nefopam / Generic mfg. - LARVOL DELTA

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Postspinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries: A Double-Blind Comparative Study. (PubMed, Anesthesiol Res Pract) - P=N/A | "A common and distressing consequence that may arise after spinal anesthesia (SA) is shivering. IV nefopam was more effective than DEX and pethidine in preventing shivering under SA, with fewer hemodynamic and sedative side effects. ClinicalTrials.gov identifier: NCT06627816."

Journal • Anesthesia

Trends of Opioids and Nefopam Use Among French Children: A Population-Based Study From 2009 to 2023. (PubMed, Clin Drug Investig) - "Tramadol was the most commonly prescribed opioid used in pediatric outpatients in France in 2023, followed by codeine. Tramadol off-label use steadily increased, whereas codeine off-label use decreased. The sharp rise in tramadol, especially in children aged 2-6 years, and nefopam prescribing, together with increasing morphine and oxycodone use, in association with frequent contraindicated use, underscores the need for enhanced surveillance and pediatric-specific safety data."

Journal • Pain • Pediatrics

Comfort-Focused Assessment and Patient-Reported Experience After Regional versus General Anaesthesia: Post Hoc Analysis of a Cluster-Randomised Trial. (PubMed, Anaesth Crit Care Pain Med) - P=N/A | "Replacing the NRS with a comfort-focused approach did not improve global patient experience after surgery. In patients receiving regional anaesthesia, however, using a comfort scale was associated with better patient-reported experience in the EVAN "Pain" dimension, while no benefit was observed after general anaesthesia."

Journal • Retrospective data • Anesthesia • Cardiovascular • Pain

A comparative study of nefopam and acetaminophen/Ibuprofen combination for postoperative pain management following gastric cancer surgery (KINGCA Week 2025) - "The incidence of dizziness and postoperative nausea and vomiting (PONV) was comparable between the two groups (dizziness: 5.1% vs. 5.6%, p = 0.848; PONV: 8.9% vs. 8.3%, p = 0.876). CONCLUSIONS : These findings suggest that both regimens are feasible options for postoperative pain management, although the FDC of APAP/IBU may offer more consistent analgesic efficacy with less need for additional analgesics."

Surgery • Gastric Cancer • Oncology • Pain • Solid Tumor

The application of continuous nefopam infusion in analgesia and sedation for mechanically ventilated patients in the ICU: Authors' reply. (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Journal • Anesthesia

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Completed | Sponsor: Kasr El Aini Hospital | Recruiting ➔ Completed | Trial completion date: Nov 2025 ➔ Jul 2025 | Trial primary completion date: Oct 2025 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date • Anesthesia

Nefopam for Analgesia Following Cardiac Surgery: A Randomized Placebo-Controlled Double-Blind Clinical Trial. (PubMed, J Cardiothorac Vasc Anesth) - "Nefopam was well tolerated and associated with statistically significant but clinically modest reductions in fentanyl use and pain scores after cardiac surgery, supporting its role as a safe adjunct in multimodal analgesia."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Critical care • Pain

Nefopam Misuse: A Cross-Sectional Study in France. (PubMed, Eur J Pain) - "This work is a snapshot of nefopam usage in France. It sheds light on contraindicated uses (in subjects under 15 years of age or with epilepsy), not recommended uses (chronic usage, or in the elderly) and reports the usage of this treatment in the most deprived patients. This article cautions against underestimating the dangers and pitfalls of this treatment, especially in light of mounting evidence of pharmacodependence."

Journal • Observational data • Retrospective data • Addiction (Opioid and Alcohol) • CNS Disorders • Epilepsy • Pain

The Analgesic Effect of Nefopam in Patients Undergoing Orthopedics Surgery with Tourniquet: a Double-blind Case-control Trial. (PubMed, Med Arch) - "Nefopam utilization was the single independent factor affecting the postoperative pain score. Compared with placebo, opioid requirement was decreased, the pain resulting from operation and tourniquet pain were decreased."

Clinical • Journal • Addiction (Opioid and Alcohol) • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

MANAGEMENT OF POST-OPERATIVE ACUTE (MODERATE TO SEVERE) PAIN IN CANCER PATIENTS - A REVIEW OF THE LATEST EVIDENCE (MASCC-ISOO 2025) - "Thoracic (12%) and colorectal procedures (11%) demonstrated no consistent pain management strategies, with varying approaches including gabapentinoids and nefopam respectively...4 gastric procedures (5%) and 4 hepatic procedures (5%) found analgesics including parecoxib to be optimal...Further studies are needed to implement standardized pain management protocols, particularly for less common procedures and cancers where evidence is limited. Furthermore, long-term follow-up studies are crucial to evaluate if pain relief was sustainable and its impact on recovery."

Clinical • Review • Oncology • Pain

The application of continuous nefopam infusion in analgesia and sedation for mechanically ventilated patients in the ICU. (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Journal • Anesthesia

Prevention of shivering post spinal anesthesia: Ondansetron vs. Nefopam ‒ a prospective randomized controlled trial. (PubMed, Braz J Anesthesiol) - "Nefopam seems to be more effective than Ondansetron in preventing PSAS with fewer cardiovascular side effects. However, Ondansetron reduces the incidence of nausea and vomiting and causes no pain during administration."

Journal • Anesthesia • Cardiovascular • Hypotension • Pain

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Recruiting | Sponsor: Kasr El Aini Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

Effect of Intraoperative Nefopam on Postoperative Analgesia in Living Liver Donors Undergoing Laparoscopic Hepatectomy with Transversus Abdominis Plane Block: A Propensity Score-Matched Study. (PubMed, Life (Basel)) - "Nefopam significantly reduced NRS at 1, 4, and 8 h postoperatively (p < 0.001) and decreased fentanyl use in the post-anesthesia care unit (26.0 ± 32.2 μg vs. 60.5 ± 37.9 μg, p < 0.001) and total intravenous patient-controlled analgesia volume (p < 0.001). Nefopam combined with a TAP block effectively reduces postoperative pain and opioid consumption in living liver donors, supporting its role in multimodal analgesia. Further research is needed to explore its broader applications."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Depression • Hepatology • Pain • Psychiatry • Transplantation

Effects of Nefopam on Postoperative Analgesia in Operating Room-Extubated Patients Undergoing Living Donor Liver Transplantation: A Propensity Score-Matched Analysis. (PubMed, Life (Basel)) - "Pain intensity was measured using the visual analog scale (VAS), and total fentanyl consumption and opioid-related complications were recorded over the first 24 h postoperatively. These findings indicate that nefopam offers effective early analgesia and an opioid-sparing effect in LDLT recipients undergoing OR extubation, suggesting its clinical utility as a component of multimodal analgesia in this high-risk group. Although the reduction in opioid use did not translate into a decreased incidence of opioid-related complications, the favorable safety profile and analgesic efficacy of nefopam support further investigation through prospective trials to define its role in enhanced recovery protocols for OR-extubated LDLT recipients."

Journal • Hepatology • Pain • Transplantation

Adjuvant nefopam versus standard of care in mechanically ventilated surgical critically ill patients: a randomized, double-blind controlled study. (PubMed, Anaesth Crit Care Pain Med) - P3 | "Nefopam was found to be an effective non-opioid option for analgesia in mechanically ventilated surgical and trauma critically ill patients, and more studies are needed to evaluate its safety."

Clinical • Journal • Anesthesia • Mood Disorders • Pain

A meta analysis of efficacy and safety of nefopam for laparoscopic cholecystectomy pain management. (PubMed, J Taibah Univ Med Sci) - "Nefopam did not cause any difference in total postoperative pain but was effective in reducing overall opioid consumption and the need for supplementary analgesics. It did not increase postoperative nausea and vomiting."

Journal • Retrospective data • Pain

Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "A single intraoperative dose of intravenous acetaminophen, combined with nefopam- and fentanyl-based PCA, did not significantly reduce analgesic requirements, pain scores at rest, or opioid-related side effects compared with placebo in laparoscopic hysterectomy patients."

Clinical • Journal • Gynecology • Pain

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Not yet recruiting | Sponsor: Kasr El Aini Hospital | Initiation date: Oct 2024 ➔ Jan 2025

Trial initiation date • Anesthesia

Safety and Efficacy of opioid-sparing Anesthesia Compared with Traditional opioid-anesthesia: A Scoping Review. (PubMed, Clin J Pain) - "The clinical implementation of OSA encompasses the perioperative use of nonopioid drugs and locoregional anesthesia techniques. The reviewed studies reported OSA as a feasible approach to reduce opioid-related complications with no impact on patient safety."

Journal • Anesthesia • Cognitive Disorders • Gastrointestinal Disorder • Inflammation • Inflammatory Bowel Disease • Pain

Management of acute pain in adults with sickle cell disease: the experience of the Clinical Hematology Department of the University of Dakar. (PubMed, Turk J Med Sci) - "The mean dose of morphine administered was 17.14 mg when morphine alone was prescribed for titration, 13.57 mg when paracetamol and morphine were combined, and 15.83 mg when nefopam and morphine were combined. This study highlights the efficacy of multimodal analgesia in the management of acute pain in patients with SCD, particularly in regard to morphine sparing. Context-specific recommendations will be needed to harmonize practices."

Journal • Review • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Opioid free versus opioid sparing strategies for multimodal antinociception during laparoscopic colectomy: a randomised controlled trial. (PubMed, Anaesth Crit Care Pain Med) - P=N/A | "In patients undergoing laparoscopic colectomy with a multimodal antinociception protocol, OFA, when compared to OSA, did not decrease postoperative opioid consumption."

Journal • Anesthesia • Cardiovascular • Pain

Letter to the Editor commenting on Nefopam: A Potential Analgesic Relief Inducer And Morphine Consumption Reducer Following Primary Total Knee Arthroplasty? (PubMed, J Arthroplasty) - No abstract available

Journal • Orthopedics • Pain

Response to Letter to the Editor commenting on Nefopam: A Potential Analgesic Relief Inducer And Morphine Consumption Reducer Following Primary Total Knee Arthroplasty. (PubMed, J Arthroplasty) - No abstract available

Journal • Orthopedics • Pain

Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. (clinicaltrials.gov) - P=N/A | N=240 | Not yet recruiting | Sponsor: Kasr El Aini Hospital

New trial • Anesthesia