mesenchymal stem cells / Tongji Hospital - LARVOL DELTA

Mesenchymal stem cells and secretome as modulators of neuroinflammation in neurological disorders. (PubMed, J Transl Med) - No abstract available

Journal • Review • CNS Disorders • Immunology • Inflammation

Therapeutic efficacy and mechanistic exploration of umbilical cord mesenchymal stem cell transplantation for non-obstructive azoospermia (EAU 2026) - No abstract available

Clinical • Transplantation

Dynamic hydrogels orchestrate the differentiation fate of mesenchymal stem cells through epigenetic regulation of SETD7 to accelerate bone defect repair. (PubMed, Bioact Mater) - "In the nucleus, β-catenin further formed a transcriptional complex with YAP to synergistically amplify downstream signals and potently activate the expression of Runx2, a key transcription factor for osteogenesis, which ultimately drove osteogenic differentiation and inhibited adipogenesis. The present study elucidated a novel mechanism by which cell-adaptive hydrogels regulate the β-catenin/YAP signaling loop through the miR-376a-3p/miR-127-5p-SETD7 axis, thereby determining the osteogenic/adipogenic differentiation of stem cells, which not only deepens our understanding of mechanotransduction but also provides new targets and material design strategies for bone regeneration."

Journal • MIR127 • RUNX2 • SETD7

A Nanococktail Strategy Regulating Circadian Clock and Re-Establishing Bone-Immune Balance for the Treatment of Senile Osteoporosis. (PubMed, ACS Nano) - "Circadian rhythm disorders impair the efferocytosis function of macrophages, leading to compensatory nonprofessional efferocytosis by bone mesenchymal stem cells (BMSCs)...Consequently, BMSCs are relieved from nonprofessional efferocytosis, leading to the restoration of their osteogenic capacity. In summary, this study introduces an innovative nanococktail strategy for the treatment of SOP by modulating both circadian clock-dependent efferocytosis function and the osteoblast/osteoclast balance."

Journal • Osteoporosis • Rheumatology • Sleep Disorder • CXCR4

Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration. (PubMed, Mater Today Bio) - "Under ultrasound stimulation, PVDF generates localized electrical cues that transiently elevate reactive oxygen species (ROS), activating the NRF2 antioxidant pathway to resolve oxidative stress, which polarizes macrophages toward pro-regenerative M2 phenotypes, enhances osteogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) and promotes angiogenesis in vitro...This platform transcends beyond passive scaffolding by recapitulating bone's electromechanical-immune axis offers a paradigm shift toward smart biomaterials for complex skeletal defects. The integration of PVDF's ultrasound-triggered piezoelectricity with SM's bioactivity establishes a multifunctional system that dynamically regulates redox homeostasis, immune modulation, and tissue remodeling, addressing unmet needs in bone tissue engineering."

Journal • Immune Modulation • Immunology

Biomimetic scaffolds with synergistic BMSC targeting and ROS scavenging for mitochondrial protection and effective bone-defect repair. (PubMed, J Nanobiotechnology) - "Exosomes (EXOs) derived from mesenchymal stem cells have emerged as promising tools for bone repair...On MitoQ incorporation, these EXOs (EXO-MitoQ, EM) exhibit the targeted scavenging of mitochondrial reactive oxygen species; moreover, on surface decoration with the nucleic acid aptamer Apt 19 S (EM-Apt), they show the enhanced recruitment and precise delivery of BMSCs...In a rat calvarial defect model, this TCP/SIS@EM-Apt scaffold increased the BV/TV by 1.9-fold compared to TCP/SIS, due to the combination of multiple multifunctional therapeutic effects (anti-inflammatory, angiogenic, and osteogenic). The mitochondria-targeting strategy proposed in this study presents a promising solution for the reconstruction of large bone defects and offers a synergistic approach for addressing complex regenerative challenges."

Journal

Proangiogenic Mechanisms and Modifications of Mesenchymal Stem Cells with a Focus on Neurological Disorders. (PubMed, Stem Cells Dev) - "This review focuses on the application of MSCs and their derivatives in neurological disorders, primarily exploring strategies to enhance their angiogenic effects, including pharmacological interventions, genetic modification, modulation of the culture environment, and the application of novel materials. Furthermore, the article prospects the potential application of MSC-mediated angiogenesis in the treatment of neurological disorders, specifically in the surgical management of ischemic cerebrovascular diseases."

Journal • Review • CNS Disorders • Vascular Neurology

Peripheral nerve repair: innovations and future directions. (PubMed, J Transl Med) - "Recent progress in biomaterial conduits, cell-free biologics, and biophysical stimulation is transforming PNI treatment and providing options that surpass conventional microsurgical repair. Continued advancement will require reliable biomarkers, standardized production and evaluation methods, and well-designed randomized controlled trials. Coordinated collaboration across research, clinical practice, industry, and regulatory agencies is essential to develop safe, effective, and widely applicable neuroregenerative therapies that restore meaningful function after peripheral nerve injury."

Journal • Review • Fibrosis • Immunology • Muscular Atrophy • Neuralgia • Pain • Transplantation

Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis. (PubMed, Cell Biol Toxicol) - "Animal study revealed that knockdown of exosomal METTL14 from AML-MSC reduced AML tumorigenesis by decreasing HOXA3 and WNT7B expression. AML-MSC-derived exosomal METTL14 facilitated AML cell growth and glycolysis by activating the HOXA3/WNT7B axis, providing a new mechanism for understanding AML-MSC-derived exosomes to promote AML progression."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • METTL14 • WNT7B

Dynamic stiffness drives BMSC chondrogenesis via Ihh-regulated H3K18 lactylation/Rcan1 axis and mitochondrial fission remodeling. (PubMed, Biomed Mater) - "Dynamic matrix stiffness, mimicking the physiological mechanical microenvironment, shows promise in directing stem cell chondrogenesis, but its molecular mechanisms remain unclear. Bone marrow mesenchymal stem cells (BMSCs) were cultured on engineered hydrogels with static soft (0.033 kPa), dynamic (0.031-0.126 kPa, time-dependent stiffening), and static stiff (0.126 kPa) conditions...Consistently, the LDHA inhibitor FX11 reduced lactate levels, diminished H3K18la, and downregulated Rcan1, confirming the metabolic dependence of this axis. RNA-seq analysis further established that Rcan1 overexpression reprogrammed signaling pathways critical for cell differentiation, including ECM-receptor interaction. Dynamic stiffness promotes BMSC chondrogenesis via the Ihh-H3K18la-Rcan1 axis, linking mechanical cues to epigenetic regulation of mitochondrial remodeling and providing a novel target for cartilage repair."

Journal • LDHA • SOX9

High Temporal-Resolution Imaging Single Immune Cell Migration in Vivo by Ultrabright NIR-II Organic Probes. (PubMed, Adv Mater) - "The neutrophil migration patterns in the stroke mouse brain and their interactions with infused therapeutic mesenchymal stem cells can be profiled with real temporal dynamics. This advancement facilitates fundamental studies on understanding complex cellular functions in vivo, paving the way for investigating the effect of single-cell temporal dynamics on immune responses or disease-related biological processes."

Journal • Preclinical • Cardiovascular • Inflammation • Oncology

Immunoaffinity-Mimetic Assembly of Peptide-Aptamer Conjugates and Stem Cell-Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair. (PubMed, Adv Sci (Weinh)) - "Mesenchymal stem cell-derived exosomes (MSC-Exo) containing various paracrine mediators have recently been recognized to promote functional recovery of spinal cord injury (SCI)...These synergistic effects ultimately enhance neuroregeneration, thereby promoting the motor function recovery of SCI mice. Our work represents a pioneering effort in harnessing the specificity of immunoaffinity-mimetic interactions between aptamers and biomacromolecules for the high-performance assembly of chemically vulnerable biologics, facilitating widespread applications across materials science and life science."

Journal • CNS Disorders • Orthopedics • CD63

Editorial: Stem cells and extracellular vesicles in bone health, disease and regeneration, volume II. (PubMed, Front Endocrinol (Lausanne)) - No abstract available

Journal • Osteoporosis • Rheumatology

The roles and clinical applications of mesenchymal stem cells and their exosomes in hematologic diseases. (PubMed, Stem Cell Res Ther) - "These characteristics make MSC-EVs particularly significant in the context of hematopoietic stem cell transplantation (HSCT). This review provides a detailed overview of the roles and clinical applications of MSCs in hematologic diseases, the properties of MSC-EVs, and their emerging significance in HSCT."

Journal • Review • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immune Thrombocytopenic Purpura • Immunology • Oncology • Thrombocytopenia • Thrombocytopenic Purpura • Transplantation

Human umbilical cord-derived mesenchymal stem cells ameliorate non-alcoholic fatty liver disease via activating TFEB-mediated autophagy in male mice. (PubMed, Stem Cell Res Ther) - "This study suggests that hUC-MSCs represent a potential therapeutic approach to treating NAFLD through activating TFEB-mediated autophagy."

Journal • Preclinical • Fibrosis • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • TFEB

Integrated Multi-Omics Profiling to Characterize Molecular Subtypes and Reveal Potential Therapeutic Strategies for Colorectal Cancer. (PubMed, MedComm (2020)) - "Moreover, it exhibited a higher stromal score, characterized by increased infiltration of fibroblasts, mesenchymal stem cells, and adipocytes, when compared with the S_II and S_III subtypes...Drug testing using cell lines and patient-derived three-dimensional (3D) bioprinted models revealed that S_I tumors were more responsive to Alisertib, suggesting subtype-specific therapeutic potential. Our study characterized the multi-omics landscape of CRC, offering critical insights into its molecular heterogeneity. These findings enhance our understanding of the molecular mechanisms underlying CRC and contribute to the development of personalized treatment strategies."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens. (PubMed, Front Immunol) - "Extended multi-injection schedules produced greater benefit. ADSCs represent a promising systemic immunomodulatory therapy for AR, with enhanced efficacy under longer treatment cycles."

Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • TGFB1

Vascular environment-responsive DNA nanoswitch controls the positive feedback system for spatiotemporal coupling of angiogenesis and osteogenesis. (PubMed, Biomaterials) - "Moreover, when modified with aptamer-19s, the nanoparticles can attract mesenchymal stem cells to perivascular areas, facilitating spatial coupling with blood vessels...Our findings provide valuable insights for designing intelligent materials that utilize endogenous stimuli to enhance spatiotemporal interactions between vascularization and ossification. Further in-depth studies on the expression of nucleolin in vivo will continue to refine this promising strategy."

Journal • MIR26A1 • NCL

Cross-Talk Between Hedgehog and PDGFRα Pathways in mMSCs Modulates Alveolar Bone Regeneration. (PubMed, Oral Dis) - "The cross-talk of Hh/PDGFRα c regulates mMSCs' osteogenic differentiation to promote alveolar bone regeneration. Targeting Hh/PDGFRα signaling may provide intervention strategies for bone regeneration therapies."

Journal • Transplantation • PDGFRA

Synergistic Effects of Therapeutic Ultrasound and Biomaterials in Osteoarthritis. (PubMed, Tissue Eng Part B Rev) - "This study elucidated the molecular mechanisms underlying the effects of US on synovium, cartilage, subchondral bone, and mesenchymal stem cells...This review highlights the innovative therapeutic potential of combining ultrasound (US), particularly low-intensity pulsed US, with biomaterials for OA treatment. By leveraging synergistic effects such as enhanced tissue repair, targeted drug delivery, and microenvironment regulation, this approach offers a noninvasive and effective strategy to mitigate OA progression and paves the way for advancements in musculoskeletal regenerative medicine."

Journal • Review • Immunology • Inflammation • Musculoskeletal Diseases • Osteoarthritis • Pain • Rheumatology

Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets. (PubMed, Nat Commun) - "We identify Sec14L6, a unique Sec14 family member, as a lipid transporter regulating phosphoinositide (PIP) homeostasis and LD biogenesis, promoting adipogenic differentiation of mesenchymal stem cells...Sec14L6 knockout significantly impaired LD formation; this defect was rescued by wild-type Sec14L6, but not by lipid-transfer-deficient mutants. Our study reveals an essential role for Sec14L6 in PIP homeostasis and promotes LD biogenesis through lipid transfer between the ER and LDs."

Journal • ACSL3

Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Patients with CKD Stages 3-4: A Randomized, Double-Blind, Placebo-Controlled Trial (KIDNEY WEEK 2025) - P1/2 | "The analysis of UC-MSCs effects on inflammatory cells revealed that UC-MSCs maintained stable NK cell counts, while placebo showed significant reduction, with between-group differences at 6 months (P=0.048) and 12 months (P=0.043) The intervention demonstrated acceptable safety, with non-significantly lower adverse events in the cell therapy group (20.0%) versus controls (30.0%) and absence of SAEs. Conclusion Cell infusion therapy demonstrates safety and potential efficacy in decelerating renal function progression in patients with stage 3-4 CKD."

Clinical • Chronic Kidney Disease • Nephrology • Renal Disease • CST3

Angiopoietin-like 8 governs osteoblast-adipocyte lineage commitment during skeletal aging. (PubMed, JCI Insight) - "A distinguishing feature of older mesenchymal stem cells (MSCs) from bone marrow (BM) is the transition in their differentiation capabilities from osteoblasts to adipocytes...Furthermore, treatment with Angptl8-Antisense Oligonucleotide (Angptl8-ASO) improved the phenotype of aging mice. The research proposes that ANGPTL8 is a critical regulator of senesence-related changes in the BM niche and the cell fate switch of MSCs."

Journal • Endocrine Disorders • Metabolic Disorders • Obesity • Orthopedics • Osteoporosis • ANGPTL8 • PPARG

Bone marrow mesenchymal stem cell-derived exosomal microRNA-335 alleviates vascular calcification by targeting SP1. (PubMed, Front Cardiovasc Med) - "In vivo studies confirmed that agomiR-335 treatment significantly lowered SP1 levels in the aorta of male SD rats, alleviating vitamin D3-induced VC. This study highlights that BMSC-derived exosomes regulate VC via the miR-335/SP1 axis, offering novel molecular targets for treating VC."

Journal • Atherosclerosis • Cardiovascular • MIR335 • RUNX2 • SP1

Sub-endometrial Injection of Human Embryonic Stem Cells-derived Immunity-and-matrix-regulatory Cells Promotes Endometrial Angiogenesis in Patients with Refractory Moderate-to-Severe Intrauterine Adhesion: An Open-label, Single-arm, Single-center, Phase I Dose-escalation Trial. (PubMed, Mol Ther) - "Clinical application of mesenchymal stem cells (MSCs) for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route...In a first-in-human, single-center, Phase I dose-escalation trial involving 18 patients with refractory IUA, high-dose sub-endometrial IMRC injection promoted angiogenesis, reduced uterine scarring, and improved pregnancy outcomes, with no safety concerns observed over three years of follow-up. These findings highlight the translational promise of IMRCs as a novel therapeutic strategy for endometrial regeneration in severe IUA."

Journal • P1 data • Fibrosis • Immunology