diclofenac sodium suppository / Generic mfg. - LARVOL DELTA

Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis (clinicaltrials.gov) - P4 | N=440 | Not yet recruiting | Sponsor: National Cheng-Kung University Hospital

New P4 trial • Pancreatitis

Indomethacin vs Diclofenac for Preventing PEP (clinicaltrials.gov) - P=N/A | N=4050 | Recruiting | Sponsor: Air Force Military Medical University, China

New trial • Pancreatitis

Utilisation and outcome of cholangioscopy in patients with primary sclerosing cholangitis – a single centre experience (BSG 2025) - "All patients were given rectal diclofenac as pancreatitis prophylaxis...On the other hand, the diagnostic yield of cholangioscopy-guided biopsies in PSC remains uncertain. The complication rate appears largely related to the risks of endobiliary procedures in PSC."

Clinical • Anesthesia • Biliary Cancer • Cholangiocarcinoma • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Inflammatory Bowel Disease • Liver Failure • Oncology • Pain • Pancreatitis • Solid Tumor

PERIPAPILLARY EPINEPHRINE INJECTION IN COMBINATION WITH RECTAL DICLOFENAC FOR PREVENTION OF POST-ERCP PANCREATITIS IN HIGH-RISK PATIENTS: A RANDOMIZED CONTROLLED TRIAL (UEGW 2025) - No abstract available

Clinical • Combination therapy • Pancreatitis

DOES RECTAL DICLOFENAC PREVENT POST-ERC PANCREATITIS? A COMPARATIVE UK COHORT ANALYSIS BEFORE AND AFTER 2020 ESGE GUIDELINES (UEGW 2025) - No abstract available

Pancreatitis

Paracetamol-Diclofenac Versus Pentazocine-Diclofenac for Post-Caesarean Section Pain Relief: A Double Blind Randomized Controlled Trial. (PubMed, West Afr J Med) - "Pentazocine-Diclofenac provided better analgesia than Paracetamol-Diclofenac in the first 24 hours after caesarean section but was associated with more side effects."

Clinical • Journal • Pain

Randomized controlled intravenous analgesia combined with diclofenac sodium supposit for multimodal analgesia after cesarean section (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: Jintang County first People's Hospital; Jintang County first People's Hospital

New trial

A network meta-analysis of optimal strategies for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis. (PubMed, Sci Rep) - "The inclusion criteria encompassed studies that featured at least two of the following interventions: pre-procedural administration of 100 mg of rectal diclofenac (D) or indomethacin (I), aggressive hydration utilizing normal saline (NS) or lactated Ringer's solution (LR), 5-french pancreatic duct stent (S), and either a placebo or an active control (C). However, D was the most effective method of prevention of moderate-to-severe PEP in this group. The findings of this network meta-analysis indicate that endoscopists should consider all available prophylactic options when performing ERCP, rather than favoring one over the others."

Clinical • Journal • Retrospective data • Pancreatitis

Effects of combined use of non-steroidal anti-inflammatory drugs and 5% lidocaine patch on postoperative analgesia after cesarean section (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Chengdu Women's and Children's Central Hospital; Beijing Red Heart Public Welfare Foundation

New trial

The study on the effect of sodium diclofenac suppositories for postoperative analgesia after repeat cesarean section. (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Hunan Provincial Maternal and Child Health Hospital; Hunan Provincial Maternal and Child Health Hospital

New trial

Effectiveness of Cheek Acupuncture Therapy for Pain Control After Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Beijing Tongren Hospital | Not yet recruiting ➔ Completed

Trial completion • Pain

The Impact of Diclofenac Suppositories on Post-Cesarean Section Pain: A Systematic Literature Review. (PubMed, Anesthesiol Res Pract) - " Combination of diclofenac suppositories with other pain relief medicines reduces the need for rescue pain medicines, which are usually opioids such as morphine, meperidine, or pentazocine. The findings also open pathways for further clinical trials to explore the appropriate combinations, dosages, and administration of NSAIDs for specific surgical populations and settings. Future research should focus on standardizing methodologies and addressing risk of bias to enhance reliability of findings related to diclofenac suppository and multimodal analgesia."

Journal • Review • Addiction (Opioid and Alcohol) • Pain

Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial. (PubMed, Gut) - P=N/A | "Pre-procedure 100 mg rectal diclofenac was not superior to the same dose of rectal indomethacin regarding preventing PEP. These findings supported current clinical practice guidelines of 100 mg indomethacin or diclofenac for PEP prophylaxis in patients without contraindications."

Journal • Pancreatitis

Rectal Versus Intramuscular Diclofenac for Pain Relief Following Caesarean Section (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: Assumpta Nnenna Nweke

New trial • Pain

Evaluation of the analgesic effect of a combination of oral acetaminophen and oxycodone after extracorporeal shock wave lithotripsy (SWL). (PubMed, Urologia) - "The present study aimed to compare the effects of suppository diclofenac (an example of NSAIDs) and oral administration of the combination of oxycodone (an example of an opioid) and acetaminophen in managing pain in patients with renal colic after SWL treatment. The combination of oxycodone and acetaminophen, including a multimodal analgesic approach, can be considered a preferred option in the clinical setting for pain management of patients undergoing SWL. It provides relief for patients as effectively as NSAIDs, with the same safety profile, leading to high patient satisfaction."

Journal • Pain • Renal Calculi • Urolithiasis

Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial. (clinicaltrials.gov) - P1 | N=111 | Not yet recruiting | Sponsor: Minia University

New P1 trial • Pain

Why is the rectal route for NSAIDS favorable for preventing post-ERCP pancreatitis? (PubMed, Pancreatology) - "Our findings suggest that the efficacy of rectal diclofenac in PEP prevention relates more to its higher and consistent systemic exposure than its absolute pancreas levels. The implications are that the rectal route provides both systemic and pancreas exposure for the full duration of PEP vulnerability."

Journal • Pancreatitis

Effectiveness of Cheek Acupuncture Therapy for Pain Control After Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: Beijing Tongren Hospital

New trial • Pain

Efficacy and Cost Savings With Diclofenac Suppository for Post-ERCP Pancreatitis: Experience From a Tertiary Care Center (ACG 2024) - "353 patients were included, of whom 171 (48.4%) received indomethacin and 182 (51.6%) received diclofenac. PEP rates were not significantly different between patients who received indomethacin {n=17 (9.9%, 95%CI=5.9–15.4)} vs. diclofenac {n=9 (4.9%, 95%CI=2.3–9.2)} (p=0.07)."

Clinical • HEOR • Pancreatitis

Diclofenac as Post-ERCP Pancreatitis Prophylaxis: A Cost-Effective Intervention (ACG 2024) - "Rectal diclofenac is not commercially available in the U.S. and rectal indomethacin costs continue to rise substantially... There were 415 ERCPs performed at UTMB from January 2023 through January 2024. Selected patients received rectal indomethacin at a dose of 100 mg, while others with minimum/no risk of PEP did not. Indomethacin suppositories currently cost the institution between $216-293 per 50 mg dose totaling $267,436 in expenditure for fiscal year 2023."

Cost effectiveness • HEOR • Hepatology • Pancreatitis

Prevention of Post-ERCP Pancreatitis by Indomethacin Vs Diclofenac (clinicaltrials.gov) - P=N/A | N=1204 | Terminated | Sponsor: Air Force Military Medical University, China | N=3612 ➔ 1204 | Trial completion date: Jun 2025 ➔ Jun 2024 | Recruiting ➔ Terminated | Trial primary completion date: Mar 2024 ➔ Jun 2024; The data from the interim analysis showed a opposite trend predicting possible of benefit of indomethacin and conditional power analysis revealed a low probability of confirming the benefit of diclofenac if this trial will be continued.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Pancreatitis

SAFETY OF EARLY DISCHARGE POST ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP): A SINGLE CENTRE EXPERIENCE IN SINGAPORE (UEGW 2024) - "All patients in this group received 100 milligrams of rectal diclofenac for prophylactically... From this study, it could be concluded that it was safe to allow early discharge for patients who had undergone ERCP, if there is a clear monitoring protocol and discharge plans. The onset of post ERCP pancreatitis tend to be earlier compared to those who developed post ERCP cholangitis. There is female predominance in the post ERCP pancreatitis group."

Clinical • Diabetes • Hepatology • Metabolic Disorders • Pain • Pancreatitis

Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia (clinicaltrials.gov) - P1 | N=114 | Not yet recruiting | Sponsor: Minia University

New P1 trial • Anesthesia • Pain

A Study of Diclofenac Sodium Suppositories for the Relief of Urinary Catheter-Associated Bladder Discomfort (CRBD) During PACU Awakening in Non-Urological Patients With General Anesthesia (ChiCTR) - P4 | N=106 | Not yet recruiting | Sponsor: Xiangya Hospital Central South University; Xiangya Hospital Central South University

New P4 trial • Anesthesia • Urology

Efficacy of Diclofenac and Indomethacin for Prevention of Post-Endoscopic Cholangiopancreatography (ERCP) Pancreatitis: A Systematic Review. (PubMed, Cureus) - "This study aims to understand the incidence of post-ERCP pancreatitis after using rectal diclofenac and Indomethacin as prophylactic measures. Studies on rectal Indomethacin also yield contradictory results; while some emphasize the drug's large reduction in PEP incidence, especially in low-risk people, others question its efficacy. We need further studies to clarify the remaining uncertainties."

Journal • Review • Pancreatitis