Angeliq (drospirenone/17ß-estradiol) / Bayer - LARVOL DELTA

Continuous wavelet transform and integration of discrete wavelet transform with principal component analysis and fuzzy inference system for the simultaneous determination of ethinyl estradiol and drospirenone in combined oral contraceptives. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The suggested methods were compared with a reference method (HPLC) using analysis of variance (ANOVA) at a 95% confidence level, and no significant difference was observed in terms of accuracy. The suggested chemometric methods are reliable, rapid, and inexpensive, and can be used as an environmentally friendly alternative to HPLC for the simultaneous estimation of the mentioned drugs in commercial pharmaceutical products."

Journal • Long-acting Reversible Contraceptives

Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women. (PubMed, Obstet Gynecol Sci) - No abstract available

Journal

Solvothermally Grown Oriented WO3 Nanoflakes for the Photocatalytic Degradation of Pharmaceuticals in a Flow Reactor. (PubMed, Nanomaterials (Basel)) - "In this study, target drugs (oxazepam, OZ, 17-α-ethinylestradiol, EE2, and drospirenone, DRO), which have been extensively detected in the effluents of WWTPs over the past decades, were selected. The photocatalytic system based on solvothermal WO3 shows much better results in terms of photocurrent generation and photocatalyst stability with respect to state-of-the-art WO3 nanoparticles. Results herein obtained demonstrate that the proposed flow system is a promising prototype for enhanced contaminant degradation exploiting advanced oxidation processes."

Journal

Evaluating the toxicity of estetrol, 17α-ethinylestradiol, and their combination with drospirenone on zebrafish larvae: A behavioural and proteomic study. (PubMed, Aquat Toxicol) - "These findings suggest that E4-based combined oral contraceptives present a more favourable environmental profile than EE2-based contraceptives, particularly during the early developmental stages of fish."

Journal

Estetrol/drospirenone versus 17α-ethinylestradiol/drospirenone: An extended one generation test to evaluate the endocrine disruption potential on zebrafish (Danio rerio). (PubMed, Environ Int) - "In contrast, E4/DRSP induced only minor histopathological changes and an increase in the proportion of males, at the highest concentration tested (∼30× PEC) in the F1 generation and had no effect on hatching success of F2 generation. Overall, this study suggests that the combination E4/DRSP has a more favourable environmental profile than EE2/DRSP."

Journal

Drugs for menopausal symptoms. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal

Metabolomic Profiling of Hormonal Contraceptive Use in Young Females Using a Commercially Available LC-MS/MS Kit. (PubMed, Metabolites) - "Although only a limited number of compounds were deemed usable, these were quantified with high reliability and facilitated the identification of meaningful biological differences among the sample groups. In addition to substantiating known drug-induced variations, new hypotheses were also generated."

Journal • Cardiovascular • Hematological Disorders • Thrombosis • Venous Thromboembolism

RP-HPLC method to assay ethinylestradiol and drospirenone with 3D chromatograph model in fixed dose in rat plasma for pharmacokinetic study analysis. (PubMed, Pak J Pharm Sci) - "The advantages of the method developed include stability under different conditions and a low limit of quantification that was in micrograms. Its applicability was confirmed by the analysis of EE and DP levels in plasma samples in a designed pharmacokinetic study in rats after oral administration."

Journal • PK/PD data • Preclinical

Ultrasound-Assisted Extraction, Followed by Gas Chromatography-Mass Spectrometry for the Simultaneous Quantification of Ethinyl Estradiol and Drospirenone in Contraceptive Formulations. (PubMed, Molecules) - "No differences were observed between the measured and the declared amount of active principle per tablet, demonstrating the applicability of the procedure. In addition, a stability study conducted on both the standards and sample extracts demonstrated that they can be stored at room temperature for a minimum period of seven days."

Journal

High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro. (PubMed, PLoS One) - "The OC hormones EE and drospirenone do not directly enhance thrombin generation potential of primary ECs in vitro."

Journal • Preclinical • Cardiovascular • Hematological Disorders • Venous Thromboembolism • CD61 • ER • SERPINE1

AMBULATORY BLOOD PRESSURE IN POSTMENOPAUSAL WOMEN ON ESTROGEN, ANDROGEN OR PROGESTERONE THERAPY. (PubMed, J Hypertens) - "We may conclude that estradiol and drospirenone combined therapy lowers blood pressure and maintains a stable body weight in postmenopausal women."

Journal

Bleeding Patterns of Oral Contraceptives with a Cyclic Dosing Regimen: An Overview. (PubMed, J Clin Med) - "However, this balance seems lost if a too low dose of ethinylestradiol (EE) (e.g., 10 µg in EE/norethindrone acetate 1 mg) is used in an attempt to lower the risk of venous thromboembolism. Replacement of EE by 17β-estradiol (E2) or E2 valerate could lead to suboptimal bleeding profile due to destabilization of the endometrium. Replacement of EE with estetrol (E4) 15 mg in the combination with drospirenone (DRSP) 3 mg is associated with a predictable and regular scheduled bleeding profile, while the POP containing DRSP 4 mg in a 24/4 regimen is associated with a higher rate of unscheduled and absence of scheduled bleeding than combined products."

Journal • Review • Cardiovascular • Venous Thromboembolism

Effects of continuous-combined oral drospirenone- estradiol on blood pressure, body weight & lipid profile in early menopausal women. (PubMed, Indian J Med Res) - "Continuous long-term therapy with DRSP 2 mg/E2 1 mg significantly lowered 24 h systolic and diastolic BPs and reduced the risk of cardiovascular disease in early menopausal women with stage 1 hypertension. Timely initiated menopausal hormone therapy can have beneficial effects on BP and can reduce the incidence of cardiovascular disease in menopausal women."

Journal • Cardiovascular • Dyslipidemia • Hypertension • APOB

Long-term efficacy and safety of levonorgestrel-releasing intrauterine system as a maintenance treatment for endometriosis. (PubMed, Medicine (Baltimore)) - "When compared with control group, the effect on pain reduction was comparable to the oral contraceptives or dienogest, with less systemic side effects such as mood change or nausea.LNG-IUS for >5 years as a postoperative maintenance therapy for endometriosis patients is an effective and feasible treatment that shows significant effect on pain reduction with less systemic side effect compared with other types of treatment. Therefore, LNG-IUS can be recommended as a long-term postoperative therapy for endometriosis patients who do not plan to become pregnant for several years."

Journal • Back Pain • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Drug-induced antiphospholipid syndrome: Analysis of from the WHO international database. (PubMed, Autoimmun Rev) - P=N/A | "This study identified 14 drugs potentially associated with drug-induced APS that may prove useful in the investigational work-up in any new diagnosis of APS."

Journal • Review • Cardiovascular • CNS Disorders • Genetic Disorders • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Oncology • Pulmonary Embolism • Respiratory Diseases • Systemic Lupus Erythematosus

"Great job @DoctorFitHeart @RussUltrasound @suzyszcz @angeliquee_93 @AndrewDeweyert @ALewisMD @dmljmd @KristyWolniak and so many other fabulous @NMCardioVasc & @NU_Pathology faculty" (@pmgarcia)

"@TentillierE @CelineRigous @angelique @Julien__Naud @ChristineLASSAL @LafitteMarianne @EocheLoic @blanchardelodi4 @RAYNAUDPhilipp1 @Raguelfreddy971 @SylvainUzac @AmandineMrto @isabel24 @jeremy33petit @BaudinetMartine @HessamfarMojgan @amaury_daste @CPIASNA 🙏" (@celine_etchetto)

"Angelique Coetzee says: do not panic!" (@chronophagus)

"Looking phenomenal team!!! Especially my girl Dr. Angelique Richardson, but I may be showing my breast team bias…." (@Dr_RShatsky)

"Thank you Angelique 💕" (@BIC_09)

Efficacy of Myo-inositol and D-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young girls with PCOS: A randomized open-label study. (PubMed, Int J Gynaecol Obstet) - "Myo-inositol and D-chiro-inositol combination (3.6:1 ratio) is effective in regularising menstrual cycles and improving insulin resistance."

Clinical • Journal • Polycystic Ovary Syndrome

Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β-estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study. (PubMed, Exp Ther Med) - "Therefore, DRSP/E2 HT was effective in reducing the fluid overload, which is characteristic of MD. The findings of the present study demonstrated that integrated therapy based on the administration of DRSP/E2 HT and rehabilitation may be more effective compared with rehabilitation alone for the management of postmenopausal exacerbation of MD."

Journal • Otorhinolaryngology

"@AbbottNews @BayerConoSur @colmedchile @MatronasdeChile @SERNAC ¿Alguna explicación por haber descontinuado #clinomat y en consecuencia desabastecimiento de #angeliq ? Las mujeres y nuestra salud merecemos respeto" (@Lolaloba69)

"hola , me pasa lo mismo tampoco están Angeliq , ni estradox que pudiesen servir" (@cespinoza_arce)

"WTA roundup: Angelique Kerber, Katerina Siniakova finalists in Bad Homburg https://t.co/n4qAB5aGYn" (@Reuters)