SOD-1 antibodies / ProMIS Neurosci - LARVOL DELTA

Development of a targeted BioPROTAC degrader selective for misfolded SOD1. (PubMed, Nat Commun) - "Delayed disease progression is associated with protection of motor neurons, a reduction of insoluble SOD1 accumulation and preservation of innervated neuromuscular junctions. These findings provide proof-of-concept evidence and a platform for developing BioPROTACs as a therapeutic strategy for the targeted degradation of neurotoxic misfolded species in the context of neurodegenerative diseases."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders • Targeted Protein Degradation • SOD1

Generation of Antibodies Selective for Misfolded Disease-associated TDP-43 (AAN 2020) - "We have found that a tryptophan (Trp68) in the TDP-43 N-terminal domain (NTD) participates in the cross-seeding of SOD1 misfolding propagation (Pokrishevsky et al, submitted), despite being inaccessible in the natively folded NTD (e.g., Afroz et al, Nature Comm 2017). We have developed a family of antibodies sensitive to solvent exposure of NTD Trp68 that are selective for misfolded/aggregated, disease-associated TDP-43 while sparing physiologically important molecular species, which may find utility in biomarker and immunotherapy applications for TDP-43 associated diseases."

IO Biomarker • Alzheimer's Disease • Amyotrophic Lateral Sclerosis • CNS Disorders • Dementia • Proteinopathy • Tauopathies And Synucleinopathies