Olanedine (olanexidine gluconate) / Otsuka - LARVOL DELTA

In vitro efficacy of disinfectants against Cutibacterium acnes. (PubMed, J Med Microbiol) - "In particular, olanexidine demonstrated a strong bactericidal effect even under in vitro acne conditions. Further in vivo validation is required to determine whether olanexidine could be a new treatment option for managing acne."

Journal • Preclinical • Acne Vulgaris • CNS Disorders • Dermatology

Impact of 1.5% Aqueous Olanexidine Against Surgical-Site Infections in Neurosurgery. (PubMed, Oper Neurosurg) - "Compared with 10% povidone-iodine, 1.5% aqueous olanexidine may be associated with the prevention of some SSIs in neurosurgical procedures."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Infectious Disease

Comparison between olanexidine gluconate and conventional antiseptics for surgical site infection in gastroenterological surgery: A meta-analysis. (PubMed, Ann Gastroenterol Surg) - "A comprehensive electronic literature search was conducted through November 2024 to identify studies comparing the occurrence of SSIs between OLG and conventional antiseptics (Conv), including povidone-iodine (PI) or chlorhexidine gluconate (CHG), for incisional site disinfection. To our knowledge, this is the first meta-analysis with a sufficient sample size to investigate the effect of OLG compared with other antiseptics, demonstrating that OLG significantly reduces overall SSIs and incisional SSIs in gastroenterological surgery without increasing adverse skin reactions. These findings may enhance SSI management for patients undergoing various types of surgeries by introducing new preventative strategies and potentially lowering SSI-related healthcare costs."

Journal • Retrospective data • Review • Infectious Disease

Efficacy of aqueous olanexidine compared with alcohol-based chlorhexidine for surgical skin antisepsis regarding the incidence of surgical-site infections in clean-contaminated surgery: a randomized superiority trial. (PubMed, Br J Surg) - "Olanexidine did not significantly reduce the occurrence of overall SSI compared with chlorhexidine-alcohol. Nevertheless, these findings provide valuable insights for developing novel surgical SSI management protocols."

Clinical • Head-to-Head • Journal • Gastrointestinal Disorder • Infectious Disease

Virucidal activity of olanexidine gluconate against SARS-CoV-2. (PubMed, Access Microbiol) - "Ethanol (EtOH) was found to be effective against SARS-CoV-2, while chlorhexidine gluconate (CHG) was less effective. The results showed that virucidal activity against SARS-CoV-2 differs depending on the class of antiseptic agents used under clean conditions. Despite belonging to the same class of biguanide antiseptics, OLG was more effective against SARS-CoV-2 than CHG."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Randomized controlled trial of olanexidine gluconate and povidone iodine for surgical site infection after gastrointestinal surgery. (PubMed, Ann Gastroenterol Surg) - "OG, as a preoperative skin antiseptic, did not reduce the occurrence rate of total SSI. However, deep incisional SSI may be reduced using OG."

Journal • Surgery • Gastrointestinal Disorder • Infectious Disease

Comparison of olanexidine versus povidone-iodine as a preoperative antiseptic for reducing surgical site infection in both scheduled and emergency gastrointestinal surgeries: A single-center randomized clinical trial. (PubMed, Ann Gastroenterol Surg) - "Organ/space SSI significantly decreased in the 1.5% olanexidine group. Our results indicate that 1.5% olanexidine has the potential to prevent SSI on behalf of povidone-iodine."

Clinical • Journal • Surgery • Gastrointestinal Disorder • Infectious Disease

Effect of aqueous olanexidine versus alcohol-based chlorhexidine for surgical skin antisepsis on incidence of surgical site infections in gastrointestinal surgery: multicentre randomised controlled clinical trial (OEDO trial) protocol. (PubMed, BMJ Open) - "The final results will be published in medical journals after international peer review. UMIN000049712."

Clinical • Journal • Surgery • Allergy • Dermatitis • Dermatology • Gastrointestinal Disorder • Immunology • Infectious Disease • Pruritus

Novel disinfectant olanexidine gluconate induced contact dermatitis. (PubMed, J Eur Acad Dermatol Venereol) - No abstract available

Journal • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Delayed-onset contact dermatitis caused by olanexidine gluconate antiseptic solution: effect of wiping off the remaining drug solution in two cases. (PubMed, JA Clin Rep) - "Wiping off the remaining Olanedine® even a few days after disinfection may be helpful not only for reducing symptoms but also for preventing the development of contact dermatitis."

Journal • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis. (PubMed, Lancet Microbe) - "For adult patients undergoing a surgical procedure of any wound classification, skin preparation using either 2·0-2·5% chlorhexidine in alcohol or 1·5% olanexidine is most effective in the prevention of SSIs. For clean surgery, no specific concentration of chlorhexidine in alcohol can be recommended. The efficacy of olanexidine was established by a single randomised trial and further investigation is needed."

Journal • Retrospective data • Review • Dermatitis • Dermatology • Immunology • Infectious Disease • Pediatrics • Pruritus

Clinical study of a new skin antiseptic olanexidine gluconate in gastrointestinal cancer surgery. (PubMed, BMC Surg) - "This retrospective study demonstrates that OLG is more effective than PVP-I in preventing SSI during gastrointestinal cancer surgery."

Journal • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Infectious Disease • Oncology • Solid Tumor

Antiviral Activity of Olanexidine-Containing Hand Rub against Human Noroviruses. (PubMed, mBio) - "By comparison, the virucidal efficiency of EtOH was strain specific, leading to loss of infectivity while retaining HBGA binding. These findings show the utility of the ex vivo HIE cultivation system to test the effectiveness of disinfectants and report a highly effective product."

Journal • Gastroenterology • Gastrointestinal Disorder • Rotavirus Infections • CDKN1A • MUC5AC • STAT3

Propensity-matched analysis of the efficacy of olanexidine gluconate versus chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy. (PubMed, BMC Surg) - "Olanexidine gluconate was well tolerated and significantly reduced incidence of surgical site infection except anastomotic leakage in comparison with chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy with three-field lymph node dissection."

Journal • Esophageal Cancer • Gastrointestinal Cancer • Infectious Disease • Oncology

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review. (PubMed, Acute Med Surg) - "Surgical site infections (SSIs) and catheter-related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone-iodine (PVP-I) are increasing...Olanexidine gluconate showed bactericidal activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, in addition to common Gram-positive and Gram-negative bacteria...Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention."

Clinical • Journal • Review • Infectious Disease

Comparison of Skin Antisepsis between Povidone-Iodine and Olanexidine Gluconate in Hepato-Biliary-Pancreatic Surgery (IHPBA 2022) - No abstract available

Disinfection efficacy and mechanism of olanexidine gluconate against norovirus. (PubMed, Am J Infect Control) - "This study suggests that olanexidine gluconate is a potential biological and environmental disinfectant against norovirus and adenovirus."

Clinical • Journal • CNS Disorders • Psychiatry

Pharmaceutical properties of a tinted formulation of a biguanide antiseptic agent, olanexidine gluconate. (PubMed, Biol Pharm Bull) - "In the ex vivo micropig skin assay, their fast-acting and persistent bactericidal activities against vancomycin-resistant Enterococcus faecalis were higher than that of PVP-I. These results suggest that OLG-T performs no worse than OLG-C in terms of its antimicrobial activity and medical adhesive compatibility. Therefore, we expect OLG-T to lead to more convenient preoperative skin preparation and further contribute to lowering SSI rates."

Journal

Severe irritant contact dermatitis to olanexidine gluconate and subsequent skin sensitization. (PubMed, Contact Dermatitis) - No abstract available

Journal • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single-blinded controlled trial. (PubMed, Vet Dermatol) - "Olanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC against S. pseudintermedius indicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine."

Clinical • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Surgical Site Infection(SSI)in Neurosurgery (PubMed, No Shinkei Geka) - "Information of medical material on SSI is presented in this article, including the Plus suture, DuraGen, DuraSeal, Adherus, ultra-high-molecular-weight polyethylene(SKULPIO, CRANIOFIT-PE), Bioglide and Bactiseal shunt systems, and olanexidine. Minimizing SSIs requires proper knowledge on infection control, taking care while performing neurosurgical procedures, and compassion for the patients. In addition, information and material must be updated over time."

Journal • Immunology • Infectious Disease • Novel Coronavirus Disease

Examination of the efficacy of olanexidine gluconate for surgical site infections in colorectal cancer elective surgery. (PubMed, J Infect Chemother) - "OLG was as effective as the conventional PVP-I for surgical site infections during colorectal cancer elective surgery. However, significantly higher skin disorders occurred in OLG, thereby making it necessary to evaluate antiseptic use in conjunction with patient burden."

Clinical • Journal • Colorectal Cancer • Dermatology • Gastrointestinal Cancer • Infectious Disease • Oncology • Solid Tumor

Cardiovascular Catheterization Using a New Antiseptic Agent Olanexidine Gluconate. (PubMed, Int Heart J) - "The efficacy and safety of Olanedine and PI seem to be equivalent. Olanedine could be a new useful option as a disinfectant of cardiovascular catheterization."

Journal • Cardiovascular • Renal Disease

Olanexidine gluconate formulations as environmental disinfectants for enveloped viruses infection control. (PubMed, J Hosp Infect) - "Furthermore, the effectiveness of olanexidine gluconate persisted even after drying on environmental surfaces. This study demonstrated the potential usage of olanexidine gluconate formulations as an environmental disinfectant in the infection control of enveloped viruses."

Journal • CNS Disorders • Infectious Disease • Novel Coronavirus Disease • Psychiatry • Respiratory Diseases

Should olanexidine be used routinely for surgical skin antisepsis? (PubMed, Lancet Infect Dis) - No abstract available

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