isosorbide dinitrate / Generic mfg. - LARVOL DELTA

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate. (PubMed, Int J Surg Case Rep) - "The treatment demonstrated a highly satisfactory clinical effect, and no severe adverse events or complications were observed during or after the intervention. Controlled hypotension via intravenous ISDN is a safe, rapidly effective, and promising therapeutic alternative for managing refractory postoperative bleeding after TURP when conventional non-surgical measures fail."

Journal • Hypotension

H-HeFT: Hydralazin-Isosorbide Dinitrate in HFrEF (ESC 2026) - No abstract available

Cardiovascular

Hydrogen-bond-mediated cross-sheath associations couple Li+ solvation with interfacial chemistry in lithium metal batteries. (PubMed, J Colloid Interface Sci) - "This cross-sheath association contributes to weaker average Li+-DEE coordination and increased participation of bis(fluorosulfonyl)imide (FSI-) and isosorbide dinitrate (ISDN), yielding a compact, anion-enriched local solvation structure. At the electrode interface, the reconstructed solvation environment cooperates with the reduction chemistry of FEC, FSI- and ISDN to suppress excessive solvent decomposition and promote a homogeneous LiNxOy/LiF-rich solid electrolyte interphase. Consequently, Li||Li symmetric cells sustain stable plating/stripping for approximately 1354 h at 1 mA cm-2 and 1 mAh cm-2, while high-loading Li||LiFePO4 cells cycle for approximately 1188 cycles at 1 C. Unlike conventional approaches focused primarily on direct regulation of the first Li+ solvation shell, this work demonstrates that engineering molecular associations across solvation environments offers an effective route to couple solvation redistribution with interfacial..."

Journal • LIFR

Serum metabolic signatures associated with maximal voluntary ventilation in native high-altitude Tibetans. (PubMed, Metabolomics) - "This study identified three serum metabolites independently correlated with MVV in native high‑altitude Tibetans using a multi‑stage metabolome‑wide screening workflow. These metabolites represent preliminary metabolic correlates of ventilatory function under chronic high‑altitude hypoxia. The marked attenuation of predictive performance from internal cross‑validation to external validation reflects limited generalisability of metabolic signatures in moderate‑sized population cohorts. This work emphasises the value of prespecified multi‑tier screening, stability evaluation and fallback strategies for metabolome‑wide association analyses."

Journal

Ultrasound-induced nitric oxide release from isosorbide dinitrate nanoparticles for on-demand therapy of periodontitis. (PubMed, Biomaterials) - "In a rat model of periodontitis, the treatment significantly decreased bacterial load and mitigated inflammation, resulting in a reduction of inflammatory gene expression by approximately 2.4-fold, while maintaining the integrity of alveolar bone structure. Overall, this study presents a highly promising clinical application for ultrasound-controlled NO delivery strategy for precision therapy of periodontitis."

Journal • Dental Disorders • Inflammation • Periodontitis • NLRP3

Isosorbide dinitrate as an effective adjunct therapy for acute urinary retention: A randomized controlled trial. (PubMed, BJUI Compass) - "Adjunctive sublingual ISDN significantly improves urinary outcomes following AUR and reduces residual urine volume without increasing adverse events. This combination therapy offers a safe and effective strategy to improve the success of TWOC in patients with BPH-related AUR."

Clinical • Journal • Benign Prostatic Hyperplasia • Urology

Anticholinergic Burden, Falls, and the Concept of Appropriate Polypharmacy in Indonesian Geriatric Clinics: A Multicentre Observational Study. (PubMed, Acta Med Indones) - "The prevalence of a high ACB score and falls were 1.8% and 16.8%, respectively. Approximately one in two older adults had polypharmacy. We observed a non-significant inverse relationship between polypharmacy and falls. This may possibly suggest appropriate polypharmacy and closer monitoring applied in geriatric settings, which requires further investigation."

Journal • Observational data • Cardiovascular • CNS Disorders • Depression • Psychiatry

"Design and development of an ethyl cellulose bulk-engineered spherule-based capsule system". (PubMed, Int J Biol Macromol) - "For this purpose, we formulated Isosorbide dinitrate (ISDN) - loaded spherules for delayed release (DR) followed by sustained release (SR) using ethyl cellulose by spheronization technique...The design of space (DOS), optimized through JMP software using the Design of Experiments (DOE) approach, confirms the targeted performance. The results of the DOE to experimental validated results were within 5% deviation."

Journal • Cardiovascular

Vasodilation, Loop Diuretics, or Their Combination in Acute Heart Failure: Rationale and Design of the Randomized Placebo-Controlled DECONGEST-AHF Trial. (PubMed, Am Heart J) - P4 | "By initiating treatment during the hyperacute phase and applying a blinded and placebo-controlled design, we aim to clarify the individual and combined effects of two widely used therapies. The use of emergency consent procedures enables the inclusion of a real-world patient population, including patients who are often excluded from clinical trials. This approach ensures broad generalizability and reflects routine emergency care. Findings from DECONGEST-AHF may improve early management of patients with acute heart failure."

Clinical • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Disease • Respiratory Diseases

Chagasic Esophagopathy With Achalasia and Megaesophagus: A Case Report. (PubMed, Case Rep Infect Dis) - "Videolaparoscopic Heller-Pinotti cardiomyotomy was performed in September 2023 after clinical optimization (isosorbide dinitrate and domperidone). This case confirms laparoscopic cardiomyotomy's efficacy (90% success in Rezende I-III) for symptom resolution in nonadvanced chagasic megaesophagus. Public health insights underscore Chagas underreporting, late diagnosis, and public health system barriers in vulnerable populations, advocating early serological screening and etiological treatment in acute phases to prevent chronic digestive forms in endemic regions."

Journal • Cardiovascular • Dyslipidemia • Gastrointestinal Disorder • Hypertension • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Rare Diseases

Optimized Treatment of Pulmonary Edema or Congestion (clinicaltrials.gov) - P4 | N=1104 | Recruiting | Sponsor: Rigshospitalet, Denmark | Trial completion date: Dec 2026 ➔ May 2027 | Trial primary completion date: Dec 2026 ➔ May 2027

Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure • Respiratory Diseases

Enabling Durable Quasi-Solid-State Li-S Batteries with an Organic Nitrate Additive for Anode Protection and Polysulfide Confinement. (PubMed, ACS Appl Mater Interfaces) - "Herein, we propose isosorbide dinitrate (ISDN), a covalent organic nitrate, as a multifunctional additive that not only promotes DOL polymerization but also enables the formation of an inorganic-rich hybrid SEI (Li3N and LiNxOy), as verified through X-ray photoelectron spectroscopy (XPS) analysis and theoretical calculations...Quasi-solid-state Li-S batteries also demonstrate excellent cycling stability, with a capacity retention of 84.7% after 100 cycles at 0.2C. This work offers a promising strategy for designing high-performance solid-state Li-S batteries based on PDOL electrolytes."

Journal

PERCUTANEOUS ANGIOPLASTY FOR RENAL ARTERY STENOSIS IN TAKAYASU ARTERITIS (ACC 2026) - "Medications included prednisolone, mycophenolate and warfarin...The patient remained hypertensive despite further addition of thiazide diuretic, isosorbide dinitrate and labetalol...Initial balloon angioplasty of the proximal right renal artery stenosis was performed using a 7 mm drug-eluting balloon (Paclitaxel)... The patient underwent successful PTA. This case highlights the importance of PTA as a therapy for hypertension in TA related RAS refractory to adequate medical therapy."

Cardiovascular • Chronic Kidney Disease • CNS Disorders • Hypertension • Vasculitis

DUAL CARDIOTOXICITY OF CAPECITABINE: CORONARY VASOSPASM AND QT PROLONGATION IN A PATIENT WITH GASTRIC ADENOCARCINOMA (ACC 2026) - "Background: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its oral prodrug capecitabine are widely used in gastrointestinal malignancies but are associated with potentially severe cardiotoxicity. Case: A 67-year-old woman with progressive abdominal pain, and weight loss with a diagnosis of sclerosing antral adenocarcinoma (pT4a pN1) underwent radical gastrectomy with D2 lymphadenectomy and adjuvant XELOX...Capecitabine re-exposure caused QT prolongation (502 ms), but prophylaxis (diltiazem, isosorbide dinitrate) normalized the interval (402ms), enabling safe continuation of chemotherapy under ECG monitoring... This case illustrates the dual cardiotoxicity of capecitabine, with both vasospastic angina and QT interval prolongation."

Clinical • Cardiovascular • Gastric Adenocarcinoma • Oncology • Pulmonary Disease • Solid Tumor

Plaque Morphology-Dependent Regression of Tandem Coronary Plaques Under Intensive Lipid-Lowering Therapy. (PubMed, Catheter Cardiovasc Interv) - "Although PCI was considered, in accordance with the patient's preference and guideline recommendations, medical therapy with high-intensity statin, ezetimibe, aspirin, nebivolol, and isosorbide dinitrate was initiated. The patient remained asymptomatic with preserved exercise capacity. This case suggests that plaque morphology may influence the response to lipid-lowering therapy and highlights the value of multimodality imaging with lesion-specific physiological assessment in individualized management of stable coronary disease."

Journal • Cardiovascular

Myocardial Stunning Induced by Vasospasm Within an Intercoronary Communication. (PubMed, JACC Case Rep) - "ICC itself may cause coronary vasospasm, resulting in myocardial ischemia."

Journal • Cardiovascular • Myocardial Ischemia

Endocannabinoids Block Headache and Anxiety Comorbidity via Two-Pronged Anterior Insular Projections. (PubMed, Research (Wash D C)) - "Here, we found that chronic isosorbide dinitrate (ISDN) injections induce c-fos expression in the anterior insula (AI), prelimbic cortex (PrL), and oval nucleus of the bed nucleus of the stria terminalis (ovBNST), suggesting their contributions to headache and anxiety comorbidity...A systemic application of eCB degradation enzyme inhibitors blocks chronic ISDN-induced headache and anxiety comorbidity, which are separately blocked by CB1R antagonist application in PrLs and ovBNSTs. Our findings reveal divergent counteracting effects of elevated eCB signaling in vAI-PrL and dAI-ovBNST circuits on comorbid headache and anxiety."

Journal • Mood Disorders • Pain • Psychiatry • FOS

Significant Antispastic Effect of Combined Fasudil and Isosorbide Dinitrate on Internal Mammary Artery in Coronary Artery Bypass Grafting. (PubMed, Basic Clin Pharmacol Toxicol) - "The combination of fasudil and ISDN effectively prevents and relieves IMA vasospasm mediated by both voltage-operated and receptor-operated calcium channels, with a long-lasting vasorelaxing effect. The FI solution offers a novel approach for preventing and relieving IMA spasm in CABG."

Journal • Cardiovascular • ROCK2

A QSPR study of coronary artery disease drugs using eccentricity-based indices. (PubMed, Sci Rep) - "This study advances QSPR modeling by using eccentricity-based graphical invariants, specifically designed to enhance the predictive accuracy for physicochemical properties of drugs used to treat coronary artery disease, including atorvastatin, simvastatin, rosuvastatin, aspirin, clopidogrel, metoprolol, atenolol, enalapril, lisinopril, amlodipine, diltiazem, nitroglycerin, isosorbide dinitrate, ranolazine, gemfibrozil, and fenofibrate. The experimental values were compared with forecasted data, revealing a strong correlation between them. This demonstrates the reliability of our regression models in assessing these vital physicochemical parameters."

Journal • Cardiovascular • Coronary Artery Disease

Ultrasound-Visualized Cuproptosis in Glioblastoma via Endogenous Copper Sequestration and Nitric Oxide-Gas Controlled Release Using a Programmable Nanoliposomal Platform. (PubMed, ACS Nano) - "Modularly assembled from tumor-targeting sphingosine-1-phosphate (S1P), GSH-responsive nitric oxide (NO) prodrug isosorbide dinitrate (ISDN), and copper-chelator disulfiram (DSF), this DSF/S1P/ISDN-Lipos first facilitates blood-brain tumor barrier traversal and glioblastoma-specific accumulation. In vivo, DSF/S1P/ISDN-Lipos demonstrated favorable biosafety and significantly suppressed orthotopic glioblastoma growth. This work presents a theranostic approach for metal homeostasis regulation, where gas therapy synergizes with endogenous metallo-reprogramming to overcome adaptive resistance."

Journal • Brain Cancer • Glioblastoma • Oncology • Respiratory Diseases • Solid Tumor • ATP7B

Treatment of Orthostatic Intolerance (clinicaltrials.gov) - P1/2 | N=150 | Active, not recruiting | Sponsor: Satish R. Raj | Trial completion date: Dec 2027 ➔ Dec 2029 | Trial primary completion date: Dec 2027 ➔ Dec 2029

Trial completion date • Trial primary completion date • Cardiovascular

Ventricular fibrillation due to coronary vasospasm triggered by hyperventilation in a patient with panic disorder: case report. (PubMed, Eur Heart J Case Rep) - "Medication with a calcium channel blocker (nifedipine 40 mg per day), nitrate (isosorbide dinitrate 40 mg per day), and statin (rosuvastatin 20 mg per day) was initiated. Herein, ventricular fibrillation was likely caused by coronary spasm induced by hyperventilation during the panic attack. Regarding the management of patients with panic disorder who present with chest pain, clinicians should carefully assess the symptoms and consider hyperventilation-induced coronary spasm as a differential diagnosis."

Journal • Acute Coronary Syndrome • Cardiovascular • CNS Disorders • Mood Disorders • Pain

Isosorbide Nitrate-Assisted Microcatheter Navigation for Successful Embolization of a Foramen Magnum Dural Arteriovenous Fistula. (PubMed, Cureus) - "Follow-up angiography at three months confirmed complete obliteration of the fistula, and the patient remained neurologically intact, with no perioperative or delayed complications. This case highlights the potential utility of intra-arterial vasodilators, such as isosorbide dinitrate, in overcoming anatomical challenges during transarterial embolization and suggests their broader applicability in complex neuroendovascular procedures."

Journal • Cardiovascular • Vascular Neurology

Sex influences the progression of cephalic mechanical and light hypersensitivities in a mouse model of chronic migraine. (PubMed, Headache) - "The progression from acute to chronic ISDN-induced cephalic mechanical and light hypersensitivities has sex-specific characteristics that mimic the clinical features of migraine. These findings support the involvement of distinct underlying mechanisms and highlight the need for tailored treatment strategies to optimize migraine management in both male and female populations."

Journal • Preclinical • CNS Disorders • Immunology • Migraine • Pain

Monomorphic sustained right ventricular outflow tract tachycardia in pregnancy with favorable outcomes: a case report. (PubMed, J Med Case Rep) - "Monomorphic sustained right ventricular outflow tract tachycardia in pregnancy is always attributed to a normal physiology of pregnancy. Despite there being no evidence from clinical trials, it can be managed with available antiarrhythmic drugs with favorable outcomes. This case underscores the importance of thoroughly evaluating all pregnant women who present with palpitation to exclude cardiac causes and provide prompt management."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia