erythromycin / Generic mfg. - LARVOL DELTA

Risk Factors Associated With Multidrug Resistant Organism (MDRO) Isolates in Infected Diabetic Foot Ulcers (DFU): An Analytical Cross-sectional Study. (PubMed, J ASEAN Fed Endocr Soc) - "For gram-negative isolates, erythromycin had the most resistance at 17.53% followed by oxacillin and clindamycin both at 13.4%. For gram-positive isolates, highest resistance were seen with ampicillin at 18.99% followed by cefuroxime at 13.57% and amoxicillin-clavulanate at 11.63%.Higher ulcer grade (Crude OR = 1.11 [95% CI 1.00 - 1.23], p-value 0.04; Crude OR = 1.29, [95% CI 1.04 - 1.60], p-value 0.02), as well as previous admission for diabetic foot ulcer (Crude OR = 2.28, [95% CI 1.10 to 4.73], p-value 0.04) were associated with multidrug resistance...There is a high burden of multidrug resistant organism infection in diabetic foot ulcers with significant association in higher ulcer grades. A previous admission for diabetic foot ulcer significantly increases the odds for MDRO infection in succeeding diabetic foot infections."

Journal • Observational data • Retrospective data • Infectious Disease • Pneumonia

Occurrence, source apportionment, and risk assessment of antibiotics in the Beiyun River system: a highly urbanized watershed in Beijing, China. (PubMed, Environ Monit Assess) - "The total concentrations of individual antibiotics varied between 2.8 ng/L (lomefloxacin) and 1235.8 ng/L (erythromycin)...However, tetracyclines showed relatively high risk quotients (RQ), and clarithromycin exhibited low risks to certain aquatic species...The former contributed most significantly to difloxacin (72.1%) and ciprofloxacin (71.4%), while the latter contributed substantially to sulfacetamide (74.8%), sulfachloropyridazine (73.9%), sulfadimethoxine (73.3%), and sulfadiazine (70.9%). These findings provide valuable insights for antibiotic pollution prevention and management of the risks to ecosystems in urban river systems."

Journal

Whole Genome Sequencing Reveals Antibiotic Resistance Heterogeneity and Metabolic Signatures of Cutibacterium acnes in Atopic Dermatitis. (PubMed, Curr Microbiol) - "The result showed that antibiotic resistance genes (ARGs) were highly clustered within specific individuals and phylogenetic subtypes of C. acnes, with erm(X) being the most prevalent determinant conferring cross-resistance to erythromycin and clindamycin...AD isolates exhibited low-level acquired resistance to tetracyclines, chloramphenicol, and fusidic acid, indicating distinct antibiotic exposure pressures in AD patients...These findings suggest that resistance in AD-associated C. acnes is linked to metabolic adaptations that may facilitate survival in the AD skin environment. Together, these findings provide a genomic and functional framework for understanding the antibiotic resistance of AD-associated C. acnes, underscoring the need for careful antibiotic stewardship in AD management."

Heterogeneity • Journal • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Associations Between Early-Life Exposure to Different Antibiotic Agents and the Risks of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: A Nationwide Population-Based Study. (PubMed, Pharmaceutics) - "For ADHD, exposure to amoxicillin/clavulanic acid, cefixime, ampicillin, and ampicillin/sulbactam was associated with increased risk, whereas erythromycin, cephalexin, and sulfamethoxazole-trimethoprim were associated with reduced risk (all p < 0.047). Associations between early-life antibiotic exposure and the risks of ASD and ADHD varied according to antibiotic agents, route of administration, and timing of exposure. These findings may help explain inconsistencies among previous studies and inform antibiotic prescribing during infancy."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders • Psychiatry

Antibacterial, Synergistic, and Antibiofilm Activities of Liquidambar orientalis Mill. Essential Oil Against Clinically Relevant Bacterial Pathogens. (PubMed, Antibiotics (Basel)) - "Synergistic interactions with erythromycin, amoxicillin, gentamicin, and enrofloxacin were assessed using fractional inhibitory concentration index (FICI) analysis. The essential oil also showed synergistic interactions with selected antibiotics and variable antibiofilm effects. These findings suggest that L. orientalis essential oil may have potential as an antibacterial agent or adjunct to antibiotic therapy; however, further in vivo and clinical studies are required to confirm its therapeutic applicability."

Journal • Infectious Disease

Isolation and Preliminary In Vitro Characterization of a Honey-Derived Bacillus licheniformis Isolate. (PubMed, Antibiotics (Basel)) - " In vitro assays revealed that Blhoney exhibits robust tolerance to simulated gastrointestinal stress, including extreme acidity (pH 1-3), bile salts (0.3-1%), pepsin, and pancreatin, maintaining viability for up to 24 h. Phenotypic antimicrobial testing demonstrated measurable inhibition zones for erythromycin, kanamycin, chloramphenicol, ampicillin, tetracycline, gentamicin, streptomycin, and spectinomycin, whereas no measurable inhibition zones were observed for penicillin G, rifampicin, ciprofloxacin, or ceftazidime. Overall, these findings indicate that the honey-derived Blhoney isolate exhibits preliminary probiotic-associated characteristics under the tested in vitro conditions. However, further strain-level genomic and safety characterization is required before its potential probiotic application can be established."

Journal • Preclinical

Cardiotoxicity of macrolide antibiotics: a pharmacovigilance study integrating FAERS and JADER databases. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Erythromycin showed the highest FAERS ROR for long QT syndrome (81.82, 95% CI 45.09-148.46), followed by azithromycin (34.71, 95% CI 25.15-47.91) and clarithromycin (18.11, 95% CI 8.61-38.08); azithromycin and clarithromycin signals were independently confirmed in JADER (ROR 24.42 and 13.17, respectively). Macrolide-associated cardiotoxicity extends beyond QT prolongation/TdP to heart failure and ischemic heart disease, with drug-specific and cross-national differences in signal pattern. As disproportionality signals, these findings are hypothesis-generating rather than causal, but support targeted cardiac monitoring in high-risk patients, particularly during the first 2 weeks of macrolide therapy."

Adverse events • Journal • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Myocardial Ischemia

Agent, Dose and Duration: The Unanswered Questions Behind Latency Antibiotic Therapy for Preterm Prelabour Rupture of Membranes. (PubMed, Antibiotics (Basel)) - "Contemporary practice descends from two protocols: the ampicillin-erythromycin regimen of the NICHD Maternal-Fetal Medicine Units Network trial and the erythromycin arm of ORACLE I. Neither was designed to identify an optimal regimen. Substitution of azithromycin for erythromycin rests predominantly on observational cohorts together with one small open-label randomised comparison that pre-specified no non-inferiority margin and is therefore pragmatic and guideline-permitted rather than confirmed by an adequately powered randomised trial...Guideline agreement reflects shared historical ancestry rather than independent confirmation of optimality. Adequately powered pragmatic trials, stratified by gestational age, remain the principal unmet need."

Journal • Review • Infectious Disease • Obstetrics

Molecular Characterization of Antimicrobial Resistance and Virulence Genotypes in Staphylococcus aureus Isolates: Investigation of mecA, pvl, and agr Groups. (PubMed, Pathogens) - "These findings characterise the local epidemiological distribution of pvl, agr groups and resistance profiles in S. aureus and confirm the independent association between pvl carriage and the MRSA phenotype. These single-centre data highlight the need for future multicentre studies incorporating sequence-based typing, whilst providing valuable information for institutional surveillance and antibiotic management."

Journal

Antimicrobial Resistance and Genomic Characterization of a Novel ST181 Streptococcus parasuis Clinical Isolate from Human Pleural Fluid. (PubMed, Antibiotics (Basel)) - "Because species-specific clinical breakpoints are unavailable, the MICs were interpreted provisionally using explicitly stated surrogate Clinical and Laboratory Standards Institute (CLSI) criteria; erythromycin, clindamycin, and levofloxacin were categorized as resistant under those criteria. HUGSPH caused dose-dependent larval mortality, reaching 100% at 107 colony-forming units (CFU) by 96 h. HUGSPH expands the genomic record of human clinical S. parasuis and highlights the diagnostic and surveillance relevance of antimicrobial resistance in this species. The susceptibility categories, source-associated genes, and larval phenotype require validation by reference susceptibility testing, broader phylogenetically balanced collections, comparative strains, and mammalian models."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Phenotypic characterization of inducible and constitutive clindamycin resistance in clinical Staphylococcus aureus isolates. (PubMed, Rev Inst Med Trop Sao Paulo) - "However, inducible resistance to clindamycin via erythromycin ribosomal methylases encoded by erm genes poses a significant clinical challenge; it often leads to treatment failure and remains undetected by routine antimicrobial susceptibility testing. Inducible clindamycin resistance, though less prevalent, remains clinically significant and can be readily detected using the D-test. Routine use of the D-test is essential to guide appropriate antimicrobial therapy and prevent clindamycin treatment failure."

Journal • Dermatology • Infectious Disease

Efficacy of Pre-Endoscopic Prokinetic Therapy in Acute Upper Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis (ACG 2026) - "Ten RCTs involving 681 patients met inclusion criteria. The majority compared intravenous erythromycin administered pre-EGD, while fewer evaluated metoclopramide. Prokinetic therapy significantly improved endoscopic visualization (pooled OR ~3.5-4.0) and reduced the need for repeat endoscopy (pooled OR ~0.5), as compared to placebo."

Retrospective data • Review • Gastroenterology

Eosinophilic Cholecystitis: A Histopathologic Surprise Following Cholecystectomy for Suspected Choledocholithiasis (ACG 2026) - "She initially improved with metoclopramide and erythromycin. She is undergoing further workup outpatient to including gastric emptying study to better understand the underlying pathology or pathologies at play. Figure: Gallbladder submucosa with eosinophilic infiltration (H&E stain"

Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders

A Hairy Tale: Rapunzel Syndrome With Abdominal Pain and Vomiting (ACG 2026) - "Patient started on piperacillinâtazobactam and fluconazole, given IV fluids and a short course of erythromycin following clozapine reinitiation. Early diagnosis may allow for less invasive management and reduce the risk of severe complications, as in this patient. Figure: CT scan of bezoar Figure: Removed Bezoar"

CNS Disorders • Crohn's disease • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Mental Retardation • Metabolic Disorders • Pain • Schizophrenia • Septic Shock • Type 2 Diabetes Mellitus

The Catâs out of the Bag: Granulomatous Hepatitis Due to Bartonella Henselae (ACG 2026) - "He received ceftriaxone and metronidazole for one week due to concerns for liver abscess...Macrolides, doxycycline, or erythromycin are typical antibiotics used to treat B. henselae...Figure: 3 month follow up CT Abdomen/Pelvis demonstrating a decrease in size of hypodense lesion in hepatic segment 7 (1.1 x 0.9 cm, previously 1.6 x 1.5 cm). and lesion in segment 3 (1.9 x 1.2 cm, previously 2.0 x 1.6 cm), thought to represent granulomatous infection."

Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Comparative Effectiveness of Metoclopramide Versus Erythromycin in Severe Non-Variceal Upper Gastrointestinal Bleeding: A Multicenter Propensity-Matched Cohort Study (ACG 2026) - "After matching, 1639 remained in each cohort and outcomes were comparable between metoclopramide and erythromycin. The need for repeat endoscopy occurred in 17.4% versus 17.0% of patients (RR 1.02, 95% CI 0.88â1.19), while transfusion requirements were similar at 19.3% versus 18.1% (RR 1.1, 95% CI 0.93â1.24). Recurrent bleeding showed no meaningful difference (33.5% vs 36.1%; RR 0.93, 95% CI 0.84â1.02), and ICU utilization was identical at 1.9% in each cohort (RR 1.00, 95% CI 0.61â1.64)."

Clinical • HEOR • Gastroenterology

Pan-Enteric Dysmotility and Small Bowel Malabsorption: A Multidisciplinary Challenge in a Patient With LADA and Hashimoto's (ACG 2026) - "Despite extensive medical therapy which included prokinetics (prucalopride, erythromycin, azithromycin) , intestinal secretagogues (lubiprostone, plecanatide), antiemetics (ondansetron, prochlorperazine) and antispasmodics (dicyclomine), (proton pump inhibitors and H2 blockers), symptoms persisted . An integrated neuro-immuno-gastroenterological approach is essential in such complex presentations. Figure: Smallbowel Figure: Autoimmune"

Clinical • Constipation • Crohn's disease • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Secondary Hyperparathyroidism • IL13 • IL6

The Forgotten Vagus: Recognizing Gastroparesis Following Radiofrequency Ablation for PVCs: An Unusual Complication (ACG 2026) - "The patient was referred to gastroenterology where she was initiated on pro-kinetic agents including prucalopride and alternating metoclopramide and erythromycin, with improvement in her symptoms at her 6-month follow-up. The temporality of symptom development following ablation argues for potential thermal-injury mediated gastroparesis. To our knowledge, this is one of the first instances of PVC ablation-mediated gastroparesis and establishes an important consideration for physicians who complete ablative procedures."

Atrial Fibrillation • Cardiovascular • Gastrointestinal Disorder • Thermal Injury • Ventricular Tachycardia

First Report of Gastric Peroral Endoscopic Myotomy for Refractory Gastroparesis in Bainbridge-Ropers Syndrome (ACG 2026) - "She was started on erythromycin, metoclopramide, an appetite stimulant and a proton pump inhibitor, however, her symptoms continued to persist. To our knowledge, this is the first G-POEM done in a patient with BRS and highlights a novel approach in the management of gastroparesis in patients with neurodevelopmental disorders. Our treatment in this particularly challenging case provides a great reference for our future clinical practice, and increases awareness of the GI manifestations of neurodevelopmental disorders and the treatment options available can significantly improve quality of life in such patients."

Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Mental Retardation

Swirling out of Control: A Unique Cause of a Hemodynamically Unstable GI Bleed (ACG 2026) - "This lesion was treated with epinephrine injection, hot coagulation graspers, and hemostatic spray...Repeat push enteroscopy was performed the following day after administration of metoclopramide and erythromycin... Postoperatively, the patient had no further hematochezia, with stabilization of hemoglobin levels. Figure: Figure A: Endoscopic view of JJ anastomosis with dilated vasculature and superficial areas of oozing Figure: Figure B: Intraoperative view of dilated vasculature around JJ anastomosis"

Gastroenterology • Hematological Disorders • Hypotension

Role of Prokinetic Drugs Prior to Endoscopy in Acute Upper Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis (ACG 2026) - "Ten randomized controlled trials involving 977 patients were included (492 receiving prokinetics and 485 placebo). Prokinetic therapy significantly improved gastric emptying compared with placebo (OR 3.27, 95% CI 1.56â6.84) and reduced the need for second-look endoscopy (OR 0.35, 95% CI 0.18â0.68). No significant effect on mortality was observed (OR 0.63, 95% CI 0.36â1.11)."

Retrospective data • Review • Gastroenterology

Nasal Carriage Rate and Antimicrobial Susceptibility Profile of Staphylococcus aureus Among Healthcare Workers and Inpatients at Shahid Beheshti Hospital, Kashan, Iran (2023-2024): A Cross-Sectional Study. (PubMed, Infect Drug Resist) - "aureus among healthcare workers and inpatients in our study was consistent with previous reports. Given the considerable resistance to erythromycin and clindamycin, alongside confirmation of the mecA gene in all MRSA isolates, we recommend implementing routine active surveillance and stringent infection control policies to limit the transmission of these potentially life-threatening strains in hospital settings."

Journal • Observational data • Infectious Disease

Efficacy and safety of erythromycin and metoclopramide, alone or in combination, for successful feeding in critically Ill patients: a systematic review and network meta-analysis. (PubMed, Front Nutr) - "These preliminary findings require confirmation in larger, well-designed trials. https://www.crd.york.ac.uk/prospero/, identifier CRD420251247900."

Journal • Retrospective data • Review • Critical care • Pediatrics

High prevalence and multidrug resistance of Methicillin-resistant Staphylococcus aureus at a provincial referral hospital in Zambia: A 5-year retrospective study. (PubMed, PLOS Glob Public Health) - "In resource-limited settings such as Zambia, staphylococcal infections are treated empirically with clindamycin or co-trimoxazole due to limited susceptibility testing...MRSA demonstrated significantly lower susceptibility than MSSA to non-beta-lactam antibiotics: clindamycin (46.2% vs. 67.7%), erythromycin (50.0% vs. 79.5%), ciprofloxacin (58.2% vs. 91.4%), and tetracycline (58.3% vs. 81.9%)...Empirical use of clindamycin and erythromycin for suspected staphylococcal skin and soft tissue infections should be reconsidered and guided by local antimicrobial susceptibility whenever available. Continued local surveillance and multicenter studies are needed to inform empirical treatment guidelines across Zambia."

Journal • Retrospective data • Infectious Disease • CAT

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P-Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes. (PubMed, J Vet Pharmacol Ther) - "Eleven drugs were assessed as canine P-gp substrates by both methods, with two identified as non-P-gp substrates (erythromycin, propranolol) and nine identified as canine P-gp substrates (clarithromycin, daunorubicin, digoxin, etoposide, paclitaxel, quinidine, ritonavir, verapamil, vinblastine). Erythromycin was identified as a canine P-gp substrate by competitive efflux assay at roughly 10-fold higher concentrations than was used for transwell assays. Concordance of these methods assessing canine P-gp substrate status using historical data supports the need for head-to-head studies comparing these two methods for identifying canine P-gp substrates."

Journal • ABCB1