JUD-001 / Judo Bio - LARVOL DELTA

JUD-001 a novel kidney targeted siRNA therapeutic for treating Gout (ACR Convergence 2026) - "STRIKERs harnesses megalin-mediated uptake to selectively deliver siRNA to PTECs, enabling potent, durable, kidney-specific gene silencing with cell-type precision. Our findings position STRIERs as a modular renal delivery platform and support Judo Bio's kidney-targeted siRNA program for gout as a differentiated therapeutic opportunity advancing toward the clinic. Fig 1: Therapeutic targeting of renal urate transporters with the STRIKER platform Fig 2: STRIKER biodistribution, target engagement, and functional activity in NHPs."

Gout • Inflammatory Arthritis • Rare Diseases • Rheumatology