glyceryl trinitrate (MED2005)
/ Futura Medical
- LARVOL DELTA
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March 02, 2022
Clinical Trial Using Topically Applied Glyceryl Trinitrate (GTN) for the Treatment of Erectile Dysfunction
(clinicaltrials.gov)
- P3 | N=1005 | Completed | Sponsor: Futura Medical Developments Ltd. | Active, not recruiting ➔ Completed
Trial completion • Erectile Dysfunction
November 05, 2020
[VIRTUAL] Ethics in medical publishing
(ISGE-I 2020)
- "Nonfinancial Conflicts of Interest in Research. N Eng J Med 2002;347(10):759-761."
Head and Neck Cancer • Oncology • Psychiatry • Solid Tumor
May 24, 2016
RNA sequencing of trigeminal ganglia in rattus norvegicus after glyceryl trinitrate infusion with relevance to migraine
(PLoS One)
- KOL: Jes Olesen; "15 genes displayed significant changes in transcription levels in response to GTN-infusion. Ten of these genes showed either sustained up- or down-regulation in the 90-minute period after infusion. The GSANOVA analysis demonstrate enrichment of pathways pointing towards an increase in immune response, signal transduction, and neuroplasticity in response to GTN-infusion. Future functional in-depth studies of these mechanisms are expected to increase our understanding of migraine pathogenesis."
Preclinical • Migraine KOL
February 20, 2020
Ethics in medical publishing
(ISGE 2020)
- "Nonfinancial Conflicts of Interest in Research. N Eng J Med 2002;347(10):759-761."
October 07, 2019
Trabecular Bone Score and Malnutrition in a Cohort of Systemic Sclerosis Patients
(ACR-ARHP 2019)
- "This study shows that a more severe microarchitectural bone defect correlates with gastrointestinal involvement in term of symptom related to intestinal disbiosis and with selected blood biochemical markers of malnutrition 1. Caimmi et al Clin Rheum 2017.37:987-997 2. Omran et al Clin_Geriatr_Med 2002.18:719-36"
Clinical
August 18, 2019
COLONIC EOSINOPHILIA IS ASSOCIATED WITH CURRENT BUT NOT INCIDENT DEPRESSION INDEPENDENT OF IBS STATUS
(UEGW 2019)
- "The random population based colonoscopy study (PopCol) was performed 2002-2006 and included colonoscopies with biopsies on 745 individuals from the general population (Kjellström et al Eur J Gastro Hep 2014)... The present result supports a direct association between colonic eosinophilia and depressive symptom severity in a general population. Future studies are needed to elucidate if this is a causal association."
January 08, 2018
Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study.
(PubMed, J Sex Med)
- "Further studies are warranted to investigate the efficacy of topical glyceryl trinitrate to include higher doses, thereby improving clinical significance, especially in cases of moderate and severe ED. Ralph DJ, Eardley I, Taubel J, et al. Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study. J Sex Med 2017;XX:XXX-XXX."
Clinical • Journal
May 09, 2019
Colonic Eosinophilia is Associated with Current But Not Incident Depression Independent of IBS Status
(DDW 2019)
- "...Methods The random population based colonoscopy study (PopCol) was performed 2002-2006 and included colonoscopies with biopsies on 745 individuals from the general population (1)...Conclusion The present result supports a direct association between colonic eosinophilia and depressive symptom severity in a general population. Future studies are needed to elucidate if this is a causal association."
April 16, 2019
Poorly chosen upper limits of normal for alanine aminotransferase may burden the patient and health system unnecessarily
(EASL-ILC 2019)
- "...Sensitivity analyses included healthy subsets (excluding patients with hepatitis B (HBsAg or anti-HBc positive) or at risk for non-alcoholic fatty liver disease (NAFLD) presenting with either elevated GGT, triglycerides, cholesterol, HbA1c, or glucose (according to Prati, Ann Intern Med 2002) and one random sample per patient)... Currently used reference values for ALT imply that subsequent diagnostics are needed for a large proportion of young men. Our data beg the question whether age-adapted reference values for ALT are needed.Figure:"
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