BRD9500 / Bayer - LARVOL DELTA

Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12. (PubMed, ACS Med Chem Lett) - "More analogs were prepared and tested with the goal of increasing metabolic stability and decreasing PDE3 inhibition while maintaining the cellular activity of BRD9500. This led to the discovery of BAY 2666605, a compound optimized for clinical testing."

Journal • Oncology • Targeted Protein Degradation • PDE3A