erythromycin / Generic mfg. - LARVOL DELTA

GD04 (P064) A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in paediatric patients in Japan (2020-2023). (PubMed, J Med Microbiol) - "Overall resistance rates to penicillin (PEN), cefotaxime, meropenem (MEM) and erythromycin (ERY) were 31.8, 15.9, 18.5 and 88.7%, respectively...Genomic analysis revealed that the predominant genotypes were 15B/C-CC199, 15A-CC63, 24B-CC2754 and 10A-CC5236.Conclusion. Non-vaccine and PEN-, MEM- and ERY-resistant clones, particularly 15A-CC63 and 35B-CC558, were prevalent among paediatric pneumococci in Japan. Even with PCV20, less than half of the IPD isolates were covered; this underscores the need for ongoing genomic surveillance, antimicrobial stewardship and consideration of expanded-valency vaccines targeting additional serotypes, such as 15A and 35B."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

P064 A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

Estimating macrolide antibiotics use in a typical region of Taihu Lake Basin, China through wastewater-based epidemiology. (PubMed, Environ Geochem Health) - "The concentrations of four MLs-erythromycin, roxithromycin, azithromycin, and clarithromycin-were determined. A significant increase in antibiotic usage was observed in January 2023 that the other sampling months, accompanying with low ambient temperatures. The data set on MLs consumption provides valuable insights for evaluating antibiotic usage patterns under varying temporal and climatic conditions."

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Lacticaseibacillus rhamnosus MS27 Potentially Prevents Ulcerative Colitis Through Modulation of Gut Microbiota. (PubMed, Int J Mol Sci) - "(3) L. rhamnosus MS27 exhibits high acid tolerance at pH 3.23 and maintains a high viable bacterial count for 24 h. It can utilize sucrose, lactose, maltose, inulin, esculin, salicin, and mannitol but not raffinose, and it is sensitive to carbenicillin, erythromycin, tetracycline, chloramphenicol, clindamycin, and penicillin. rhamnosus MS27 exhibits distinctive metabolic characteristics in lactic acid utilization, acetic acid and oleic acid production. Furthermore, it contributes to systemic homeostasis regulation by modulating Turicibacter to link intestinal microbiota composition with host immune function."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Characterization of Lactococcus isolated from diseased yellowtail in Japan using whole-genome sequencing. (PubMed, J Vet Med Sci) - "The isolates showed resistance rates of 85.0% to lincomycin and 12.5% for erythromycin, and no resistance to tetracycline, ampicillin, or florfenicol was detected. Because high lincomycin resistance was observed, susceptibility testing is recommended to guide appropriate antimicrobial selection. Overall, the elucidation of the WGS-based characteristics of field isolates of Lactococcus provides useful information for vaccine use and antimicrobial therapy for the prevention and treatment of lactococcosis."

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Antibiotic-Adjuvants Abolish Resistance Conferred by the Staphylococcus aureus Erythromycin Resistance Methyltransferase in an Escherichia coli Model. (PubMed, ACS Infect Dis) - "Assessment of test compounds using this resistance model revealed candidates that displayed promising adjuvant activity when combined with erythromycin or clindamycin. Competition experiments suggested that JNAL-016 competes with SAM for its binding pocket on the enzyme, and this compound exhibited no toxicity against human embryonic kidney cells. These findings establish a practical strategy for targeting Erm-mediated resistance, which could lead to a viable adjuvant-based therapy against bacterial pathogens that weaponize variants of this class of methyltransferases."

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Elucidating VOC dynamics and molecular mechanisms in nonanal-treated postharvest tomatoes infected with Botrytis cinerea. (PubMed, Food Chem (Oxf)) - "In this study, an 0.054 mol·L-1 nonanal treatment decreased the incidence rate of gray mold on tomato and enhanced the defense capacity by altering the activities of the main defense-related enzymes, including NADPH-cytochrome c reductase, aminopyrine-n-demethylase, aniline-4-hydroxylase, and erythromycin N-demethylase...and the genes in the plant-pathogen interaction pathway were up-regulated in the control group. This indicated that the nonanal treatment increased the postharvest tomato plant's resistance capability and helped maintain cell integrity, which meant that less genes and substances were required to fight the Botrytis cinerea infection."

Journal • Infectious Disease • FANCD2

Characterization of Methicillin-Resistant Staphylococcus Aureus Resistance and Hematological Profiles in Diabetic Foot Infections. (PubMed, Clin Lab) - "This study examined the characteristics of DFU-associated MRSA infection, particularly its multidrug resistance features. MRSA infection demonstrated 100% sensitivity to vancomycin and linezolid. The findings suggest that combined detection of MCHC, D-dimer, ALB, ALP, Na+, Cl-, and Ca2+ may serve as a valuable reference for the early identification of DFU-associated MRSA infection in clinical settings. Clinicians should be mindful of MRSA infection risks in patients with DFU and develop individualized anti-infection regimens based on drug sensitivity profiles to improve prognosis."

Journal • Retrospective data • Hematological Disorders • Infectious Disease

Antisense Oligomer Targeting the Antibiotic Resistance Gene ermC Augments Erythromycin, Azithromycin, and Virginiamycin Sensitivity in Staphylococcus aureus. (PubMed, ACS Infect Dis) - "The specific effect of the ASO is evident as a decrease in the methylation activity of the ErmC protein. Sequence comparisons reveal a subset of bacterial species where both the ErmC protein and the antisense target site on the ermC mRNA are strictly conserved."

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Development of an HPLC method for the simultaneous determination of azithromycin, clarithromycin, and erythromycin in wastewater. (PubMed, RSC Adv) - "Application of the validated method to hospital and livestock wastewater samples revealed macrolide concentrations up to 13.36 mg L-1 (CLR), 11.27 mg L-1 (ERY), and 7.80 mg L-1 (AZM). The developed HPLC-PDA method is therefore suitable for routine environmental monitoring, providing a simple and reliable tool for assessing macrolide antibiotic contamination in wastewater."

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Prevalence of PVL and TSST-1 genes in nasal Staphylococcus aureus carriage among healthcare workers in a tertiary hospital. (PubMed, J Infect Dev Ctries) - "A high rate of S. aureus/MRSA carriage among HCWs was observed . The presence of PVL and TSST-1 raises concern due to poor infection control compliance. Periodic screening and improved infection prevention protocols are recommended."

Journal • Infectious Disease

Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Syrian patients. (PubMed, J Infect Dev Ctries) - "These findings underscore the importance of being able to adapt the general World Health Organization recommendations according to local evidence. It is crucial to emphasize the need for continuous local monitoring, functioning and well-equipped laboratories, and well-trained specialists in infectious diseases in hospitals to be able to make these decisions."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities. (PubMed, Nat Commun) - "A genome-wide association study of 308 jail isolates from 2015-2018 revealed a plasmid encoding the ermC clindamycin/erythromycin resistance gene was associated with a 6-fold increased odds of MRSA genetic linkages among detainees. Lastly, topical clindamycin exposure before MRSA infection was associated with ermC plasmid presence in both settings, but exposure prevalence was higher in jail versus community cases (7.5% vs. 0.9%), suggesting antibiotic use in the jail may have created a favorable environment for the spread of ermC-carrying strains. These findings highlight the impact of antibiotic use in jails on antibiotic resistance in both jails and their surrounding communities."

Journal • Infectious Disease

Macrolide Antibiotics as Modulators of Cellular Oxidative Stress: Mechanisms, Pathways, and Therapeutic Implications. (PubMed, FASEB J) - "While erythromycin's protective redox effects are therapeutically promising, concerns over chronic use, antioxidant suppression, and other context-dependent outcomes merit the need for systems-level multi-omics approaches to define therapeutic thresholds and ecological risks. This review provides a consolidative overview of our up-to-date understanding of macrolides as redox modulators, and advocates for future investigation into the broad physiological and environmental impacts."

Journal • Review • Chronic Obstructive Pulmonary Disease • CNS Disorders • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • CAT • PPARG

Nasopharyngeal carriage of Streptococcus pneumoniae, its associated factors, and antimicrobial susceptibility patterns among school children in Babile district, eastern Ethiopia. (PubMed, PLoS One) - "A considerable proportion of asymptomatic nasopharyngeal carriage of Streptococcus pneumoniae in school children was associated with having a history of respiratory tract infection, being passive smokers, having greater than or equal to two siblings under 5 years old in the house, and living in a single-room house. A higher resistance of isolated Streptococcus pneumoniae was observed to tetracycline and trimethoprim-sulfamethoxazole. Thus, it is necessary to regularly assess the trend of antibiotic resistance andthe prevalence of pneumonia among asymptomatic children, and it is impretive to focus on modifiable associated factors in controlling the diseases."

Journal • Hematological Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Probiotic characteristics and safety evaluation of acid-tolerant lactic acid bacteria isolated from Suancai, a popular fermented vegetable in Northeast China. (PubMed, Folia Microbiol (Praha)) - "Additionally, all strains displayed antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Salmonella paratyphi B. Safety assessment revealed that the strains were sensitive to ampicillin, erythromycin, and penicillin, resistant to gentamycin, and negative for indole production and hemolytic activity. In conclusion, the four selected strains demonstrated favorable probiotic characteristics and safety profile, supporting their potential as candidate probiotics for functional food application."

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Effect of Multiple Pharmacological Interventions and Magnetic Control on Capsule Endoscopy Gastrointestinal Transit Time and Diagnostic Yield: A Systematic Review and Meta-Analysis. (PubMed, JGH Open) - "Erythromycin and magnetic guidance were consistently associated with faster gastric passage, while lubiprostone and polyethylene glycol (PEG) shortened SBTT compared with control groups. For improving overall completion, metoclopramide remains a dependable option. These findings support individualized preparation strategies tailored to the specific diagnostic goals of CE."

Journal • Retrospective data

Comprehensive chemical profiling and bioactivity assessment of Porodaedalea pini and Phellinus tremulae. (PubMed, Sci Rep) - "Both extracts inhibited the growth of S. aureus 4459 (MIC = 6.25 mg/ml), the clinical strain resistant to erythromycin. Cytotoxicity assessment showed that only the P. tremulae extract significantly decreased HaCaT cell viability by 37% and 42% at concentrations of 400 and 800 µg/ml, respectively."

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Reevaluating Neonatal Erythromycin Prophylaxis Policy Amid Advances in Sexually Transmitted Infection Screening, Antenatal Treatment, and Antibiotic Stewardship. (PubMed, J Obstet Gynecol Neonatal Nurs) - "Risk-based prevention models already adopted in many high-income countries offer a safer and more evidence-aligned alternative. Nurses are uniquely positioned to lead this transition through patient education, antibiotic stewardship, and advocacy for evidence-based neonatal care."

Journal • Infectious Disease • Ophthalmology

Revealing the most contaminated stages and spots of foodborne pathogens and antibiotic resistance along the whole fish production chain in Greek aquaculture. (PubMed, Food Microbiol) - "These potential pathogens, mainly isolated from surfaces and water of weaning and pre-fattening tanks, fish feeds, working surfaces, fish transport boxes, concrete floors and fish especially from transport boxes and harvesting, presented a noteworthy resistance to most antibiotics tested (e.g., Clindamycin, Nalidixic acid, Streptomycin, Sulphonamides, Ceftazidime, Erythromycin, Vancomycin, Penicillin G, and Cefoxitin). The findings underscore the importance of early detection and intervention strategies to mitigate ARB transmission, thereby enhancing the safety and quality of aquaculture products."

Journal • Infectious Disease • Pneumonia

Characteristics of Patients with Type 2 Diabetes Mellitus with Sodium-Glucose Cotransporter Protein-2 Inhibitor-Related Urinary Tract Infections: Pathogen Distribution and Drug Resistance. (PubMed, Arch Esp Urol) - "The distribution of pathogenic bacteria complicated by UTI in patients with T2DM treated with SGLT-2 inhibitors was dominated by Gram-negative bacteria such as E. coli, some Gram-positive bacteria, and a small number of fungi. Antibiotics should be used appropriately in this population because of the pharmacological mechanism of SGLT-2 inhibitors."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Type 2 Diabetes Mellitus

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics. (PubMed, Chemistry) - "Selected alkyne-containing exoglycals were further functionalized through cycloaddition with azidothymidine...To contextualize the inhibitory potential of exoglycals, we evaluated three clinically relevant macrolide antibiotics-erythromycin, clarithromycin, and azithromycin...Our results demonstrate exoglycals as tunable scaffolds for glycosidase inhibition of GH3 glycosidases and provide mechanistic distinctions between carbohydrate mimics and macrolide antibiotics. These insights could guide the development of next-generation glycosidase inhibitors with improved specificity."

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One Health surveillance of multidrug-resistant Escherichia coli in broilers and market environments in Aceh, Indonesia: A triangulated sampling approach. (PubMed, Vet World) - "Percentage of resistance of isolates from all sample types were uniformly high to ampicillin (100%). Isolates from fecal and display table were 100% resistant to erythromycin and kanamycin, as well as to streptomycin...The triangulated One Health design demonstrates the added value of integrating animal, human, and environmental sampling for AMR surveillance. Strengthening antimicrobial stewardship, upgrading market hygiene infrastructure, and expanding integrated surveillance into national AMR monitoring frameworks are essential steps to mitigate public health risks."

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