Undisclosed PAR2 pepducin / Oasis Pharma - LARVOL DELTA

FIRST-IN-HUMAN PHASE 1 STUDY OF THE SAFETY AND PHARMACODYNAMIC EFFECTS OF OA-235I, A PAR2 PEPDUCIN, IN ADULTS WITH METABOLIC-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) AND STEATOHEPATITIS (MASH) (AASLD 2024) - "Resmetirom, a thyroid hormone-derived metabolic drug, recently received conditional FDA approval based on its safety and efficacy on surrogate endpoints of MASH resolution and fibrosis regression. OA-235i, a PAR2 inhibitor, is safe and well-tolerated. Early efficacy signals on metabolic parameters justify further investigation of PAR2 as a therapeutic target for treatment of MASH."

Clinical • P1 data • PK/PD data • Diabetes • Fibrosis • Genetic Disorders • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity