clonidine extended release / Generic mfg. - LARVOL DELTA

Nonstimulant Medications for Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. (PubMed, Pediatr Ann) - "The recommended nonstimulant ADHD medications include alpha agonists (eg, guanfacine extended-release [ER], clonidine ER) and norepinephrine reuptake inhibitors (eg, atomoxetine, viloxazine)...[Pediatr Ann. 2025;54(1):e27-e33.]."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Pediatrics • Psychiatry

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1 | N=150 | Active, not recruiting | Sponsor: University of Utah | Enrolling by invitation ➔ Active, not recruiting | Trial completion date: Mar 2023 ➔ Mar 2026 | Trial primary completion date: Mar 2023 ➔ Mar 2026

Enrollment closed • Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

Interoception in Practice: The Gut-Brain Connection. (PubMed, J Dev Behav Pediatr) - "There was known prenatal exposure to tobacco and methamphetamine and inadequate prenatal care...Treatment history included gabapentin and subsequently divalproex for seizure-like episodes (despite negative EEG) described as frequent staring spells with repetitive biting of his lips. Psychotropic medications were risperidone for irritability associated with autism and clonidine extended release for ADHD...Comprehensive medical workup including upper endoscopy and biopsy resulted in a diagnosis of eosinophilic esophagitis (EoE). What would be your next step?"

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • Bipolar Disorder • CNS Disorders • Eosinophilic Esophagitis • Epilepsy • Gastrointestinal Disorder • Genetic Disorders • Immunology • Infectious Disease • Insomnia • Mood Disorders • Musculoskeletal Pain • Pain • Psychiatry • Sleep Disorder

Evaluating the pharmacokinetics of extended release viloxazine in the treatment of children with attention-deficit/hyperactivity disorder. (PubMed, Expert Opin Drug Metab Toxicol) - "Current treatments include stimulants, which inhibit the reuptake of dopamine and norepinephrine, a nonstimulant norepinephrine reuptake inhibitor (NRI) atomoxetine, and alpha-2 agonists clonidine extended release (ER) and guanfacine ER...Although they have not been directly compared, the effect size of viloxazine ER is less than has been observed for stimulants. However, its pharmacokinetic properties and tolerability make viloxazine ER a useful addition to the collection of FDA approved ADHD treatments."

Journal • PK/PD data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Psychiatry

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1; N=150; Enrolling by invitation; Sponsor: University of Utah

New P1 trial • Musculoskeletal Diseases • Orthopedics • Pain