clonidine / Generic mfg. - LARVOL DELTA

Loneliness, serotonin, and medial prefrontal cortex: some empirical and theoretical considerations. (PubMed, Pharmacol Biochem Behav) - No abstract available

Journal

Off-Label but On the Rise: National Trends of Clonidine Use in U.S. NICUs, 2008–2022 (PAS 2026) - No abstract available

Pediatrics

EFFECTS OF CLONIDINE, A GI PROTEIN-COUPLED Α2-ADRENERGIC RECEPTOR AGONIST, IN RATS WITH POLYCYSTIC KIDNEY DISEASE (ISN-WCN 2026) - No abstract available

Preclinical • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

Short Stature and Growth Hormone Deficiency in POMC Deficiency: An Unexpected Clinical Association. (PubMed, J Clin Res Pediatr Endocrinol) - "After euthyroidism had been achieved and estrogen priming had been completed, GH stimulation testing with L-DOPA and clonidine showed peak GH levels of 0.52 and 1.0 µg/L, respectively...This case expands the clinical spectrum of POMC deficiency by demonstrating short stature with biochemically confirmed GHD and a notable early growth response to GH therapy. Further studies are needed to clarify the underlying mechanisms and to guide follow-up and management."

Journal • Endocrine Disorders • Genetic Disorders • Growth Hormone Deficiency • Obesity • POMC-null Obesity • IGF1 • IGFBP3

Deprescribing methadone for chronic non-cancer pain: management of withdrawal symptoms (PubMed, Ugeskr Laeger) - "Withdrawal symptoms were managed through an individually tailored plan, supportive consultations with a nurse, and the use of clonidine. The patient regained function after deprescribing methadone. Deprescribing opioids can be managed through a patient-centered approach and close monitoring."

Journal • Oncology • Pain

Unilateral Nephrectomy: An Effective Temporizing Measure for Refractory Hypertension in ARPKD (SCCM 2026) - "During this period, she developed severe hypertension refractory to high doses of anti-hypertensives, including amlodipine, diuretics, labetalol, minoxidil, clonidine, and parenteral drips. She continued to require mechanical ventilation but was successfully supported on a conventional ventilator. Palliative unilateral nephrectomy is an effective tool for blood pressure control and temporizing of thoracoabdominal competition, allowing time for growth until renal transplant is feasible. Delaying eventual bilateral nephrectomy is beneficial given concerns surrounding effective dialysis in an anuric neonate."

Cardiovascular • Genetic Disorders • Hypertension • Nephrology • Polycystic Kidney Disease • Renal Disease • Respiratory Diseases

Management of Status Dystonicus in the PICU: A Scoping Review of Recent Literature (SCCM 2026) - "There is broad agreement, with some regional variation, on the medical management, with antipyretics, analgesia, sedation (lorazepam), anticholinergics (trihexyphenidyl), muscle relaxants (primarily baclofen and benzodiazepines), alpha-2-adrenergic agonists (clonidine, tizanidine), and the vesicular monoamine transporter (VMAT2) tetrabenazine. Titratable infusions, including midazolam, dexmedetomidine, opioids, and pentobarbital may be needed... Prevention of SD episodes is key. A multidisciplinary, systematic approach to care is essential, with the input of medical, surgical and other subspecialists. Early consideration of interventional approaches in critically ill children with SD is warranted."

Review • CNS Disorders • Dystonia • Infectious Disease • Movement Disorders • Respiratory Diseases • Sleep Disorder

Management of Combined Opioid and Medetomidine Withdrawal at an Academic Medical Center (SCCM 2026) - "The regimen included treatment with dexmedetomidine infusion (an enantiomer of medetomidine), clonidine (an α2 agonist), long- and short-acting opioids, and multimodal symptom management with agents such as olanzapine and ketamine. We reviewed a sample of 61 patients who had 69 ICU admissions for opioid withdrawal from September 2024 to July 2025. Patients with concomitant opioid and medetomidine withdrawal often required multiple days in the ICU to receive high-dose dexmedetomidine for extended periods, along with multimodal symptomatic treatment. Our experience highlights the challenge of managing withdrawal in the rapidly evolving landscape of opioid adulterants and the importance of timely development and implementation of effective treatment protocols."

Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Movement Disorders

Guanfacine for Dexmedetomidine Withdrawal (SCCM 2026) - "Historically, clonidine has been used for this purpose, however its use is limited by cardiovascular effects, namely hypotension... The results of this evaluation reveal a lack of standardized guanfacine dosing strategies in dexmedetomidine weaning, suggesting an opportunity for protocol development. Additionally, the findings suggest an education opportunity for providers on ensuring the appropriate guanfacine formulation is ordered for the planned route of administration. Immediate future directions for this project include a research project designed to evaluate the comparative efficacy of dexmedetomidine weaning strategies."

Cardiovascular • Hypotension

WHEN LYING HURTS: SUPINE HYPERTENSION WITH ORTHOSTATIC HYPOTENSION IN A MISDIAGNOSED CASE OF POTS (ACC 2026) - "Patient was advised to elevate the head of the bed ≥45°, use compression garments, and midodrine during the day. Clonidine was started at night to help with SH. Improvement was noted in SH from his charted readings."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Hypertension • Hypotension • Nephrology • Pulmonary Disease • Renal Disease

A HEAVY PRICE FOR HEAVY METAL: INTRAVENOUS IRON INDUCED TYPE II KOUNIS SYNDROME (ACC 2026) - "Case: A 62-year-old woman with drug-induced lupus admitted for clonidine-associated angioedema was receiving IV iron dextran for anemia when she developed acute respiratory distress, chest pain, tachycardia, and hypoxemia, requiring epinephrine, steroids, antihistamines and BiPAP. Type II KS results from allergen-triggered, mast-cell-mediated plaque/thrombus disruption causing ischemia with variable, often underdiagnosed presentations. Temporal association with an allergic trigger is key, and further studies should clarify epidemiology and standardize treatment."

Acute Coronary Syndrome • Acute Respiratory Distress Syndrome • Cardiovascular • Heart Failure • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Myocardial Infarction • Respiratory Diseases • Thrombosis • Vasculitis • MPO

STRESS-INDUCED TAKOTSUBO CARDIOMYOPATHY TRIGGERED BY A MALFUNCTIONING INTRATHECAL PAIN PUMP (ACC 2026) - "We present a unique case of morphine (MOR), clonidine (CLO), and bupivacaine (BUP) associated TCM following intrathecal pump (IP) malfunction. To our knowledge, this represents the first reported case of Takotsubo cardiomyopathy secondary to intrathecal pump malfunction. Clinicians are encouraged to include drug-related etiologies in the differential diagnosis of acute cardiomyopathy when no other clear trigger is identified."

Acute Coronary Syndrome • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Pain

An unusual presentation of acute kidney injury secondary to Influenza A-induced rhabdomyolysis (UKKW 2026) - "Oseltamivir was initiated but subsequently withdrawn as symptom duration exceeded 7 days...The patient transferred to the intensive care unit for management of a hypertensive emergency, requiring labetalol infusion, amlodipine, doxazosin, clonidine and furosemide for blood pressure control... This case illustrates a rare but serious complication of influenza infection and highlights the importance of screening for influenza virus in the setting of non-traumatic rhabdomyolysis, even in those without typical symptoms and outside of the usual flu season."

Acute Kidney Injury • Cardiovascular • CNS Disorders • Epilepsy • Glomerulonephritis • Hepatology • Immunology • Infectious Disease • Influenza • Liver Failure • Lupus Nephritis • Musculoskeletal Diseases • Myocardial Infarction • Myositis • Nephrology • Renal Disease • Respiratory Diseases

Deletion of TRPA1 Ion Channel Modulates the Central Stress Responses in a Mouse Model of Posttraumatic Stress Disorder. (PubMed, Cells) - "Clonidine, a central sympatholytic drug, can inhibit LC activity and reduce PTSD-related symptoms, suggesting noradrenergic involvement...Corticosterone levels remained unchanged. TRPA1 may support stress adaptation in PTSD by regulating LC noradrenergic output and PVN neuroinflammation, independently of α2-adrenergic signaling."

Journal • Preclinical • CNS Disorders • Inflammation • Mood Disorders • Post-traumatic Stress Disorder • TRPA1

The Management of Evolving Neuropsychiatric Symptoms in a Female with Fragile X Syndrome: A Case Report. (PubMed, Psychopharmacol Bull) - "Over time, stimulant medication, adjunctive clonidine, intermittent low-dose antipsychotic use, selective serotonin reuptake inhibitors, and antiseizure medications formed the core of treatment...Medication choices and dosing shifted in response to developmental stage, psychiatric symptom emergence, metabolic side-effects, neurologic comorbidity, and family preference. This case illustrates the need for continuous reassessment, metabolic and neurologic monitoring, and flexible, interdisciplinary management in patients with FXS and evolving psychiatric symptoms."

Journal • ADHD (Impulsive Aggression) • Alzheimer's Disease • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Cognitive Disorders • Developmental Disorders • Epilepsy • Fragile X Syndrome • Genetic Disorders • Mental Retardation • Mood Disorders • Psychiatry

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012-2022. (PubMed, Crit Care Explor) - "Patients with a higher cumulative IV opioid dose, an IV opioid wean in the preceding 8-12 hours, and greater than or equal to 2 CCC-V2 categories had the highest odds of withdrawal in this single-center study. Morphine was associated with increased odds of withdrawal as well."

Journal • Retrospective data • Cardiovascular • Heart Failure • Pediatrics • Pulmonary Disease • Respiratory Diseases

Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine (clinicaltrials.gov) - P3 | N=96 | Completed | Sponsor: The University of Hong Kong | Active, not recruiting ➔ Completed

Trial completion • Musculoskeletal Diseases • Orthopedics • Pain

Perioperative Challenges in a Patient With Sturge-Weber and Obesity Hypoventilation Syndromes. (PubMed, Case Rep Med) - "Premedication included intramuscular clonidine (2 μg/kg)...Anesthesia was maintained with propofol and remifentanil via target-controlled infusion...Awake fiberoptic intubation and the use of HFNO under strict ventilatory monitoring, as a rescue or bridging strategy, can facilitate safe anesthetic management in high-risk patients with SWS and OHS who are CPAP-intolerant. This case highlights the importance of multidisciplinary planning and individualized respiratory support strategies."

Journal • Anesthesia • Genetic Disorders • Obesity • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Improvement in Resistant Hypertension Following Thymoma Resection: A Case of Paraneoplastic Hypertension (NKF-SCM 2026) - "Prior to surgery, his primary care provider had him on an unusual BP regimen that included sacubitril-valsartan, chlorthalidone, guanfacine, clonidine, and potassium chloride. CONCLUSION This case highlights the importance of thorough evaluation and individualized management in patients with complex resistant hypertension and multiple comorbidities. It also suggests potential effect of thymomas on increasing blood pressure."

Clinical • Cardiovascular • Cerebral Hemorrhage • Chronic Kidney Disease • Cushing’s Disease • Endocrine Disorders • Genetic Disorders • Hematological Disorders • Hypertension • Immunology • Obesity • Obstructive Sleep Apnea • Renal Disease • Respiratory Diseases • Sleep Disorder • Solid Tumor • Thymoma • Thymus Cancer

Tizanidine withdrawal presenting as hypertensive emergency with recurrent acute kidney injury (NKF-SCM 2026) - "On day 3, she developed hypotension and lethargy requiring vasopressors, attributed to sedative and antihypertensive polypharmacy (tizanidine, clonidine, labetalol, gabapentin, methocarbamol)...A structured tizanidine taper was initiated with concurrent titration of nifedipine and metoprolol...In patients with refractory or labile hypertension and chronic tizanidine use, withdrawal should be included in the differential. Gradual tapering and careful medication reconciliation are essential to prevent recurrent adrenergic crises and end-organ injury"

Acute Kidney Injury • Back Pain • Cardiovascular • Hematological Disorders • Hypertension • Hypotension • Movement Disorders • Musculoskeletal Pain • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Migraine Across the Menopausal Transition: Clinical Challenges and Management Considerations (AAN 2026) - "Non-hormonal options such as SSRIs, SNRIs, gabapentin, and clonidine are useful for both migraine and vasomotor symptoms. Traditional migraine therapies (triptans, NSAIDs, beta-blockers, topiramate, antidepressants) remain central but require tailoring to vascular and metabolic health... Migraine during the menopausal transition reflects the interplay between hormonal dynamics and systemic health. Management requires balancing efficacy with vascular and metabolic safety while incorporating patient preferences. Evidence gaps include the lack of trials stratified by menopausal stage or migraine subtype."

Clinical • Cardiovascular • CNS Disorders • Gynecology • Ischemic stroke • Metabolic Disorders • Migraine • Mood Disorders • Pain • Sleep Disorder

Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients (clinicaltrials.gov) - P2 | N=110 | Recruiting | Sponsor: University of Arkansas | Trial completion date: Sep 2027 ➔ Sep 2028 | Trial primary completion date: Jul 2026 ➔ Jul 2027

Trial completion date • Trial primary completion date • Breast Cancer • Oncology • Solid Tumor

Abstract for REasonS for DiscONtinuation of Non-HormonAl Therapy in MenopausE (RESONATE) Study (ISGE 2026) - "NHTs included antidepressants (selective serotonin reuptake inhibitors [SSRIs] and serotonin–norepinephrine reuptake inhibitors [SNRIs]), anticonvulsants (gabapentin), and α2A-adrenergic receptor agonists (clonidine)...Median treatment duration ranged from 1.4 months for paroxetine (SSRI) to 5.5 months for sertraline (SSRI)...There is a need for additional, effective treatment options for menopausal women experiencing VMS. Abstract previously presented at TMS 2025."

Efficacy of clonidine and melatonin for treating insomnia in anxious children: a randomized comparison. (PubMed, BMC Pediatr) - No abstract available

Journal • CNS Disorders • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

The effect of adding a second multimodal analgesic component to anesthesia regimens on acute postoperative pain outcomes: a systematic review and meta-analysis. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Retrospective data • Review • Anesthesia • Pain