, increases the anti-Mycobacterium abscessus activity of imipenem. (PubMed, Int J Antimicrob Agents) - "The elevated anti-MABC activity exhibited by imipenem combined with FL058 suggests a potential new approach to treating MABC infections."

Journal • Infectious Disease

Bioequivalence of cefdinir dispersible tablets in healthy Chinese subjects under fasting and fed conditions: a single-centred, randomized, open, single-dose, two-preparation, two-cycle, two-sequence, double-crossover trial. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The results demonstrated that these formulations were bioequivalent in healthy Chinese subjects under fasting and fed conditions, supporting the further clinical development of cefdinir dispersible tablets. This trial was registered in the China Drug Trials Registry (registration number: CTR20210441; registration date: March 11, 2021)."

Journal • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

Comparative Analysis of Cefdinir Cephalexin Nitrofurantoin and Trimethoprimsulfamethoxazole for the Treatment of Urinary Tract Infections in Adults in the Emergency Department A Retrospective Study (ASHP 2024) - No abstract available

Retrospective data • Infectious Disease • Nephrology

Efficacy of Cefdinir versus AmoxicillinClavulanate for CommunityAcquired Pneumonia in Pediatric Patients (ASHP 2024) - No abstract available

Clinical • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Evaluation of Cefdinir for the Treatment of CommunityAcquired Pneumonia in Pediatric Patients Appropriateness Efficacy and Patient Outcomes (ASHP 2024) - No abstract available

Clinical • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Evaluating the Efficacy of Cefdinir in Treatment of Urinary Tract Infections with CeftriaxoneSensitive Bacterial Pathogens (ASHP 2024) - No abstract available

Clinical • Infectious Disease • Nephrology