SLC-149 / SignalChem Lifesci - LARVOL DELTA

Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells. (PubMed, J Enzyme Inhib Med Chem) - "Several representative CA IX inhibitors were tested for their efficacy to inhibit the proliferation of glioblastoma, pancreatic, and breast cancer cells expressing CA IX, in hypoxic conditions. Unlike previous literature data on SLC-149, a structurally related sulphonamide to compounds investigated here, our data reveal that these derivatives possess promising anti-proliferative effects, comparable to those of SLC-0111."

Journal • Brain Cancer • Breast Cancer • Glioblastoma • Oncology • Pancreatic Cancer • Solid Tumor

Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors. (PubMed, Expert Opin Investig Drugs) - "Alone or in combination with other chemotherapeutic agents or radiotherapy, CA IX/XII inhibitors such as SLC-0111, SLC-149, S4, 6A10, etc., were shown to inhibit the growth of the primary tumor, metastases and invasiveness of many tumor types, being also amenable for the development of imaging agents. A large number sulfonamide and non-sulfonamide inhibitors have been developed using SLC-0111 as lead in the last three years, together with hybrid agents incorporating CA inhibitors and other anticancer chemotypes, including cytotoxins, telomerase, thioredoxin or P-glycoprotein inhibitors, adenosine AA receptor antagonists, pyrophosphatase/phosphodiesterase-3 inhibitors or antimetabolites. All of them showed significant antitumor activity."

Journal • Immunology • Oncology

Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. (PubMed, J Med Chem) - "We show that SLC-149 is a better inhibitor than acetazolamide against CAIX. However, SLC-149 has little effect on cytotoxicity, and high concentrations are required to inhibit cell growth, migration, and invasion. These data support the hypothesis that CAIX activity, shown to be important in regulating extracellular pH, does not underlie its ability to control cell growth."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CA9