QuilliChew ER (methylphenidate extended release chewable tablet) / Tris Pharma - LARVOL DELTA

Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics. (PubMed, Polymers (Basel)) - "In this study, methylphenidate hydrochloride extended-release chewable tablets compounded by methylphenidate hydrochloride and ion-exchange resin were selected for a drug extraction study. Meanwhile, the reaction rate was confirmed by the Boyd model, and the film diffusion and matrix diffusion were both shown to be rate-limiting steps. In conclusion, this study aims to provide technological and theoretical support for establishing a quality assessment and control system of ion-exchange resin-mediated preparations, promoting the applications of ion-exchange resins in the field of drug preparation."

Journal

[VIRTUAL] A Novel Extended-Release Stimulant Formulation for ADHD (APA 2021) - "The resulting release characteristics allow for customized, sustained release of active drug for up to 24 hours post-dose.The LiquiXR drug delivery technology has already been successfully utilized in the development of treatment options (liquid suspension and chewable tablet) that offer rapid absorption and sustained plasma levels after once- daily dosing: amphetamine extended-release oral suspension (AMPH EROS), methylphenidate for extended-release oral suspension (MEROS), and methylphenidate extended-release chewable tablets (MRCT)...The LiquiXR drug delivery technology provides for an immediate release followed by extended-release profile that demonstrated efficacy in treatment of ADHD for these patient populations, with an acceptable safety profile."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Optimization of Methylphenidate Extended-Release Chewable Tablet Dose in Children with ADHD: Open-Label Dose Optimization in a Laboratory Classroom Study. (PubMed, J Child Adolesc Psychopharmacol) - "Dose-optimization period results describing relationships between change in ADHD symptom scores and final optimized MPH ERCT dose will be valuable for clinicians optimizing MPH ERCT dose."

Clinical • Journal

Relative Bioavailability of Methylphenidate Extended-release Chewable Tablets Chewed Versus Swallowed Whole. (PubMed, Clin Ther) - "There was no difference in overall rate or extent of exposure of methylphenidate when MPH ERCT was chewed versus swallowed whole by healthy volunteers."

Journal