prazosin / Generic mfg. - LARVOL DELTA

Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids. (PubMed, J Dermatolog Treat) - "The following local treatment options are described: capsaicin, calcineurin inhibitors, menthol, pramoxine/lidocaine/prilocaine, ambroxol, phenytoin, strontium, amitriptyline, doxepin, duloxetine, baclofen, gabapentin, cannabinoids, loperamide, naltrexone, clonidine, prazosin, acetylsalicylic acid, diclofenac, aprepitant, ketamine, calamine, polidocanol, and botulinum toxin type A. Local therapy offers a valuable and often well-tolerated first step in managing ND...Clinicians are advised to start with low concentrations, discuss off-label use, and monitor for side effects. Until robust guidelines are available, a cautious trial-and-error approach remains the cornerstone of management."

Journal • Review • Dermatology • Neuralgia • Pain • Pruritus

SGLT- 2I: "CAN BE A HOPE FOR PERITONEAL DIALYSIS PATIENTS." (ISN-WCN 2026) - "At baseline, his blood pressure was 168/88 mmHg with telmisartan 80 mg/day, amlodipine 10 mg /day, prazosin 10 mg/day, and torsemide 100 mg/day. Other medications were dapagliflozin 10mg/day, linagliptin 5 mg/day, sodium bicarbonate 1000 mg twice daily, insulin, atorvastatin 10mg/day, and aspirin 75 mg/day...There was no hospitalization in this follow-up period.Conclusion As the drug is well tolerated and no adverse effects are noted in this 35-month follow-up, we may hope to use this drug in some dialysis-dependent patients. The findings in this case report need to be confirmed in a large prospective study with a longer follow-up period."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hypertension • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

ANURIA FOLLOWING LEFT RENAL VEIN LIGATION IN A LONE KIDNEY: A SURGICAL MYTH IS VIGOROUSLY CHALLENGED - AN EVOLVING CASE REPORT FROM SEPTEMBER 2025 (ISN-WCN 2026) - "Outpatient medications included Dapagliflozin 10 mg daily, insulin, glipizide 20 mg daily, Losartan 25 mg daily, Prazosin 1 mg at bedtime and Dulaglutide 0.75 mg subcutaneous, weekly.During the open periaortic lymph node biopsy, the left renal vein was ligated to mobilize the inferior vena cava. In solitary kidney patients, the absence of collateral outflow makes ligation particularly dangerous and irreversible renal loss and need for permanent dialysis have been described. Recent studies continue to highlight the variability of renal tolerance and emphasize cautious, individualized operative planning regarding the practice of pre-emptive left renal vein ligation performed intraoperatively to improve surgical exposure and to control bleeding."

Case report • Clinical • Breast Cancer • Diabetes • Diabetic Nephropathy • Hypertension • Metabolic Disorders • Nephrology • Solid Tumor • Type 2 Diabetes Mellitus • Urothelial Cancer

TIRZEPATIDE FOR RESISTANT HYPERTENSION IN NON-DIABETIC IGA NEPHROPATHY (ISN-WCN 2026) - "SGLT2 inhibitors and spironolactone were previously discontinued due to recurrent balanoposthitis and hyperkalemia...BP normalized dramatically (200/100→118/70 mmHg, 82/30 mmHg reduction), achieving KDIGO targets and enabling 50% medication reduction (6→3 drugs: discontinued minoxidil, prazosin, clonidine; continued telmisartan, chlorthalidone, cilnidipine)...This represents a paradigm shift toward metabolic intervention in proteinuric non-diabetic CKD with obesity and resistant hypertension. GLP-1 receptor agonists merit investigation as cornerstone therapies alongside RAAS inhibitors and SGLT2 inhibitors, particularly in advanced fibrosis where immunosuppression risks may outweigh benefits."

Cardiovascular • Chronic Kidney Disease • Diabetic Nephropathy • Fibrosis • Genetic Disorders • Glomerulonephritis • Hypertension • IgA Nephropathy • Immunology • Lupus Nephritis • Obesity • Renal Disease

Loneliness, serotonin, and medial prefrontal cortex: some empirical and theoretical considerations. (PubMed, Pharmacol Biochem Behav) - No abstract available

Journal

Adrenergic receptor activation triggers stress-induced dystonia in a CACNA1A mutant mouse model. (PubMed, Front Neurosci) - "Systemic administration of the α1-AR antagonist prazosin increased dystonia frequency, but shortened attack duration, while the α1D-AR selective antagonist BMY-7378 significantly reduced dystonia occurrence without altering onset or duration...These findings strengthen the idea that stress-induced dystonia formation is facilitated by increased noradrenergic innervation to cerebellar PCs and suggest that α2-AR signalling contributes to dystonia in EA2. Our findings emphasise cerebellar ARs as promising therapeutic targets in EA2."

Journal • Preclinical • Ataxia • CNS Disorders • Dystonia • Movement Disorders • CACNA1A

A Study to Learn How Different Forms of the Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults (clinicaltrials.gov) - P1 | N=72 | Recruiting | Sponsor: Pfizer | Active, not recruiting ➔ Recruiting | N=36 ➔ 72

Enrollment change • Enrollment open • Congestive Heart Failure

Management of trauma-related nightmares in PTSD: Can doxazosin serve as a pragmatic alternative to prazosin? (PubMed, Encephale) - "Doxazosin may represent a pragmatic pharmacological option for managing TRNs in PTSD, especially in the context of prazosin withdrawal. Its use should complement, rather than replace, first-line psychotherapeutic approaches and be integrated into a comprehensive, coordinated, and individualized treatment plan with careful monitoring of adverse effects. Larger, well-designed randomized controlled trials are needed to determine optimal dosing, treatment duration, and predictors of response."

Journal • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP-00). (PubMed, Prostate) - "Our study demonstrated that coadministration of prazosin during radiotherapy is feasible. However, the incidence of hypotension resulted in a protocol-defined MTD (under conservative blood pressure based DLT definition) of 0 mg, although 16 of the 17 reports were asymptomatic. Combined with monitoring used in other studies utilizing prazosin, this suggests that our safety monitoring and dose-limiting toxicity (DLT) definition may have been too strict and did not accurately reflect a clinically relevant MTD. As this study achieved its primary aim and demonstrated the feasibility of the administration of prazosin during radiotherapy, further prospective studies are justified, with greater consideration given to the definition of DLTs."

Journal • Genito-urinary Cancer • Hypotension • Oncology • Prostate Cancer • Solid Tumor

Effects of endothelium-derived catecholamines on heart rate, blood pressure and gill ventilation in the rainbow trout. (PubMed, Comp Biochem Physiol A Mol Integr Physiol) - "Then, α₁-adrenoceptor blockade with prazosin (2.38 μmol/kg) was performed and a single 10 nmol/kg bolus challenge of the newly discovered catecholamine, adrenaline and dopamine in a random order. Fish were instrumented with a dorsal aortic catheter to allow bolus drug administration and measurement of mean arterial pressure and heart rate, as well as a buccal cannula to monitor ventilatory rate and amplitude...None of the catecholamines affected ventilation. We provide new in vivo evidence that ultra-low doses of 6-substituted catecholamines elevate arterial pressure and trigger bradycardia via α₁-adrenoceptor independent mechanisms, suggesting alternative vascular pathways and a potential physiological role in fish."

Journal • Cardiovascular • Hypertension

Exploration of the rare 5/6/7-fused diterpenoids with anti-hypertrophy activity from Strophioblachia glandulosa via bioactivity-guided strategy. (PubMed, Phytochemistry) - "All the isolates were tested for the anti-hypertrophic effect with compound 8 showing a comparable anti-hypertrophic effect to the positive control prazosin with remarkably lower cytotoxicity. The molecular docking result revealed that 8 formed two hydrogen bonds with amino acid ARG-49 locking the MAPK14 in an inactive conformation. This work provided a natural scaffold for developing anti-hypertrophic positive agents."

Journal • MAPK14

Effects of Prazosin and Other Alpha-1 Adrenergic Antagonist Drugs on Nightmares and Sleep Disturbances in Posttraumatic Stress Disorder. (PubMed, J Clin Psychopharmacol) - "When available and clinically tolerated, prazosin continues to have the best evidence base for use in PTSD-related nightmares. When prazosin use is not feasible, alternative alpha-1 blockers may be effective in a subset of patients."

Journal • Alzheimer's Disease • Behavior Disorders • CNS Disorders • Cognitive Disorders • Depression • Insomnia • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • Sleep Disorder • Substance Abuse

Vanillin suppresses seizure-induced mortality in the DBA/1 mouse model of SUDEP. (PubMed, Neurosci Lett) - "Vanillin, ondansetron (a 5-HT3 receptor antagonist), ketanserin (a 5-HT2A antagonist), GR 125487 (a 5-HT4 antagonist), yohimbine (a α2 adrenoceptor antagonist), prazosin (a α1 antagonist), ICI 118,551 (a β2 antagonist), SB 366791 (a TRPV1 antagonist) or vehicle was administered intraperitoneally 30-60 min before acoustic stimulation, and the effects of each drug or drug combination (an antagonist + vanillin) on seizure-induced mortality, apnea or seizures were examined. Notably, the reduction in seizure-induced mortality by vanillin was not reversed by antagonists of monoaminergic receptors, despite their reported involvement in seizure-induced deaths, nor by an antagonist of TRPV1 receptors, a known direct target of vanillin. These findings demonstrate that vanillin suppresses seizure-induced mortality in DBA/1 mice, with associated effects on respiratory dysfunction and tonic seizures, and suggest that this protection is unlikely to be mediated by monoaminergic or..."

Journal • Preclinical • CNS Disorders • Epilepsy • Respiratory Diseases

Medication Use Patterns, Polypharmacy, and Potentially Inappropriate Medications among Institutionalized Older Adults in East Coast Malaysia: A Cross-sectional Study. (PubMed, J Res Pharm Pract) - "Identified PIMs include prazosin, colchicine, lorazepam, and chlorpromazine, each prescribed to a minority of residents. The prevalence of polypharmacy in this study was moderate, reflecting the need for continued attention to medication management among institutionalized older adults. Despite the low prevalence of PIM, regular monitoring remains essential to minimize adverse drug reactions and improve the quality of care for this population."

Journal • Observational data

A0281007: A Study to Learn How Different Forms of The Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults (clinicaltrialsregister.eu) - P1 | N=72 | Recruiting | Sponsor: Pfizer Inc.

New P1 trial • Cardiovascular • Heart Failure • Hypertension

Involvement of Serotonergic and Dopaminergic Systems in Aloysia gratissima var. gratissima: Antidepressant-like Effect, UPLC-DAD-MS Chemical Characterization, and Computational Evidence. (PubMed, Pharmaceuticals (Basel)) - "The reduction in immobility time during the FST caused by the ethyl acetate fraction was reversed by pretreating mice with WAY100635 (5-HT1A antagonist), ketanserin (a 5-HT2A antagonist, ondansetron (5-HT3 antagonist), or haloperidol (D2 antagonist)... These results suggest that the Agg ethyl acetate fraction possesses antidepressant-like activities, altering dopaminergic and serotonergic system functions. Computational simulations also suggest that some of the identified compounds have binding affinities to the 5-HT1A, 5-HT2A, 5-HT3, and D2R receptors."

Journal • CNS Disorders • Depression • Psychiatry

A primary cell-based fluidic co-culture model to investigate drug transport across the human placenta. (PubMed, J Physiol) - "Using fluorescent substrates and specific inhibitors (ABCB1: Rhodamine 123/Cyclosporin A; ABCG2: Bodipy-FL-Prazosin/Ko123), we confirmed that both transporters are not only expressed in the primary co-cultures, but also actively restrict the passage of compounds in the mother-to-fetus direction. The model effectively mimics key features of the placental barrier properties, including polarized expression and functional activity of major placental drug efflux transporters. The dynamic primary cell based flow systems offer a physiologically relevant human in vitro model to investigate and predict transplacental drug transfer."

Journal • Obstetrics • ABCB1 • ABCG2

What is the Cost of Selectivity? Selective and Nonselective Alpha Blockade Costs Associated with Adrenalectomy for Pheochromocytoma. (PubMed, Ann Surg Oncol) - "When compared with nonselective alpha blockers, selective alpha blockers are associated with lower medication costs but equivalent hospitalization and post-hospitalization costs."

Journal • Critical care • Oncology • Solid Tumor

Structural Diversity of 2-O-(β-d-Glucopyranosyl)benzyl Quinates from Casearia tardieuae and Their Anti-Myocardial Hypertrophy Activity in Rat Cardiomyocytes. (PubMed, J Agric Food Chem) - "Biological evaluation showed that compound 1 exhibited antihypertrophic potency comparable to the positive control prazosin, and its cytotoxicity was significantly lower than that of prazosin. Preliminary mechanism investigations revealed that compound 1 suppressed hypertrophy markers ANP/MYH7 at the protein level and downregulated Nppa/Myh7 genes at the transcriptional level, while inhibiting the cellular hypertrophy phenotype. This study first reports undescribed 2-O-(β-d-glucopyranosyl)benzyl quinates from C. tardieuae with significant anticardiac hypertrophy activity, providing important experimental basis for the development of antimyocardial hypertrophy candidate drugs and the study of active components of Casearia species."

Journal • Preclinical • MYH7

Efficacy and Spinal Noradrenergic Mechanisms of Contralateral Melittin Acupuncture Against Paclitaxel-Induced Peripheral Neuropathic Pain in Rats. (PubMed, J Pain Res) - "For neuropharmacological analysis, prazosin (an α1-adrenoceptor antagonist) or idazoxan (an α2-adrenoceptor antagonist) was administered before apitherapy (n=6/group). This modulation induced a significant reorganization of nociceptive processing within dorsal horn pain-transmitting neurons, leading to attenuated neuropathic signs in the contralateral limb of rats. Collectively, our behavioral and neurophysiological findings provide pre-clinical evidence supporting melittin-based pharmacoacupuncture as a potential therapy for paclitaxel-induced neuropathic pain."

Journal • Preclinical • Immunology • Neuralgia • Pain • Peripheral Neuropathic Pain

Brain Blood Vessel Responses to Changes in Blood Flow (clinicaltrials.gov) - P2 | N=36 | Recruiting | Sponsor: University of Wisconsin, Madison | Not yet recruiting ➔ Recruiting

Enrollment open

A Study to Learn How Different Forms of the Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults (clinicaltrials.gov) - P1 | N=36 | Active, not recruiting | Sponsor: Pfizer | Recruiting ➔ Active, not recruiting | N=72 ➔ 36

Enrollment change • Enrollment closed • Congestive Heart Failure

Doxazosin for the treatment of mental health disorders: A scoping review. (PubMed, PLOS Ment Health) - "Although prazosin is the most well-known alpha-1 antagonist used for these disorders, doxazosin has a longer half-life, which allows for more convenient once-daily dosing. Current clinical trials continue to be focused on PTSD and cocaine use disorder, given promising evidence. More randomized controlled trials need to be completed for recommendations of doxazosin's use for other PTSD hyperarousal symptoms (e.g., flashbacks, intrusive thoughts) and other substance use disorders, including nicotine and alcohol use disorders."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Noradrenergic Input to Hypoglossal Motoneurons is Mediated by Interneurons Located in Pre-Hypoglossal Region (PHR). (PubMed, J Appl Physiol (1985)) - "We used microinjections of phenylephrine or prazosin, α1-adrenoceptor agonist and antagonist, respectively, into the medullary reticular formation rostral to the hypoglossal nucleus to locate these neurons...In isoflurane-anesthetized mice, phenylephrine injected into the PHR induced large increases in GG muscle activity (21.8 ± 3.5 vs. baseline 4.50 ± 0.86, arbitrary units)...However, in ketamine/xylazine-anesthetized mice, phenylephrine's ability to activate the GG muscle from the PHR was substantially blunted, which suggests that the ketamine-induced systemic antagonism of glutamatergic NMDA receptors may interfere with the response. Our findings suggest that the PHR contains interneurons that mediate the state-dependent noradrenergic drive to hypoglossal motoneurons, and that glutamate may be used as mediator by PHR circuitry."

Journal • Anesthesia • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation. (PubMed, Front Physiol) - "Electrical Field Stimulation (EFS) (2, 4 and 8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, or guanethidine (10-6 M)...Concentration-response curves to GS-967, GS-6615 or RAN were constructed in rings precontracted with noradrenaline, endothelin-1 or KCl with or without specific inhibitors (L-NAME, nimesulide, SC-560, verapamil, nifedipine, apamin or charybdotoxin)...Taken together, our results indicate that GS-967, GS-6615 and RAN decrease vasoconstrictor responses due to both neural and noradrenaline-induced adrenergic stimuli. We can suggest that the use of GS-967, GS-6615 and Ranolazine may be interesting in clinical procedures involving hyperstimulation of the adrenergic nervous system."

Journal • Preclinical • EDN1