sotalol / Generic mfg. - LARVOL DELTA

Pharmacologic rhythm control for atrial fibrillation with dronedarone versus sotalol in patients with and without heart failure. (PubMed, Curr Probl Cardiol) - No abstract available

Journal • Review • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

Sotalol Continuous Infusions in Critically Ill Neonates and Children (SCCM 2026) - "Sotalol was initiated most commonly as a third-line anti-arrhythmic. There was variability between patients for the dosing and duration of sotalol. Four patients required dose adjustments or other interventions for an adverse event."

Clinical • Cardiovascular • Heart Failure • Hypotension • Ventricular Tachycardia

ASSESSING THE FEASIBILITY OF ICM-DERIVED QTC MEASUREMENT FOR LONG-TERM ARRHYTHMIA MANAGEMENT (ACC 2026) - " Patients admitted for sotalol or dofetilide initiation from March to August 2025 were enrolled. The presented feasibility study demonstrates that ICM sECGs may have the ability to support long-term QTc monitoring, with a mean absolute error within the accepted interobserver variability of 20 ms, although further work is needed. The SafeBeat platform displayed a promising ability to consistently monitor heart rhythms over several days to months, suggesting its potential to aid in long-term management of AF patients."

Cardiovascular

IT'S A NEW DAWN, IT'S A NEW DELTA WAVE - RECALCITRANT NEONATAL SVT CEASES WITH THE MANIFESTATION OF PREEXCITATION (ACC 2026) - "Therapy with amiodarone, flecainide, and propranolol finally achieved sinus rhythm with frequent AP echoes...The child remains SVT free on sotalol, propranolol and digoxin while weaning amiodarone at 1 year... Multidrug SVT therapy may create complex interactions."

Cardiovascular • Ventricular Tachycardia

VENTRICULAR TACHYCARDIA IN PREGNANCY (ACC 2026) - "Previously diagnosed with idiopathic VT from the cardiac crux and declined ablation, treated with Diltiazem 20mg and Flecainide 100mg...For recurrent VT antiarrhythmic therapy with Flecainide, Sotalol, or Mexiletine is recommended. VT is a rare but important to recognize complication of pregnancy. Arrhythmia in pregnancy should be managed with a multidisciplinary approach."

Cardiovascular • Ventricular Tachycardia

A COMPLEX CASE OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY REQUIRING MULTIPLE ABLATIONS AND HEART TRANSPLANTATION (ACC 2026) - "Management was complicated by intolerance and inefficacy of several antiarrhythmics, including sotalol, flecainide, mexiletine, and amiodarone. ARVC presents ongoing therapeutic challenges. Antiarrhythmic drugs and catheter ablation remain mainstays, though recurrence is common. A 2019 study showed an average of two ablations per patient."

Clinical • Cardiomyopathy • Cardiovascular • Fibrosis • Genetic Disorders • Immunology • Transplantation • Ventricular Tachycardia

COEXISTING CARDIAC SARCOIDOSIS AND LONG-STANDING SYSTEMIC LUPUS ERYTHEMATOSUS (ACC 2026) - "Decision-Making: An implantable cardioverter-defibrillator was placed, sotalol and guideline-directed medical therapy were initiated, and hydroxychloroquine was discontinued. The patient was later treated with prednisone for systemic symptoms but developed worsening heart failure, prompting discontinuation of steroids... The coexistence of cardiac sarcoidosis and SLE may be underrecognized. Clinicians should maintain a high index of suspicion for cardiac sarcoidosis in patients with SLE presenting with cardiac symptoms or arrhythmias and consider early utilization of advanced cardiac imaging. Future research is needed to better understand the overlap between autoimmune and granulomatous cardiovascular disease and to guide diagnostic and therapeutic strategies."

Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Sarcoidosis • Systemic Lupus Erythematosus • Ventricular Tachycardia • IL2

AVOID PREMATURE ABLATION: IDENTIFYING SYSTEMIC ETIOLOGIES IN WIDE COMPLEX TACHYCARDIA (ACC 2026) - "Amiodarone restored sinus rhythm and uncovered frequent monomorphic premature ventricular complexes (PVCs)...The working diagnosis was systemic sarcoidosis with cardiac involvement, and the patient was started on prednisone, methotrexate, sotalol, and an implantable cardioverter-defibrillator for secondary prevention... Monomorphic VT can be the initial manifestation of cardiac sarcoidosis, even in the absence of systemic symptoms. Maintaining a high clinical suspicion and utilizing advanced imaging enables the timely initiation of targeted therapy."

Cardiovascular • Heart Failure • Immunology • Sarcoidosis • Ventricular Tachycardia

WHEN SEPSIS, RDS AND PULMONARY HYPERTENSION AREN'T THE WHOLE STORY: DELAYED DIAGNOSIS OF INFRACARDIAC OBSTRUCTED INFRACARDIAC TOTAL ANOMALOUS PULMONARY VENOUS CONNECTION (TAPVC) IN A PREMATURE INFANT (ACC 2026) - "Postoperatively, ectopic atrial tachycardia was managed with sotalol... In premature infants with persistent or unexplained respiratory failure, TAPVC must remain on the differential, even in the presence of sepsis, RDS or pulmonary hypertension"

Cardiovascular • Hypertension • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock

CONTINUATION VERSUS INTERRUPTION OF MAINTENANCE ANTIARRHYTHMIC THERAPY IN ADULT INTENSIVE CARE UNIT PATIENTS (ACC 2026) - "Background: For patients admitted to an intensive care unit (ICU), there is limited guidance regarding the management of maintenance antiarrhythmic drug (AAD) therapy such as flecainide, propafenone, dofetilide, dronedarone, and sotalol...For patients who developed unstable arrhythmias, acute treatment with direct current cardioversion (DCCV) or pharmacological therapy, such as amiodarone, beta or non-dihydropyridine calcium channel blockers, or digoxin, will be recorded... Research is currently ongoing with the objective of gaining insight to prescribing patterns and clinical outcomes."

Clinical • Cardiovascular • Critical care • Ventricular Tachycardia

UNMASKING SOTALOL-INDUCED VASOSPASM: THE DIAGNOSTIC ROLE OF CORONARY MICROVASCULAR DYSFUNCTION TESTING (ACC 2026) - "This was resolved with nitroglycerin...Brief self-terminating SVT occurred following dobutamine discontinuation... Sotalol can precipitate coronary vasospasm in susceptible patients. Recognition of this association is essential, as discontinuation and transition to calcium channel blockers may significantly improve symptoms."

Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

ABLATION OF INTRA-ATRIAL REENTRANT TACHYCARDIA WITHIN THE LATERAL TUNNEL IN A PATIENT WITH FONTAN CIRCULATION (ACC 2026) - "Sotalol was precluded by prolonged QTc interval and dronedarone was trialed...Amiodarone was initiated; however, long term therapy was felt unfavorable due to younger age and co-existing liver disease... Patients with Fontan circulation have a proclivity for atrial arrhythmias, and AV dyssynchrony is poorly tolerated compared to two ventricle circulations. This case presents an example of successful intra-tunnel ablation of IART in a IALT Fontan with closed fenestrations."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology

EFFECTIVENESS AND SAFETY OF SOTALOL VERSUS DOFETILIDE IN PATIENTS WITH ATRIAL FIBRILLATION: A COMPARATIVE STUDY (ACC 2026) - "Preliminary findings are expected to provide comparative insights into the safety and effectiveness of sotalol versus dofetilide in patients with atrial fibrillation or atrial flutter."

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

ENHANCING RISK STRATIFICATION IN ATRIAL FIBRILLATION: PREDICTIVE VALUE OF INITIAL QTC PROLONGATION DURING ANTIARRHYTHMIC DRUG THERAPY (ACC 2026) - " We conducted a retrospective study of patients admitted for dofetilide or sotalol loading between July 2022 and April 2023 at a single center. An initial QTc increase >10.5% was the strongest predictor of adverse events during AAD initiation, outperforming traditional risk factors. This novel biomarker may serve as a simple, early indicator of AF patients that may be at higher risk for adverse events, enhancing risk stratification and patient-specific care strategies."

Atrial Fibrillation • Cardiovascular

SIROLIMUS FOR REFRACTORY SUPRAVENTRICULAR TACHYCARDIA IN A NEONATE WITH TUBEROUS SCLEROSIS COMPLEX AND MULTIPLE CARDIAC RHABDOMYOMAS (ACC 2026) - "He reliably converted to sinus rhythm by DOL 22 with a combination of sotalol (started DOL 12, maximum 9 mg/kg/day), amiodarone (10-20 mg/kg/day DOL 4-12; restarted DOL 19 at 5 mg/kg/day) and Sirolimus (trough 5-15 ng/mL). CRs associated with TSC are a rare but important cause of neonatal SVT. In addition to antiarrhythmic agents, mTOR inhibitors may play a role in treating patients with refractory arrhythmia and associated hemodynamic instability."

Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia • TSC1 • TSC2

TIMING AND MANAGEMENT OF RECURRENT ATRIAL FIBRILLATION IN PATIENS WITH HYPERTROPHIC CARDIOMYOPATHY (ACC 2026) - "After initial episode, 33 of the patients (22%) were started on an antiarrhythmic drug (AAD; most commonly amiodarone in 21; sotalol in 7), while 78% received no AAD. After an initial AF episode, almost half of HCM patients experience a recurrent episode within one year, with a similar rate of recurrence independent of AAD. Maintenance of SR was not significantly improved after CA, although the AF burden was significantly higher raising consideration for earlier CA. These data inform patient expectation on future AF risk, enhancing patient management discussion and underscore the unmet need for more effective therapy to improve rhythm control strategies in HCM."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy

EIGHT-YEAR SURVIVAL ON CONTINUOUS INOTROPIC THERAPY IN AN 86-YEAR-OLD WOMAN WITH END-STAGE HEART FAILURE: A CASE REPORT (ACC 2026) - "She later transitioned to Milrinone and was started on Sotalol to minimize VT burden...Milrinone was chosen for improved arrhythmia tolerance over Dobutamine... Personalized decision-making, caregiver support, cardiac rehabilitation, and multidisciplinary follow-up transformed "palliative" inotrope therapy into a viable destination strategy when Left Ventricular Assist Device and cardiac transplantation were not options."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Gastroenterology • Heart Failure • Infectious Disease • Palliative care • Thrombosis • Ventricular Tachycardia

COMPARISON OF SOTALOL AND DOFETILIDE FOR ANTIARRHYTHMIC DRUG LOADING IN PATIENTS WITH ATRIAL FIBRILLATION (ACC 2026) - "Compared to D, S is associated with lower rates of QTc PRO, drug discontinuation or dose reduction, and chemical cardioversion during AAD loading for AF. These findings may affect drug selection for antiarrhythmic drug loading."

Clinical • Atrial Fibrillation • Cardiovascular

WHEN ATRIAL FLUTTER IN ADOLESCENCE SIGNALS MORE: A CASE OF INVASIVE CARDIAC LIPOMA (ACC 2026) - "He was initially medically managed with sotalol and rivaroxaban, though cardiac transplantation was discussed and deferred by family...Following cardioversion with restoration of sinus rhythm, he was stabilized with amiodarone monotherapy... This case illustrates the complexity of invasive cardiac lipoma management, requiring a multimodal approach that balances surgical feasibility, medical stabilization, and transplant consideration, with close longitudinal follow-up to mitigate the risk of recurrent arrhythmias and cardiovascular compromise."

Clinical • Cardiovascular

DON'T GET UNDER MY SKIN: WHEN TO AVOID SUBCUTANEOUS IMPLANTABLE CARDIOVERTER DEFIBRILLATORS IN THE TREATMENT OF VENTRICULAR TACHYCARDIA (ACC 2026) - "Case: A 51-year-old male with non-ischemic cardiomyopathy, heart failure with reduced ejection fraction with primary prevention S-ICD, VT (previously trialed on carvedilol, sotalol, amiodarone) presented for symptomatic episodes of sustained monomorphic VT with cycle length 400 ms (heart rate 150 bpm) which were not treated by S-ICD. Prior to S-ICD implantation, it is important to consider the possibility of future episodes of slow VT occurring at rates below the device's therapeutic parameters (<170 bpm). The newly developed S-ICD systems should incorporate algorithms that can safely discriminate and treat slower VT in specific clinical scenarios."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

HOME IS WHERE THE HEART IS: TRANSLATING EVIDENCE INTO PRACTICE FOR A HYBRID SOTALOL INITIATION PROTOCOL (ACC 2026) - "This hybrid outpatient initiation sotalol protocol is feasible, safe, and sustainable. Standardizing workflows can decrease inpatient LOS, optimize resource use, and enhance patient experience. This model may be scalable across institutions to improve efficiency in antiarrhythmic initiation."

Clinical • Atrial Fibrillation • Cardiovascular

PREPROCEDURAL CLASS III ANTIARRHYTHMIC THERAPY AND CONDUCTION DISTURBANCES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) (ACC 2026) - "The effect of class III antiarrhythmic drugs (AADs; sotalol, amiodarone, dronedarone and dofetilide) on these complications remains unclear. Pre-procedural class III AAD use was associated with reduced new-onset AF following TAVI but did not significantly influence conduction disturbances or PPM implantation. Further prospective studies are needed to clarify their role in optimizing post-TAVI outcomes."

Atrial Fibrillation • Cardiovascular

COMPARATIVE OUTCOMES OF ANTIARRHYTHMIC THERAPY ALONE VERSUS COMBINED IMMUNOSUPPRESSIVE STRATEGIES IN SARCOIDOSIS WITH VENTRICULAR TACHYCARDIA (ACC 2026) - " We used TriNetX to identify adults with sarcoidosis and VT treated with antiarrhythmic drugs (AAD: amiodarone/sotalol). Patients were grouped into three groups: AAD only, AAD+steroids, and AAD+steroids+immunosuppressants (e.g., methotrexate, azathioprine, infliximab)... In this 5-year retrospective study, adding immunosuppressive therapy to AADs in sarcoidosis with VT was linked to reduced all-cause mortality."

Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Sarcoidosis • Ventricular Tachycardia

SAFETY AND EFFICACY OF EXTENDED OUTPATIENT MONITORING WITH SAME DAY DISCHARGE AFTER IV SOTALOL LOADING IN PATIENTS WITH ATRIAL FIBRILLATION (ACC 2026) - "IV sotalol was effective for rhythm control, and structured outpatient cardiac monitoring enabled safe early discharge while helping prevent readmissions and mortality from pro-arrhythmic complications."

Clinical • Atrial Fibrillation • Cardiovascular

DIFFERENTIAL ADVERSE EVENT PATTERNS IN SOTALOL AND DOFETILIDE USE FOR ATRIAL FIBRILLATION (ACC 2026) - "Cardiac AEs and AF recurrence are commonly reported to the FDA in patients taking sotalol and dofetilide. While TdP was found to be more common in patients prescribed sotalol, AF recurrence was most commonly reported with dofetilide use. These factors may influence decision-making when selecting AADs for AF patients."

Adverse events • Atrial Fibrillation • Cardiovascular • Ventricular Tachycardia