clonidine extended release / Generic mfg. - LARVOL DELTA

Relative Bioavailability of Once-Daily Clonidine XR Oral Suspension Versus Twice-Daily XR Tablets in Healthy Volunteers. (PubMed, J Atten Disord) - "These results demonstrate that clonidine XR OS is bioequivalent to clonidine XR TABs and could fulfill a treatment gap as a liquid, once-daily, non-stimulant ADHD treatment option."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Letter: Clonidine Hydrochloride Extended-Release Oral Suspension for Pediatric Attention-Deficit/Hyperactivity Disorder: A Meaningful Addition to Clinical Practice? (PubMed, J Child Adolesc Psychopharmacol) - No abstract available

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Pediatrics • Psychiatry

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1 | N=150 | Active, not recruiting | Sponsor: University of Utah | Trial completion date: Mar 2026 ➔ Mar 2028 | Trial primary completion date: Mar 2026 ➔ Mar 2028

Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

Efficacy and Safety of Extended-Release Clonidine Hydrochloride for Attention Deficit Hyperactivity Disorder in Chinese Children and Adolescents: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. (PubMed, J Child Adolesc Psychopharmacol) - "CLON-XR was efficacious and well tolerated in Chinese children and adolescents with ADHD, supporting its potential as a nonstimulant treatment option in this population. These findings provide evidence for ADHD management in China and suggest that further investigations in longer-term and real-world settings are needed."

Clinical • Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

A Study to Assess the Effectiveness and Safety of Clonidine Extended-Release OnydaTM XR in Children With ADHD and ODD (clinicaltrials.gov) - P4 | N=162 | Not yet recruiting | Sponsor: Las Vegas Medical Research, LLC DBA Vector Clinical Trials

New P4 trial • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Behavior Disorders • CNS Disorders • Psychiatry

Nonstimulant Medications for Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. (PubMed, Pediatr Ann) - "The recommended nonstimulant ADHD medications include alpha agonists (eg, guanfacine extended-release [ER], clonidine ER) and norepinephrine reuptake inhibitors (eg, atomoxetine, viloxazine)...[Pediatr Ann. 2025;54(1):e27-e33.]."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Pediatrics • Psychiatry

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1 | N=150 | Active, not recruiting | Sponsor: University of Utah | Enrolling by invitation ➔ Active, not recruiting | Trial completion date: Mar 2023 ➔ Mar 2026 | Trial primary completion date: Mar 2023 ➔ Mar 2026

Enrollment closed • Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

Interoception in Practice: The Gut-Brain Connection. (PubMed, J Dev Behav Pediatr) - "There was known prenatal exposure to tobacco and methamphetamine and inadequate prenatal care...Treatment history included gabapentin and subsequently divalproex for seizure-like episodes (despite negative EEG) described as frequent staring spells with repetitive biting of his lips. Psychotropic medications were risperidone for irritability associated with autism and clonidine extended release for ADHD...Comprehensive medical workup including upper endoscopy and biopsy resulted in a diagnosis of eosinophilic esophagitis (EoE). What would be your next step?"

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • Bipolar Disorder • CNS Disorders • Eosinophilic Esophagitis • Epilepsy • Gastrointestinal Disorder • Genetic Disorders • Immunology • Infectious Disease • Insomnia • Mood Disorders • Musculoskeletal Pain • Pain • Psychiatry • Sleep Disorder

Evaluating the pharmacokinetics of extended release viloxazine in the treatment of children with attention-deficit/hyperactivity disorder. (PubMed, Expert Opin Drug Metab Toxicol) - "Current treatments include stimulants, which inhibit the reuptake of dopamine and norepinephrine, a nonstimulant norepinephrine reuptake inhibitor (NRI) atomoxetine, and alpha-2 agonists clonidine extended release (ER) and guanfacine ER...Although they have not been directly compared, the effect size of viloxazine ER is less than has been observed for stimulants. However, its pharmacokinetic properties and tolerability make viloxazine ER a useful addition to the collection of FDA approved ADHD treatments."

Journal • PK/PD data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Psychiatry

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1; N=150; Enrolling by invitation; Sponsor: University of Utah

New P1 trial • Musculoskeletal Diseases • Orthopedics • Pain