erythromycin / Generic mfg. - LARVOL DELTA

Carbon Metabolism of Multidrug-Resistant Strains of Bacillus mobilis and Cupriavidus campinensis Isolated from Elevated Cadmium-Amended Soil (ASM Microbe 2025) - "Antibiotic susceptibility testing revealed distinct growth dynamics under exposure to ceftriaxone, ciprofloxacin, gentamicin, and tetracycline...campinensis exhibited extended lag phases and concentration-dependent growth inhibition, with delayed recovery following exposure to ceftriaxone and tigecycline. In contrast, B. mobilis displayed resistance to multiple antibiotics, including erythromycin and vancomycin, as well as adaptive responses to ciprofloxacin and nitrofurantoin, indicating robust resistance mechanisms...Furthermore, the observed co-selection of resistance to both heavy metals and antibiotics underscores the ecological intricacies of polluted environments. Future research should focus on elucidating the molecular mechanisms underlying these adaptive traits and refining susceptibility testing protocols to account for prolonged bacterial responses to environmental and antibiotic stressors."

The Characterization of a Novel Spore Septation Gene in Streptomyces Coelicolor (ASM Microbe 2025) - "Based on the largest differences in the zones of inhibition, erythromycin, kanamycin, and tetracycline all significantly restrained the mutant bacterial growth and interestingly, they all play a role in inhibiting protein synthesis. Characterizing this newly identified gene and those in the rest of the potential operon is expected to further the knowledge regarding the complex process of division and spore formation in filamentous bacteria."

Infectious Disease

Genomic Features of Biofilm-Forming and Drug-Resistant Cutibacterium acnes Isolates (ASM Microbe 2025) - "We evaluated hemolytic activity and the minimum inhibitory concentrations (MICs) of five antibiotics—tetracycline, clindamycin, erythromycin, minocycline, and doxycycline—using E-strip® assays. The results showed the genetic factors contributing to both antibiotic resistance and biofilm formation in Cutibacterium acnes. These results emphasize the potential clinical challenges posed by multidrug-resistant and biofilm-forming C. acnes isolates."

Acne Vulgaris • Infectious Disease

Community-Engaged Course-Based Undergraduate Research of Multidrug Resistance in Escherichia coli in Water Near Dairy and Hog Farms in Michigan (ASM Microbe 2025) - "Purified isolates of EC selected without antibiotics were characterized by the Kirby Bauer Disk Diffusion method; antibiotics tested included ampicillin, tetracycline, cefotaxime, cefoxitin, streptomycin, nalidixic acid, kanamycin, ciprofloxacin, and erythromycin. Interestingly, the percent of isolates resistant to AMP correlated quite well with MDR. This work highlights the importance of MDR characterization at livestock-impacted surface water sites and how that can translate into affecting human and global health."

Hipervirulent Group A Streptococcus emm1/ST28: Could It Be the New Healthcare Threat in Brazil? (ASM Microbe 2025) - "All five strains were susceptible to penicillin, vancomycin and levofloxacin. emm94/ST89 was resistant to erythromycin, clindamycin and tetracycline and carried ermA and tetM genes, while emm44/ST1516 was resistant to tetracycline carrying tetM gene...Our results show the emergence of emm1/ST28 in iGAS in Brazil in the last year, suggesting the rise of a new regional M1 clone with potential to spread rapidly in the country. Maintaining epidemiological surveillance is necessary to evaluate this hypothesis."

Infectious Disease

Serotype Prevalence and Antimicrobial Susceptibility Rates of Streptococcus agalactiae from Blood Cultures in Two Tertiary-Care Hospitals (ASM Microbe 2025) - "All isolates, except for one, were susceptible to ampicillin, benzylpenicillin, cefotaxime, ceftriaxone, trimethoprim/sulfamethoxazole, vancomycin, and linezolid. The susceptibility rates for clindamycin, erythromycin, levofloxacin, and tetracycline were 67.5%, 74.2%, 72.4%, and 58.1%, respectively. This study highlights the prevalence of limited serotypes in blood culture isolates, with serotype VIII being the most common, a pattern differing from reports in neonates or pregnant women. Further investigation into the relationships between serotypes, antimicrobial resistance, and their clinical implications in systemic infections is warranted."

CNS Disorders • Infectious Disease • Septic Shock

Prevalence and Antimicrobial Susceptibility Profiles of Campylobacter Isolates from Sheep Flocks of the United States (ASM Microbe 2025) - "Species identification was conducted by MALDI-TOF, and a subset of isolates were tested for susceptibility to azithromycin (AZI), ciprofloxacin (CIP), clindamycin (CLI), erythromycin (ERY), florfenicol (FFN), tetracycline (TET), gentamycin (GEN), and nalidixic acid (NAL). These results indicate the broad distribution of Campylobacter on sheep farms and the varied resistance to antibiotics. The project highlights the needs for interventions to reduce Campylobacter prevalence in sheep, and once completed, the generated information may be useful for risk assessment of Campylobacter carriage and antimicrobial resistance on sheep farms."

Gastroenterology • Gastrointestinal Disorder

Testing Antibiotic Resistance of Probiotic Bacteria Using Raman Spectroscopy (ASM Microbe 2025) - "Resistance of these bacteria extracted from gummies was tested in both its endospore and vegetative forms, using a wide range of antibiotics (ampicillin, erythromycin, ciprofloxacin, colistin, and cefepime). There were also differences in how spore and vegetative forms were impacted by antibiotics based on its resistance or susceptibility, which was also reflected in the Raman spectra. This study provides a basis that SERS can be an effective tool for identifying resistant bacteria that is more rapid than phenotypic and sequence-based methods, which still maintaining accuracy."

Infectious Disease

Emergence of Macrolide-Resistant Bordetella pertussis in Brazil: The First Reported Case in South America (ASM Microbe 2025) - "A total of 245 B. pertussis isolates were tested by disk diffusion to assess resistance to three macrolides (15 µg azithromycin, erythromycin, and clarithromycin disks) on Regan-Lowe plates, incubated and interpreted. This study describes the first documented cases of macrolide-resistant B. pertussis in Brazil and South America. Our findings highlight the importance of AMR surveillance in detecting emerging resistance which can inform public health policy and guide evidence-based actions."

Clinical • Infectious Disease • Novel Coronavirus Disease • Pertussis • Respiratory Diseases

Carbon Metabolism of Multidrug-Resistant Strains of Bacillus mobilis and Cupriavidus campinensis Isolated from Elevated Cadmium-Amended Soil (ASM Microbe 2025) - "Antibiotic susceptibility testing revealed distinct growth dynamics under exposure to ceftriaxone, ciprofloxacin, gentamicin, and tetracycline...campinensis exhibited extended lag phases and concentration-dependent growth inhibition, with delayed recovery following exposure to ceftriaxone and tigecycline. In contrast, B. mobilis displayed resistance to multiple antibiotics, including erythromycin and vancomycin, as well as adaptive responses to ciprofloxacin and nitrofurantoin, indicating robust resistance mechanisms...Furthermore, the observed co-selection of resistance to both heavy metals and antibiotics underscores the ecological intricacies of polluted environments. Future research should focus on elucidating the molecular mechanisms underlying these adaptive traits and refining susceptibility testing protocols to account for prolonged bacterial responses to environmental and antibiotic stressors."

Group B Streptococcus Isolates from Human Semen in Brazil (ASM Microbe 2025) - "All strains were susceptible to penicillin and vancomycin, while non-susceptibility to tetracycline, erythromycin, levofloxacin and clindamycin were observed in 86%, 35.6%, 8.5% and 5% of the strains, respectively. Levofloxacin-resistant strains also harbored other resistance genes. Our results show that GBS from semen belong to serotypes and STs commonly found among women in Brazil, and show a high resistance rate to antibiotics, especially erythromycin and levofloxacin, indicating the need for additional studies on semen as a source of GBS isolates."

Infectious Disease

Microbiological Contamination and Antibiotic Resistance in Soil and Water: Implications for the Water-Energy-Food Nexus in Ulaanbaatar, Mongolia (ASM Microbe 2025) - "Over 90% of isolates showed resistance to commonly used antibiotics such as ampicillin and erythromycin, signaling uncontrolled antibiotic use in human and livestock sectors. Mitigation measures such as soil and water sterilization, robust contamination monitoring systems, and public health interventions are recommended to curb the spread of antibiotic-resistant pathogens and promote ecosystem and human health. The findings provide a foundation for developing integrated strategies to strengthen the WEF nexus, addressing environmental sustainability and public health in rapidly urbanizing regions like Ulaanbaatar."

Infectious Disease

Proteomics Study of Erythromycin Resistance in Streptococcus pneumoniae (ASM Microbe 2025) - "This protein also showed a reduced abundance following the growth of the bacteria in the presence of erythromycin but not when the bacteria were grown in the presence of penicillin. It is proposed that the absence of the lysyl-tRNA synthetase in the M phenotype is a potential mechanism involved in the resistance to erythromycin in the M phenotype."

Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • GAPDH

Development of Six PspA Clade-Switched Mutants for a Multiplexed Opsonophagocytic Killing Assay of Anti-PspA Antibodies in Streptococcus pneumoniae (ASM Microbe 2025) - "These mutants were further transfected with an antimicrobial resistance gene corresponding to one of the following antibiotics: streptomycin (Sm), erythromycin (Em), or chloramphenicol (Cm)... We successfully established a multiplex OPK assay for anti-PspA antibodies using engineered PspA clade-switched mutants."

Infectious Disease • Otorhinolaryngology • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Monitoring the Antimicrobial Resistance (AMR) Load of the Microbial Communities and Detection of Antibiotics in the Polluted Stretch of Narmada River - An Environmental View in the One Health Approach (ASM Microbe 2025) - "Bacterial isolates were susceptible to chloramphenicol, whereas resistance against cefotaxime, ceftriaxone, ceftazidime – third generation cephalosporins, along with erythromycin and clindamycin – macrolides, and imipenem – a carbapenem drug was observed. Several treatment methods have been applied in the wastewater treatment plant for the removal of biological contaminants but are proved to be inefficient. New and improved methods are required for the removal of antibiotics from the effluents before it is released into the running stream like river."

Trends in Coliforms and Antibiotic Resistance in a Los Angeles Watershed (ASM Microbe 2025) - "Water quality was assessed using environmental sensors, IDEXX Colilert-18, and a modified IDEXX method incorporating antibiotics (tetracycline and erythromycin). These findings suggest the presence of an environmental reservoir of diverse AR genes. This study highlights the importance of regular time series measurements for identifying trends and predicting future water quality impacts, which is important for scientific research and regulatory decision-making in a changing climate."

Tracking the Prevalence of Panton-Valentine Leucocidin-Positive CC5-Methicilllin-Resistant Staphylococcus aureus -IVc Clone in Kuwait Hospitals (ASM Microbe 2025) - "Eighty-three (61.0%) of the isolates were resistant to erythromycin and clindamycin mediated by erm (C). Twenty-three, nine and four isolates were resistant to fusidic acid, trimethoprim and tetracycline mediated by fusC or fusB, dfrG, and tet(K), respectively... The study revealed the introduction and transmission of the 'Sri Lankan clone' Of MRSA among patients in Kuwait that had gone undetected for years. The isolation of the 'Sri Lankan clone' from different clinical samples indicates its capacity to cause different types of infections."

Clinical • Infectious Disease

Whole Genome Sequencing and Characterization of the First Macrolide-Resistant Bordetella pertussis Strain in Mexico: Implications for Public Health and Surveillance in Latin America (ASM Microbe 2025) - " Macrolide susceptibility testing was conducted using the disk diffusion (DD) method on Regan-Lowe agar for three macrolides: azithromycin, clarithromycin, and erythromycin. This study presents the whole genome sequencing results of the first confirmed case of macrolide-resistant B. pertussis reported in Latin America. The findings highlight the importance of expanding genomic monitoring and integrating molecular diagnostics to detect and strengthen public health measures, enhance surveillance systems, and continue antimicrobial resistance monitoring to effectively detect and respond to emerging resistance patterns."

Whole genome sequencing • Infectious Disease • Pertussis • Respiratory Diseases • PTX3

Genotypic and Phenotypic Characterization of Antimicrobial Resistance in Campylobacter spp. Recovered from Environments of Commercial Integrated Broiler Complexes (ASM Microbe 2025) - "Among 9 antibiotics tested for phenotypic resistance, 23%, 9%, 7%, 4%, 2%, and 2% of total isolates (n=57) showed phenotypic resistance to tetracycline, clindamycin, azithromycin, nalidixic acid, erythromycin, and ciprofloxacin respectively. There was high consistency in genotypic and phenotypic results for tetracycline while there were high discrepancies in resistance results for the rest of the antibiotics tested. The presence of drug-resistant Campylobacter in the surroundings of farms and facilities poses a significant risk of entering these bacteria into the complex and can potentially contaminate the final raw chicken product in the poultry processing plant."

Prevalence and Antimicrobial Resistance of Salmonella and Campylobacter from Raw Retail Meat in Iowa, 2017 - 2021 (ASM Microbe 2025) - "Phenotypic resistance rates in Salmonella were 9.5% to gentamicin, 1.8% to amox-clav, 25% to ampicillin, 8.1% ceftriaxone, 1.36% to cefoxitin, 1.3% to colistin, 0.45% to azithromycin, 8.1% to chloramphenicol, 22.7% to sulfisoxazole, 46.3% to tetracycline, 4.5% to co-trimoxazole, and 0% to each meropenem and ciprofloxacin. For Campylobacter, 39.2% was phenotypically resistant to tetracycline, 17.8% to ciprofloxacin, 1% to gentamicin, and 0% to each erythromycin, clindamycin, and meropenem...This study provides important information on the contamination levels of raw retail meats with the two leading zoonotic foodborne bacteria in Iowa in recent years, and indicates the presence of substantial levels of AMR in both pathogens, including to medically important antibiotics. The findings should be useful for risk assessment and mitigation strategy to reduce the public health burden due to foodborne illness and AMR."

Infectious Disease

Antimicrobial Susceptibility Trends Amongst Invasive Streptococcus pneumoniae Blood Culture Isolates, a Review during 2012-2024 at a Reference Laboratory in the United States (ASM Microbe 2025) - "Linezolid, vancomycin, meropenem, levofloxacin demonstrated 100% susceptibility. Notably, intravenous penicillin and ceftriaxone non-susceptibility among meningitis isolates was higher at 17.8% and 5.7% respectively compared to non-meningitis isolates, underscoring the need for initial empiric vancomycin therapy in cases of suspected meningitis... Non-susceptibility to several first line antibiotics, especially oral antibiotics, remains a significant concern. Compared to intravenous drugs, we observed increased resistance amongst oral antibiotics (erythromycin, oral penicillin, tetracycline and TMP-SMX) that are preferred agents for outpatient management of streptococcus pneumonia infections. Continued efforts in antibiotic stewardship and vaccination programs are essential to mitigate the global spread of pneumococcal resistance"

Review • CNS Disorders • Infectious Disease • Otorhinolaryngology • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Septic Shock • Sinusitis

"Clinico-Microbiological Profile and Virulence Genes Associated with Infections with Group B Streptococcus in a Tertiary Care Hospital in India (ASM Microbe 2025) - "Maximum antibiotic susceptibility was seen with Ertapenem (100%), Linezolid (98.6%) Vancomycin (98%), Cefotaxime (98%) and maximum resistance towards Gentamicin (34.66%), Tetracycline (32%), Erythromycin (22.66%) and Penicillin (20.60%). GBS incidence, especially in skin and soft tissue infections among non pregnant adults is on the rise in the Indian subcontinent, even more so, among the elderly and immunocompromised. Prevalence of GBS Virulence genes was higher in the non-pregnant population (40.6%,61) than in the Pregnant population (7.3%,11), indicating more propensity for infection in non pregnant adults."

Clinical • Infectious Disease • Septic Shock

Prevalence and Genetic Diversity of Listeria monocytogenes Isolated from Fruits and Vegetables (ASM Microbe 2025) - "However, high resistance against sulfamethoxazole (80.58%), amoxicillin (58.25%) and erythromycin (49.52%) were observed...Furthermore, twenty (20) resistance genes encoding tetracyclines, sulphonamides, phenicols, aminoglycosides, β-lactamases, and variants of the extended- spectrum of β-lactamases (ESBLs) resistance were detected among the L. monocytogenes isolates...The dendrogram signatures generating seven clades is an indication of the high genetic diversity among the isolates. We conclude that the presence of L. monocytogenes in fruits and vegetables is a potential threat to consumers and a potential public health hazard, particularly to the high-risk group of the population."

Collateral sensitivity and cross-resistance in six species of bacteria exposed to six classes of antibiotics. (PubMed, Microbiol Spectr) - "These six species were induced to become resistant to amoxicillin/cefepime, enrofloxacin, kanamycin, tetracycline, erythromycin, and chloramphenicol (T. In this case, genetic analysis revealed that fusA consistently mutated in the five bacterial species that exhibited de novo resistance to kanamycin. The observed collateral sensitivity can be explained by these mutations."

Journal • Infectious Disease

Antibiotic resistance rates in Cutibacterium acnes isolated from patients with acne vulgaris: a systematic review and meta-analysis. (PubMed, Front Microbiol) - "A total of 8,846 studies were systematically retrieved and 23 studies were included, corresponding to 2,046 isolates of C. acnes, which have shown antibiotic resistance rates ranging from high to low: 48.17% (95% CI: 41.16-55.24%) for roxithromycin, 45.64% (95% CI: 20.49-73.22%) for clarithromycin, 43.33% (95% CI: 27.81-60.29%) for azithromycin, 29.20% (95% CI: 22.14-37.43%) for erythromycin, 22.38% (95% CI: 14.69-32.56%) for clindamycin, 5.93% (95% CI: 2.91-11.69%) for levofloxacin, 2.44% (95% CI: 0.99-5.89%) for doxycycline, 1.47% (95% CI: 0.00-85.72%) for trimethoprim-sulfamethoxazole (TMP-SMX), 1.31% (95% CI: 0.45-3.70%) for tetracycline, 0.28% (95% CI: 0.04-1.94%) for chloramphenicol, 0.22% (95% CI: 0.03-1.89%) for minocycline. In addition, the resistance rates to levofloxacin, erythromycin, and clindamycin markedly increased over time (p < 0.05). This emphasizes the significance of rational use of the antibiotics in acne treatment."

Journal • Retrospective data • Review • Acne Vulgaris • Dermatology