Omnicef (cefdinir) / Abbott - LARVOL DELTA

Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing. (PubMed, J Antimicrob Chemother) - "Prediction of oral second-generation cephalosporins may warrant cefazolin MIC ≤2 mg/L, despite limitations regarding false resistance and susceptibility discordant. Ceftriaxone/cefotaxime demonstrates a more reliable surrogate for predicting oral third-generation cephalosporins susceptibility. Future investigations are necessary to clinically corroborate these findings."

Journal • Infectious Disease

Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir's Dissolution and Stability Via Predictive Modeling. (PubMed, Br J Biomed Sci) - "This was attributed to the confinement of the drug within silica pores and the absence of hygroscopic excipients. Overall, this study highlights the distinct advantages of each approach, emphasising the importance of balancing dissolution enhancement with solid-state stability, and supports the use of theoretical modelling to guide rational formulation design for poorly soluble drugs to improve oral bioavailability and enable more targeted therapeutic outcomes."

Journal

Recurrent Pyelonephritis in Quadriplegia: Rethinking Oral Cefdinir in the Presence of Nephrolithiasis. (PubMed, Cureus) - "Choosing antibiotics that align with the patient's clinical presentation and pharmacological requirements can significantly reduce recurrence and improve outcomes in quadriplegic patients with recurrent kidney stones. This case report demonstrates that selecting antibiotics with sufficient renal tissue penetration can improve outcomes in complicated pyelonephritis, with symptom resolution after antibiotic change."

Journal • Cerebral Palsy • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Nephrology • Renal Calculi

Cefdinir-Associated Myopericarditis. (PubMed, Cureus) - "Cefdinir was subsequently held with diarrhea and chest pain improving shortly afterwards. He was started on ibuprofen 600mg TID for two weeks, as well as colchicine 0.5mg daily for six weeks. The patient finished his treatment regimen and does not endorse recurrence of his chest pain or any symptoms of heart failure, such as orthopnea, lower extremity edema, or shortness of breath."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Nephrology • Pain

Expanding the phenotype of ZNF462 (ACMG 2026) - "Treatment and Management Continued to follow with cardiology, referred to feeding therapy, saw allergy and immunology due to concerns for penicillin/cefdinir allergy, audiology for hearing loss concerns with normal evaluation, neurodevelopmental assessment which diagnosed him with global developmental delay...Balanced AV canal should be considered in future reviews of the disease as described in our patient. This case is reported to add to the low number of publications previously reported regarding ZNF462-related neurodevelopmental disorder with multiple anomalies and expands understanding of clinical features and diagnosis of this syndrome."

Autism Spectrum Disorder • Cardiovascular • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Hematological Disorders • Immunology • Otorhinolaryngology • Thrombocytopenia

Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis. (PubMed, Nat Commun) - "In lung bacterial infections and bacteremia models, hybrid vesicle-encapsulated cefdinir outperforms free antibiotics in eliminating infections. Notably, this approach also mitigates adverse effects on the intestinal microbiota, safeguarding the animals from dysbiosis-associated metabolic syndromes and opportunistic pathogen infections. This innovative hybrid vesicle system holds promise for the oral delivery of other drugs that suffer from limited absorption or cause gut dysbiosis."

Journal • Infectious Disease • Metabolic Disorders

Cefpodoxime Versus Cefdinir for the Treatment of Urinary Tract Infections in the Emergency Department: A Retrospective Cohort Study (ASHP 2025) - No abstract available

Retrospective data • Infectious Disease • Nephrology

The Risk of Treatment Failure in Cefdinir in Susceptible Gram-Negative Bacteremia (ASHP 2025) - No abstract available

Gram negative • Infectious Disease

Cefdinir versus cefpodoxime for the treatment of f cefazolin-resistant, ceftriaxone-susceptible Enterobacterales infections (ASHP 2025) - No abstract available

Infectious Disease

Comparison of Cefdinir vs First-Line Antibiotics for the Treatment of Pyelonephritis in an Urban Emergency Department (ASHP 2025) - No abstract available

Clinical • Nephrology

Study Title: Comparing Cefazolin versus Ceftriaxone Sensitivities as Predictors of Cefdinir Clinical Success in Complicated and Uncomplicated Urinary Tract Infections. (ASHP 2025) - No abstract available

Clinical • Infectious Disease • Nephrology

Analyzing Outpatient Failure Rates of Cefdinir for Urinary Tract Infections (ASHP 2025) - No abstract available

Clinical • Infectious Disease • Nephrology

Clinical Outcomes of Using Cefdinir Versus Other Beta-Lactams for Oral Transition Therapy in Community Acquired Pneumonia (ASHP 2025) - No abstract available

Clinical • Clinical data • Infectious Disease • Pneumonia

Comparative efficacy of cefdinir plus metronidazole versus other oral stepdown therapies for the treatment of complicated diverticulitis (ASHP 2025) - No abstract available

Clinical • Gastrointestinal Disorder

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Tunisia: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Few therapeutic options with ≥90% susceptibility for the treatment of S. pneumoniae from CA-RTIs in Tunisia remain. Although H. influenzae isolates displayed higher susceptibility, only ceftriaxone provides 100% coverage for both species following CLSI and EUCAST guidelines. Continued surveillance is important for guiding empiric therapy."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Pakistan: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Although antimicrobial resistance was observed, many therapeutic options remain to treat S. pneumoniae and H. influenzae from CA-RTI in Pakistan despite concerns about high levels of inappropriate antibiotic use. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Oncology • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in India: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Some therapeutic options against S. pneumoniae and H. influenzae from CA-RTI in India remain, but only ceftriaxone covers both bacterial species using both guidelines. Continued surveillance of antibiotic susceptibility is important to monitor changes and trends in susceptibilities and for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Case report of peritoneal dialysis-associated peritonitis caused by Mycobacterium abscessus in a child, successfully treated with dual β-lactam combination therapy. (PubMed, ASM Case Rep) - "Many regimens use amikacin, which can worsen renal function and cause deafness...Based on predicted synergy testing, the patient was treated with a combination that included meropenem and ceftaroline for the initial intensified intravenous phase, followed by a regimen that included amoxicillin combined with cefdinir for step-down therapy...This case highlights the potential benefit of dual β-lactam therapy for the treatment of M. abscessus infection as a well-tolerated regimen for a difficult-to-treat infection. To our knowledge, this is the first report using this approach for the treatment of M. abscessus peritonitis."

Journal • Infectious Disease • Nephrology • Otorhinolaryngology • Renal Disease

Nutcracker Syndrome in an 11-Year-Old Girl with ADPKD (KIDNEY WEEK 2025) - "Urinalysis (UA) showed “large amounts of blood and some tissue” for which she was prescribed Cefdinir, and a renal US revealed new renal cysts and enlargement of previous cysts...She was again diagnosed with a UTI and discharged on Cephalexin...In this case, flank pain and hematuria were initially suspected to be caused by an enlarging, infected, or hemorrhagic cyst. Treatment of NCS in patients with ADPKD should involve an individualized approach and may require a lower threshold for more aggressive management, such as endovascular stenting or surgical intervention, as well as closer monitoring to preserve kidney function."

Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Hematological Disorders • Nephrology • Pediatrics • Polycystic Kidney Disease • Renal Disease

Adverse events associated with third-generation cephalosporins: Analysis of the FDA adverse event reporting system database. (PubMed, Medicine (Baltimore)) - "The most reported adverse events of cefotaxime were pain, eosinophilia, and ineffective drugs. Ineffective medication, pyrexia, and sepsis were the most frequently reported adverse effects of ceftazidime. The most reported events of cefdinir were diarrhea, drug hypersensitivity, and rash. The most reported events of ceftriaxone included off-label use, ineffective drugs, and eosinophilia...The most reported adverse events of cefixime included diarrhea, clostridium colitis, and ineffective drugs. This study highlights that gastrointestinal issues, hypersensitivity reactions, and inadequate medication responses are the most commonly reported adverse effects of third-generation cephalosporins. Despite their effectiveness in treating various infections, healthcare professionals must remain vigilant about the potential side effects of these drugs."

Adverse events • Journal • Anorexia • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Pain • Pruritus • Septic Shock

Prescribing Patterns in Pediatric Cellulitis: A Multi-State Analysis Stratified by Penicillin Allergy Status (ACAAI 2025) - "Results Among 1,051,086 pediatric cellulitis patients, cephalexin was the most prescribed antibiotic (n=398,547; 37.92%), followed by mupirocin and amoxicillin/clavulanate. Of 28,871 patients with documented penicillin allergy, cephalexin (n=8,682; 30.07%) remained most prescribed, followed by TMP-SMX, clindamycin, and cefdinir...Conclusions Despite allergy labels, lower-cost β-lactams like cephalexin were still frequently prescribed, resulting in slightly lower average drug costs in the penicillin-allergic group. These findings support the need for improved allergy documentation, de-labeling strategies, and adherence to evidence-based guidelines to optimize both care quality and cost-effectiveness."

Clinical • Allergy • Dermatology • Immunology • Infectious Disease • Pediatrics

Ulcerative Colitis Unmasked by a Clostridioides difficile Infection: A Case Report (ACG 2025) - "Symptoms began after completing a 7-day course of Cefdinir...There was no prior history of IBD, IBS, celiac disease, or pancreatitis.He initially tested positive for C. difficile and was treated with a 2-week course of oral vancomycin, with only brief symptom improvement...Biopsies showed active colitis with chronic architectural changes.He was started on IV methylprednisolone, transitioned to a prednisone taper, and initiated on vedolizumab...Early colonoscopy is essential when symptoms persist. The patient improved with corticosteroids and vedolizumab, aligning with standard UC therapy.Figure: Colonoscopy images #1Figure: Colonoscopy images #2"

Case report • Clinical • Anemia • Celiac Disease • Colorectal Cancer • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Pancreatitis • Type 2 Diabetes Mellitus • Ulcerative Colitis

Nontyphoid Salmonella-Associated Hepatitis: A Rare Infectious Case (ACG 2025) - "The patient was diagnosed with sepsis secondary to Salmonella hepatitis and was treated with intravenous ceftriaxone 2g for 4 days. His liver enzymes improved, and he was discharged on oral cefdinir 300 mg twice daily for a 7-day course Salmonella is a Gram-negative bacterium primarily transmitted through contaminated food, particularly undercooked meat, eggs, and produce...The patient had a pet chihuahua but no contact with farm animals or turtles, and no recent international travel. This case highlights the rare occurrence of Salmonella-induced hepatitis in an immunocompetent individual and underscores the need for consideration of extraintestinal manifestations in severe Salmonella infections."

Clinical • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Herpes Simplex • Infectious Disease • Inflammation • Leukopenia • Septic Shock • Varicella Zoster

DIFFUSE ALVEOLAR HEMORRHAGE IN IGA VASCULITIS: A RARE COMPLICATION AND DIAGNOSTIC CHALLENGE (CHEST 2025) - "She was diagnosed with a urinary tract infection and treated with cefdinir and fluconazole...She was given a one-time dose of furosemide along with a steroid taper and referred to both outpatient dermatology and rheumatology...She developed acute kidney injury (AKI); therefore, trimethoprim/sulfamethoxazole was discontinued and replaced with atovaquone...A skin punch biopsy of her rash revealed vasculopathic changes, lumen occlusion, epidermal necrosis, and re-epithelialization.Given her pulmonary-renal syndrome, skin biopsy findings and high clinical suspicion for IgAV, plasmapheresis, and rituximab were promptly initiated while awaiting confirmation with renal biopsy... DAH in adults with IgAV is a severe complication with significant morbidity and mortality; although rare, this can be effectively managed if recognized and treated early. Therefore, it is crucial to maintain a high index of clinical suspicion for IgAV with DAH in patients presenting with pulmonary-renal..."

Acute Kidney Injury • Breast Cancer • Chronic Obstructive Pulmonary Disease • CNS Disorders • Dermatology • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Multiple Sclerosis • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases • Rheumatology • Solid Tumor • Vasculitis

UNMASKING THE UNCOMMON: CMV PNEUMONIA WITH CAVITARY ASPERGILLUS FUMIGATUS SUPERINFECTION IN ADVANCED HIV (CHEST 2025) - "Upon presentation, she was being treated for pneumonia and a urinary tract infection with Bactrim, Cefdinir, and Prednisone...The patient was started on Valganciclovir and Voriconazole with prophylactic Atovaquone, clinically improved, and was discharged home...Given the patient's history, the potential overlap of multiple opportunistic infections necessitated a broad-spectrum antimicrobial approach with Voriconazole and Ganciclovir, Atovaquone, and Biktarvy and close monitoring... This case highlights the diagnostic and therapeutic challenges in managing pulmonary infections in immunocompromised individuals. CMV pneumonia, though rare, should be considered in HIV patients with respiratory symptoms and cavitary lung lesions, particularly when other common etiologies are excluded. The presence of co-infections, such as Aspergillus fumigatus, further complicates treatment and underscores the importance of a multidisciplinary approach."

Metastases • Cardiovascular • Cytomegalovirus Infection • Human Immunodeficiency Virus • Infectious Disease • Leukopenia • Nephrology • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Tuberculosis • CD4