diclofenac sodium suppository / Generic mfg. - LARVOL DELTA

Intramuscular Versus Rectal Diclofenac for Pain Relief After Cesarean Section in Women (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: CMH Multan Institute of Medical Sciences

New P4 trial • Pain

Comparison of topical diltiazem, diclofenac suppository and periprostatic nerve block with periprostatic nerve block alone for pain control during transrectal ultrasonography-guided prostate biopsy: An RCT (EAU 2026) - No abstract available

Biopsy • Pain

Comparison of oral versus rectal NSAIDs for perioperative analgesia in pediatric circumcision using a disposable circumcision suture device: a randomized controlled trial. (PubMed, BMC Anesthesiol) - "Rectal diclofenac sodium suppositories are an effective and well-tolerated option for perioperative analgesia in pediatric circumcision using DCSD, providing improved comfort, sleep quality, and caregiver satisfaction compared to oral ibuprofen. However, due to the study's single-center design, short follow-up period, and the use of different NSAIDs between groups, the results should be interpreted with caution. Larger multicenter trials are necessary to confirm these findings and inform broader clinical application."

Journal • Anesthesia • Pain • Pediatrics

Rectal Diclofenac Versus Indomethacin in Preventing Post-ERCP Pancreatitis: A Systematic Review and Meta-Analysis. (PubMed, Dig Dis Sci) - "Diclofenac and indomethacin demonstrate equivalent efficacy and safety, allowing cost and availability to inform the choice of PEP prophylaxis."

Journal • Retrospective data • Review • Pancreatitis

Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis (clinicaltrials.gov) - P4 | N=440 | Recruiting | Sponsor: National Cheng-Kung University Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Pancreatitis

Comparison of Rectal Indomethacin and Diclofenac for post ERCP Pancreatitis Prophylaxis: A Single Center Study. (PubMed, Clin Res Hepatol Gastroenterol) - "This study suggests that rectal diclofenac may offer a slight advantage over indomethacin in preventing PEP, particularly in high-risk groups, such as patients undergoing sphincterotomy; which was not previously published in the existing literature."

Journal • Pancreatitis

Ultrasound-Guided Transversus Abdominis Plane Block with Dexmedetomidine Combined with Ropivacaine Plus Diclofenac Sodium Suppository for Post-Cesarean Section Analgesia: A Non-Inferiority Randomized Controlled Trial (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hanzhong Central Hospital; Hanzhong Central Hospital

Head-to-Head • New trial • Pain

Effectiveness of Rectal Versus Oral Diclofenac for Perineal Pain Relief following Episiotomy Repair at a Tertiary Hospital in Port Harcourt, Nigeria: A randomized controlled study. (PubMed, Niger Med J) - "The mean time interval (hours) between drug administration and the first urine void was similar in both groups (3.19±3.13 vs. 3.29±3.11, t=0.29, p=0.74), and there was no difference in the requirement for additional analgesia (12.1% vs. 9.1%, χ2=0.32, p=0.57). Diclofenac suppository was more effective in management of perineal pain following episiotomy repair and the participants in the rectal route group expressed more satisfaction than their counterparts who received the oral drug."

Journal • Pain

UTILISATION AND OUTCOME OF CHOLANGIOSCOPY IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS – A EUROPEAN COHORT (UEGW 2025) - "Most patients received rectal diclofenac (98%) and antibiotics (96.5%)... This is one of the largest cohort of cholangioscopies in PSC patients performed in two high volume centre. Cholangioscopy had a high technical success rate. Previous concern that strictures preclude technical success was not seen."

Clinical • Biliary Cancer • Cholangiocarcinoma • Fibrosis • Gastrointestinal Disorder • Hepatology • Immunology • Inflammatory Bowel Disease • Liver Failure • Pancreatitis • Solid Tumor

PERIPAPILLARY EPINEPHRINE INJECTION IN COMBINATION WITH RECTAL DICLOFENAC FOR PREVENTION OF POST-ERCP PANCREATITIS IN HIGH-RISK PATIENTS: A RANDOMIZED CONTROLLED TRIAL (UEGW 2025) - "Compared to rectal diclofenac, peripapillary epinephrine injection significantly reduced the incidence of PEP, post-procedure hyperamylasemia, and sphincterotomy-related bleeding."

Clinical • Combination therapy • Ampulla of Vater Carcinoma • Biliary Cancer • Gastrointestinal Disorder • Pancreatic Cancer • Pancreatitis

DOES RECTAL DICLOFENAC PREVENT POST-ERC PANCREATITIS? A COMPARATIVE UK COHORT ANALYSIS BEFORE AND AFTER 2020 ESGE GUIDELINES (UEGW 2025) - "Despite the increased use of NSAIDs suppositories following the 2020 ESGE guidelines, no significant reduction in PEP incidence was observed. These findings call into question the practical effectiveness of NSAIDs in PEP prevention. Most studies demonstrating a beneficial effect of NSAIDs were conducted in younger females and non-European populations, which may limit their applicability to our cohort."

Pancreatitis

Comparison of two analgesia applied to periprostatic nerve blockage during transrectal ultrasound guided prostate biopsy. (PubMed, North Clin Istanb) - "In this study, we highlight that when applied as an adjuvant to PPNB, either 5% prilocaine-lidocaine cream or a 100 mg diclofenac suppository reduced pain levels relative to PPNB alone. When compared to a 100 mg diclofenac suppository, prilocaine-lidocaine cream significantly reduces pain during the insertion and manipulation of the ultrasound probe."

Journal • Aesthetic Medicine • Anesthesia • Oncology • Pain

Effectiveness of prophylactic pancreatic stents in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a 16-year comprehensive study. (PubMed, Ann Gastroenterol) - "From 2015 onward, rectal diclofenac was administered to all patients as a preventive measure for PEP...There were 3 deaths, 1 related to PEP (0.2%). PS placement effectively reduces severe PEP risk following difficult CBD cannulation and supports high success rates in repeat ERCP, while diclofenac showed no significant additional benefit."

Journal • Pancreatitis

Indomethacin vs Diclofenac for Preventing PEP (clinicaltrials.gov) - P=N/A | N=4050 | Recruiting | Sponsor: Air Force Military Medical University, China

New trial • Pancreatitis

Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis (clinicaltrials.gov) - P4 | N=440 | Not yet recruiting | Sponsor: National Cheng-Kung University Hospital

New P4 trial • Pancreatitis

Utilisation and outcome of cholangioscopy in patients with primary sclerosing cholangitis – a single centre experience (BSG 2025) - "All patients were given rectal diclofenac as pancreatitis prophylaxis...On the other hand, the diagnostic yield of cholangioscopy-guided biopsies in PSC remains uncertain. The complication rate appears largely related to the risks of endobiliary procedures in PSC."

Clinical • Anesthesia • Biliary Cancer • Cholangiocarcinoma • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Inflammatory Bowel Disease • Liver Failure • Oncology • Pain • Pancreatitis • Solid Tumor

Paracetamol-Diclofenac Versus Pentazocine-Diclofenac for Post-Caesarean Section Pain Relief: A Double Blind Randomized Controlled Trial. (PubMed, West Afr J Med) - "Pentazocine-Diclofenac provided better analgesia than Paracetamol-Diclofenac in the first 24 hours after caesarean section but was associated with more side effects."

Clinical • Journal • Pain

Randomized controlled intravenous analgesia combined with diclofenac sodium supposit for multimodal analgesia after cesarean section (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: Jintang County first People's Hospital; Jintang County first People's Hospital

New trial

A network meta-analysis of optimal strategies for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis. (PubMed, Sci Rep) - "The inclusion criteria encompassed studies that featured at least two of the following interventions: pre-procedural administration of 100 mg of rectal diclofenac (D) or indomethacin (I), aggressive hydration utilizing normal saline (NS) or lactated Ringer's solution (LR), 5-french pancreatic duct stent (S), and either a placebo or an active control (C). However, D was the most effective method of prevention of moderate-to-severe PEP in this group. The findings of this network meta-analysis indicate that endoscopists should consider all available prophylactic options when performing ERCP, rather than favoring one over the others."

Clinical • Journal • Retrospective data • Pancreatitis

Effects of combined use of non-steroidal anti-inflammatory drugs and 5% lidocaine patch on postoperative analgesia after cesarean section (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Chengdu Women's and Children's Central Hospital; Beijing Red Heart Public Welfare Foundation

New trial

The study on the effect of sodium diclofenac suppositories for postoperative analgesia after repeat cesarean section. (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Hunan Provincial Maternal and Child Health Hospital; Hunan Provincial Maternal and Child Health Hospital

New trial

Effectiveness of Cheek Acupuncture Therapy for Pain Control After Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Beijing Tongren Hospital | Not yet recruiting ➔ Completed

Trial completion • Pain

The Impact of Diclofenac Suppositories on Post-Cesarean Section Pain: A Systematic Literature Review. (PubMed, Anesthesiol Res Pract) - " Combination of diclofenac suppositories with other pain relief medicines reduces the need for rescue pain medicines, which are usually opioids such as morphine, meperidine, or pentazocine. The findings also open pathways for further clinical trials to explore the appropriate combinations, dosages, and administration of NSAIDs for specific surgical populations and settings. Future research should focus on standardizing methodologies and addressing risk of bias to enhance reliability of findings related to diclofenac suppository and multimodal analgesia."

Journal • Review • Addiction (Opioid and Alcohol) • Pain

Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial. (PubMed, Gut) - P=N/A | "Pre-procedure 100 mg rectal diclofenac was not superior to the same dose of rectal indomethacin regarding preventing PEP. These findings supported current clinical practice guidelines of 100 mg indomethacin or diclofenac for PEP prophylaxis in patients without contraindications."

Journal • Pancreatitis

Rectal Versus Intramuscular Diclofenac for Pain Relief Following Caesarean Section (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: Assumpta Nnenna Nweke

New trial • Pain