mesenchymal stem cells / Tongji Hospital - LARVOL DELTA

Integrated Multi-Omics Profiling to Characterize Molecular Subtypes and Reveal Potential Therapeutic Strategies for Colorectal Cancer. (PubMed, MedComm (2020)) - "Moreover, it exhibited a higher stromal score, characterized by increased infiltration of fibroblasts, mesenchymal stem cells, and adipocytes, when compared with the S_II and S_III subtypes...Drug testing using cell lines and patient-derived three-dimensional (3D) bioprinted models revealed that S_I tumors were more responsive to Alisertib, suggesting subtype-specific therapeutic potential. Our study characterized the multi-omics landscape of CRC, offering critical insights into its molecular heterogeneity. These findings enhance our understanding of the molecular mechanisms underlying CRC and contribute to the development of personalized treatment strategies."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens. (PubMed, Front Immunol) - "Extended multi-injection schedules produced greater benefit. ADSCs represent a promising systemic immunomodulatory therapy for AR, with enhanced efficacy under longer treatment cycles."

Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • TGFB1

Vascular environment-responsive DNA nanoswitch controls the positive feedback system for spatiotemporal coupling of angiogenesis and osteogenesis. (PubMed, Biomaterials) - "Moreover, when modified with aptamer-19s, the nanoparticles can attract mesenchymal stem cells to perivascular areas, facilitating spatial coupling with blood vessels...Our findings provide valuable insights for designing intelligent materials that utilize endogenous stimuli to enhance spatiotemporal interactions between vascularization and ossification. Further in-depth studies on the expression of nucleolin in vivo will continue to refine this promising strategy."

Journal • MIR26A1 • NCL

Cross-Talk Between Hedgehog and PDGFRα Pathways in mMSCs Modulates Alveolar Bone Regeneration. (PubMed, Oral Dis) - "The cross-talk of Hh/PDGFRα c regulates mMSCs' osteogenic differentiation to promote alveolar bone regeneration. Targeting Hh/PDGFRα signaling may provide intervention strategies for bone regeneration therapies."

Journal • Transplantation • PDGFRA

Synergistic Effects of Therapeutic Ultrasound and Biomaterials in Osteoarthritis. (PubMed, Tissue Eng Part B Rev) - "This study elucidated the molecular mechanisms underlying the effects of US on synovium, cartilage, subchondral bone, and mesenchymal stem cells...This review highlights the innovative therapeutic potential of combining ultrasound (US), particularly low-intensity pulsed US, with biomaterials for OA treatment. By leveraging synergistic effects such as enhanced tissue repair, targeted drug delivery, and microenvironment regulation, this approach offers a noninvasive and effective strategy to mitigate OA progression and paves the way for advancements in musculoskeletal regenerative medicine."

Journal • Review • Immunology • Inflammation • Musculoskeletal Diseases • Osteoarthritis • Pain • Rheumatology

Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets. (PubMed, Nat Commun) - "We identify Sec14L6, a unique Sec14 family member, as a lipid transporter regulating phosphoinositide (PIP) homeostasis and LD biogenesis, promoting adipogenic differentiation of mesenchymal stem cells...Sec14L6 knockout significantly impaired LD formation; this defect was rescued by wild-type Sec14L6, but not by lipid-transfer-deficient mutants. Our study reveals an essential role for Sec14L6 in PIP homeostasis and promotes LD biogenesis through lipid transfer between the ER and LDs."

Journal • ACSL3

Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Patients with CKD Stages 3-4: A Randomized, Double-Blind, Placebo-Controlled Trial (KIDNEY WEEK 2025) - P1/2 | "The analysis of UC-MSCs effects on inflammatory cells revealed that UC-MSCs maintained stable NK cell counts, while placebo showed significant reduction, with between-group differences at 6 months (P=0.048) and 12 months (P=0.043) The intervention demonstrated acceptable safety, with non-significantly lower adverse events in the cell therapy group (20.0%) versus controls (30.0%) and absence of SAEs. Conclusion Cell infusion therapy demonstrates safety and potential efficacy in decelerating renal function progression in patients with stage 3-4 CKD."

Clinical • Chronic Kidney Disease • Nephrology • Renal Disease • CST3

Angiopoietin-like 8 governs osteoblast-adipocyte lineage commitment during skeletal aging. (PubMed, JCI Insight) - "A distinguishing feature of older mesenchymal stem cells (MSCs) from bone marrow (BM) is the transition in their differentiation capabilities from osteoblasts to adipocytes...Furthermore, treatment with Angptl8-Antisense Oligonucleotide (Angptl8-ASO) improved the phenotype of aging mice. The research proposes that ANGPTL8 is a critical regulator of senesence-related changes in the BM niche and the cell fate switch of MSCs."

Journal • Endocrine Disorders • Metabolic Disorders • Obesity • Orthopedics • Osteoporosis • ANGPTL8 • PPARG

Bone marrow mesenchymal stem cell-derived exosomal microRNA-335 alleviates vascular calcification by targeting SP1. (PubMed, Front Cardiovasc Med) - "In vivo studies confirmed that agomiR-335 treatment significantly lowered SP1 levels in the aorta of male SD rats, alleviating vitamin D3-induced VC. This study highlights that BMSC-derived exosomes regulate VC via the miR-335/SP1 axis, offering novel molecular targets for treating VC."

Journal • Atherosclerosis • Cardiovascular • MIR335 • RUNX2 • SP1

Sub-endometrial Injection of Human Embryonic Stem Cells-derived Immunity-and-matrix-regulatory Cells Promotes Endometrial Angiogenesis in Patients with Refractory Moderate-to-Severe Intrauterine Adhesion: An Open-label, Single-arm, Single-center, Phase I Dose-escalation Trial. (PubMed, Mol Ther) - "Clinical application of mesenchymal stem cells (MSCs) for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route...In a first-in-human, single-center, Phase I dose-escalation trial involving 18 patients with refractory IUA, high-dose sub-endometrial IMRC injection promoted angiogenesis, reduced uterine scarring, and improved pregnancy outcomes, with no safety concerns observed over three years of follow-up. These findings highlight the translational promise of IMRCs as a novel therapeutic strategy for endometrial regeneration in severe IUA."

Journal • P1 data • Fibrosis • Immunology

Bio-Scaffold Developed With Decellularized Human Amniotic Membrane Composite 3D Umbilical Cord Mesenchymal Stem Cell Spheroids Accelerate the Repair of Rat Defective Wounds. (PubMed, FASEB J) - "In rat animal experiments, histopathological examination confirmed that the healing quality of the biological dressing treatment group was higher; infiltrating fibroblasts were present in the dermis, neovascularization occurred, inflammatory infiltration was reduced, myofibroblast proliferation was reduced, collagen matrix production was reduced, and epidermal regeneration was complete. The biological dressing of 3D-UCMSCs-dHAM on the full-thickness defect wound of rats accelerates the remodeling and maturation of tissues, promotes the generation of neovascularization and the regeneration of skin attachments, and provides a new way for the treatment of 3D-UCMSCs in skin wounds in the future."

Journal • Preclinical

Engineering modification of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorates polycystic ovary syndrome by enhancing the ovarian environment and regulating follicular development. (PubMed, Stem Cell Res Ther) - "In this study, we engineered sEVs to deliver the 740Y-P peptide, demonstrating their capacity to mitigate ovarian inflammation, normalize follicular development, and enhance fertility in a PCOS mouse model. These findings propose a novel therapeutic strategy for PCOS, pending further optimization of delivery protocols and clinical validation."

Journal • Endocrine Disorders • Infertility • Inflammation • Polycystic Ovary Syndrome • Sexual Disorders • CD63

Unveiling exosomes in combating skin aging: insights into resources, mechanisms and challenges. (PubMed, Stem Cell Res Ther) - "Exosomes derived from mesenchymal stem cells (MSCs), adipose-derived stem cells (ADSCs), and other sources have shown promising results in enhancing skin cell proliferation and collagen synthesis and reducing oxidative stress, thereby mitigating both intrinsic and extrinsic skin ageing...However, despite their potential, the clinical application of exosome-based therapies faces challenges such as scalability of production, standardization of purification methods, and understanding of long-term effects. This comprehensive investigation emphasised the potential of exosomes in the fields of dermatology and regenerative medicine in combating skin ageing."

Journal • Review • Dermatology • Inflammation

LncRNA GABARAPL2 promotes non‑union long bone fractures by suppressing bone mesenchymal stromal cell osteogenesis. (PubMed, J Orthop Surg Res) - "These findings establish that lnc_GABARAPL2 may as a regulator of fracture healing and a promising predictive biomarker for non-union and targeting miR-302a-3p to modulate bone marrow mesenchymal stem cell functions, providing new insights for the development of RNA-based therapeutic strategies for impaired bone repair."

Journal • Inflammation • Musculoskeletal Diseases • Orthopedics • GABARAPL2 • RUNX2

Editorial: Diabetic wound: multifaceted mechanisms and future of diabetic wound healing, volume II. (PubMed, Front Endocrinol (Lausanne)) - No abstract available

Journal • Infectious Disease

pH-Dependent Osteoimmunomodulation: Molecular Mechanisms and Therapeutic Targeting in Bone Disorders. (PubMed, Pharmacol Res) - "The bone microenvironment represents a highly sophisticated ecosystem comprising diverse cellular components-including osteoblasts, osteoclasts, immune cells, endothelial cells, and mesenchymal stem cells-that interact dynamically to maintain skeletal homeostasis and facilitate repair...This review provides a comprehensive examination of: (1) the physiological principles governing acid-base balance in bone; (2) the pathological consequences of its dysregulation on bone remodeling via osteoimmune networks; and (3) the therapeutic promise of pH-modulating strategies for bone disorders such as osteoporosis and osteoarthritis. Our synthesis positions bone as a precision acid-base regulatory organ while establishing a mechanistic framework for developing targeted therapies that restore pH equilibrium in skeletal tissues."

Journal • Review • Immunology • Orthopedics • Osteoarthritis • Osteoporosis • Pain • Rheumatology

Precision medicine in premature ovarian insufficiency: a focus on the precision therapeutic strategies for mesenchymal stem cells. (PubMed, Stem Cell Res Ther) - "Additionally, it highlights the application potential of fetal adnexa sources, in site transplantation, hypoxic environment and three-dimensional cultivation strategy for MSCs and provides an integrated analysis of MSCs' dose efficacy inverted U-shaped relationship. Given the crucial role of MSCs' targeting ability and therapeutic duration in precision medicine, this paper further explores the challenges, existing strategies, and future development directions of MSCs in this field, intending to provide a comprehensive reference for future research and clinical translation of MSCs in female ovarian diseases."

Journal • Review • Transplantation • Women's Health

Stem Cell-Derived Exosomes with High Expression of PD-L1 as Nanotherapeutics in Rheumatoid Arthritis Model Mice. (PubMed, Int J Nanomedicine) - "To explore a novel therapeutic strategy targeting these cells, we aimed to develop mesenchymal stem cell-derived exosomes with enhanced PD-L1 expression (Exo-PD-L1) and evaluate their therapeutic potential in RA...No histological abnormalities were observed in the main organs of the mice. Exo-PD-L1 can be homed to inflammatory lesions and have the potential to treat RA."

IO biomarker • Journal • Preclinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IFNG • PD-L1

Dual-Mode Antibacterial Orthodontic Composite: Contact-Killing QACs and Sustained CHX Release via Large-Pore Mesoporous Silica Nanoparticles. (PubMed, Int J Mol Sci) - "The composite demonstrated good biocompatibility with human dental pulp mesenchymal stem cells at clinically relevant concentrations. This dual-mode design provides a clinically viable strategy to combat bacterial contamination in orthodontic treatments, with potential applications in other oral infections. Future studies will focus on validating efficacy in complex in vivo biofilm models."

Journal • Infectious Disease

Extracellular Vesicle-Integrated Biomaterials in Bone Tissue Engineering Applications: Current Progress and Future Perspectives. (PubMed, Int J Nanomedicine) - "Additionally, we summarize strategies for integrating EVs with various biomaterial scaffolds, with a specific focus on the latest advances in achieving controlled and sustained release of EVs from scaffolds at bone defect sites. Collectively, this review aims to offer key insights into the translational potential of EV-functionalized biomaterials and guide future directions in the development of next-generation bone regenerative therapies."

Journal • Review

Global research hotspots of stem cell therapy for rotator cuff injuries: A bibliometric and visualized analysis. (PubMed, J Orthop) - "Keyword analysis indicates a temporal shift, with "mesenchymal stem cells" and "rotator cuff repair" identified as predominant keywords...Stem cell therapy for rotator cuff injuries is a rapidly evolving field. Our analysis provides valuable insights into research trends and future directions, highlighting the potential of regenerative medicine and the necessity for collaborative efforts to advance this promising therapeutic approach."

Journal • Musculoskeletal Pain • Pain

Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development. (PubMed, Int J Nanomedicine) - "The E-EVs were using the EVs derived from Human Umbilical Cord Mesenchymal Stem Cells (HUMSCs)...This study offers valuable insights into the potential role of miR-218-5p in RIF and presents. The utilization of engineered vesicles containing anti-miR-218-5p may present a promising avenue for patients facing challenges with RIF."

Journal • Gynecology • CDX2 • MIR218 • NANOG • SOX2 • TEAD4 • YAP1

Poly-ε-caprolactone/chitosan/whitlockite electrospun bionic membrane conjugated with an E7 peptide for bone regeneration. (PubMed, Stem Cell Res Ther) - "The PCL/CS/WH/E7 membrane to achieve efficient repair of bone tissue and enriches clinical solutions for the treatment of critical bone defects."

Journal

miR-143-3p boosts extracellular vesicles to improve the dermal fibrosis of localized scleroderma. (PubMed, J Autoimmun) - "Bone marrow mesenchymal stem cells (BMSCs) derived extracellular vesicles (EVs) have been demonstrated promising therapeutic effects on the LoSc mouse model in our previous study...IGF1R, highly expressed in the skin of LoSc, was identified as a potential target of miR-143-3p and was inhibited by miR-143-3p-reinforced EVs, thereby modulating the IGF1/IGF1R-AKT/MAPK pathway. In conclusion, miR-143-3p-enriched EVs could be a more efficient candidate for treating dermal fibrosis in LoSc."

Journal • Fibrosis • Immunology • Scleroderma • Systemic Sclerosis • IGF1 • IGF1R • MIR143

Optimal dose of bone marrow mesenchymal stem cell transplantation for experimental ulcerative colitis. (PubMed, Regen Ther) - "There were more cells in colon on 14 day than 7 day, and less in the surrounding normal tissue on 14 day than 7 day. The density 5 × 106 is proper of bone mesenchymal stem cells for treatment of ulcerative colitis."

Journal • Bone Marrow Transplantation • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Transplantation • Ulcerative Colitis