Akeega (abiraterone/niraparib) / J&J - LARVOL DELTA

MAGNITUDE: A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer (clinicaltrials.gov) - P3 | N=765 | Active, not recruiting | Sponsor: Janssen Research & Development, LLC | Trial completion date: Feb 2027 ➔ Dec 2027

Trial completion date • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • BRCA • HRD

Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer. (PubMed, Asia Pac J Clin Oncol) - "Recently, based on positive results from the phase III AMPLITUDE trial, niraparib was approved in the United States for the treatment of patients with BRCA2-mutated mHSPC. Positive results have also recently been obtained from the phase III TALAPRO-3 trial; talazoparib added to enzalutamide led to significantly better imaging-based progression-free survival than placebo plus enzalutamide among patients with mHSPC harboring HRR alterations...However, in Australia there is currently no reimbursement for HRR mutation testing in the mHSPC setting. Here, we review the current knowledge of the clinical relevance of HRR alterations and highlight the benefits of genomic profiling of hormone-sensitive disease prior to the development of castrate resistant disease."

Journal • Review • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Hormone Sensitive Prostate Cancer • Oncology • Prostate Cancer • Solid Tumor • BRCA2 • HRD

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex. (PubMed, Biol Psychiatry) - "Physiologically, PFC L3PNs display higher spontaneous excitatory post-synaptic current (sEPSC) frequency and amplitude, indicating functionally more potent individual synapses in PFC than in V1 L3PNs. Although sEPSC differences are less pronounced between PPC and PFC L3PNs, the greater spine density in PFC suggests stronger excitatory drive in PFC L3PNs. We conclude by identifying open questions that are relevant for understanding schizophrenia pathophysiology: i) What are the sources of synaptic input on L3PNs in each area?, ii) What is the significance of dendritic spine density differences across areas?, and iii) Do NMDAR-mediated synaptic currents differ in strength between L3PNs in PFC, PPC, and V1?"

Journal • Review • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Behavioral and electrophysiological changes following an auditory-cognitive telerehabilitation program in children with cochlear implants. (PubMed, Int J Pediatr Otorhinolaryngol) - "Across the eight-week study period, both CI and NH groups showed faster behavioral responses and shorter P300 latency These findings support the feasibility of multimodal outcome assessment in pediatric auditory rehabilitation. Because no untreated control group was included, the observed changes cannot be attributed specifically to İŞİTGEL. Larger randomized controlled trials are needed to determine treatment-specific effects."

Journal • Otorhinolaryngology • Pediatrics

Shear stress and blood coagulation: A comparative study of smokers and diabetics, with healthy individuals. (PubMed, Microvasc Res) - "Amplitude sweep experiments first established a linear viscoelastic region between 1 and 10 Pa, and subsequent rheological measurements were performed within a conservative stress range of 1-4 Pa...FESEM revealed denser fibrin networks with reduced pore size at higher shear stresses, whereas fluorescence microscopy demonstrated increased CD62P expression, confirming progressive shear-induced platelet activation. These findings demonstrate that rheologically determined TGP is sensitive to both mechanical loading and underlying health status and, when complemented by structural and biological analyses, provides a quantitative marker for assessing patient-specific haemostatic function and thrombotic risk."

Journal • Diabetes • Metabolic Disorders • Thrombosis • Type 2 Diabetes Mellitus • SELP

Post-Exercise Circulatory Occlusion Differently Affects Soleus Spinal/Supraspinal Excitability. (PubMed, Int J Sports Med) - "Maximal voluntary isometric contraction, electromyographic amplitude, H-reflex recruitment curve and V-wave normalized amplitude were determined...The muscle pain rated+5.8 points (p<0.001) and the mean arterial pressure was higher 22.4±2.8 mm Hg (p<0.001) with post-exercise circulatory occlusion. Thus, the lower-limb group III/IV afferent feedback inhibits supraspinal, but not spinal, pathway."

Clinical • Journal • Musculoskeletal Pain • Pain

Neural processing of natural speech by adults with and without dyslexia: Evidence for atypical temporal sampling of speech information in the delta and theta EEG bands. (PubMed, Cortex) - "Additional complementary analyses examined band power, cross-frequency phase-amplitude coupling (PAC), and cross-frequency phase-phase coupling (PPC). Dyslexic adults exhibited less accurate delta- and theta-band decoding in the between-group analysis and reduced theta-band decoding accuracy in the within-participant analysis, alongside reduced theta-band coherence and increased delta-band power, particularly over the right temporal region. No group differences were found for PAC or PPC."

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Artificial intelligence-designed ultra-low-power broadband universal π2 and π pulses for NMR spectroscopy: Application to 19F NMR. (PubMed, J Magn Reson) - "Specifically, the bandwidth-to-RF amplitude (ΔΩ/νrf) ratio of these pulses is ∼40, with an average fidelity greater than 99% over the entire bandwidth...We tested these new pulses with a spin-echo sequence to observe the 1D 19F spectrum of a mixture of fluorinated organic compounds. The pulses developed here are particularly well-suited for NMR spectroscopy of nuclei exhibiting large chemical-shift dispersions and can be used to circumvent the power-handling limitations of current cryogenic probes."

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Electrophysiological signatures of visual cortical dysfunction in Parkinson's disease: An integrative EEG-based review. (PubMed, Neurophysiol Clin) - "2) Early visual encoding: prolonged pattern-reversal P100 latency is the most reproducible finding, including a pooled 6.04-ms delay across 20 case-control studies, whereas amplitude findings are inconsistent...Overall, PD is characterized by multilevel visual-pathway dysfunction rather than a single cortex-specific biomarker. Ophthalmic status, retinal physiology, medication state, cognition, mood, sleep, and recording quality should be controlled before electrophysiological measures are used for localization, stratification, or prognosis."

Journal • Review • CNS Disorders • Movement Disorders • Ophthalmology • Parkinson's Disease

ERP-XTTN: interpretable prototype-guided cross-attention for cross-subject ERP classification. (PubMed, J Neural Eng) - "ERP-XTTN generalizes across diverse ERP morphologies under causal, calibration-free conditions, while retaining competitive performance and decisions that depend directly on physiological prototype content at a three-channel montage. Unlike post-hoc explanation methods for black-box models, the basis of each decision is directly observable in the trained model itself. To our knowledge, this is the first epoch-level LOSO benchmark on ERP CORE."

Journal • CNS Disorders

Static Anatomical Measurements and Dynamic Endometrial Peristalsis in Young Women During Different Menstrual Cycle Phases: A Study with 3 T MRI. (PubMed, Acad Radiol) - "Static uterine morphology and dynamic endometrial peristalsis undergo predictable, hormone-driven cyclic remodeling in young women. The novel observation of anteroposterior amplitude asymmetry during the ovulatory window highlights localized functional specialization. These findings provide a normative MRI reference for uterine physiology and a basis for investigating uterine dysmotility in reproductive disorders."

Journal • Uterine Cancer

Analyzing the outcome of centripetal and coriolis acceleration on a nonlocal thermoelastic material using the modified Green-Lindsay hypothesis. (PubMed, Sci Rep) - "The results reveal that increasing the rotation parameter significantly alters the propagation and amplitude of thermoelastic waves, while the nonlocality parameter reduces the peak stress and temperature distributions by approximately 45% and 25%, respectively...Compared with the corresponding reference model, the present temperature-dependent nonlocal formulation provides more realistic predictions of the coupled thermoelastic response, particularly in the presence of rotational effects. These findings are relevant to the design and analysis of advanced engineering materials used in aerospace structures, refractory components, and laser-assisted technologies."

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Developmental changes in Ca2+ signaling mediated by A2A adenosine and mGluR5 glutamate receptors in olfactory bulb astrocytes. (PubMed, Sci Rep) - "Both the fraction of astrocytes that respond to stimulation of mGluR5 and A2A/B receptors with Ca2+ responses and the amplitude of the responses significantly decreased during the first four weeks of postnatal development. Our results show that olfactory bulb astrocytes create glutamatergic and adenosinergic Ca²⁺ signaling that is downregulated as the olfactory bulb matures."

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Temporal progression of auditory brainstem dysfunction and behavioral phenotypes in mouse models of tauopathy. (PubMed, J Neurosci) - "In contrast, ApoE4/PS19 mice showed reduced ABR amplitudes and shortened response latencies that persisted with age, accompanied by altered anxiety-like behavior and motor performance...Genetic background also significantly influenced disease progression, with the ApoE4 allele altering both the timing and nature of auditory and behavioral phenotypes. Together, these findings demonstrate that tau pathology disrupts auditory processing at early disease stages and suggest that ABR-based measures as sensitive, non-invasive approach for early detection and monitoring of tau-related neurodegeneration."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Dementia • Frontotemporal Lobar Degeneration • Mood Disorders • Psychiatry • APOE

Asymmetric Vibration Animal Phonation Model with A Reconstructive Curved and Medialized Titanium Implant Vocal Fold to Repair Defective Vocal Fold. (PubMed, J Voice) - "Curved-surface reconstruction with increased stiffness can preserve near-normal phonatory characteristics despite elevated aerodynamic thresholds. Titanium-based asymmetric reconstruction following vocal fold resection maintains vibratory periodicity but alters regional vibratory dynamics and acoustic harmonic structure."

Journal • Otorhinolaryngology

A Physics-Informed Neural Network Scheme for Shortcuts to Adiabaticity in Three-Level Non-Hermitian Quantum Systems. (PubMed, Entropy (Basel)) - "The PINN is used to solve an inverse control problem in which the state amplitudes and the auxiliary driving field are learned simultaneously from the Schrödinger residual, the initial and target population constraints and a probability conservation constraint on the control pulse...Numerical simulations and independent propagation with the fitted control field verify the population inversion and exhibit strong generalization capability over a range of coupling strengths and dissipation rates, as verified by retraining the network independently for each parameter set. The results demonstrate that PINNs provide a flexible inverse design tool for non-Hermitian shortcut to adiabaticity protocols when the governing dynamics and physical constraints are explicitly incorporated into the loss function."

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Effects of Vonoprazan on Isolated Rat Lower Esophageal Sphincter and Ileum. (PubMed, Pharmaceuticals (Basel)) - "The direct relaxant effects of cumulative vonoprazan were assessed in tissues precontracted with carbachol. These results indicate that vonoprazan directly inhibits gastrointestinal smooth muscle contractile activity by decreasing spontaneous ileal contraction amplitudes and attenuating muscarinic and serotonergic contractile responses in isolated rat ileum and LES. Further studies are required to determine the underlying mechanisms and clinical relevance of these effects."

Journal • Preclinical • Gastroenterology • Gastroesophageal Reflux Disease

Design and Experimental Validation of a Piezoelectrically Controlled Micro-Newton Cold-Gas Thruster Head. (PubMed, Micromachines (Basel)) - "In addition, thrust-resolution testing at a baseline thrust of approximately 98.4 micro-Newton demonstrates a minimum resolvable step of 50 nano-Newton, and the measured thrust-noise amplitude spectral density remains below 0.07 micro-Newton/sqrt(Hz) over the 10 mHz-1 Hz band for the tested thrust levels. These results support the feasibility of the proposed integrated cold-gas microthruster head and its device-level validation approach for future space-based gravitational-wave detection applications."

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Occupational Computer-Use Duration and Ulnar Nerve Electrodiagnostic Findings: An Exploratory Observational Study. (PubMed, Biomedicines) - "The associations between occupational computer-use duration, bilateral ulnar sensory nerve action potential (SNAP) amplitudes, across-elbow motor nerve conduction velocities (NCV), and the presence of ulnar neuropathy were assessed using univariable and multivariable analyses... The findings do not support an independent association between the number of years of occupational computer use and ulnar nerve electrodiagnostic abnormalities beyond the effects of age and sex. However, small associations cannot be excluded because of the limited sample size, the indirect assessment of biomechanical exposure, and the inclusion of a selected symptomatic referral population."

Journal • Observational data • Musculoskeletal Diseases • Pain

Muscle Fatigue Investigation Using sEMG Signals and a DAQ Card Data Acquisition System in LabVIEW. (PubMed, Sensors (Basel)) - "The results indicated that with the onset of muscle fatigue, the participant exhibited a decrease in amplitude parameters and a shift in the power spectrum toward lower frequencies...The obtained results confirm the technical feasibility of the developed virtual instrument for sEMG signal analysis. Furthermore, they suggest its potential utility for objective muscle condition assessment, establishing an engineering baseline for future research."

Journal • Fatigue

Effects of Treatment with Citicoline Plus Nicotinamide Oral Solution on Retinal Ganglion Cells and Visual Pathways in Glaucomatous Impairment. (PubMed, Pharmaceuticals (Basel)) - "The HFA MD and RNFL-T changes were not significantly different (p > 0.05) between groups. In OAG patients, treatment with Citicoline plus Nicotinamide oral solution for three months induces RGC functional enhancement (increase in PERG amplitude) and improves the neural conduction along the visual pathways (shortening of VEP implicit time and increased amplitude), without significant changes in visual field or RNFL-T."

Journal • Glaucoma • Ophthalmology

A Safe and Portable CMUT Array Ultrasonic System for Bubble Sizing in Industrial Silicone Sealing Rings. (PubMed, Micromachines (Basel)) - "The silicone thickness is determined using the time-of-flight (TOF) method, while bubble size is quantitatively estimated by combining received signal amplitude analysis, which characterizes bubble-induced attenuation, with correlation function evaluation...Compared with X-ray inspection, the proposed system is safer, more portable, and suitable for real-time on-site monitoring, thereby significantly improving quality control efficiency in silicone manufacturing. This study provides a novel CMUT-array-based solution for quantitative bubble detection in silicone media, offering both high resolution and practical application potential."

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Adaptive Inverse Control Using the Krasnosel'skii-Pokrovskii Model for Hysteresis Compensation in Piezoelectric Flexure Micro-Positioning Stage. (PubMed, Micromachines (Basel)) - "Tracking experiments under 0.1-2 Hz sinusoidal waveforms and 3-7 V variable-amplitude sinusoidal waveforms are implemented. Experimental results show that the proposed approach reduces the root-mean-square error (RMSE) by 7.41-85.65% and the mean absolute percentage error (MAPE) by 7.56-87.81% compared with uncompensated open-loop micromotion control. The combined micro-flexure mechanical design and adaptive hysteresis compensation strategy greatly improves positioning accuracy and anti-interference capacity, offering a low-computation technical route for high-performance micro-positioning systems."

Journal • Cardiovascular • KRAS

State-Dependent Alterations of Hippocampal Theta-Gamma Coupling in 5xFAD Mice and Their Differential Modulation by Donepezil. (PubMed, Brain Sci) - "Hippocampal theta-gamma coupling shows frequency- and context-dependent abnormalities in 5xFAD mice. Theta-low-gamma coupling is sensitive to short-term cholinergic modulation during exploration, whereas donepezil's effect on theta-high-gamma coupling remains inconclusive. Animal-level PAC may provide a candidate functional readout, but longitudinal and cross-model validation is required before biomarker claims are justified."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders

Does Feeling Bad Lead to Eating Bad? How Emotion, Deliciousness (Mis)match, and Weight Status Alter Food Choice and ERPs. (PubMed, Behav Sci (Basel)) - "The deliciousness-incongruent condition elicited less negative N1 amplitudes and marginally less negative N2 amplitudes...Deliciousness advantage facilitates high-calorie food choices, whereas negative emotion selectively increases such choices among OWs. ERP results suggest that these effects involve both early attentional processing and later evaluative processing."

Journal • Obesity