clonidine / Generic mfg. - LARVOL DELTA

Nocturnal Tactile and Visual Hallucinations Associated with Clonidine Use. (PubMed, Innov Clin Neurosci) - No abstract available

Journal

Postoperative Analgesic Efficacy of Extended Opioid-free Anesthesia Regimen with Intravenous Lignocaine versus Morphine Following Major Head and Neck Surgeries. (PubMed, Ann Afr Med) - "Intravenous lignocaine significantly reduced inadequate analgesia and need for rescue medications with optimal hemodynamics in the immediate postoperative period following major head and neck surgeries. Further large-scale, prospective, randomized controlled trials are warranted."

Clinical • Journal • Observational data • Retrospective data • Anesthesia • Critical care • Oncology • Otorhinolaryngology • Pain

Practical guide to intrathecal drug delivery: short-term and long-term management and complications. (PubMed, Reg Anesth Pain Med) - "Intrathecal pharmacologic strategies for pain are examined, including opioids, local anesthetics, ziconotide, clonidine, and baclofen, with attention to indication-specific dosing, titration, and safety considerations.Clinical outcomes are framed beyond pain intensity alone, emphasizing functional improvement, quality of life, and reduction in systemic medication use as clinically meaningful endpoints. International and regional practice variations are also discussed to contextualize differences in drug availability, compounding practices, and reimbursement. By consolidating pragmatic guidance across the full lifecycle of intrathecal therapy, this guide aims to support consistent, safe, and effective use of IDD for complex pain management in contemporary practice."

Journal • Review • Anesthesia • Oncology • Pain

A Novel Multiple Sensory Nerve Block Combination Using Ultrasound Guidance in Knee Arthroplasty: A Randomized Clinical Trial. (PubMed, A A Pract) - "No differences were observed in pain scores between the eight-nerve block combination and LIA. Secondary outcomes revealed a reduction in 48-hour opioid consumption and a modestly shorter hospital stay with nerve block compared to LIA."

Clinical • Journal • Orthopedics • Pain

Active Smoking is Associated with Amplified Acute Cardiovascular Risk After Inferred Clonidine Withdrawal: A Propensity Score Matched Cohort Study (AHA 2026) - "Abstract is embargoed at this time."

Cardiovascular

Biphasic Refractory Cardiogenic and Vasoplegic Shock in Combined Amlodipine and Clonidine Overdose (AHA 2026) - "Abstract is embargoed at this time."

Prolactin suppression and recovery dynamics during clonidine testing: A clinical biomarker for Somatotropic Axis dysfunction in children with short stature (ESPE 2026) - No abstract available

Biomarker • Clinical

Comparison of L-dopa and Clonidine Stimulation Tests in the Diagnosis of Growth Hormone Deficiency: Is It Possible to Reach a Diagnosis with Fewer Measurements? (ESPE 2026) - No abstract available

Endocrine Disorders • Growth Hormone Deficiency

Hallucinogen Persisting Perception Disorder in a Young Adult Case Report. (PubMed, Case Rep Psychiatry) - "He was treated with olanzapine, leading to mood stabilization and remission of psychosis. Post treatment, WA continued to experience perceptual disturbances and "visual snow." Medications clonidine and clonazepam were trialed for HPPD...As LSD-assisted therapies continue to be investigated for conditions such as anxiety and depression, recognition and management of persistent adverse effects such as HPPD are becoming increasingly important in both psychiatric and general medical practice. This case demonstrates the limited effectiveness and lack of knowledge on HPPD treatments as well as the need for longitudinal assessments in management."

Journal • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Depression • General Anxiety Disorder • Mental Retardation • Mood Disorders • Psychiatry

Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study. (PubMed, Hypertens Res) - "The most used drugs were intravenous furosemide, nitroglycerin, clonidine and labetalol for HE. Finally, regarding the exploratory analysis, BP at ED admission and its management didn't present significant association with in-hospital mortality. In conclusions, our study demonstrated that adherence to guidelines in the management of HE/UH could be further improved."

Journal • Retrospective data • Acute Coronary Syndrome • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Reinstatement of escitalopram and clonidine administration reverses the cessation-induced enhanced activation of rat norepinephrine and serotonin neuronal firing activity. (PubMed, J Psychopharmacol) - "These results show that abrupt cessation of the SRI escitalopram resulted in robust overactivation of both NE and 5-HT neurons. Normalization of the SRI cessation-induced overactivation of NE and 5-HT neurons by the acute inhibition of the 5-HT reuptake transporter is consistent with the rapid relief of discontinuation symptoms observed in patients resuming their SRI. A similar effect of clonidine on NE and 5-HT neuronal firing would support its use in managing discontinuation symptoms seen after SRI cessation."

Journal

Adjunct Medications for Single-Injection Pediatric Regional Blocks: Implications for Peripheral Nerve Blocks. (PubMed, Curr Pain Headache Rep) - "This narrative review synthesizes the evidence for adjuncts added to local anesthetics for single-injection PNBs and caudal blocks in patients aged 0 to 18 years, including dexamethasone, dexmedetomidine, clonidine, conventional opioids, buprenorphine, magnesium sulfate, midazolam, ketamine, neostigmine, tramadol, nalbuphine, and epinephrine. Adult evidence should not be extrapolated directly given developmental pharmacology and pediatric-specific safety considerations. Prospective trials in true pediatric PNBs and pediatric rebound-pain studies remain the critical evidence gaps."

Journal • Review • Anesthesia • Pain • Pediatrics

A Rare Case of Therapeutic Amphetamine-Dextroamphetamine-Induced Ischemic Colitis in a Middle-Aged Woman Without Traditional Vascular Risk Factors (ACG 2026) - "Amphetamine-dextroamphetamine (Adderall), commonly prescribed for ADHD, has rarely been implicated...Medications included amphetamine-dextroamphetamine ER 15 mg daily, semaglutide, escitalopram, clonidine, and rosuvastatin...The medication was discontinued, and the patient improved with IV fluids, ceftriaxone, and metronidazole...As prescription stimulant use increases, clinicians should remain aware of this rare adverse effect, as early recognition and discontinuation of the offending agent may prevent recurrent ischemia and complications. Figure: Ischemic-type changes characterized by hyalinization of the lamina propria (highlighted by the Sirius red stain), surface erosion, withering crypts and focal pseudomembranous exudates Figure: Segmental mucosal friability and ulcerative ischemic injury involving the sigmoid colon"

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Endometriosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Hematological Disorders • Immunology • Inflammation • Women's Health

Prescription Stimulant Therapy and Risk of Constipation in Adults With ADHD: A Propensity-Matched Multicenter Cohort Study (ACG 2026) - "The stimulant cohort included patients receiving amphetamine or amphetamine-like stimulants, excluding prior stimulant exposure and non-stimulant ADHD medication exposure. The non-stimulant cohort included patients receiving atomoxetine, guanfacine, clonidine, or viloxazine, excluding prior non-stimulant exposure and stimulant exposure... After matching, 36,501 patients were included in each cohort. At 1 year, constipation occurred in 617/33,224 stimulant users versus 832/32,541 non-stimulant users (1.9% vs 2.6%; RR 0.726, 95% CI 0.655â0.805; p< 0.001). Stimulant therapy was also associated with lower laxative/constipation medication use (5.3% vs 5.8%; RR 0.916, 95% CI 0.857â0.980; p=0.011) and ileus risk (0.04% vs 0.10%; RR 0.371, 95% CI 0.196â0.701; p=0.001)."

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Psychiatry

The Gut on Tranq: A Rare Case of Xylazine-Induced Ischemic Colitis (ACG 2026) - "Upon admission, she experienced severe withdrawal, including 20-30 bowel movements daily, and was treated with buprenorphine, clonidine, and tizanidine. Colonoscopy findings of Xylazine-induced ischemic colitis. Panels show continuous ulceration, bleeding, pallor, and friability throughout the (A) rectum, (B) sigmoid, (C) descending, (D) transverse, and (E) hepatic flexure/ascending colon."

Clinical • Cardiovascular • CNS Disorders • Depression • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hypotension • Immunology • Inflammation

Fruquintinib-Induced Hypertensive Crisis in a 23-Year-Old With Early-Onset Metastatic Rectal Adenocarcinoma (ACG 2026) - "The day before, he started lisinopril, clonidine, and tramadol for suspected drug-induced and pain-related hypertension. He completed two weeks of fruquintinib (previously on FOLFOXIRI)...Clinicians should suspect fruquintinib toxicity if HTN-C occurs. Holding therapy may be needed while evaluating end-organ injury."

Metastases • Colorectal Adenocarcinoma • Colorectal Cancer • Hepatocellular Cancer • Hypertension • Oncology • Pulmonary Disease • Rectal Adenocarcinoma • Solid Tumor

Psychotropic medication use in school-aged children in foster care and residential care within child protective services. (PubMed, Child Abuse Negl) - "Further research is needed to better understand the high rates of ADHD diagnosis and ADHD-medication among children in the care of child protective services, particularly given that ADHD medications account for most prescriptions."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Psychiatry • Tourette Syndrome

A prospective study comparing magnesium sulphate versus clonidine as adjuvants to epidural bupivacaine for lower limb and lower abdominal surgeries. (PubMed, Bioinformation) - "Magnesium sulphate produced a faster onset of block, while clonidine resulted in prolonged analgesia and motor block, with mild hypotension and bradycardia observed more frequently. Thus, we show that both agents safely optimize epidural anesthesia magnesium for quicker onset and clonidine for extended pain control depending on surgical needs."

Journal • Anesthesia • Cardiovascular • Hypotension • Pain

The Use of Intravenous Clonidine in Postoperative Pain Management: A Scoping Review. (PubMed, Acta Anaesthesiol Scand) - "Evidence for the use of intravenous clonidine in postoperative pain management is heterogeneous and limited, providing no consistent clinical benefit and underscoring the need for further research."

Journal • Review • Pain

Pharmacologic treatment of dystonia (PubMed, Medicina (B Aires)) - "The main medications used to treat dystonia include anticholinergics, baclofen, and benzodiazepines...Other drugs such as levodopa, gabapentin, clonidine, and vesicular monoamine transporter inhibitors are also frequently used. The most common adverse effects are discussed. Medication selection should consider etiology, subtype of dystonia, potential adverse effects, and associated comorbidities."

Journal • Review • CNS Disorders • Dystonia • Movement Disorders • Pain

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

A novel combination therapy for effective treatment of cancer by designed anti-immunosuppressive nanoregulator and radiofrequency ablation. (PubMed, Biomaterials) - "To overcome this therapeutic hurdle, we designed a completely new ZIF-8-NH2-based nanoplatform (NP) that contained a CpG oligodeoxynucleotide, clonidine (CLD), and an α2-adrenergic receptor agonist...In a clinically relevant mouse HCC model, we validated this new therapeutic concept as an effective approach for treatment of HCC. Together, these data pave a new therapeutic avenue for effective treatment of HCC and likely other types of cancer."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • CD8 • CXCL10

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (clinicaltrials.gov) - P4 | N=90 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2026 ➔ Jun 2027 | Trial primary completion date: Dec 2026 ➔ Jun 2027

Trial completion date • Trial primary completion date • Orthopedics

Benzodiazepine Withdrawal Masked by Clonidine: An Emergency Presentation With a Diagnostic Challenge. (PubMed, Subst Use Addctn J) - "This case highlights the need for awareness of drug interactions that may mask typical withdrawal symptoms of benzodiazepines. Furthermore, it emphasises the need for thorough collateral history particularly when the patient is incapacitated and highlights the importance of addressing complex pain needs to prevent self-medication."

Journal • Cardiovascular • CNS Disorders • Hypertension • Insomnia • Movement Disorders • Pain • Psychiatry • Sleep Disorder

Paediatric clonidine medication errors: Findings from a multicentre French study. (PubMed, Br J Clin Pharmacol) - "Medication errors involving clonidine in paediatric patients are predominantly linked to challenges during hospital administration, exacerbated by the absence of paediatric formulations. Addressing these risks requires regulatory changes, including the development of ready-to-use paediatric formulations and standardized dosing protocols, to enhance clonidine safety in clinical practice."

Journal • Cardiovascular • Hypotension • Pediatrics