isosorbide dinitrate / Generic mfg. - LARVOL DELTA

Endocannabinoids Block Headache and Anxiety Comorbidity via Two-Pronged Anterior Insular Projections. (PubMed, Research (Wash D C)) - "Here, we found that chronic isosorbide dinitrate (ISDN) injections induce c-fos expression in the anterior insula (AI), prelimbic cortex (PrL), and oval nucleus of the bed nucleus of the stria terminalis (ovBNST), suggesting their contributions to headache and anxiety comorbidity...A systemic application of eCB degradation enzyme inhibitors blocks chronic ISDN-induced headache and anxiety comorbidity, which are separately blocked by CB1R antagonist application in PrLs and ovBNSTs. Our findings reveal divergent counteracting effects of elevated eCB signaling in vAI-PrL and dAI-ovBNST circuits on comorbid headache and anxiety."

Journal • Mood Disorders • Pain • Psychiatry • FOS

Significant Antispastic Effect of Combined Fasudil and Isosorbide Dinitrate on Internal Mammary Artery in Coronary Artery Bypass Grafting. (PubMed, Basic Clin Pharmacol Toxicol) - "The combination of fasudil and ISDN effectively prevents and relieves IMA vasospasm mediated by both voltage-operated and receptor-operated calcium channels, with a long-lasting vasorelaxing effect. The FI solution offers a novel approach for preventing and relieving IMA spasm in CABG."

Journal • Cardiovascular • ROCK2

A QSPR study of coronary artery disease drugs using eccentricity-based indices. (PubMed, Sci Rep) - "This study advances QSPR modeling by using eccentricity-based graphical invariants, specifically designed to enhance the predictive accuracy for physicochemical properties of drugs used to treat coronary artery disease, including atorvastatin, simvastatin, rosuvastatin, aspirin, clopidogrel, metoprolol, atenolol, enalapril, lisinopril, amlodipine, diltiazem, nitroglycerin, isosorbide dinitrate, ranolazine, gemfibrozil, and fenofibrate. The experimental values were compared with forecasted data, revealing a strong correlation between them. This demonstrates the reliability of our regression models in assessing these vital physicochemical parameters."

Journal • Cardiovascular • Coronary Artery Disease

Ultrasound-Visualized Cuproptosis in Glioblastoma via Endogenous Copper Sequestration and Nitric Oxide-Gas Controlled Release Using a Programmable Nanoliposomal Platform. (PubMed, ACS Nano) - "Modularly assembled from tumor-targeting sphingosine-1-phosphate (S1P), GSH-responsive nitric oxide (NO) prodrug isosorbide dinitrate (ISDN), and copper-chelator disulfiram (DSF), this DSF/S1P/ISDN-Lipos first facilitates blood-brain tumor barrier traversal and glioblastoma-specific accumulation. In vivo, DSF/S1P/ISDN-Lipos demonstrated favorable biosafety and significantly suppressed orthotopic glioblastoma growth. This work presents a theranostic approach for metal homeostasis regulation, where gas therapy synergizes with endogenous metallo-reprogramming to overcome adaptive resistance."

Journal • Brain Cancer • Glioblastoma • Oncology • Respiratory Diseases • Solid Tumor • ATP7B

Treatment of Orthostatic Intolerance (clinicaltrials.gov) - P1/2 | N=150 | Active, not recruiting | Sponsor: Satish R. Raj | Trial completion date: Dec 2027 ➔ Dec 2029 | Trial primary completion date: Dec 2027 ➔ Dec 2029

Trial completion date • Trial primary completion date • Cardiovascular

Ventricular fibrillation due to coronary vasospasm triggered by hyperventilation in a patient with panic disorder: case report. (PubMed, Eur Heart J Case Rep) - "Medication with a calcium channel blocker (nifedipine 40 mg per day), nitrate (isosorbide dinitrate 40 mg per day), and statin (rosuvastatin 20 mg per day) was initiated. Herein, ventricular fibrillation was likely caused by coronary spasm induced by hyperventilation during the panic attack. Regarding the management of patients with panic disorder who present with chest pain, clinicians should carefully assess the symptoms and consider hyperventilation-induced coronary spasm as a differential diagnosis."

Journal • Acute Coronary Syndrome • Cardiovascular • CNS Disorders • Mood Disorders • Pain

Isosorbide Nitrate-Assisted Microcatheter Navigation for Successful Embolization of a Foramen Magnum Dural Arteriovenous Fistula. (PubMed, Cureus) - "Follow-up angiography at three months confirmed complete obliteration of the fistula, and the patient remained neurologically intact, with no perioperative or delayed complications. This case highlights the potential utility of intra-arterial vasodilators, such as isosorbide dinitrate, in overcoming anatomical challenges during transarterial embolization and suggests their broader applicability in complex neuroendovascular procedures."

Journal • Cardiovascular • Vascular Neurology

Sex influences the progression of cephalic mechanical and light hypersensitivities in a mouse model of chronic migraine. (PubMed, Headache) - "The progression from acute to chronic ISDN-induced cephalic mechanical and light hypersensitivities has sex-specific characteristics that mimic the clinical features of migraine. These findings support the involvement of distinct underlying mechanisms and highlight the need for tailored treatment strategies to optimize migraine management in both male and female populations."

Journal • Preclinical • CNS Disorders • Immunology • Migraine • Pain

Monomorphic sustained right ventricular outflow tract tachycardia in pregnancy with favorable outcomes: a case report. (PubMed, J Med Case Rep) - "Monomorphic sustained right ventricular outflow tract tachycardia in pregnancy is always attributed to a normal physiology of pregnancy. Despite there being no evidence from clinical trials, it can be managed with available antiarrhythmic drugs with favorable outcomes. This case underscores the importance of thoroughly evaluating all pregnant women who present with palpitation to exclude cardiac causes and provide prompt management."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

Erythropoietin-isosorbide dinitrate-loaded nanocomplex cryogel scaffold: a multifunctional smart dressing for diabetic wound healing. (PubMed, Life Sci) - "Our findings demonstrate that the developed cryogel may enhance diabetic wound healing through the sustained delivery of EPO and ISDN."

Journal

Nonsurgical Approach to Treat Post-Rhinoplasty Vascular Complication With Hyaluronic Acid Injection. (PubMed, J Cosmet Dermatol) - "Combined therapies effectively manage HA-induced vascular compromise, with early intervention critical for reducing ischemic complications and improving patient outcomes."

Journal • Retrospective data • Aesthetic Medicine • Hypotension

Painless Coronary Spastic Angina First Diagnosed Perioperatively: Importance of Spasm Provocation Testing Under Medication to Confirm Optimal Therapy. (PubMed, Intern Med) - "Emergent coronary angiography revealed diffuse narrowing of the coronary arteries, which was reversed with isosorbide dinitrate...Intracoronary injection of acetylcholine induced spasm in the coronary artery, although no chest symptoms were observed. We diagnosed the patient with painless coronary spastic angina."

Journal • Cardiovascular • Pain • Ventricular Tachycardia

Managing Chemotherapy-Associated Cardiotoxicity: A Case of 5-Fluorouracil and Mitomycin-Induced Chest Pain. (PubMed, Cureus) - "She was initially managed with verapamil and Imdur; however, persistent pain during the second cycle required adding ranolazine and a switch from Imdur to Isordil. This case highlights the potential for 5-FU-induced cardiotoxicity and the need for individualized cardiovascular management in patients with an oncologic history. Calcium channel blockers and nitrates can be effective in symptom control, underscoring the importance of early recognition and intervention."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia • Oncology • Pain • Squamous Cell Carcinoma • NPPB

Post-transfusional hypertensive pulmonary edema – Is it always a transfusion reaction? (Euroanaesthesia 2025) - "Clinical improvement occurred after administration of a bolus of furosemide, morphine, and hydrocortisone, along with an infusion of isosorbide dinitrate. Recommendations were provided to ensure safety in future transfusions. This case highlights the importance of considering a broad differential diagnosis for acute hypertensive pulmonary edema after transfusion. Timely recognition and multidisciplinary management ensured a positive outcome for both mother and fetus."

Anesthesia • Cardiovascular • Hematological Disorders • Hypertension • Hypotension • Immunology • Obstetrics • Pulmonary Disease • Respiratory Diseases

A balancing act: Anesthetic management for aortic dissection in a pregnant patient (Euroanaesthesia 2025) - "Continuous infusions of labetalol and isosorbide dinitrate were used to manage blood pressure, with fentanyl for acute pain relief...Rapid sequence induction with propofol and remifentanil preceded an urgent C-section, resulting in the birth of a healthy male infant...NIRS monitoring confirmed adequate cerebral perfusion, and procedures utilized total intravenous anesthesia.Despite successful surgery, including 99 minutes of aorta clamping and resuscitation with noradrenaline, dobutamine, and plasma, the patient was unresponsive on postoperative day one...The neonate was discharged without complications. This case underscores the importance of anesthetic management in high-risk cardiovascular surgeries during pregnancy. Effective monitoring and medication adjustments are critical to balancing maternal stability and fetal safety."

Clinical • Anesthesia • Cardiovascular • CNS Disorders • Hypertension • Pain

Acute pulmonary edema in hysteroscopy - intravascular absorption syndrome (Euroanaesthesia 2025) - "Surgery was stopped and a set of measures were taken: oxygen was increased to 100%, secretions were suctioned and isosorbide dinitrate plus furosemide were administered. We aim to increase awareness to this condition and highlight the importance of rigorous monitoring of the fluid balance. Normal saline fluids decreases the development of hyponatremia and neurological symptoms."

Anesthesia • Cardiovascular • CNS Disorders • Crohn's disease • Depression • Gastroenterology • Gynecology • Heart Failure • Hypertension • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Psychiatry • Respiratory Diseases • Women's Health

Identification of potentially effective drugs for metabolic dysfunction-associated steatotic liver disease against liver cirrhosis: In-silico drug repositioning-based retrospective cohort study. (PubMed, PLoS One) - "This study is limited to drugs registered in the Korean NHIS, potentially excluding other relevant candidates. Additionally, the absence of dietary and genetic data in the NHIS database may introduce residual confounding. Lastly, as the study population consists solely of Korean adults, the findings may not be generalizable to other populations."

Journal • Retrospective data • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

Contribution of peripheral and central delta opioid receptors in the relief of migraine-like headache in female and male rats. (PubMed, Br J Pharmacol) - "DOP-mediated antimigraine effect is stronger in female than male rats and appears to be mediated in chronic conditions through peripheral DOPs in females and central DOPs in males. The results strengthen the relevance of using DOP agonists to treat migraine."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Immunology • Migraine • Pain

The role of mitochondrial dysfunction in the pathogenesis of atherosclerosis: A new exploration from bioinformatics analysis. (PubMed, Medicine (Baltimore)) - "3 potential drugs, ISOSORBIDE DINITRATE, Benzaldehyde, and Hydroperoxycycloofosfamide - were identified as interacting with ALDH1B1, with interactions verified through molecular docking...These findings suggest avenues for new AS treatments. Future experimental validation further exploration AS-MD interactions and MD-based therapies are warranted."

Journal • Atherosclerosis • Cardiovascular • Metabolic Disorders • CRY1 • KRAS

Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate. (PubMed, Polymers (Basel)) - "These findings suggest that starch/ECM/ISDN scaffolds hold potential for wound healing applications. Further studies should focus on in vivo evaluation and cytotoxicity assessments to confirm their clinical applicability."

Journal • Hematological Disorders

Vocal Cord Paralysis as an Insidious Onset of Cardiogenic Shock (ATS 2025) - "The electronic medical record showed that the patient was on isosorbide dinitrate and ranolazine for multiple anginal episodes prior to this hospitalization and may have been a reason for a lack of chest pain with an atypical presentation of a coronary artery syndrome. There are no reported cases of Ortner Syndrome being the initial finding of a patient with cardiogenic shock. This case serves as an example of the importance of having a broad differential diagnosis for physical exam findings that may seem typical or out of place."

Asthma • Cardiovascular • Coronary Artery Disease • Dysphonia • Heart Failure • Hypotension • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Otorhinolaryngology • Pain • Respiratory Diseases • Septic Shock

Anesthetic management of coronary artery reconstruction in a patient with myocardial ischemia caused by an anomalous origin of the right coronary artery running between the great vessels: a case report. (PubMed, JA Clin Rep) - "Targeted pharmacologic blood pressure control and multimodal monitoring are vital for safe perioperative outcomes in anomalous coronary artery origin cases."

Journal • Anesthesia • Cardiovascular • Hypertension • Myocardial Infarction • Myocardial Ischemia • Pain

Efficacy and safety of 2% isosorbide cream in systemic sclerosis patients with digital ulcers and Raynaud's phenomenon. (PubMed, Rheumatol Immunol Res) - "We aimed to determine the eficacy and safety of 2% isosorbide dinitrate (ISDN) cream as an adjunctive for treating DUs and RP...Dosages of sustained-release nifedipine ranged from 10-80 mg and sildenafil ranged from 12.5-150 mg...When used as an adjunct to PDE-5i as background therapy, it resulted in stability or improvement of RP in 13.5% of patients, DUs in 13.8% of patients, and both RP and DUs in 15.4% of patients. Topical 2% ISDN cream may help to reduce anxiety when DUs were improved and improve overall QoL."

Journal • Cardiovascular • Hypotension • Immunology • Mood Disorders • Pain • Psychiatry • Rheumatology • Scleroderma • Systemic Sclerosis

INTRACTABLE SHOCK AND ARREST FROM SUDDEN NATIVE AND GRAFT CORONARY VASOSPASM POST-CABG - Nahush Bansal (ACC 2025) - "Angiography showed vasospasm in the native left anterior descending (LAD) artery and the left internal mammary artery (LIMA) graft, which responded to intracoronary nitroglycerin...By day six, the Impella was removed, and diuretic therapy with mannitol and furosemide was initiated. The patient was discharged in a stable condition on day ten on isosorbide dinitrate, metoprolol, statin, aspirin, and clopidogrel.Decision-making: Coronary vasospasm following CABG is typically identified by ST-segment changes or angina... Coronary vasospasm post-CABG can follow a malignant course, underscoring the importance of early recognition and prompt intervention. Close monitoring and timely angiography are critical for diagnosis, and this case demonstrates a structured approach to managing intricate hemodynamics. It highlights the necessity for individualized treatment strategies in the absence of clear guidelines."

Cardiovascular • Myocardial Infarction

Application of nitrates and NO-donors as a transdermal therapy for erectile dysfunction: a comprehensive review. (PubMed, Sex Med Rev) - "Based on these findings, it appears that novel formulations with enhanced absorption of these compounds could play a significant role in the treatment of ED, either as a standalone therapy or as an adjunctive treatment. Currently, most of the data are from preclinical studies and future clinical research can reveal the precise efficacy of such transdermal formulations."

Journal • Erectile Dysfunction • Urology