ultra-rapid-acting concentrated insulin aspart (AT278) / Arecor - LARVOL DELTA

Ethylenediamine-Enhanced Iodic Acid Nucleation: Mechanistic Insights into Marine New Particle Formation. (PubMed, Environ Sci Technol) - "Alternatively, bases with similar properties could also be responsible, and the synergistic effects of multiple precursors require further investigation. These findings address a key gap in understanding marine aerosol formation and highlight the importance of incorporating IA-EDA nucleation into global climate models."

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Removal of the Metal Ion Lead II from Aqueous Effluents Using the Stem Bark of Ximenia americana L. (PubMed, ACS Omega) - "The process was endothermic, with ΔH° = 77.4 kJ mol-1, and showed increased system disorder, as indicated by ΔS° = 0.29 kJ mol-1 K-1. In view of these findings, this study contributes to the development of sustainable alternatives for environmental decontamination and highlights X. americana as a promising natural resource for the treatment of wastewater and industrial effluents, its bark, although little explored, presents high efficiency, low cost, selectivity and reuse, characteristics that position this biosorbent as a viable alternative, compared to conventional technologies such as activated carbon, membranes and nanomaterials."

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A new highly concentrated insulin aspart AT278 (500 IU/ml) demonstrates ultra-rapid pharmacokinetic and pharmacodynamic properties in type 2 diabetes regardless of BMI (EASD 2025) - "AT278 exhibited significantly accelerated early PK/PD properties compared with IAsp in overweight and obese people with type 2 diabetes. Whilst IAsp showed slower early glucose-lowering action with increasing BMI, AT278 maintained its ultra-fast properties regardless of BMI, potentially improving quality of life for people with diabetes on high-dose insulin therapy."

PK/PD data • Diabetes • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

Extracting rubber tree parameters and estimating carbon storage using airborne LiDAR. (PubMed, PLoS One) - "The proposed linear regression model for DBH estimation effectively predicts DBH, enabling precise biomass estimation. The total biomass estimated in the study area was 592,770.57 kg (aboveground biomass: 550,336.17 kg, belowground biomass: 42,434.39 kg), with the corresponding total carbon stock estimated at 278,602.17 kg."

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Significance of halogen bonding in the synergistic nucleation of iodine oxoacids and iodine oxides. (PubMed, Chem Sci) - "Such a basicity enhancement effect can be extended to other iodine-containing species, e.g., HIO2 and the more acidic HIO3, suggesting a common feature in interactions between iodine-containing species. Our findings clarify the synergistic nucleation of iodine oxoacids and iodine oxides and highlight the necessity of considering the effect of halogen bond-induced basicity enhancement on the formation of iodine-containing particles."

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Does Volume Matter? Trends and Outcomes in Right-Sided Living Donor Nephrectomy (WTC 2025) - "Our study suggests that overall RLDN continues to decrease in utilization and risks becoming a lost skill amongst future transplant surgeons. Overall graft and recipient survival appeared to be similar between high and low volume centers. However, secondary differences noted could be attributed to higher risk tolerance and more aggressive patient selection at high volume centers."

Eco-sustainable production of bioactive peptides: Antioxidant and antihypertensive potential of Priacanthus hamrur fish skin waste hydrolysate using protamex enzyme. (PubMed, Int J Biol Macromol) - "The Angiotensin-converting enzyme (ACE) inhibitory activity was 57.45 ± 0.53 % at a 2 mg/ml protein. This study presents PrMPH with significant antioxidant and antihypertensive effects, feasible in the nutritional, food, and pharmaceutical sectors."

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AT278, a Novel Ultra-fast Highly Concentrated Insulin Aspart (500 IU/ml), Shows Ultra-fast Properties Independent of BMI (ADA 2025) - "Concentrated AT278 (500 IU/ml) offers ultra-fast characteristics independent of BMI and thus has the potential to improve quality of life for people with diabetes with high prandial insulin needs."

Diabetes • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

D-Amino acid analysis in solution using the photochemical properties of protonated adenosine. (PubMed, Photochem Photobiol Sci) - "This ability, which was discovered in the gas phase, was used in quantitative-analysis applications in solution. The molar fractions of L-histidine and D-histidine in solution were determined by measuring the relative abundance of the precursor and product ions in the single product-ion spectrum of the hydrogen-bonded clusters generated from solution and with reference to a calibration curve."

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Structural and luminescent properties of Dy3+-doped Ca3WO6 phosphors for white-light display applications. (PubMed, RSC Adv) - "PL decay lifetime analysis at λ ex = 278 nm and λ em = 576 nm elucidated the decay kinetics, affirming the phosphor's high external quantum yield (∼59%). CIE chromaticity coordinates place the emission squarely in the white light spectrum, underscoring the exceptional potential of these phosphors for advanced white light-emitting display technologies."

Journal • CNS Disorders • Psychiatry

Urea-Formaldehyde Strengthened by Polyvinyl Alcohol: Impact on Mulch Film Properties and Cucumber Cultivation. (PubMed, Polymers (Basel)) - "Compared to no mulching (NM), BioT1 increased both the specific root length and root density, as well as improved the plant height, stem diameter, and total biomass of the cucumbers by 43.5%, 34.1%, and 33.9%, respectively. Therefore, a mass ratio of paper powder, water, and W4UF of 1:30:2 produced a biodegradable mulch film that could be used as an alternative to LDPE, mitigating the environmental pollution rendered by synthetic plastic mulch films and offering the potential for a sustainable agricultural application."

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Waste-derived marigold flower carbon dot spray and gel formulations exhibit enhanced wound healing in deep excisional cutaneous and burn wounds. (PubMed, J Mater Chem B) - "Histology and immunohistochemistry supported enhanced collagen synthesis and remodeling in the treated tissue; however, the gel demonstrated marginally superior results compared to the spray, as it adhered more securely. These results show that the developed marigold-derived CDs are biocompatible, promote angiogenesis, and enhance healing of deep excisional and burn wounds."

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Green and Sensitive Investigation for Estimation of Anticancer Medication in Raw Material and Dosage Form: Greenness Assessment Consideration. (PubMed, Luminescence) - "These three methods were effectively utilized to quantify larotrectinib in both its raw form and its pharmaceutical formulation. Greenness of the developed methodologies was concerned and evaluated via three different tools including analytical ecoscale, green analytical procedure index (GAPI), and analytical greenness metric approach (AGREE)."

Journal • Cerebral Hemorrhage • Oncology • Pediatrics

Molecular Simulations of the Adsorption Behavior of NH3 and O2 in Xiaolongtan Lignite. (PubMed, ACS Omega) - "Under identical temporal conditions, the mean square displacement and diffusion coefficients of the gases increased with temperature, with O2 exhibiting a higher diffusion coefficient than NH3. Furthermore, the interaction energy of the lignite/NH3 and lignite/O2 systems decreased as the temperature increased, with NH3 exhibiting the strongest interactions with lignite at the same temperature."

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Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation. (PubMed, Ecotoxicol Environ Saf) - "This study helps to identify the hot spots and pollution patterns of heavy metal pollution in polymetallic mining areas and provides a theoretical basis for the study of local countermeasures against pollution. Based on the research results, management measures and ecological restoration suggestions are proposed, which are important for reducing soil insecurity and coping with climate change."

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Photoluminescence and Decay Kinetic Studies of Eu3+ Activated Novel Magnesium Tungstate Double Perovskite for Lighting Application. (PubMed, J Fluoresc) - "The CIE color coordinates significantly falling within red region of the CIE diagram, confirming standard color emission and related photometric parameters were determined. As a result, the synthesized phosphor series under investigation found capable in their application in light illumination devices."

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Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. (PubMed, Molecules) - "On the other hand, the solubility data were modeled by using the van't Hoff-Yalkowsky-Roseman model, obtaining an overall average relative deviation of 3.9%. In general terms, it can be concluded that the solution process of SMR in {MeCN (1) + EtOH (2)} mixtures is thermodependent, favored by the entropy of the solution and mixture; additionally, the van't Hoff-Yalkowsky-Roseman model allows very good approximations to be obtained and is a simple model that starts from only four experimental data."

Journal • Infectious Disease • Nephrology • Pulmonary Disease • Respiratory Diseases

Effects of Community-Led Total Sanitation on improving hygiene and sanitation in 3 villages of the East Region, Cameroon, April - September 2023 (ASTMH 2024) - "However, some practices need to be improved on latrine utilization and handwashing practices. We recommend a close follow-up to ensure the sustainability of these actions."

Colonic Light Chain Amyloidosis Discovered on Screening Colonoscopy (ACG 2024) - "Timely diagnosis is of particular concern as median survival time has been shown to decrease significantly in more advanced stages of disease. Our case highlights a rare presentation of AL discovered on screening colonoscopy, and demonstrates the importance of close inspection during the procedure leading to timely diagnosis and treatment."

Amyloidosis • Bone Marrow Transplantation • Colorectal Cancer • Constipation • Dermatology • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Oncology • Pruritus • Solid Tumor • CCND1 • SDC1

UV-vis absorbance spectra, molar extinction coefficients and circular dichroism spectra for the two cyanobacterial metabolites anabaenopeptin A and anabaenopeptin B. (PubMed, Data Brief) - "Molar extinction coefficients were determined at 278 nm as 4190 M-1 cm-1 and 2300 M-1 cm-1 in methanol for anabaenopeptin A and anabaenopeptin B, respectively. Circular dichroism spectra and secondary fragmentation mass spectra are also reported."

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Dynamic spectroscopic and optical characterization and modeling of bovine serum albumin corona during interaction with N-hydroxysulfo-succinimide-covalently functionalized gold nanourchins. (PubMed, Biointerphases) - "By increasing the GNU, the resistance of the solution decreased in the order of A > S1 > S3, where S3 exhibited the highest initial transmission with a longer desorption time. MATLAB modeling showed 80% surface coverage by the protein in 15 s at 0.05M, equivalent to a thickness of 1.7 nm, which was in agreement with the value determined by using the Stokes-Einstein relation."

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allopurinol induced dress sundrome complicated with pancreatitis and ascites: Always look beyond the skin (EADV 2024) - "Pancreatic involvement most commonly manifests as type 1 diabetes mellitus, while acute pancreatitis is the second commonest manifestation seen in 37.9% of patients with pancreatic involvement, with reported causes being lamotrigine, allopurinol, and cotrimoxazole...A 32-year-old patient reported leflunomide-induced dress syndrome with systemic involvement, including minimal ascites... Allopurinol-induced DRESS syndrome is associated with significant mortality due to systemic manifestations. Judicious use of allopurinol for accepted indications is the only way to decrease the incidence and morbidity caused by this syndrome."

Cardiovascular • Dermatology • Diabetes • Diabetic Nephropathy • Eosinophilia • Gout • Hepatology • Hypertension • Inflammation • Inflammatory Arthritis • Nephrology • Pancreatitis • Pruritus • Renal Disease • Rheumatology • Type 1 Diabetes Mellitus

Pharmacokinetic and pharmacodynamic properties of highly concentrated insulin aspart AT278 U500 in overweight and obese people with type 2 diabetes (EASD 2024) - "AT278 U500 demonstrated significantly accelerated early PK/PD profiles compared with IAsp U100 in overweight and obese people with type 2 diabetes. The results confirm previous findings in people with type 1 diabetes and show that AT278 U500 can maintain the faster action profile irrespective of diabetes type and BMI."

Late-breaking abstract • PK/PD data • Diabetes • Metabolic Disorders • Obesity • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Allopurinol induced Dress syndrome complicated with pancreatitis and ascites: always look beyond the skin. (EADV-Sp 2024) - "Pancreatic involvement most commonly manifests as type 1 diabetes mellitus, while acute pancreatitis is the second commonest manifestation seen in 37.9% of patients with pancreatic involvement, with reported causes being lamotrigine, allopurinol, and cotrimoxazole...A 32-year-old patient reported leflunomide-induced dress syndrome with systemic involvement, including minimal ascites... Allopurinol-induced DRESS syndrome is associated with significant mortality due to systemic manifestations. Judicious use of allopurinol for accepted indications is the only way to decrease the incidence and morbidity caused by this syndrome."

Cardiovascular • Dermatology • Diabetes • Diabetic Nephropathy • Eosinophilia • Gout • Hepatology • Hypertension • Inflammation • Inflammatory Arthritis • Nephrology • Pancreatitis • Pruritus • Renal Disease • Rheumatology • Type 1 Diabetes Mellitus

Allopurinol induced Dress syndrome complicated with pancreatitis and ascites: always look beyond the skin. (EADV-Sp 2024) - "Pancreatic involvement most commonly manifests as type 1 diabetes mellitus, while acute pancreatitis is the second commonest manifestation seen in 37.9% of patients with pancreatic involvement, with reported causes being lamotrigine, allopurinol, and cotrimoxazole...A 32-year-old patient reported leflunomide-induced dress syndrome with systemic involvement, including minimal ascites... Allopurinol-induced DRESS syndrome is associated with significant mortality due to systemic manifestations. Judicious use of allopurinol for accepted indications is the only way to decrease the incidence and morbidity caused by this syndrome."

Cardiovascular • Dermatology • Diabetes • Diabetic Nephropathy • Eosinophilia • Gout • Hepatology • Hypertension • Inflammation • Inflammatory Arthritis • Metabolic Disorders • Nephrology • Pancreatitis • Pruritus • Renal Disease • Rheumatology • Type 1 Diabetes Mellitus