Spectracef (cefditoren pivoxil) / Meiji Seika - LARVOL DELTA

Epidemiology and antimicrobial resistance of pathogens in pediatric sinus infections: a retrospective study at a Japanese otolaryngology clinic (2023-2025). (PubMed, Front Cell Infect Microbiol) - "Among the 697 H. influenzae isolates, 44.8% were ampicillin-resistant, and 31.3% of all isolates were β-lactamase-negative ampicillin-resistant (BLNAR) strains. Some BLNAR strains exhibited reduced susceptibility to amoxicillin-clavulanic acid (MIC90 = 8 μg/mL). Cefotaxime, cefditoren, and levofloxacin remained highly active. Among the 625 S. pneumoniae isolates, 66.6% were penicillin-susceptible, 31.0% were intermediate, and 2.4% were resistant; resistance to clarithromycin was observed in 84.3% of isolates...Age-specific trends, including increased methicillin-resistant S. aureus in older children, should guide empiric therapy. Ongoing AMR surveillance and culture-based management are essential."

Journal • Retrospective data • Infectious Disease • Influenza • Otorhinolaryngology • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Sinusitis

Eudragit-Based Electrospun Nanofibers for Improving the Solubility and permeability of Cefditoren Pivoxil: In-vitro, Ex-vivo and Histological assessment. (PubMed, Pharm Dev Technol) - "Histology of the intestinal segment after 90 minutes showed the appearance of nanoparticles in the cytoplasm of the enterocytes, indicating that the drug absorption mechanism is mainly transcellular. Histology of the intestinal segment at the end of the experiment showed a highly significant increase in the mean length of the intercellular space of EL100-55 (p < 0.001), indicating drug enhancement via the paracellular pathway."

Journal • Preclinical

Pharmacokinetic Study of Cefditoren Pivoxil in Breast Milk and Blood of Lactating Women. (PubMed, Biopharm Drug Dispos) - "Based on the M/P ratio and RID, it is inferred that the infant's exposure is low, that is, the absolute dose of cefditoren transmitted to the infant through breastfeeding is low and is unlikely to cause any significant adverse effects. The results of this study will provide information for the use of cefditoren pivoxil in lactating women."

Journal • PK/PD data

Latent Non-typhoidal Salmonella in Macrophages as a Potential Cause of Persistent Appendicitis. (PubMed, Cureus) - "Stool cultures revealed Salmonella O7, leading to treatment with fosfomycin...The patient was treated with ceftriaxone and oral cefditoren pivoxil, which relieved temporary symptoms...This case suggests that mesenteric lymph nodes may act as a long-term reservoir where macrophages harbor intracellular Salmonella, ultimately leading to persistent appendicitis. Clinicians should consider appendicitis due to NTS​​​​​​​ in patients with prolonged or recurrent abdominal pain following gastroenteritis."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain • Pediatrics

A Febrile 67-Year-Old Man With Pulmonary Consolidation and Contralateral Nodules. (PubMed, Chest) - "Outpatient treatment with cefditoren and moxifloxacin did not improve his symptoms. No remarkable medical history was reported. The patient was admitted for further evaluation."

Journal • Anorexia • Cough • Pulmonary Disease • Respiratory Diseases

Localized Leg Erythema as the Primary Symptom of Scarlet Fever: An Atypical Presentation. (PubMed, Cureus) - "The patient was treated with cefditoren pivoxil, resulting in the complete resolution of symptoms. This case highlights the importance of a thorough patient history, physical examination, and awareness of local epidemiological data in diagnosing scarlet fever."

Journal • Dermatology • Infectious Disease • Otorhinolaryngology • Pain

Comparing the activity of oral cefditoren with other cephalosporins in Streptococcus pneumoniae clinical isolates non-susceptible to penicillin, 2019-2020 (ESCMID Global 2025) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections • Pneumonia

Antibiotic susceptibility of pathogens isolated in respiratory tract samples of recently hospitalized patients. (PubMed, Microbiol Spectr) - "In a sub-cohort, we assessed the bacteria's susceptibility to cefditoren...By analyzing specimens from recently admitted patients with CA-LRTI, we aim to provide physicians with the relevant microbiologic data of the more severe CA-LRTI cases, i.e., those that resulted in hospital admission. Such microbiological data would provide primary care and emergency room physicians with additional insights as to the causative agents of severe CA-LRTI."

Journal • Critical care • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

A case series study on the safety of cefditoren pivoxil use during the first trimester of pregnancy in Japan. (PubMed, Congenit Anom (Kyoto)) - "Among 262 live births, the rates of preterm birth, low birth weight, and major congenital malformations were 4.6%, 5.7%, and 1.2%, respectively. Our results suggest that exposure to cefditoren pivoxil during the first trimester of pregnancy does not significantly increase the risk of adverse pregnancy outcomes and infant outcomes."

Journal

Affinity of cefditoren for penicillin-binding proteins in bacteria and its relationship with antibiotic sensitivity. (PubMed, Arch Microbiol) - "The Kd of cefditoren toward PBP1A was 0.005 ± 0.004 µM, which was lower than those of other cephalosporins (cefcapene, cefixime and cefdinir)...Additionally, the biotinylated ampicillin (BIO-AMP) method was employed to evaluate the affinity of cefditoren toward PBPs of Haemophilus influenzae, and the results demonstrated that cefditoren and PBP3A/B had the lowest IC50 values (0.060 ± 0.002 µM)...Cefditoren has a high affinity toward the PBP1As of S. pneumoniae and PBP1A and PBP3A/B of H. influenzae, which may contribute to the effective antibacterial effects of cefditoren against clinical strains and its low propensity for inducing resistance. The data presented in this article help elucidate the mechanism by which cefditoren, an oral third-generation cephalosporin, binds to PBPs and provide theoretical support for the wider use of cefditoren as an antibiotic therapy."

Journal • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

RID: Pharmacokinetic Study of Cefditoren Pivoxil in Breast Milk and Blood of Lactating Women (clinicaltrials.gov) - P=N/A | N=12 | Completed | Sponsor: West China Second University Hospital

New trial

Letter to the Editor. (PubMed, Pharm Res) - No abstract available

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid. (PubMed, Rev Esp Quimioter) - "Cefditoren exhibited activity against 90% of isolates, with superior potency over amoxicillin/clavulanic acid. These findings underscore the utility of cefditoren in empirical treatment of DFI, although a larger sample size would be desirable for further validation."

Journal • Preclinical • Infectious Disease

Analysis of antimicrobial drug usage in psychiatric specialized hospitals during the pandemic in China. (PubMed, Expert Rev Anti Infect Ther) - "The most dominant drug in DDDs was cefditoren, a third-generation cephalosporin. During the pandemic years, our hospital not only met the requirements for antimicrobial drug usage, microbiological examination, AUD, and cumulative DDDs when compared to Jiangsu Province and China but also demonstrated a consistent year-by-year decrease in drug usage and DDDs. This underscores our hospital's effective progress in maintaining rational antimicrobial drug use."

Journal • Psychiatry

Do dietary interventions exert clinically important effects on the bioavailability of β-lactam antibiotics? A systematic review with meta-analyses. (PubMed, J Antimicrob Chemother) - "Factors such as physicochemical features of antibiotics, drug formulation, type of intervention, and patient's health state may influence interactions. Due to the poor actuality and diverse methodology of included studies and unproportionate data availability for individual drugs, we judged the quality of evidence as low."

Journal • Review

Cephalosporins for the treatment of uncomplicated pyelonephritis: a systematic review. (PubMed, J Am Pharm Assoc (2003)) - "Cephalosporins may be viable treatment options for the management of uncomplicated APN."

Journal • Review • Infectious Disease • Nephrology

In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model. (PubMed, Pharm Res) - "Cefditoren pivoxil has good therapeutic efficacy against acute pneumonia caused by S. pneumoniae with a MIC ≤ 0.031-0.063 mg/L at approved doses in adults and children."

Journal • PK/PD data • Preclinical • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Acute cholangitis with common bile duct stone caused by Lactococcus garvieae: A case report (IPBM 2023) - "He had an uneventful clinical course and was sent home with oral cefditoren pivoxil. The patient occasionally ingested raw fish and had a history of gastric ulcer with acid suppression therapy, which could be possible risk factors for L. garvieae infection. This is the first case of L. garvieae bacteremia in acute cholangitis"

Clinical • Hepatology • Infectious Disease • Pain • Peptic Ulcer

Cefditoren: a clinical overview. (PubMed, New Microbiol) - "with a reduction of adverse effects and hospital costs. Eventually, due to its supposed binding to enterococcal penicillin binding proteins (PBPs) cefditoren, in combination with other beta-lactams, might have a role in partial oral enterococcal endocarditis treatment.."

Journal • Cardiovascular • Chronic Obstructive Pulmonary Disease • Infectious Disease • Influenza • Nephrology • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Sinusitis

A comparative performance evaluation of cephalosporin's drugs for fluoride recognition. (PubMed, Anal Sci) - "In this manuscript, readily available cephalosporin's drugs cefuroxime axetil (L1) cefpdoxime proxetil (L2), and cefditoren pivoxil (L3) possess dihydrothiazine ring as signaling unit, and -NH groups as the binding site were used for the sensing of fluoride (F) ions. The presence of F was monitored in various spiked water and Colgate toothpaste samples. Overall, cephalosporin's drug demonstrates a promising potential for the detection of F ions in the semi-aqueous phase."

Journal

Trend of oral antimicrobial use after removal of broad-spectrum antimicrobials from the formulary at a pediatric primary emergency medical center. (PubMed, J Infect Chemother) - "We suggest that after the removal of broad-spectrum antimicrobials and achieving a reduction in the prescription rate of oral antimicrobials, it is necessary to evaluate whether narrow-spectrum antimicrobials are used properly in pediatric PECs."

Journal • Pediatrics

Combination of Cefditoren and N-acetyl-l-Cysteine Shows a Synergistic Effect against Multidrug-Resistant Streptococcus pneumoniae Biofilms. (PubMed, Microbiol Spectr) - "We demonstrated a synergy between CDN and NAC that inhibited and treated pneumococcal biofilms, impaired pneumococcal adherence to the lung epithelium, and treated pneumonia in a mouse pneumonia model. We propose the widely used cephalosporin CDN and the repurposed drug NAC as a new antibiofilm therapy against S. pneumoniae biofilms, including those formed by antibiotic-resistant clinical isolates."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia • Pulmonary Disease • Respiratory Diseases

Primary septic arthritis of the knee caused by Neisseria meningitidis serogroup B in an elderly patient. Case report and review of the literature. (PubMed, Infection) - "Two grams of ceftriaxone twice a day were administered for 21 days; than cefditoren pivoxil 400 mg twice a day for further 6 weeks after discharge. A total of 41 cases of PMA caused by N. meningitidis was reported in the literature, but only four occurred in elderly. To our knowledgements, no cases of PMA caused by MenB were previously reported among patients of more than 65 years of age."

Journal • Review • Immunology • Infectious Disease • Meningococcal Infections • Pain • Rheumatology

Rapid and Sensitive Electrochemical Assay of Cefditoren with MWCNT/Chitosan NCs/FeO as a Nanosensor. (PubMed, Micromachines (Basel)) - "Model drugs (cefdinir, cefpodoxime, cephalexin, and ceftazidime compounds) were used to enlighten the CFT oxidation mechanism. Moreover, the nanosensor was used to analyze CFT in a pharmaceutical dosage form and commercial deproteinated human serum samples. The accuracy of these methods was proven in the recovery studies, with values of 96.98 and 98.62% for the pharmaceutical dosage form and commercial deproteinated human serum sample, respectively."

Journal

Effect of pneumococcal conjugate vaccines and SARS-CoV-2 on antimicrobial resistance and the emergence of Streptococcus pneumoniae serotypes with reduced susceptibility in Spain, 2004-20: a national surveillance study. (PubMed, Lancet Microbe) - "The increase in non-PCV13 serotypes associated with antibiotic resistance is concerning, especially the increase of penicillin resistance linked to serotypes 11A and 24F. The future use of PCVs with an increasingly broad spectrum (such as PCV20, which includes serotype 11A) could reduce the impact of antibiotic resistance for non-PCV13 serotypes. The use of antibiotics to prevent co-infections in patients with COVID-19 might have affected the increased proportion of pneumococcal-resistant strains. Cefotaxime as a parenteral option, and cefditoren as an oral choice, were the antibiotics with the highest activity against non-PCV20 serotypes."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases