S-1117 / Seismic Therap - LARVOL DELTA

Genotypic and Phenotypic Characterisation of Staphylococcus aureus Enterotoxins Using Single-Cell Raman Spectroscopy and Metabolomics. (PubMed, Pathogens) - "Furthermore, the CNN analysis identified characteristic spectral peaks for S. aureus enterotoxin genotypes at 1663-1665 cm-1, 1570 cm-1, and 1117-1119 cm-1, corresponding to protein α-helices, guanine, and nucleic acid backbones respectively...Thus, this study employed S. aureus as a proof-of-concept, establishing for the first time a method combining Raman laser tweezers with convolutional neural networks for identifying S. aureus enterotoxin genotypes and phenotypes. It clarified the Raman spectral differential peaks and their corresponding biomarkers among five classical enterotoxin genotypes and phenotypic strains, providing a novel approach for accurate toxin typing and virulence characterisation."

Journal

Rift Valley Fever Virus Exposure in Camels and Horses Across Northern Nigeria Livestock Markets. (PubMed, Pathogens) - "A total of 1117 animals were sampled, comprising camels (812) and horses (305), across three major livestock markets (Maigatari, Maiduguri, and Illela)...However, in horses, females were significantly more likely to test positive than males (OR = 0.27, 95% CI: 0.07-0.97). These findings demonstrate endemic RVFV circulation in Nigerian livestock, highlighting species- and location-specific differences, and underscore the zoonotic risks within regional and transboundary livestock trade networks."

Journal • Respiratory Diseases

Mouse Models Drive Progress in Alport Syndrome Therapy Development (IMMUNOLOGY 2026) - "Finally, Col4a5-R471X mice were employed to evaluate the efficacy of ACEi (ramipril) monotherapy. Phenotypic analysis revealed that both Col4a5-R471X and Col4a5-R373X mice developed AS-like pathology, characterized by elevated urinary albumin, albumin-to-creatinine ratio, serum urea, creatinine and total protein levels. In conclusion, these COL4A5 mutant mouse models offer an valuable preclinical platform for investigating AS pathogenesis and developing new therapeutic interventions."

Preclinical • Fibrosis • Genetic Disorders • Immunology • Inflammation • Nephrology • Renal Disease • COL4A5

S-1117, an engineered pan-IgG cleaving enzyme, reduces IgG BCR mediated B cell activation and removes Fc fragments from tissue-bound anti-AChR IgG (IMMUNOLOGY 2026) - "Collectively, these mechanisms have the potential to drive superior clinical outcomes in autoantibody-driven diseases."

Immunology • SYK

Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases. (PubMed, Proc Natl Acad Sci U S A) - "S-1117 cleavage of IgG reduces circulating levels of IgG, including pathogenic IgG autoantibodies and IgG immune-complexes, and reduces IgG antibody effector functions, such as complement fixation, antibody-dependent cellular cytotoxicity, and antibody-dependent cell phagocytosis. The polypharmacology of S-1117 further extends to cleaving the antigen receptor on IgG-positive memory B cells, thereby modulating activation of memory B cells."

Journal • Immunology

Exploring the use of GLP-1 and GIP/GLP-1 medications in people on renal replacement therapy, an observational cohort study. (UKKW 2026) - "Thirty-five were on HD (3.1% of 1117 patients on HD) and five on PD (2.6% of 191 patients on PD)...Semaglutide injection was the most prescribed medication (28%), followed by Tirzepatide (23%), Semaglutide tablets (20%), Liraglutide (17%), and Dulaglutide (12%)... GLP-1 and GLP-1/GIP medications are being used in the local RRT population, with over half of the patients showing meaningful weight loss and increases in transplant eligibility. Better integration of dietetic care may enhance outcomes, both in terms of weight loss but also nutritional adequacy."

Observational data • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Sarcopenia • Type 2 Diabetes Mellitus

Natural Polymer-Based Mechanically Strong Hydrogel with Fast Self-Healing for Heavy Metal Ions Removal and Supercapacitor Applications. (PubMed, Polymers (Basel)) - "It demonstrates tunable mechanical strength with toughness of 137 kJ/m3 and elongation at break up to 1117%, alongside exceptional swelling capacity (448 g/g)...Protonic modulation via H2SO4 soaking significantly enhances ionic conductivity, electrochemical performance, and cycling stability. These findings highlight the potential of natural polymer-based, mechanically robust, self-healing hydrogels for sustainable wastewater treatment and advanced energy storage applications."

Journal

Predictors for the Development of Invasive Infection of Fluconazole Non-Susceptible or Echinocandin Non-Susceptible Candida Species Across the Veterans Health Administration. (PubMed, Ann Pharmacother) - "These findings can inform antifungal stewardship efforts to curb the rise of resistant Candida sp."

Journal • Candidiasis • Infectious Disease

CCR-CCL axes as key upstream influencers of pancreatic ductal adenocarcinoma: CCR2-CCL2, CCR5-CCL5, CCR4-CCL17/22, CCR6-CCL20, CCR7-CCL19/21. (PubMed, Front Immunol) - "We further detail past and ongoing therapeutic efforts and trials addressing these axes in both PDAC and relevant non-PDAC settings via several small-molecule antagonists and monoclonal antibodies: BMS-813160, Maraviroc, Leronlimab, FLX475, PF-07054894, IDOR- 1117-2520, and CAP-100. Despite continuous advances in the field, the current body of evidence remains limited and presents significant research gaps in areas such as spatial profiling, stage-specific analyses, and general mechanistic validation in PDAC-specific settings. Addressing these shortcomings will be key to developing a more comprehensive knowledge of the field and improving future therapeutic strategies to overcome PDAC."

IO biomarker • Journal • Review • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • CCL19 • CCL2 • CCL20 • CCR2 • CCR4 • CCR6 • CCR7

Perivitelline Membrane-Bound Sperm as a Source of Paternal Genomic DNA to Inform Breeding Male Marine Turtle Genetics and Demographics. (PubMed, Ecol Evol) - "Sampled offspring genotypes (620 loggerhead and 1117 green turtle) provided ground-truthing of PVM sperm allele detections...Its scalability across space and time enables long-term monitoring of MP and BSR, key demographic metrics for assessing population viability under climate change. Male genotypes generated from the PVM in single paternity nests may also inform population assignment, assessments of genetic connectivity, and relatedness analyses."

Journal

Clinical Evidence Linkage From the American Society of Clinical Oncology 2024 Conference Poster Images Using Generative AI: Exploratory Observational Study. (PubMed, JMIR AI) - "This study presents a novel artificial intelligence-driven methodology for enhancing research discovery and attention analysis from nontraditional clinical scholarly outputs. The American Society of Clinical Oncology was used as an example, but this methodology could be used for any conference and clinical poster."

Journal • Observational data • Breast Cancer • Oncology • Solid Tumor

Individual characteristics associated with youth symptom reports and persisting symptoms after concussion. (PubMed, J Neuropsychol) - "This analysis involved 1947 Post-Concussion Symptom Scale reports from 1117 youths (11-21 years): 380 with mTBI, 737 without mTBI (194 healthy non-mTBI; 543 non-mTBI with underlying medical conditions)...Medical and sociodemographic factors affect concussion symptom reports and influence PSaC rates. A single-item screener for PSaC may be useful but risks over-detection among certain youths."

Journal • CNS Disorders • Orthopedics • Pediatrics • Psychiatry • Vascular Neurology

Differential Toxicity of Ionic Silver and Silver Nanoparticles: A Meta-Analysis of Ecotoxicological Studies. (PubMed, Toxics) - "We screened 1117 studies published between 1945 and 2024, systematically applied the screening criteria and analyzed 28 data sets from 11 studies that met the eligibility and data quality criteria...A key point in this study is that the evidence base covers the years representing the broadest temporal scope among comparable studies. The results provide a quantitative synthesis of the existing literature, allowing for the identification of generalizable trends regarding the ecotoxicological effects of silver and shed light on the environmental risk assessment processes of silver forms."

Journal • Retrospective data

Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial. (PubMed, BMJ) - P=N/A | "In ovulatory women, a natural ovulation regimen for endometrial preparation was as effective as programmed regimen in terms of achieving a healthy live birth after frozen embryo transfer, but with a lower risk of maternal complications during pregnancy."

Clinical • Journal • Gynecology • Postpartum Hemorrhage

Blood-Based Immunoglobulin-Bound Neoantigen Signatures Associated with Multiple Endocrine Neoplasia Type 1-Related Duodenopancreatic Neuroendocrine Tumor Progression. (PubMed, J Am Coll Surg) - "We have uncovered antigenic protein signatures in the form of a humoral response that is associated with development and progression of MEN1-related dpNETs."

IO biomarker • Journal • CNS Disorders • Endocrine Disorders • Gastrointestinal Neuroendocrine Tumor • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Solid Tumor • TP53

Economic Evaluation and Budget Impact Analysis of Secukinumab as a Second-Line Treatment Among Patients With Psoriatic Arthritis Who Were Tumor Necrosis Factor Inadequate Responders in Thailand. (PubMed, Value Health Reg Issues) - "Secukinumab provided clinical benefits for PsA patients who were TNF-IR, but it is not a cost-effective option at its current price."

HEOR • Journal • Immunology • Inflammatory Arthritis • Oncology • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies • TNFA

Regulatory roles of three Zn(II)2Cys6 cluster-coding genes in insect pathogenicity and environmental fitness of Beauveria bassiana. (PubMed, Pestic Biochem Physiol) - "Three representative C6 TFs (138, 359, and 1117 aa) with an N-terminal GAL4 domain alone were proven to be regulators of insect pathogenicity, named Rip1-3...Notably, numerous co-dysregulated genes were linked to the mutants' main phenotypes, such as attenuated virulence and reduced stress tolerance. Conclusively, Rip1-3 played similar regulatory roles determined by the N-terminal GAL4 domain, suggesting convergent evolution in their mediating insect pathogenicity and environmental fitness of B. bassiana."

Journal • Infectious Disease • RIPK1

Biomarkers. (PubMed, Alzheimers Dement) - "We optimized our method for identification of endogenous CSF autoantibodies on various mass spectrometric platforms using an internal antibody control that assures optimal performance of all experimental runs. We believe that this assay will be instrumental in identifying novel autoantibodies that may be related to AD pathogenesis."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders • Immunology • KLK6

Understanding the menopause transition in sickle cell disease: An analysis of the implementation of the adapted menopause quick 6 (ASH 2025) - "Treatment use included hydroxyurea (45%mean dose: 1117 ± 444 mg/day; median: 1000), chronic exchange transfusion (10%), L-glutamine (2%),and voxelotor (7%). Half reported chronic opioid use (mean: 113 ± 115 MME/day), and 21% were takingmedications against neuropathic pain (e.g., gabapentin)...Midlife women with SCD report a substantial burden of menopausal symptoms—particularly hot flashes,sleep disturbances, and joint pain. Symptom burden appears influenced by age and hematologicparameters, while disease-modifying therapies may mitigate reported symptoms or individuals withsevere disease may not experience the typical hormonal related menopausal symptoms. These findingslay some foundational groundwork for future studies examining the interplay between disease severity,treatment, and reproductive aging in women with SCD."

CNS Disorders • Genetic Disorders • Hematological Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Sickle Cell Disease • Sleep Disorder • Women's Health

Persistent organic pollutants in migratory birds from wetlands of southern Primorye, Russia. (PubMed, Sci Total Environ) - "The total POP content in feathers ranged from 0.4 to 44.5 ng/g dry weight (dw); in muscles, from 9.0 to 282.4 ng/g lipid weight (lw); and in the liver, from 12.1 to 1117.1 ng/g lw...The observed differences between the species in POP accumulation are associated with their ecological characteristics including diet, migration routes, and habitats. The results show that the pollution levels in southern Primorye are lower or comparable to those reported for other Asian regions, but the global background of pesticides still continues to have an impact on ecosystems."

Journal

Machine learning-assisted prediction of speech outcomes at age 5 in patients with nonsyndromic cleft palate after double-opposing Z-plasty. (PubMed, J Plast Reconstr Aesthet Surg) - "This retrospective cohort comprised 1117 patients with nonsyndromic cleft palate (NSCP) who underwent double-opposing Z-plasty (DOZ) by a single surgeon between 1988 and 2017...Early small fistulae contributed moderately to hypernasality prediction but were negligible for therapy prediction. This machine learning model, implemented as a web-based calculator (https://cp-speech.mdbcdss.com/), provides an accessible decision-support tool for early risk stratification of speech outcomes at age 5 after DOZ in patients with NSCP."

Journal

Prevalence and associated plasmid resistant genome of ESBL and AmpC producing commensal E. coli isolated from lactating cows and pre-weaned calves on dairy farms in Western Australia. (PubMed, Prev Vet Med) - "Phenotypic analysis of 1117 faecal samples from 26 Western Australian dairy farms revealed a low overall prevalence (7.3 %) of ESBL and/or AmpC-producing commensal E. coli, with 3.2 % in cows (n = 633) and 12.8 % in calves (n = 484). All isolates were classified 'non-wildtype' for ampicillin and ceftiofur, with 95.1 % classified as 'non-wildtype' multidrug resistant (MDR)...Multiple correspondence analysis (with chi-square-based 95 % confidence ellipses) showed variation in pDNA AMR genes and replicons by farm, with generally distinct plasmid profiles, though some clustering suggests possible farm-to-farm plasmid transmission. In conclusion, though low in prevalence, ESBL and/or AmpC producing commensal E. coli having high phenotypic AMR, MDR, and pDNA diversity were isolated from dairy cattle on 65.4 % of screened farms."

Journal

Comparative Efficacy of Negative Pressure Wound Therapy and Conventional Treatments in the Management of Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis. (PubMed, J Clin Med) - " A total of 11 clinical trials involving 1117 subjects...Although no significant differences were found in amputations or infections, this therapy reduces pain and decreases the use of antibiotics and analgesics. Its use requires individual and expert assessment to maximize its benefits."

Journal • Retrospective data • Review • Diabetes • Infectious Disease • Metabolic Disorders • Obesity • Pain

Ultrasound-Guided Regional Anesthesia as Primary Analgesic Management in the Orthopedic-Surgical Emergency Department of an Affiliated Hospital: A Retrospective Analysis over a 6-Year Period. (PubMed, Medicina (Kaunas)) - " A total of 1292 patients (3.7%) underwent either pRA (n = 1117; 3.2%) or PS (n = 175; 0.5%)... US-guided pRA proved to be an effective and safe alternative to PS, GA, or systemic analgesia for selected indications, allowing immediate treatment without the need for operative capacities. To ensure safe application, these techniques should be an integral part of the training curriculum for ED personnel."

Journal • Retrospective data • Anesthesia • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A continuous-wave photon-pair source operating in L-band through spontaneous four-wave mixing in birefringent ZBLAN fiber. (PubMed, Sci Rep) - "Then, we experimentally generated signal and idler photons with center wavelengths of 1117 and 1578 nm using a 1310 nm CW laser as a pump light source and measured their quantum optical properties. The maximum coincidence-to-accidental ratio was calculated to be 22, resulting in a photon-pair brightness of 3.16 × 104 pairs/s/nm/mW. The results show the feasibility of using ZBLAN fibers in quantum optics as an efficient platform for generating a quantum light source."

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