S-1117 / Seismic Therap - LARVOL DELTA

Understanding the menopause transition in sickle cell disease: An analysis of the implementation of the adapted menopause quick 6 (ASH 2025) - "Treatment use included hydroxyurea (45%mean dose: 1117 ± 444 mg/day; median: 1000), chronic exchange transfusion (10%), L-glutamine (2%),and voxelotor (7%). Half reported chronic opioid use (mean: 113 ± 115 MME/day), and 21% were takingmedications against neuropathic pain (e.g., gabapentin)...Midlife women with SCD report a substantial burden of menopausal symptoms—particularly hot flashes,sleep disturbances, and joint pain. Symptom burden appears influenced by age and hematologicparameters, while disease-modifying therapies may mitigate reported symptoms or individuals withsevere disease may not experience the typical hormonal related menopausal symptoms. These findingslay some foundational groundwork for future studies examining the interplay between disease severity,treatment, and reproductive aging in women with SCD."

CNS Disorders • Genetic Disorders • Hematological Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Sickle Cell Disease • Sleep Disorder • Women's Health

Persistent organic pollutants in migratory birds from wetlands of southern Primorye, Russia. (PubMed, Sci Total Environ) - "The total POP content in feathers ranged from 0.4 to 44.5 ng/g dry weight (dw); in muscles, from 9.0 to 282.4 ng/g lipid weight (lw); and in the liver, from 12.1 to 1117.1 ng/g lw...The observed differences between the species in POP accumulation are associated with their ecological characteristics including diet, migration routes, and habitats. The results show that the pollution levels in southern Primorye are lower or comparable to those reported for other Asian regions, but the global background of pesticides still continues to have an impact on ecosystems."

Journal

Machine learning-assisted prediction of speech outcomes at age 5 in patients with nonsyndromic cleft palate after double-opposing Z-plasty. (PubMed, J Plast Reconstr Aesthet Surg) - "This retrospective cohort comprised 1117 patients with nonsyndromic cleft palate (NSCP) who underwent double-opposing Z-plasty (DOZ) by a single surgeon between 1988 and 2017...Early small fistulae contributed moderately to hypernasality prediction but were negligible for therapy prediction. This machine learning model, implemented as a web-based calculator (https://cp-speech.mdbcdss.com/), provides an accessible decision-support tool for early risk stratification of speech outcomes at age 5 after DOZ in patients with NSCP."

Journal

Prevalence and associated plasmid resistant genome of ESBL and AmpC producing commensal E. coli isolated from lactating cows and pre-weaned calves on dairy farms in Western Australia. (PubMed, Prev Vet Med) - "Phenotypic analysis of 1117 faecal samples from 26 Western Australian dairy farms revealed a low overall prevalence (7.3 %) of ESBL and/or AmpC-producing commensal E. coli, with 3.2 % in cows (n = 633) and 12.8 % in calves (n = 484). All isolates were classified 'non-wildtype' for ampicillin and ceftiofur, with 95.1 % classified as 'non-wildtype' multidrug resistant (MDR)...Multiple correspondence analysis (with chi-square-based 95 % confidence ellipses) showed variation in pDNA AMR genes and replicons by farm, with generally distinct plasmid profiles, though some clustering suggests possible farm-to-farm plasmid transmission. In conclusion, though low in prevalence, ESBL and/or AmpC producing commensal E. coli having high phenotypic AMR, MDR, and pDNA diversity were isolated from dairy cattle on 65.4 % of screened farms."

Journal

Comparative Efficacy of Negative Pressure Wound Therapy and Conventional Treatments in the Management of Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis. (PubMed, J Clin Med) - " A total of 11 clinical trials involving 1117 subjects...Although no significant differences were found in amputations or infections, this therapy reduces pain and decreases the use of antibiotics and analgesics. Its use requires individual and expert assessment to maximize its benefits."

Journal • Retrospective data • Review • Diabetes • Infectious Disease • Metabolic Disorders • Obesity • Pain

Ultrasound-Guided Regional Anesthesia as Primary Analgesic Management in the Orthopedic-Surgical Emergency Department of an Affiliated Hospital: A Retrospective Analysis over a 6-Year Period. (PubMed, Medicina (Kaunas)) - " A total of 1292 patients (3.7%) underwent either pRA (n = 1117; 3.2%) or PS (n = 175; 0.5%)... US-guided pRA proved to be an effective and safe alternative to PS, GA, or systemic analgesia for selected indications, allowing immediate treatment without the need for operative capacities. To ensure safe application, these techniques should be an integral part of the training curriculum for ED personnel."

Journal • Retrospective data • Anesthesia • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A continuous-wave photon-pair source operating in L-band through spontaneous four-wave mixing in birefringent ZBLAN fiber. (PubMed, Sci Rep) - "Then, we experimentally generated signal and idler photons with center wavelengths of 1117 and 1578 nm using a 1310 nm CW laser as a pump light source and measured their quantum optical properties. The maximum coincidence-to-accidental ratio was calculated to be 22, resulting in a photon-pair brightness of 3.16 × 104 pairs/s/nm/mW. The results show the feasibility of using ZBLAN fibers in quantum optics as an efficient platform for generating a quantum light source."

Journal

Proportion of Fast Progressors in the Central versus Global Visual Field Across Varying Glaucoma Severity Groups. (PubMed, Am J Ophthalmol) - "Selective analysis of the MTD10 detected a greater proportion of eyes that exhibited fast progression across all disease severity groups compared to measurements from the entire VF, underscoring the importance of close monitoring for progressive central VF changes in all stages of glaucoma."

Journal • Glaucoma • Ophthalmology

Variation in the efficiency of English general practices and associated factors: A cross-sectional study of 5069 general practices. (PubMed, Eur J Gen Pract) - "Of 5069 practices, 1117 were classified as efficient, 2773 as neutral, and 1179 as inefficient...Smaller practices were more efficient. Therefore, policies that encourage practice mergers may not deliver the efficiency gains expected."

Journal • Observational data

Quantitative T1 and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T1-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts. (PubMed, Imaging Neurosci (Camb)) - "PD* maps and high precision T1 maps were produced at 7T with 0.65 mm resolution in 7:18 min:s from an MP2RAGE protocol, previously optimised for UNI and FLAWS-related contrasts by incorporating the excitation flip angle and inversion efficiency B1 + effects into the fit. Average WM T1 values of adults and children were very similar (1092 vs. 1117 ms) while expected reductions in T1 with age were found in deep GM."

Journal

Cancer risks for MSH6 pathogenic variant carriers. (PubMed, Eur J Cancer) - "These refined, age- and sex-specific risk estimates for MSH6 PV carriers inform tailored surveillance strategies, supporting delayed CRC screening and individualised counselling on risk-reducing surgery for women."

Journal • Biliary Cancer • Biliary Tract Cancer • Breast Cancer • Colorectal Cancer • Endometrial Cancer • Genetic Disorders • Oncology • Ovarian Cancer • Solid Tumor • MSH6

Autologous Stem Cell Transplantation for Multiple Myeloma in Algeria (ASH 2023) - "Patients and Over a period of 23 years, from April 1998 to December 2021, 1117 pts with MM (mainly of the IgG type: 604 pts, 54.1%) benefited from ASCT in 8 Algerian centers (Oran: 478, Algiers CPMC: 376, Batna: 76, Blida: 55, Tlemcen: 38, Algiers Military hospital: 32, Oran military hospital: 32, Beni Messous: 30)...Several induction protocols were used depending on the period and the department: VAD (200 pts, 17.9%) and Bortezomib-based (799 pts, 80.7%)...Conditioning based on Melphalan 140 or 200 mg/m2 is widely used (977 pts, 87.4%), followed by reinjection of grafts made of PBSC obtained after mobilization by G-CSF alone, administered, at a dose of 10 at 15 µg/kg/d, including 755 (67.6%) no-cryopreserved cells...Six hundred and twenty-one pts (55.6%) received consolidation treatment combining Bortezomid (VRD, VCD or VTD) and 614 pts (55%) received maintenance treatment mainly with thalidomide (533 pts, 47.7%)... This long-term follow-up study shows the..."

Hematological Malignancies • Multiple Myeloma • Oncology • Transplantation

Outcomes and Prognostic Factors in Patients with Primary Mediastinal B Cell Lymphoma: An Experience from Hematology Cancer Consortium (ASH 2023) - "The median LDH at presentation was 673 units/Litre(IQR: 405 – 1117.5). A total of 79 patients(83.2%) received DA-R-EPOCH as first-line chemotherapy, 9 patients(9.5%) received R-CHOP and the remaining patients received other regimens(COP, CHOP-E)...In contrast to the previous DA-REPOCH trials, close to 40% of the patients received RT as consolidation. Being a retrospective study, selection bias remains a major limitation of this analysis."

Biomarker • Clinical • B Cell Lymphoma • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Lymphoma • Mediastinal B Cell Lymphoma • Mucositis • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Primary Mediastinal Large B-Cell Lymphoma • Rare Diseases

Preclinical Polypharmacology of S-1117, a Novel Engineered Fc-Fused IgG Degrading Enzyme, for Chronic Treatment of Autoantibody-Mediated Diseases (ASH 2024) - "Advantages of enzymatic degradation, sustained PK and titratable PD demonstrate superiority in human IgG cleavage compared to a benchmark FcRn inhibitor and are expected to enable a convenient patient-tailored treatment regimen. Given its ability to addresses multiple pathogenic mechanisms as a single drug, S-1117 has the potential to provide improved clinical outcomes in autoantibody-mediated diseases with complex pathology, such as ITP and other cytopenias, as demonstrated in the prophylactic and therapeutic ITP murine models."

Preclinical • Anemia • Autoimmune Hemolytic Anemia • Hematological Disorders • Immune Thrombocytopenic Purpura • Immunology • Inflammation • Thrombocytopenia • Thrombocytopenic Purpura

BTK Inhibition Prevents the Induction of Myeloid-Derived Suppressor Cells in Malignancy and Improves CART Function (ASH 2024) - P1, P2 | "2016 Mar : 1117-27)...Since ibrutinib inhibits several kinases, we tested a more selective BTK inhibitor (acalabrutinib) and again found that immunophenotypic and functionally defined MDSC formation was prevented (p < 0.0001 for both analyses)...These data suggest that ibrutinib improves CART19 therapy in CLL not by generating functionally superior CART cells per se, but by preventing the formation of MDSC, thus removing a critical counter-regulatory break on CART function. These results provide a mechanism by which ibrutinib can enhance CART therapy in CLL and beyond."

Myeloid-derived suppressor cells • Chronic Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology • Pancreatic Cancer • Solid Tumor • CD14 • CD33 • IFNG • IL10 • IL13 • IL2 • IL4 • IL6 • TNFA

Protein carbamylation is associated with increased mortality and CKD progression in patients with CKD: results from the EQUAL study. (PubMed, Clin Kidney J) - "In a subgroup of 1117 patients, C-Alb was measured at baseline using combined liquid chromatography and mass spectrometry...HR 1.59, 95%CI 1.21-2.09). In older advanced CKD patients not on dialysis, increased levels of C-Alb were associated with higher mortality and need for dialysis."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure

Low-Residue Diets Paired With Low Volume Preparations: A New Paradigm for Colonoscopy Bowel Prep – A Meta Analysis (ACG 2025) - "A total of 8 studies with 2338 patients were included. 1117 patients underwent CLD preparation, and 1221 patients underwent LRD preparation. Findings suggest that LRD is non-inferior to CLD regarding bowel preparation adequacy (OR: 0.70, CI [0.26, 1.88], p = 0.48)."

Retrospective data

Acupuncture for polycystic ovary syndrome. (PubMed, Cochrane Database Syst Rev) - "We found no clear evidence of a difference between acupuncture and sham acupuncture in rates of live birth, multiple pregnancy, ovulation, clinical pregnancy, miscarriage, or restoration of regular menstrual periods. Acupuncture is probably associated with a greater risk of adverse events. It is unclear whether acupuncture improves ovulation rate compared with relaxation or Diane-35. In studies that compared acupuncture with exercise, no intervention, clomiphene, and Diane-35, adverse events reported in the acupuncture group included vaginal bleeding, weight gain, fatigue, dizziness, nausea, and subcutaneous haematoma. The limited number of RCTs and variability in outcome reporting mean that the effectiveness of acupuncture for PCOS remains uncertain."

Journal • Review • Fatigue • Gynecology • Infertility • Pain • Polycystic Ovary Syndrome • Sexual Disorders

Characterization of S-1117, a novel pan-IgG protease engineered for reduced immunogenicity using the IMPACT platform (ACR Convergence 2025) - "S-1117 is a novel pan-IgG protease engineered with our machine learning enabled platform to reduce immunogenicity. It demonstrates rapid, deep, and sustained reduction of IgG levels, IgG effector function, and cleavage of the IgG+ BCR on memory B cells, reducing BCR mediated B cell activation. Advantages of enzymatic degradation, sustained PK, and titratable PD are expected to enable a convenient patient-tailored treatment regimen."

ANCA Vasculitis • Genetic Disorders • Glomerulonephritis • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Myositis • Nephrology • Sjogren's Syndrome • Vasculitis • CD4

Exploring the role of the gut microbiome in gout: Prospective analysis of dietary fiber intake and the risk of gout (ACR Convergence 2025) - "We used multivariable Cox proportional hazard models to evaluate the associations between quintiles of dietary fiber intake and incident gout. We documented 1117 gout cases over 2,218,527 person-years of follow-up... Long-term dietary intake of fiber, particularly fiber sourced from cereals and fruits, is independently associated with a lower risk of incident gout among women. These findings support a role for fiber in the pathogenesis of gout, potentially by modulating the gut microbiome."

Clinical • Addiction (Opioid and Alcohol) • Gout • Inflammatory Arthritis • Rheumatology

Rhabdias aegyptiaca El-Garhy & Garo, 2006 (Nematoda: Rhabdiasidae), parasitic in Sclerophrys regularis (Reuss) (Anura: Bufonidae) with a preliminary treatment of the problematic taxonomic status of North African Rhabdias. (PubMed, Zootaxa) - "Rhabdias aegyptiaca differs from other African congeners in the combination of the following characteristics: truncate anterior end, buccal capsule 1117 (15 0.4) m wide, four submedian circumoral lips with two lateral pseudolabia, esophagus with dilatation at end of first third and tail wholly covered with inflated cuticle except for its end tip...Rhabdias bufonis sensu Moravec, Baru & Ryav, 1987 is considered a highly likely stand-alone Saharo-Arabian species, distinguished from the complex of Rhabdias bufonis (Schrank, 1788) Stiles & Hassall, 1905 by its pre-equatorial vulva, and largely sized buccal capsule and eggs. However, their specimens still need futural re-investigation for an appropriate description and designating type specimens."

Journal

SmallBARNA 2026: a kingdom-wide bacterial sRNA resource. (PubMed, Nucleic Acids Res) - "In this paper, we hand-curate 1117 articles from the literature to find 746 sRNAs that have been confirmed by northern blotting, quantitative polymerase chain reaction (qPCR), mutagenesis, or other functional validation methods...Finally, we also quantify these sRNAs in a filtered subset of 5292 isolates with available RNA-seq data from the Sequence Read Archive. The bona fide set, alignment, and expression information is available for download and interactive exploration at https://web.ccb.uni-saarland.de/smallbarna/."

Journal

Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology. (PubMed, Proc Natl Acad Sci U S A) - "These findings highlight the therapeutic potential of S-1117 in neutralizing AChR-IgG Fcγ-mediated effector functions and reveal an MG subset driven by IgM pathology. Our study shows that targeting both IgG- and IgM-mediated mechanisms with therapeutic proteases provides an approach to MG treatment and establishes a framework for patient stratification based on disease mechanisms, advancing precision medicine in MG."

Journal • CNS Disorders • Immunology • Myasthenia Gravis

Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria. (PubMed, Cochrane Database Syst Rev) - "Pyronaridine-artesunate was efficacious against uncomplicated P falciparum malaria; achieved a PCR-adjusted treatment failure rate of less than 8% at days 28 and 42; and may be at least as good as artesunate-amodiaquine and artesunate-mefloquine (based on 1 RCT per drug) and may be at least as good as, or better than, artemether-lumefantrine. Pyronaridine-artesunate increases the risk of episodes of abnormally raised ALT and AST compared to other studied therapeutics."

Clinical • Journal • Review • Hepatology • Infectious Disease • Liver Failure • Malaria

Transcriptomic and gut microbiome markers of treatment-resistant schizophrenia (ECNP 2025) - "TRS has been suggested to be heritable, and the elucidation of its molecular underpinnings would be of help to move towards early detection and treatment with clozapine, the only antipsychotic approved for TRS...Analyses of the gut microbiota composition showed lower alpha-diversity in patients with TRS based on the ACE (Mann-Whitney U = 1142, p = 0.03) and Fisher (Mann-Whitney U = 1117, p = 0.048) metrics, but not the Chao1 (Mann-Whitney U = 1106, p = 0.06) and Shannon metrics (Mann-Whitney U = 927, p = 0.76)... Our findings suggest overexpression of the XIST lncRNA (previously suggested to be involved in schizophrenia and affective disorders), lower gut microbiome diversity and differences in the abundance of specific gut microbiome features in patients with TRS."

CNS Disorders • Mental Retardation • Psychiatry • Schizophrenia • XIST