mesenchymal stem cells / Tongji Hospital - LARVOL DELTA

PDGFRβ in Stem Cell Microenvironments: Cross-Tissue Evidence and Hypotheses for the Limbal Stem Cell Niche. (PubMed, Stem Cells Int) - "Evidence from hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), tumor stem cells (TSCs), renal glomerular cells, and limbal stem cells (LSCs) indicates that PDGFRβ+ stromal or perivascular cells contribute to niche architecture and function in a context-dependent manner...Collectively, available evidence supports PDGFRβ as a candidate link between vascular-stromal organization and stem cell functional states, while underscoring the need for direct PDGFRβ perturbation studies in LNCs to define its functional relevance in limbal niche stability and corneal epithelial regeneration. This framework may guide future studies of PDGFRβ-associated stromal regulation in corneal epithelial regeneration and LSC niche dysfunction."

Journal • Review • Fibrosis • Immunology • Oncology • PDGFRB

Human Umbilical Cord Mesenchymal Stem Cell Injection for Diabetic Nephropathy (clinicaltrials.gov) - P1 | N=15 | Recruiting | Sponsor: Tongji Hospital

New P1 trial • Diabetic Nephropathy • Nephrology • Renal Disease

Exosomal METTL16 from mesenchymal stem cells promotes malignant progression and M2 macrophage polarization in acute myeloid leukemia via IGF2BP2-dependent GPX1 m6A modification. (PubMed, Biochim Biophys Acta Mol Basis Dis) - "Exosomal METTL16 from AML-MSCs plays a crucial role in promoting leukemic cell survival and M2 polarization. Targeting this axis may provide a potential theoretical foundation to reverse M2 macrophage polarization and inhibit AML progression."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • GPX1 • IGF2BP2 • METTL16

Source-Dependent Mitochondrial Transplantation Drives Schwann Cell Bioenergetic Reprogramming and Peripheral Nerve Regeneration. (PubMed, Adv Healthc Mater) - "We systematically compared the differential effects of mitochondria derived from human induced pluripotent stem cells (iPSCs, iP-MT) and induced mesenchymal stem cells (iMSCs, iM-MT) on regulating SC metabolism and promoting peripheral nerve regeneration...MT reduced ROS accumulation, increased ATP production, and attenuated apoptosis under oxidative stress. This study reveals that MT promotes nerve repair by driving metabolic reprogramming rather than merely providing temporary energy, offering a new theoretical basis for optimizing the selection of mitochondrial donors."

Journal • Metabolic Disorders • Transplantation

The subacromial bursa in rotator cuff injury: from pathological contributor to regenerative resource? (PubMed, Front Bioeng Biotechnol) - "It contains mesenchymal stem cells (MSCs) with promising proliferative and tenogenic potential, secretes bioactive growth factors, and modulates the local immune microenvironment to promote reparative and anti-inflammatory responses conducive to tendon healing...Furthermore, we integrate multi-omics insights into bursa biology aimed at moderating the local microenvironment. Finally, we highlight current translational challenges and future directions to inform biologically guided and evidence-based management of the SAB for rotator cuff repair."

Journal • Review • Fibrosis • Inflammation • Musculoskeletal Pain • Orthopedics • Pain

Neuroprotective effect of mesenchymal stem cell-derived miR-143-3p on dopaminergic neurons via the TLR3/NF-κB/p53 signaling pathway. (PubMed, Stem Cell Res Ther) - "This study demonstrates that MSC-CM or its component miR-143-3p exert protective effects on mDANs against inflammatory injury, primarily by inhibiting the TLR3/NFκB/p53 signaling pathway."

Journal • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • Transplantation • IFNG • MIR143 • TLR3 • TNFA

Low frequency sinusoidal electromagnetic field accelerating intervertebral fusion through YAP/β-catenin axis. (PubMed, Stem Cell Res Ther) - "LF-SEMF promotes the differentiation of bone marrow mesenchymal stem cells into osteoblasts through YAP/β-catenin signaling pathway. The hydroxyapatite/collagen I composite scaffold loaded with bone marrow mesenchymal stem cells can effectively improve the fusion effect of caudal vertebral fusion by LF-SEMF."

Journal • CTNNB1

Multifunctional scaffold inspired by hepatocyte exosomes promotes bone regeneration by regulating osteogenic differentiation via PI3K/AKT pathway. (PubMed, Mater Today Bio) - "These PH/PDA scaffolds substantially enhanced bone mesenchymal stem cells (BMSCs) adhesion and proliferation, while the incorporated h-EXOs significantly promoted angiogenesis and osteogenic differentiation...Following implantation, PH/PDA/h-EXOs scaffolds induced substantial defect closure and fostered a regenerative microenvironment similar to native calvarial tissue, characterized by an expansion of anti-inflammatory M2 macrophages and osteoblasts alongside pronounced vascularization. Overall, this study leverages inter-organ crosstalk in conjunction with personalized scaffold fabrication to propose a novel tissue-engineering strategy for enhancing tissue repair."

Journal

Safety and Efficacy of Short-course Infusion of Human Umbilical Cord Mesenchymal Stem Cells for patients with CKD Stages3-4:A 2-Year, Double-Blind RCT (ERA 2026) - No abstract available

Clinical • Chronic Kidney Disease

Source-Dependent Mitochondrial Transplantation Drives Schwann Cell Bioenergetic Reprogramming and Peripheral Nerve Regeneration (ISPRM 2026) - "Mitochondrial transplantation (MT) has been proposed as a therapeutic strategy, but its effects beyond transient energy supplementation remain unclear.Design: Mitochondria from human induced pluripotent stem cells (iPSCs) and induced mesenchymal stem cells (iMSCs) were characterized by LC/MS metabolomics... Collectively, our findings demonstrate that iMSC-derived mitochondria promote nerve repair by driving metabolic reprogramming rather than merely providing transient bioenergetic support, thereby offering a mechanistic framework for optimizing mitochondrial donor selection in regenerative therapies."

Metabolic Disorders • Transplantation

Source-Dependent Mitochondrial Transplantation Drives Schwann Cell Bioenergetic Reprogramming and Peripheral Nerve Regeneration (ISPRM 2026) - "This study systematically compared mitochondria derived from human induced pluripotent stem cells (iPSCs) and induced mesenchymal stem cells (iMSCs) in regulating SC metabolism and promoting peripheral nerve regeneration, focusing on the two mechanistic hypotheses of "energy supplementation" and "metabolic reprogramming."Design: iPSCs and iMSCs were characterized by LC/MS-based metabolomics, and their mitochondria were analyzed via TEM... Collectively, our findings demonstrate that iMSC-derived mitochondria promote nerve repair by driving metabolic reprogramming rather than merely providing transient bioenergetic support, thereby offering a mechanistic framework for optimizing mitochondrial donor selection in regenerative therapies."

Metabolic Disorders • Transplantation

Sec31a and its impact on ER stress and Bmp/Smad signaling in senescent BMSCs. (PubMed, Tissue Cell) - "Cellular senescence diminishes the osteogenic potential of bone marrow mesenchymal stem cells (BMSCs), leading to age-related maxillofacial bone loss...Therefore, Sec31a modulates osteogenic differentiation in aged BMSCs through the Bmp4/Smad signaling pathway and via ER stress through a mechanism independent of this pathway. Our findings provide a theoretical perspective for treating age-related maxillofacial bone defects."

Journal • Osteoporosis • BMP4 • SEC31A

Targeting Tumor Stroma: Current Challenges and Future Directions. (PubMed, MedComm (2020)) - "Tumor stroma consists of both noncellular elements, particularly the extracellular matrix (ECM), and diverse stromal cells such as cancer-associated fibroblasts and mesenchymal stem cells...In addition, recent progress in preclinical studies and clinical trials of stromal-targeted therapies is highlighted. By integrating advances in tumor biology, nanomedicine, and translational oncology, this review provides a comprehensive perspective on stroma-targeted cancer therapy and outlines future directions for precision medicine."

Journal • Review • Oncology

A bilayer hydrogel enables spatiotemporal delivery of distinct hepcidin forms to reprogram macrophage responses for repair of infected bone defect. (PubMed, J Control Release) - "The upper layer, consisting of a PC10A-Hamp hydrogel loaded with hepcidin-overexpressing mesenchymal stem cells (PHMH), undergoes rapid degradation to provide early-stage antimicrobial immune activation, effectively eliminating bacteria, inhibiting biofilm formation, and scavenging excessive reactive oxygen species...Mechanistically, spatiotemporal hepcidin delivery orchestrates phase-adaptive macrophage reprogramming by maintaining M1 polarization during the infectious phase while driving Twist1-mediated M2 polarization during the resolution phase. Collectively, this bilayer hydrogel platform establishes a phase-adaptive immunomodulatory delivery strategy and offers a promising therapeutic approach for infected bone defect repair."

Journal • Immunology • Infectious Disease • Inflammation • TWIST1

Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies. (PubMed, Stem Cell Rev Rep) - No abstract available

Journal • Review • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology

Mesenchymal stem cells and secretome as modulators of neuroinflammation in neurological disorders. (PubMed, J Transl Med) - No abstract available

Journal • Review • CNS Disorders • Immunology • Inflammation

Therapeutic efficacy and mechanistic exploration of umbilical cord mesenchymal stem cell transplantation for non-obstructive azoospermia (EAU 2026) - No abstract available

Clinical • Transplantation

Dynamic hydrogels orchestrate the differentiation fate of mesenchymal stem cells through epigenetic regulation of SETD7 to accelerate bone defect repair. (PubMed, Bioact Mater) - "In the nucleus, β-catenin further formed a transcriptional complex with YAP to synergistically amplify downstream signals and potently activate the expression of Runx2, a key transcription factor for osteogenesis, which ultimately drove osteogenic differentiation and inhibited adipogenesis. The present study elucidated a novel mechanism by which cell-adaptive hydrogels regulate the β-catenin/YAP signaling loop through the miR-376a-3p/miR-127-5p-SETD7 axis, thereby determining the osteogenic/adipogenic differentiation of stem cells, which not only deepens our understanding of mechanotransduction but also provides new targets and material design strategies for bone regeneration."

Journal • MIR127 • RUNX2 • SETD7

A Nanococktail Strategy Regulating Circadian Clock and Re-Establishing Bone-Immune Balance for the Treatment of Senile Osteoporosis. (PubMed, ACS Nano) - "Circadian rhythm disorders impair the efferocytosis function of macrophages, leading to compensatory nonprofessional efferocytosis by bone mesenchymal stem cells (BMSCs)...Consequently, BMSCs are relieved from nonprofessional efferocytosis, leading to the restoration of their osteogenic capacity. In summary, this study introduces an innovative nanococktail strategy for the treatment of SOP by modulating both circadian clock-dependent efferocytosis function and the osteoblast/osteoclast balance."

Journal • Osteoporosis • Rheumatology • Sleep Disorder • CXCR4

Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration. (PubMed, Mater Today Bio) - "Under ultrasound stimulation, PVDF generates localized electrical cues that transiently elevate reactive oxygen species (ROS), activating the NRF2 antioxidant pathway to resolve oxidative stress, which polarizes macrophages toward pro-regenerative M2 phenotypes, enhances osteogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) and promotes angiogenesis in vitro...This platform transcends beyond passive scaffolding by recapitulating bone's electromechanical-immune axis offers a paradigm shift toward smart biomaterials for complex skeletal defects. The integration of PVDF's ultrasound-triggered piezoelectricity with SM's bioactivity establishes a multifunctional system that dynamically regulates redox homeostasis, immune modulation, and tissue remodeling, addressing unmet needs in bone tissue engineering."

Journal • Immune Modulation • Immunology

Biomimetic scaffolds with synergistic BMSC targeting and ROS scavenging for mitochondrial protection and effective bone-defect repair. (PubMed, J Nanobiotechnology) - "Exosomes (EXOs) derived from mesenchymal stem cells have emerged as promising tools for bone repair...On MitoQ incorporation, these EXOs (EXO-MitoQ, EM) exhibit the targeted scavenging of mitochondrial reactive oxygen species; moreover, on surface decoration with the nucleic acid aptamer Apt 19 S (EM-Apt), they show the enhanced recruitment and precise delivery of BMSCs...In a rat calvarial defect model, this TCP/SIS@EM-Apt scaffold increased the BV/TV by 1.9-fold compared to TCP/SIS, due to the combination of multiple multifunctional therapeutic effects (anti-inflammatory, angiogenic, and osteogenic). The mitochondria-targeting strategy proposed in this study presents a promising solution for the reconstruction of large bone defects and offers a synergistic approach for addressing complex regenerative challenges."

Journal

Proangiogenic Mechanisms and Modifications of Mesenchymal Stem Cells with a Focus on Neurological Disorders. (PubMed, Stem Cells Dev) - "This review focuses on the application of MSCs and their derivatives in neurological disorders, primarily exploring strategies to enhance their angiogenic effects, including pharmacological interventions, genetic modification, modulation of the culture environment, and the application of novel materials. Furthermore, the article prospects the potential application of MSC-mediated angiogenesis in the treatment of neurological disorders, specifically in the surgical management of ischemic cerebrovascular diseases."

Journal • Review • CNS Disorders • Vascular Neurology

Peripheral nerve repair: innovations and future directions. (PubMed, J Transl Med) - "Recent progress in biomaterial conduits, cell-free biologics, and biophysical stimulation is transforming PNI treatment and providing options that surpass conventional microsurgical repair. Continued advancement will require reliable biomarkers, standardized production and evaluation methods, and well-designed randomized controlled trials. Coordinated collaboration across research, clinical practice, industry, and regulatory agencies is essential to develop safe, effective, and widely applicable neuroregenerative therapies that restore meaningful function after peripheral nerve injury."

Journal • Review • Fibrosis • Immunology • Muscular Atrophy • Neuralgia • Pain • Transplantation

Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis. (PubMed, Cell Biol Toxicol) - "Animal study revealed that knockdown of exosomal METTL14 from AML-MSC reduced AML tumorigenesis by decreasing HOXA3 and WNT7B expression. AML-MSC-derived exosomal METTL14 facilitated AML cell growth and glycolysis by activating the HOXA3/WNT7B axis, providing a new mechanism for understanding AML-MSC-derived exosomes to promote AML progression."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • METTL14 • WNT7B

Dynamic stiffness drives BMSC chondrogenesis via Ihh-regulated H3K18 lactylation/Rcan1 axis and mitochondrial fission remodeling. (PubMed, Biomed Mater) - "Dynamic matrix stiffness, mimicking the physiological mechanical microenvironment, shows promise in directing stem cell chondrogenesis, but its molecular mechanisms remain unclear. Bone marrow mesenchymal stem cells (BMSCs) were cultured on engineered hydrogels with static soft (0.033 kPa), dynamic (0.031-0.126 kPa, time-dependent stiffening), and static stiff (0.126 kPa) conditions...Consistently, the LDHA inhibitor FX11 reduced lactate levels, diminished H3K18la, and downregulated Rcan1, confirming the metabolic dependence of this axis. RNA-seq analysis further established that Rcan1 overexpression reprogrammed signaling pathways critical for cell differentiation, including ECM-receptor interaction. Dynamic stiffness promotes BMSC chondrogenesis via the Ihh-H3K18la-Rcan1 axis, linking mechanical cues to epigenetic regulation of mitochondrial remodeling and providing a novel target for cartilage repair."

Journal • LDHA • SOX9