clonidine / Generic mfg. - LARVOL DELTA

CLOWNFISH: Comparison of clonidine and oxycodone following tonsillotomy surgery in children to help pain management. (ANZCTR) - P4 | N=100 | Recruiting | Sponsor: Perth Children's Hospital | Not yet recruiting ➔ Recruiting | Initiation date: Jan 2026

Enrollment open • HEOR • Trial initiation date • Pain

Bilateral Thalamic Lesion: An Extremely Rare Presentation of Neuromyelitis Optica Spectrum Disorder (ACTRIMS Forum 2026) - "Tocilizumab was initiated for relapse prevention; however, after three doses, she developed intractable headache, vomiting, and encephalopathy...Her course was complicated by pneumonia, Clostridioides difficile infection, and paroxysmal sympathetic hyperactivity, managed with clonidine and diazepam. She was subsequently transitioned to eculizumab for long-term relapse prevention... This case describes a rare pediatric presentation of NMOSD with internal capsule and sequential bilateral thalamic involvement, initially presenting with hemiplegia and mimicking both stroke and neoplasm, later complicated by intractable paroxysmal sympathetic hyperactivity. While thalamic volume loss and nuclear atrophy are more characteristic of multiple sclerosis, thalamic involvement in NMOSD is rare and typically affects nuclei associated with inflamed pathways—such as the lateral geniculate and ventral posterior nuclei—secondary to optic neuritis or transverse myelitis. Our patient,..."

Cardiovascular • CNS Disorders • Infectious Disease • Multiple Sclerosis • Neuromyelitis Optica Spectrum Disorder • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pneumonia • Rare Diseases • Respiratory Diseases

Effectiveness of Bleeding Control Methods in Rhinoplasty: A Systematic Review and Meta-Analysis. (PubMed, Arch Plast Surg) - "The bleeding control methods evaluated included tranexamic acid (TXA), desmopressin, steroids, magnesium sulfate, clonidine, remifentanil, and patient positioning (reverse Trendelenburg position). However, further studies with larger sample sizes and standardized designs are recommended for magnesium sulfate, clonidine, and remifentanil methods. Level of Evidence I."

Journal • Retrospective data • Aesthetic Medicine

Isobolographic analysis of clonidine and clozapine's antidepressant- and anxiogenic-like effects. (PubMed, Neuroscience) - "The dual interaction profile between clonidine and clozapine highlights both the therapeutic potential and limitations of targeting the noradrenergic system for mood disorder treatment."

Journal • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry

MIRAGE: Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (clinicaltrials.gov) - P4 | N=100 | Not yet recruiting | Sponsor: Istituto Giannina Gaslini

New P4 trial • Anesthesia • Pain

A prospective, multicenter, double-blind, double-dummy, randomized controlled clinical study to evaluate the efficacy and safety of clonidine in the treatment of primary restless legs syndrome (RLS) (ChiCTR) - P=N/A | N=116 | Not yet recruiting | Sponsor: Shanghai General Hospital; Shanghai General Hospital

New trial • Movement Disorders • Restless Legs Syndrome • Sleep Disorder

A comparative study of clonidine and dexmedetomidine as an adjuvant to levobupivacaine for caudal analgesia in children undergoing below umbilical surgeries: A randomized double-blind controlled trial. (PubMed, Agri) - "Dexmedetomidine (1 µg/kg) added to 0.2% levobupivacaine (1 ml/kg) for caudal block provides prolonged analgesia with better sedation scores when compared to clonidine (1 µg/kg) with 0.2% levobupivacaine (1 ml/kg) for below umbilical surgeries in pediatric patients, without increasing the incidence of adverse effects. Hence, we would recommend the use of 1 µg/kg dexmedetomi-dine as an adjuvant to 0.2% levobupivacaine."

Clinical • Journal • Anesthesia • Pain • Pediatrics

Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery: A Systematic Review and Network Meta-Analysis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Randomized clinical trials of patients undergoing ESS and receiving dexmedetomidine, clonidine, esmolol, labetalol, bisoprolol, metoprolol, diltiazem, nifedipine, or verapamil vs placebo. In this systematic review and network meta-analysis, controlled hypotension improved surgical field quality in ESS with comparable safety. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine was associated with reduced MAP the most, and esmolol favored recovery."

Clinical • Journal • Retrospective data • Hypotension • Otorhinolaryngology

Dexmedetomidine Versus Clonidine as an Adjuvant to Lidocaine Spinal Anesthesia in an Ovine Experimental Model. (PubMed, Animals (Basel)) - "Animals were sedated with diazepam (0.4 mg kg-1) and buprenorphine (10 μg kg-1) intravenously. Recovery times (minute) from the spinal block were recorded: anal sphincter tone (AS), recovery of sensibility (RoS), first limb movements (FMov), time of standing (ToS), and first rescue analgesia; ataxia (ATA) was also measured after standing. Dexmedetomidine increased the duration of spinal anesthesia, affecting both motor and sensory functions."

Journal • Anesthesia • Ataxia • Movement Disorders • Orthopedics • Pain

Accurate Estimation of Glomerular Filtration Rate in Critically Ill Infants and Children Using a Iohexol Population Pharmacokinetic Modeling Approach. (PubMed, Clin Pharmacokinet) - P=N/A | "A model-derived GFR estimation formula based on iohexol population pharmacokinetic modeling might allow for an accurate bedside assessment of kidney function in critically ill children, outperforming the Schwartz and Smeets/Pierce formulas, particularly in infants. External validation in larger pediatric intensive care unit populations, across the full age and GFR range, is warranted to confirm the generalizability of this equation and its potential for broader clinical application."

Journal • PK/PD data • Critical care • Pediatrics • CST3

Altered Mental Status Secondary to Clonidine Addiction and Withdrawal: A Cautionary Tale. (PubMed, J Psychiatr Pract) - "This case demonstrates the importance of understanding the multiple etiologies of AMS, including drug intoxication and withdrawal, particularly with commonly prescribed medications. Clonidine has abuse potential, and clonidine withdrawal must be considered in the differential diagnosis of a patient with a hypertensive crisis and AMS."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Critical care • Hypertension • Mental Retardation • Movement Disorders • Psychiatry • Substance Abuse

Validation of Peak Growth Hormone Levels After Clonidine and Glucagon Stimulation Tests in Children With Severe Short Stature. (PubMed, Cureus) - "Conclusions CST and GST show high concordance in the evaluation of GHD using modern ECLIA-based assays, with GST demonstrating relatively higher specificity. Optimization of sampling time points permits protocol simplification without compromising diagnostic agreement, improving clinical utility."

Journal • Endocrine Disorders • Growth Hormone Deficiency • Idiopathic Short Stature

Clonidine Provides Superior Hemodynamic Stability and Analgesia over Midazolam-fentanyl under Monitored Anesthesia Care: Role of Catechol-O-methyltransferase Polymorphism. (PubMed, Ann Afr Med) - "Clonidine-based MAC provided better intraoperative hemodynamic stability, prolonged analgesia, and reduced postoperative pain compared with midazolam-fentanyl, with minimal respiratory complications. The COMT rs4680 polymorphism did not significantly influence pain perception, highlighting the multifactorial nature of postoperative analgesic response."

Journal • Anesthesia • Pain • Varicose Veins • COMT

Comparison of Analgesic Efficacy of Hyperbaric Levobupivacaine With or Without Clonidine in Patients Undergoing Intramedullary Nailing for Fracture Femur Under Subarachnoid Block: A Randomised Controlled Trial. (PubMed, Cureus) - "No major side effects were observed in either of the groups except one patient (6.7%) in group LC and one patient (6.7%) in group LN developed nausea, and five patients (33.3%) in group LC and three patients (20.0%) in group LN had shivering, which was managed promptly. Conclusion Addition of 15 mcg of clonidine to 3 mL (15 mg) of 0.5% hyperbaric levobupivacaine provides a longer duration of effective analgesia with minimal side effects."

Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Beyond the Usual: Novel Therapeutic Roles for Established Antidotes. (PubMed, Ther Drug Monit) - "The repurposing of antidotes such as fomepizole, l-carnitine, and naloxone represents a promising frontier in precision toxicology. As the understanding of molecular toxicology deepens, it is becoming increasingly feasible to match antidotes to specific molecular signatures of toxicity, rather than relying solely on syndromic classifications."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Metabolic Disorders • CYP2E1

Evaluation of Clonidine Utilization for Dexmedetomidine Discontinuation in the Intensive Care Unit. (PubMed, J Intensive Care Med) - "Incidence of bradycardia (5% clonidine vs 16% dexmedetomidine, p = 0.04) and withdrawal (0% vs 49%, p < 0.0001) were higher while patients were on dexmedetomidine.ConclusionsClonidine was efficacious in weaning dexmedetomidine within 24 h in 52% of patients; however, the ideal dose and period for initiation remains unclear. Results of this study warrant further investigation to identify optimal clonidine dosing for dexmedetomidine weaning and to characterize patient populations that would benefit most from this intervention."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Critical care • Hypotension • Mental Retardation • Pediatrics • Psychiatry

Pharmacological treatment strategies to manage precipitated withdrawal following the administration of buprenorphine in opioid use disorder: A systematic review. (PubMed, Addiction) - "There is a paucity of research into pharmacological management of buprenorphine precipitated opioid withdrawal. The limited very low to low quality evidence suggests treatment regimens that include magnesium sulphate and additional doses of transmucosal buprenorphine are potentially the most salient current options and avenues for future research in the management of buprenorphine precipitated opioid withdrawal."

Journal • Review • Addiction (Opioid and Alcohol) • Substance Abuse

Clonidine as an Analgesic in Adult Palliative Care: Efficacy and Safety-Systematic Review. (PubMed, BMJ Support Palliat Care) - "However, further research is required to form a stronger evidence base and gain further insight into its future role in this field. Further insight is also required into more easily accessible delivery, such as oral, subcutaneous and transdermal routes."

Journal • CNS Disorders • Depression • Oncology • Pain • Palliative care • Psychiatry

Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study (clinicaltrials.gov) - P1 | N=120 | Not yet recruiting | Sponsor: University of Wisconsin, Madison

New P1 trial

BALIA: Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty (clinicaltrials.gov) - P4 | N=200 | Not yet recruiting | Sponsor: Region Skane

New P4 trial • Immunology • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Rheumatology

Adverse drug events from paediatric use of extemporaneously compounded medicines in community pharmacy settings: a scoping review. (PubMed, BMJ Paediatr Open) - "This review highlights the importance of thoroughly verifying active ingredients and their concentrations when compounding paediatric formulations in community pharmacies."

Adverse events • Journal • Pediatrics

Enhancing Caudal Analgesia in Children: A Narrative Review of Clonidine and Dexmedetomidine as Adjuvants. (PubMed, Cureus) - "While dexmedetomidine is better for longer and more painful surgeries, clonidine offers a balanced option when quick recovery and stable blood pressure are priorities. Future large-scale studies and long-term neurodevelopmental safety research are necessary to optimize their clinical use."

Journal • Review • Anesthesia • Cardiovascular • Hypotension • Pain • Pediatrics

Relative and bedside nurse assessment of comfort and communication during propofol, dexmedetomidine, or clonidine-based sedation: pre-planned analysis within the A2B RCT. (PubMed, Health Technol Assess) - "Additional mixed-methods research of sedation quality with different agents from staff and relative perspectives. This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 16/93/01."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Critical care • Pain

Expanding the Phenotypic Spectrum of Warburg Micro Syndrome (ACMG 2026) - "Medications include clonidine for insomnia...Diagnostic Workup Brain MRI revealed bilateral polymicrogyria involving the frontal, parietal, and temporal lobes, perisylvian syndrome, corpus callosum dysplasia, cerebellar hypoplasia, and bilateral optic nerve atrophy. Genetic testing identified a biallelic pathogenic nonsense variant c.1039C>T (p.R347*) in RAB3GAP1 , consistent with a molecular diagnosis of Warburg Micro syndrome."

Cataract • Cerebral Palsy • CNS Disorders • Developmental Disorders • Genetic Disorders • Glaucoma • Infectious Disease • Insomnia • Mental Retardation • Movement Disorders • Musculoskeletal Diseases • Ocular Inflammation • Ophthalmology • Orthopedics • Rubella • Sleep Disorder • RAS

Neurobehavioral Profiles in Primary Mitochondrial Disorders – Overview of Select Cases from A Single Center Multi-Disciplinary Mitochondrial Disorders Program (ACMG 2026) - "ABA therapy and clonidine were initiated for behavioral regulation and sleep stabilization...A safety plan was developed with protective restraints and behavior therapy; naltrexone was considered but not initiated... Across cases, overlapping features included intellectual disability, irritability, impulsivity, anxiety, emotional dysregulation, and low adaptive functioning. Behavioral symptoms were often intrinsic to the neurodevelopmental course rather than secondary to acute metabolic instability. These findings underscore that neurobehavioral issues significantly affect quality of life and caregiver burden, often as much as medical complications."

Clinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Developmental Disorders • Dystonia • Epilepsy • Infectious Disease • Mental Retardation • Metabolic Disorders • Mood Disorders • Movement Disorders • Respiratory Diseases • Sleep Disorder • PDHA1