CU-NP / Capricor - LARVOL DELTA

A Reversible Nanolamp for Instantaneous Monitoring of Cyanide Based on an Elsner-like Reaction. (PubMed) - Anal Chem - "Attributed to the unique Elsner-like reaction between CN- and the Cu atoms, high selectivity was achieved for CN- monitoring by the nanolamp, with practical applications in real water and food samples. In addition, because of the highly-efficient in situ formation of DNA-CuNPs and the approximative stoichiometry between CN- and Cu2+ in the fluorescence switching, the nanolamp could be reversibly turned on and off through the alternate regulation of CN- and Cu2+, displaying potential for developing reusable nanosensors and constructing optical molecular logic circuits."

Journal • Biosimilar

Copper(ii)-benzimidazole complexes as efficient fluorescent probes for l-cysteine in water. (PubMed, Dalton Trans) - "...The molecular structure of 2 adopted a square pyramidal geometry (τ = 0.2545), with the Cu-Npy bond (1.958 Å) of its middle pyridine unit being shorter than the other two Cu-Nbenzim bonds (Cu-N, 1.995, 2.000 Å)...The quantum yield for the detection of Cys by 1 (14.7%) was much lower than by 2 (23%). The fluorescence intensity of 1 and 2 were also slightly enhanced by histidine, but at a relatively lower level than that exhibited by Cys."

Journal • Biosimilar • Ophthalmology

Synthesis of Metal Nanoparticles and Metal Fluoride Nanoparticles from Metal Amidinate Precursors in 1-Butyl-3-Methylimidazolium Ionic Liquids and Propylene Carbonate. (PubMed) - ChemistryOpen - "The crystalline phases of the metal or metal fluoride synthesized in [BMIm][BF4] were identified by powder X-ray diffraction (PXRD) to exclusively Ni- and Cu-NPs or to solely MF2-NPs for M=Mn, Fe, and Co. The characterization was complemented by energy-dispersive X-ray spectroscopy (EDX). Electrochemical investigations of the CoF2-NPs as cathode materials for lithium-ion batteries were simply evaluated by galvanostatic charge/discharge profiles, and the results indicated that the reversible capacity of the CoF2-NPs was much lower than the theoretical value, which may have originated from the complex conversion reaction mechanism and residue on the surface of the nanoparticles."

Journal • Biosimilar • Complement-mediated Rare Disorders • Gene Therapies • Ophthalmology

Label-free and sensitive assay for deoxyribonuclease I activity based on enzymatically-polymerized superlong poly(thymine)-hosted fluorescent copper nanoparticles. (PubMed) - Talanta - "...Herein, by effectively combining the special functions of DNase I and terminal deoxynucleotidyl transferase (TdT), a simple, green, cost-effective, label-free and ultrasensitive assay for DNase I activity has been constructed based on superlong poly(thymine)-hosted copper nanoparticles (poly T-CuNPs)...Then, the strategy was successfully applied to detect DNase I in diluted serum with a standard addition method, thus implying its reliability and practicability for biological samples. The proposed strategy might be promising as a sensing platform for related molecular biology and disease studies."

Biomarker • Journal • Biosimilar

Direct fluorescence detection of microRNA based on enzymatically engineered primer extension poly-thymine (EPEPT) reaction using copper nanoparticles as nano-dye. (PubMed) - Biosens Bioelectron - "By directly using miR-21 as the primer, the simple, rapid and sensitive miRNA detection was successfully achieved with a good linearity between 1pM and 1nM and a detection limit of 100fM. Thus, the EPEPT strategy holds great potential in biochemical sensing research as an efficient and universal platform."

Journal • Biosimilar

Difficulties and flaws in performing accurate determinations of zeta potentials of metal nanoparticles in complex solutions-Four case studies. (PubMed, PLoS One) - "Surface compositional changes were illustrated for sonicated and non-sonicated Cu NPs. In all, it can be concluded that accurate measurements and interpretations are possible in most cases by collecting and reporting complementary data on characteristics such as particle size, ZP distributions, blank sample information, and particle oxide composition."

Journal • Biosimilar

Copper-based nanoparticles induce high toxicity in leukemic HL60 cells. (PubMed) - "No acellular ROS was induced by the CuO NPs, and the levels of intracellular ROS and DNA damage were limited after 2 h exposure. Necrosis was the main type of cell death observed after 18 h exposure to CuO NP and dissolved copper."

Journal • Biosimilar

Downregulation of NF-kB by nanoconjugates to overcome drug resistance in ovarian tumors (AACR 2017) - "Recurrence can lead to development of resistance to first line agents such as platinum analogs, taxanes, and doxorubicin. NF-κB expression was decreased by two folds compared to native Cu-DSF complex. Detailed cellular and mechanistic studies along with the evaluation of [Au(DSF-Cu)NP] in human multi-drug resistant (NCI-ADR/RES) mouse xenografts will be presented."

Biosimilar • Gynecologic Cancers • Oncology • Ovarian Cancer

Formation of copper nanoparticles on poly(thymine) through surface-initiated enzymatic polymerization and its application for DNA detection. (PubMed) - "In addition, it avoids rigorously controlled temperature, complex synthesis of the fluorescent probe and prelabeling of DNA strands and eliminates the use of sophisticated experimental techniques and equipment. Armed with these intriguing properties, the proposed system could provide an efficient tool for early diagnosis and risk assessment of malignancy."

Journal • Biosimilar

Room-temperature ferroelectricity in CuInP2S6 ultrathin flakes. (PubMed) - Nat Commun - "To demonstrate the potential of this 2D ferroelectric material, we prepare a van der Waals (vdW) ferroelectric diode formed by CIPS/Si heterostructure, which shows good memory behaviour with on/off ratio of ∼100. The addition of ferroelectricity to the 2D family opens up possibilities for numerous novel applications, including sensors, actuators, non-volatile memory devices, and various vdW heterostructures based on 2D ferroelectricity."

Journal • Biosimilar

Interface engineering for a rational design of poison-free bimetallic CO oxidation catalysts. (PubMed) - Nanoscale - "...By calculating the adsorption chemistry under CO oxidation conditions, we find that the Pt@Cu NPs will be active for CO oxidation with resistance to CO-poisoning...Additional computational screening shows that this separation of reactant binding sites is possible for several other core@shell NPs. Our results indicate that the metal-metal interface within a single NP can be optimized for design of bifunctional catalytic systems with improved performance."

Journal • Biosimilar

Response of microbial communities colonizing salt marsh plants rhizosphere to copper oxide nanoparticles contamination and its implications for phytoremediation processes. (PubMed) - Sci Total Environ - "So, Cu NP may cause disturbances in ecosystems functions, ultimately affecting phytoremediation processes. These facts should be considered regarding the use of appropriate salt marshes plants to remediate moderately impacted areas such as estuaries, where NPs can be found."

Journal • Biosimilar

The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles. (PubMed) - Nanoscale - "The dissolution rate was also shown to impact both the cellular Cu dosimetry and associated oxidative stress responses. The convergent results from dissolution and dosimetry measurements demonstrate that both intracellular and extracellular (i.e., NP uptake-independent) release of ionic species from Cu NPs greatly affect the cytotoxicity."

Journal • Biosimilar