Imunorix (pidotimod) / Almirall - LARVOL DELTA

Pidotimod plus recombinant human interferon α-2b suppository boosts HPV clearance in high-risk patients following loop electrosurgical excision procedure. (PubMed, Am J Transl Res) - "PDT plus rh-IFN-α2b suppository can effectively improve HPV negative conversion, accelerate vaginal microecology recovery, and modulate serum inflammatory responses in high-risk HPV patients after LEEP."

Journal • Human Papillomavirus Infection • Infectious Disease • Inflammation • Oncology • IFNA1 • IFNG • IL12A • IL4

Clinical Efficacy of Pidotimod-Assisted Erythromycin in Treating Lobar Pneumonia in Children Over 3 Years Old. (PubMed, Br J Hosp Med (Lond)) - "Additionally, there was no significant difference in the incidence of adverse reactions in both groups (p > 0.05). Conclusion Pidotimod-assisted erythromycin treatment can significantly improve the treatment efficiency in children with lobar pneumonia, improving clinical signs and symptoms and enhancing the cellular immune function without increasing the risk of adverse drug reactions."

Journal • Retrospective data • Asthma • Cough • Immunology • Infectious Disease • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • CD4 • CD8

Pidotimod in pediatrics: new evidence and future perspectives. (PubMed, Multidiscip Respir Med) - "The present review presents and discusses the most recent studies conducted in children with asthma, allergic rhinitis, recurrent respiratory infections and acute infections. Lastly, pidotimod is safe and well-tolerated in children."

Journal • Allergic Rhinitis • Allergy • Asthma • Immunology • Infectious Disease • Inflammation • Pediatrics • Pulmonary Disease • Respiratory Diseases

Tandem Mass Spectrometry Approaches for Differentiation and Quantification Pidotimod and Its Three Isomers in the Gas Phase. (PubMed, Chirality) - "Additionally, the logarithm of the CuII complexes' characteristic fragment ion abundance ratio demonstrated a strong linear relationship with enantiomeric excess (ee). This study presents a novel strategy for chiral drug quality control that eliminates chromatographic separation."

Journal

Reappraisal of Pidotimod: an immunomodulatory agent with 30-year evidence. (PubMed, Minerva Med) - "Preliminary experience suggests that Pidotimod can shorten the duration of COVID-19 infection and reduce clinical severity by modulating the immune response, as well as prevent vaccination-related adverse events. In conclusion, the immunomodulatory properties of Pidotimod indicate that it may be a valuable option in managing patients with respiratory infections and other immune-mediated disorders, including allergy, chronic obstructive pulmonary disease, and asthma."

Immunomodulating • Journal • Allergic Rhinitis • Allergy • Asthma • Bronchiectasis • Chronic Obstructive Pulmonary Disease • CNS Disorders • Depression • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Nephrology • Novel Coronavirus Disease • Pneumonia • Psychiatry • Pulmonary Disease • Respiratory Diseases

Analysis of Factors and T-Lymphocyte Subset Changes in Pediatric Recurrent Respiratory Infections Post-Pidotimod Treatment. (PubMed, Altern Ther Health Med) - "Daily outdoor activity among children, family members' history of smoking, parental allergy history, education level, and micronutrient intake emerged as independent factors influencing pediatric RRTIs. Furthermore, PI was identified as a significant treatment option for RRTIs."

Journal • Allergy • Cough • Immunology • Infectious Disease • Pediatrics • Respiratory Diseases • CD4 • CD8

Investigation on the Efficacy of Two Food Supplements Containing a Fixed Combination of Selected Probiotics and β-Glucans or Elderberry Extract for the Immune System: Modulation on Cytokines Expression in Human THP-1 and PBMC. (PubMed, Foods) - "We compared formulations with single ingredients, with bacterial lipopolysaccharide (LPS) and the drug pidotimod; cytokines expression level was evaluated testing different concentrations of samples at two exposure times...Probiotics were shown to play a major role, but β-glucans and elderberry extract exerted a synergistic activity. This work demonstrated that combining selected probiotics with other natural products having immunomodulatory properties is an interesting strategy to develop innovative formulations in the sector of food supplements."

Journal • CXCL8 • IL10 • IL2 • IL6

Are monoclonal antibodies effective in patients with severe obesity in SARS-CoV-2 infected? (PubMed, Immun Inflamm Dis) - "Our study found that there are no differences in the therapeutic response between obese and nonobese patients with SARS-CoV-2 infection undergoing MonoAbs therapy, in fact, none of them underwent hospitalization. Furthermore, the effect of the immunostimulant Pidotimod and cholecalciferol may have contributed to the resolution of COVID-19 symptoms in these patients."

Journal • Genetic Disorders • Infectious Disease • Novel Coronavirus Disease • Obesity • Respiratory Diseases

New Therapeutic Options in Mild Moderate COVID-19 Outpatients. (PubMed, Microorganisms) - "In the first phase of disease, pidotimod can represent an effective, low-cost, weapon, without restrictions of use, that is able to prevent a second aggressive phase and promote faster virological recovery."

Journal • Immune Modulation • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases

Immunostimulants versus placebo for preventing exacerbations in adults with chronic bronchitis or chronic obstructive pulmonary disease. (PubMed, Cochrane Database Syst Rev) - "In participants with chronic bronchitis or COPD, we are moderately confident that treatment with immunostimulants is associated with a small reduction in the likelihood of having an exacerbation and a moderate reduction in the requirement for antibiotics. Low numbers of events limit interpretation of the effect of immunostimulants on all-cause and respiratory-related mortality. We are uncertain whether immunostimulants improve quality of life, and whether they are associated with a reduction in exacerbation and respiratory-related hospitalisation durations, although immunostimulants were generally associated with a positive effect direction in the studies that examined these outcomes. Immunostimulants appear to be safe and well-tolerated, and are not associated with an increased risk of adverse events."

Journal • Review • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection: A randomized clinical trial. (PubMed, Pediatr Investig) - "The safety profile did not significantly differ among the groups. YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children, and were superior to placebo, with a high safety profile."

Clinical • Journal • Asthma • Immune Modulation • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases

Podotimod in pediatric recurrent respiratory tract infections: a cost-utility analysis. (PubMed, BMC Pulm Med) - "In conclusion our study shows that PDT is a cost-effective strategy to reduce the incidence rate of recurrent respiratory tract infections in children. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines."

HEOR • Journal • Infectious Disease • Pediatrics • Respiratory Diseases

Improving BNT162b2 mRNA Vaccine Tolerability without Efficacy Loss by Pidotimod Supplementation. (PubMed, Mediterr J Hematol Infect Dis) - No abstract available

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

P-CRESCENT: Study of Pidotimod in Children With Recurrent Respiratory Tract Infections (RRI) (clinicaltrials.gov) - P4 | N=338 | Completed | Sponsor: Almirall, S.A. | Recruiting ➔ Completed

Trial completion • Infectious Disease • Respiratory Diseases

Efficacy and Safety of Pidotimod in Persistent Asthma: A Randomized Triple-Blinded Placebo-Controlled Trial. (PubMed, Indian Pediatr) - "Addition of pidotimod for 8 weeks to standard ICS therapy did not enhance asthma control compared to placebo."

Clinical • Journal • Allergy • Asthma • Immunology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Anti-Inflammatory Effects of Immunostimulation in Patients with COVID-19 Pneumonia. (PubMed, J Clin Med) - "Immunomodulation exerted by PDT and systemic corticosteroids may foster a restoration in the innate response to the viral infection. These results should be confirmed in larger RCTs."

Clinical • Journal • Immune Modulation • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • CCL11 • IFNG • IL4

Pidotimod increases inflammation in wounded zebrafish embryos. (PubMed, Fish Shellfish Immunol) - "However, we did not observe protection of uropathogenic Escherichia coli or Mycobacterium marinum infected zebrafish larvae following PDT treatment. This study provides a new platform for PDT research, which is worthy of further research to identify further effects of PDT therapy."

Journal • Immunology • Infectious Disease • Inflammation • IL1B

Treatment of Psoriasis Vulgaris with Medicated Thread Moxibustion of Zhuang Medicine: A Multicenter Randomized, Parallel Controlled Trial. (PubMed, Chin J Integr Med) - "ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction. (Trial Registration No. ChiCTR-IOR-16008159)."

Clinical • Journal • Dermatology • Immunology • Mood Disorders • Psoriasis • Psychiatry

Effects of adjuvant pidotimod therapy on levels of inflammatory factors and expressions of serum GM-CSF and KL-6 in elderly patients with mycoplasma pneumonia. (PubMed, Am J Transl Res) - "Adjuvant pidotimod therapy in the treatment of elderly patients with mycoplasma pneumonia can ameliorate patients' inflammatory responses and pulmonary functions, and reduce the serum GM-CSF and KL-6 factor levels, as well as the recurrence rate. Moreover, the combined medication is safe, and no significant increase in toxicity was found."

Clinical • Journal • Infectious Disease • Inflammation • Oncology • Pneumonia • Respiratory Diseases • CSF2 • CXCL8 • IL6 • TNFA

Expert Opinion on Usage of Pidotimod in Adult Patients with Chronic Obstructive Pulmonary Disease: An Indian Perspective. (PubMed, J Assoc Physicians India) - "Modulation of the immune system with Pidotimod along with standard-of-care (SOC) treatment has proven efficacious in the past two decades in patients with recurrent respiratory tract infections (RRTIs), bronchitis, COPD, and pneumonia. In this article, we have reviewed the current unmet needs in the management of COPD in India and evaluated the usage of Pidotimod in adult COPD patients based on expert panel discussion."

Clinical • Journal • Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Immune Modulation • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Whether immunostimulants are effective in susceptible children suffering from recurrent respiratory tract infections: a modeling analysis based on literature aggregate data. (PubMed, J Clin Pharmacol) - "OM-85 BV and pidotimod reduced the incidence of respiratory tract infections by 0.21 (95% CI: 0.16, 0.26) and 0.19 (95% CI: 0.17, 0.21) compared to placebo per month, respectively...Pidotimod and OM-85 BV can effectively reduce the incidence of respiratory tract infections in susceptible children, with no significant increase in the incidence of drug-related adverse events when compared with placebo [RR values were 1.07 (95% CI: 0.66, 1.71) and 1.31 (95% CI: 0.54, 3.19), respectively]. This study provides quantitative support for the application of immunostimulants for the prevention of recurrent respiratory tract infections in children."

Clinical • Journal • Infectious Disease • Pediatrics • Respiratory Diseases

Pidotimod as add-on therapy in patients with pollen-induced allergic rhinitis and asthma and associated respiratory infections. (PubMed, J Biol Regul Homeost Agents) - No abstract available

Clinical • Journal • Allergic Rhinitis • Allergy • Asthma • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Pidotimod and Immunological Activation in Individuals Infected with HIV. (PubMed, Curr HIV Res) - "The study findings showed that the HIV population receiving Pidotimod achieved a rebalancing of proinflammatory and anti-inflammatory cytokines as well as a significant reduction in cystatin C levels. The treatment further allowed for an increase in salivary IgA levels at all the analyzed times, as secondary event to a remodulation of the immunological status obtained with pidotimod. This approach could represent a new way to design new intervention strategies aimed at improving the persistent immune activation status in the virologically suppressed HIV population."

Clinical • Journal • Human Immunodeficiency Virus • Immune Modulation • Immunology • Infectious Disease • Inflammation • Renal Disease • CST3 • IFNG • IL10 • IL18 • IL1B • IL2 • IL4 • TNFA

Pidotimod in children with infectious mononucleosis: a preliminary randomized controlled study. (PubMed, J Biol Regul Homeost Agents) - No abstract available

Clinical • Journal • Epstein-Barr Virus Infection • Otorhinolaryngology

Prevention of New Respiratory Episodes in Children with Recurrent Respiratory Infections: An Expert Consensus Statement. (PubMed, Microorganisms) - "The problems of dosage and the schedule of administration are not solved also for vitamin D, despite some promising efficacy results. While we wait for new knowledge, the elimination or reduction as much as possible of the environmental factors that favor RTIs, vaccination when available and/or indicated, and the systematic application of the traditional methods for infection prevention, such as hand washing, remain the best measures to prevent recurrent infections in RTI-prone children."

Clinical • Journal • Review • Asthma • Infectious Disease • Respiratory Diseases