nefopam / Generic mfg. - LARVOL DELTA

Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (clinicaltrials.gov) - P4 | N=93 | Recruiting | Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

NEFOPAIN kinet: Pharmacokinetic Study of the Use of Nefopam 30 mg Tablets in Patients Suffering From Acute Pain in Rheumatology (clinicaltrials.gov) - P4 | N=24 | Not yet recruiting | Sponsor: University Hospital, Rouen

New P4 trial • Musculoskeletal Pain • Pain • Rheumatology

CHDR2501: Research into new test methods to measure pain with two existing drugs (nefopam and oxycodone) (clinicaltrialsregister.eu) - P1 | N=24 | Completed | Sponsor: Centre for Human Drug Research | Recruiting ➔ Completed

Trial completion • Pain

Clinical Applications and Safety Analysis of Nefopam and Flupirtine as Examples of Non-Opioid Analgesics. (PubMed, Curr Pharm Des) - "Although these agents are beneficial in reducing opioid consumption, their use should be tailored to each patient, with careful follow-up. Patients receiving NOAAs should be monitored for adverse effects, particularly during treatment initiation. Monitoring is also essential for elderly patients and those with cardiovascular or neurological conditions to ensure safe administration. In conclusion, the clinical use of NOAAs requires careful consideration of potential adverse effects, contraindications, and drug interactions. Further well-designed studies are needed to better define these agents' characteristics, limitations, and comparisons with alternative pain management approaches."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Depression • Pain • Psychiatry

CHDR2501: Research into new test methods to measure pain with two existing drugs (nefopam and oxycodone) (clinicaltrialsregister.eu) - P1 | N=24 | Recruiting | Sponsor: Centre for Human Drug Research

New P1 trial • Pain

2022/0355/HP: Pharmacokinetic study of the use of Nefopam 30 mg tablet in patients suffering from acute pain in rheumatology - NEFOPAIN kinetics (clinicaltrialsregister.eu) - P4 | N=29 | Not yet recruiting | Sponsor: Centre Hospitalier Universitaire Rouen

New P4 trial • Musculoskeletal Pain • Pain • Rheumatology

Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (clinicaltrials.gov) - P4 | N=93 | Not yet recruiting | Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy

New P4 trial • Pain

Opioid-based versus opioid-sparing patient-controlled analgesia using ketorolac and nefopam after total knee arthroplasty: a randomized, double-blind, non-inferiority trial. (PubMed, Korean J Anesthesiol) - "In this prospective, randomized, double-blind, non-inferiority study, 98 patients undergoing TKA under spinal anesthesia received either opioid-based PCA (continuous infusion of 1200 μg fentanyl, n = 49) or opioid-sparing PCA (continuous infusion of 150 mg ketorolac tromethamine and 100 mg nefopam hydrochloride, n = 49). Nausea and vomiting on POD 1 were more frequent with opioid-based group (34.7% vs. 12.2%, P = 0.009). Opioid-sparing PCA with ketorolac and nefopam provides non-inferior analgesia to opioid-based PCA, while reducing opioid consumption and drug-related adverse effects after TKA."

Clinical • Head-to-Head • Journal • Addiction (Opioid and Alcohol) • Anesthesia • Musculoskeletal Pain • Orthopedics • Pain

Effect of combined acetaminophen and nefopam on postoperative pain in patients undergoing robot-assisted urological surgery: a retrospective propensity score-matched analysis. (PubMed, J Robot Surg) - "Rescue opioid consumption was lower in the preventive group during the PACU (2.5 vs. 7.5 mg morphine equivalent, P < 0.001) and 24-h periods (5 vs. 10 mg, P < 0.001). Their PACU stay was also shorter (34 vs. 40.5 min, P < 0.001). Preventive acetaminophen-nefopam administration was associated with significantly lower postoperative pain severity and opioid requirements and faster recovery after robot-assisted urological surgery."

Journal • Retrospective data • Anesthesia • Pain

Analgesic effect of intravenous nefopam for postoperative pain in spine surgery: a meta-analysis of RCTs. (PubMed, Int J Physiol Pathophysiol Pharmacol) - "The use of intra-venous nefopam offers a small analgesic benefit in spine surgery, which is best seen when applied intermittently or as a bolus rather than as a continuous infusion. Though it is not particularly effective as a standalone agent, bolus does have potential as an adjunct and should be included as part of a more multimodal analgesia approach. Further high quality RCTs with larger sample sizes are warranted to better define the optimal application of nefopam and dosing in patients undergoing spinal surgery."

Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Depression • Orthopedics • Pain • Psychiatry

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Postspinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries: A Double-Blind Comparative Study. (PubMed, Anesthesiol Res Pract) - P=N/A | "A common and distressing consequence that may arise after spinal anesthesia (SA) is shivering. IV nefopam was more effective than DEX and pethidine in preventing shivering under SA, with fewer hemodynamic and sedative side effects. ClinicalTrials.gov identifier: NCT06627816."

Journal • Anesthesia

Trends of Opioids and Nefopam Use Among French Children: A Population-Based Study From 2009 to 2023. (PubMed, Clin Drug Investig) - "Tramadol was the most commonly prescribed opioid used in pediatric outpatients in France in 2023, followed by codeine. Tramadol off-label use steadily increased, whereas codeine off-label use decreased. The sharp rise in tramadol, especially in children aged 2-6 years, and nefopam prescribing, together with increasing morphine and oxycodone use, in association with frequent contraindicated use, underscores the need for enhanced surveillance and pediatric-specific safety data."

Journal • Pain • Pediatrics

Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial. (PubMed, Anaesth Crit Care Pain Med) - P=N/A | "Replacing the NRS with a comfort-focused approach did not improve global patient experience after surgery. In patients receiving regional anaesthesia, however, using a comfort scale was associated with better patient-reported experience in the EVAN "Pain" dimension, while no benefit was observed after general anaesthesia."

Journal • Retrospective data • Anesthesia • Cardiovascular • Pain

A comparative study of nefopam and acetaminophen/Ibuprofen combination for postoperative pain management following gastric cancer surgery (KINGCA Week 2025) - "The incidence of dizziness and postoperative nausea and vomiting (PONV) was comparable between the two groups (dizziness: 5.1% vs. 5.6%, p = 0.848; PONV: 8.9% vs. 8.3%, p = 0.876). CONCLUSIONS : These findings suggest that both regimens are feasible options for postoperative pain management, although the FDC of APAP/IBU may offer more consistent analgesic efficacy with less need for additional analgesics."

Surgery • Gastric Cancer • Oncology • Pain • Solid Tumor

The application of continuous nefopam infusion in analgesia and sedation for mechanically ventilated patients in the ICU: Authors' reply. (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Journal • Anesthesia

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Completed | Sponsor: Kasr El Aini Hospital | Recruiting ➔ Completed | Trial completion date: Nov 2025 ➔ Jul 2025 | Trial primary completion date: Oct 2025 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date • Anesthesia

Nefopam for Analgesia Following Cardiac Surgery: A Randomized Placebo-Controlled Double-Blind Clinical Trial. (PubMed, J Cardiothorac Vasc Anesth) - "Nefopam was well tolerated and associated with statistically significant but clinically modest reductions in fentanyl use and pain scores after cardiac surgery, supporting its role as a safe adjunct in multimodal analgesia."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Critical care • Pain

Nefopam Misuse: A Cross-Sectional Study in France. (PubMed, Eur J Pain) - "This work is a snapshot of nefopam usage in France. It sheds light on contraindicated uses (in subjects under 15 years of age or with epilepsy), not recommended uses (chronic usage, or in the elderly) and reports the usage of this treatment in the most deprived patients. This article cautions against underestimating the dangers and pitfalls of this treatment, especially in light of mounting evidence of pharmacodependence."

Journal • Observational data • Retrospective data • Addiction (Opioid and Alcohol) • CNS Disorders • Epilepsy • Pain

The Analgesic Effect of Nefopam in Patients Undergoing Orthopedics Surgery with Tourniquet: a Double-blind Case-control Trial. (PubMed, Med Arch) - "Nefopam utilization was the single independent factor affecting the postoperative pain score. Compared with placebo, opioid requirement was decreased, the pain resulting from operation and tourniquet pain were decreased."

Clinical • Journal • Addiction (Opioid and Alcohol) • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

MANAGEMENT OF POST-OPERATIVE ACUTE (MODERATE TO SEVERE) PAIN IN CANCER PATIENTS - A REVIEW OF THE LATEST EVIDENCE (MASCC-ISOO 2025) - "Thoracic (12%) and colorectal procedures (11%) demonstrated no consistent pain management strategies, with varying approaches including gabapentinoids and nefopam respectively...4 gastric procedures (5%) and 4 hepatic procedures (5%) found analgesics including parecoxib to be optimal...Further studies are needed to implement standardized pain management protocols, particularly for less common procedures and cancers where evidence is limited. Furthermore, long-term follow-up studies are crucial to evaluate if pain relief was sustainable and its impact on recovery."

Clinical • Review • Oncology • Pain

The application of continuous nefopam infusion in analgesia and sedation for mechanically ventilated patients in the ICU. (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Journal • Anesthesia

Prevention of shivering post spinal anesthesia: Ondansetron vs. Nefopam ‒ a prospective randomized controlled trial. (PubMed, Braz J Anesthesiol) - "Nefopam seems to be more effective than Ondansetron in preventing PSAS with fewer cardiovascular side effects. However, Ondansetron reduces the incidence of nausea and vomiting and causes no pain during administration."

Journal • Anesthesia • Cardiovascular • Hypotension • Pain

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Recruiting | Sponsor: Kasr El Aini Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

Effect of Intraoperative Nefopam on Postoperative Analgesia in Living Liver Donors Undergoing Laparoscopic Hepatectomy with Transversus Abdominis Plane Block: A Propensity Score-Matched Study. (PubMed, Life (Basel)) - "Nefopam significantly reduced NRS at 1, 4, and 8 h postoperatively (p < 0.001) and decreased fentanyl use in the post-anesthesia care unit (26.0 ± 32.2 μg vs. 60.5 ± 37.9 μg, p < 0.001) and total intravenous patient-controlled analgesia volume (p < 0.001). Nefopam combined with a TAP block effectively reduces postoperative pain and opioid consumption in living liver donors, supporting its role in multimodal analgesia. Further research is needed to explore its broader applications."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Depression • Hepatology • Pain • Psychiatry • Transplantation

Effects of Nefopam on Postoperative Analgesia in Operating Room-Extubated Patients Undergoing Living Donor Liver Transplantation: A Propensity Score-Matched Analysis. (PubMed, Life (Basel)) - "Pain intensity was measured using the visual analog scale (VAS), and total fentanyl consumption and opioid-related complications were recorded over the first 24 h postoperatively. These findings indicate that nefopam offers effective early analgesia and an opioid-sparing effect in LDLT recipients undergoing OR extubation, suggesting its clinical utility as a component of multimodal analgesia in this high-risk group. Although the reduction in opioid use did not translate into a decreased incidence of opioid-related complications, the favorable safety profile and analgesic efficacy of nefopam support further investigation through prospective trials to define its role in enhanced recovery protocols for OR-extubated LDLT recipients."

Journal • Hepatology • Pain • Transplantation