Tri-Moxi (triamcinolone acetonide/moxifloxacin) / Harrow Health - LARVOL DELTA

Efficacy and safety of 'dropless vitrectomy surgery' and comparison of outcomes to standard of care topical therapy. (PubMed, Front Ophthalmol (Lausanne)) - "To compare the effectiveness of intravitreal injection of triamcinolone acetonide/moxifloxacin (Tri-Moxi) with the standard eye drop regimen for controlling postoperative inflammation, intraocular pressure, infections, macular thickness, and visual acuity (VA) in patients undergoing pars plana vitrectomy for various retinal disorders...There was no statistically significant difference in the rate of elevated intraocular pressure between the two groups or anterior chamber cell reaction severity, and no cases of endophthalmitis were observed in either group. Tri-Moxi is effective after vitrectomy and is not inferior to standard postoperative topical therapy."

Journal • Surgery • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

RETINAL DEPOSITS OF TRIAMCINOLONE-MOXIFLOXACIN AFTER DROPLESS CATARACT SURGERY. (PubMed, Retin Cases Brief Rep) - "Transzonular triamcinolone acetonide delivered during cataract surgery can deposit on the retinal surface for long periods. These epiretinal crystalline deposits are benign and generally do not interfere with visual acuity. Nevertheless, clinicians should be aware of this differential diagnosis because clinical misdiagnosis can lead to unwarranted evaluation and treatment."

Journal • Surgery • Cataract • Ophthalmology

Non-Infectious Outcomes of Intravitreal Antibiotic-Steroid Injection with Topical NSAID Versus Standard Topical Drops Regimen (ASCRS-ASOA 2023) - "Purpose To evaluate the efficacy of pars plana intravitreal triamcinolone-moxifloxacin (TriMoxi) injections compared against the standard three-drop topical regimen in post-operative cataract patients.MethodsA retrospective chart review of 2143 eyes undergoing cataract surgeries across three medical institutions was conducted.Factors including patients’ age, race, iris color, and previous medical and ocular history was collected.Post-operative visual acuity, intraocular pressure (IOP), need for IOP lowering medications were also recorded at 1 week, 1 month, 6 month, and most recent timepoints.Rates of persistent anterior chamber inflammation (PACI), rebound inflammation (RI), cystoid macular edema (CME), corneal edema, and any complications requiring re-surgery were also tracked.Statistical significance was defined as α = 0.05ResultsOf the 2143 total eyes, 1079 received IVAS injections with the use of a postoperative topical NSAID.Postoperative visual acuities and..."

Cataract • Inflammation • Macular Edema • Ophthalmology

"The trimoxi nebula is one of the lesser known interstellar, err intraocular findings." (@n8radcliffe)

Advances in drug delivery: Less is more (Healio) - "We have gone from the days of finally having a topical NSAID eye drop to now having it as a once-daily brominated formulation with greater potency (Prolensa, Bausch + Lomb; BromSite, Sun Pharmaceuticals), from the days of finally having an ester topical steroid (Lotemax suspension, Bausch + Lomb) to now having submicron- and nano-formulations of the same with greater aqueous penetration (Lotemax SM, Bausch + Lomb; Inveltys, Kala), from the days of hourly topical steroid prednisolone dosing to now having emulsion formulations (Durezol, Novartis) with greater potency and lower dosing."

Online posting

Acute-onset postoperative endophthalmitis after cataract surgery and transzonular intravitreal triamcinolone-moxifloxacin. (PubMed, J Cataract Refract Surg) - "Postoperative endophthalmitis can occur after dropless cataract surgery with intravitreal triamcinolone-moxifloxacin."

Journal

Triamcinolone acetonide-moxifloxacin controls inflammation after cataract surgery (Healio) - "The present study shows that intravitreal triamcinolone acetonide-moxifloxacin injection can be as effective as topical drops and decreases the patient burden by using one drop postoperatively instead of multiple drops. Inflammation was well controlled in both groups but was reduced at a faster rate in the injection group, although this did not impact incidence of cystoid macular edema or rate of infection. A major question is the safety of intravitreal injection at the time of cataract surgery, which was not assessed by the authors."

Online posting