Angeliq (drospirenone/17ß-estradiol) / Bayer - LARVOL DELTA

Anxiety and Depression in Adolescent PCOS (clinicaltrials.gov) - P=N/A | N=42 | Completed | Sponsor: Ege University | Recruiting ➔ Completed

Trial completion • CNS Disorders • Depression • Mood Disorders • Polycystic Ovary Syndrome • Psychiatry

Severe hyperandrogenism in an adolescent with polycystic ovary syndrome and suspected late-onset adrenal hyperplasia – case report (ISGE 2026) - " Laboratory findings: DHEA-S 1066 μg/dL, total testosterone 1.122 ng/mL, calculated free testosterone 3.8, SHBG 5.9 nmol/L (low), progesterone <0.5 ng/mL, 17-hydroxyprogesterone 1.84 ng/mL (borderline)...THERAPEUTIC APPROACH: Initiated ethinylestradiol 0.03 mg + drospirenone 3 mg (21+7 regimen) for menstrual regulation and ovarian androgen suppression, combined with cyproterone acetate 50 mg in the first 10 days of each cycle for 3 months, followed by spironolactone 50 mg daily... This case underscores the complexity of differentiating severe PCOS from LOCAH in adolescents with marked hyperandrogenism. A multidisciplinary, individualized therapeutic approach combining hormonal, antiandrogenic, and metabolic measures achieved symptom control and targeted long-term risk reduction."

Case report • Clinical • Acne Vulgaris • Congenital Adrenal Hyperplasia • Endocrine Disorders • Gynecology • Hematological Disorders • Polycystic Ovary Syndrome • CYP1A2 • CYP21A2

RC10-2-2025: Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding (clinicaltrials.gov) - P=N/A | N=166 | Completed | Sponsor: Benha University | N=80 ➔ 166

Enrollment change • Women's Health

Predicting venous thromboembolism risk from endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral contraceptives. (PubMed, Res Pract Thromb Haemost) - "Predicted VTE risks for ethinylestradiol 30 μg with dienogest 2 mg, ethinylestradiol 20 μg with drospirenone 3 mg, estradiol 1.5 mg with nomegestrol acetate 2.5 mg, and estetrol 15 mg with drospirenone 3 mg were 4.36, 3.43, 1.50, and 1.45, respectively, consistent with or complementary to existing epidemiological evidence. Our model, based on mean nAPCsr, provides a reliable, biomarker-based approach for predicting population-based COC-related VTE risk. This strategy could help shorten the time between product launch and population-based risk assessment."

Journal • Cardiovascular • Venous Thromboembolism

Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS (clinicaltrials.gov) - P=N/A | N=150 | Recruiting | Sponsor: Ege University | Not yet recruiting ➔ Recruiting

Enrollment open • Polycystic Ovary Syndrome

RC10-2-2025: Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Benha University | N=58 ➔ 80

Enrollment change • Women's Health

Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS (clinicaltrials.gov) - P=N/A | N=150 | Not yet recruiting | Sponsor: Ege University

New trial • Polycystic Ovary Syndrome

Anxiety and Depression in Adolescent PCOS (clinicaltrials.gov) - P=N/A | N=42 | Recruiting | Sponsor: Ege University

New trial • CNS Disorders • Depression • Mood Disorders • Polycystic Ovary Syndrome • Psychiatry

Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding (clinicaltrials.gov) - P=N/A | N=58 | Completed | Sponsor: Benha University

New trial • Women's Health

Combined oral contraceptive administration in female mice attenuated high-fat diet-induced obesity but not hepatic inflammation or fibrosis. (PubMed, An Acad Bras Cienc) - "In this study, we aimed to investigate the effects of COC administration, composed of 17α-ethinylestradiol (EE2) and drospirenone (DRSP), on obesity, glucose tolerance, and hepatic steatosis in female mice...These females also exhibited a lower hepatic steatosis score than CTL-HFD mice; however, their liver parenchyma showed an increased number of inflammatory foci, and up-regulation of the Il-1β gene. Thus, COC administration in female mice attenuated obesity development induced by HFD, possibly through modulation of BAT function, while the increased hepatic expression of the pro-inflammatory cytokine IL-1β suggests that COC exacerbated HFD-induced liver inflammation."

Journal • Preclinical • Fibrosis • Genetic Disorders • Immunology • Inflammation • Obesity • IL1B • PRDM16

HISTOLOGICAL INJURY PATTERNS IN CHILDREN WITH DRUG-INDUCED LIVER INJURY (AASLD 2025) - "Causative agents were minocycline (5), azithromycin (3), atomoxetine (3), lamotrigine (2), and nicotine, drospirenone/estradiol, Trikafta, carbamazepine, doxycycline, infliximab, amoxicillin, amoxicillin/clavulanate, and isoniazid (1 each). Children with DILI experienced similar range of pathology as seen in adults, with both hepatocellular and cholestatic liver injury represented. Eosinophilia was seen in less than half, and plasmacytosis in one third of biopsies. While most cases showed mild injury overall, a few showed severe inflammation, necrosis, or bridging fibrosis."

Clinical • Cholestasis • Eosinophilia • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Pediatrics

Temporal Trends and Determinants of Low-Dose Estrogen-Progestin Prescription in Japan During 2014-2022: An Ecological Study Using a Nationwide Claims Database. (PubMed, J Obstet Gynaecol Res) - "This study provides the first comprehensive analysis of real-world LEP prescription patterns in Japan, revealing significant regional disparities."

Journal • Obstetrics • Women's Health

HOLTER CO-PRE: Prospective Evaluation on the Role Exerted by Hormonal Contraceptives on 24-h Blood Pressure. A Prospective Observational Study (clinicaltrials.gov) - P=N/A | N=96 | Recruiting | Sponsor: Ospedale Policlinico San Martino

New trial • Cardiovascular

Pharmacological Treatments for Menopausal Vasomotor Symptoms: A Systematic Review and Bayesian Network Meta-Analysis of Efficacy and Safety. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Conjugated estrogens and drospirenone with estradiol are the most effective options for reducing VMS frequency and severity, and Fezolinetant and Elinzanetant showed moderate efficacy, with overall similar safety across treatments."

Journal • Retrospective data • Review

Effects of Continuous Use of Oral Drospirenone/Estradiol on Lipid Profile, Body Weight, and BP in Females from Early Menopause. (PubMed, J Pharm Bioallied Sci) - "No significant change in nocturnal 24-hour BP, significant day-time and night-time reduction at follow-up in HR, significant reduction in BMI, apolipoprotein B, and cholesterol were observed. The present study concludes that continuous and long-term therapy using oral drospirenone/estradiol leads to a significant reduction in cardiovascular diseases and better BP control."

Journal • Cardiovascular • Hypertension • APOB

Continuous wavelet transform and integration of discrete wavelet transform with principal component analysis and fuzzy inference system for the simultaneous determination of ethinyl estradiol and drospirenone in combined oral contraceptives. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The suggested methods were compared with a reference method (HPLC) using analysis of variance (ANOVA) at a 95% confidence level, and no significant difference was observed in terms of accuracy. The suggested chemometric methods are reliable, rapid, and inexpensive, and can be used as an environmentally friendly alternative to HPLC for the simultaneous estimation of the mentioned drugs in commercial pharmaceutical products."

Journal • Long-acting Reversible Contraceptives

Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women. (PubMed, Obstet Gynecol Sci) - No abstract available

Journal

Solvothermally Grown Oriented WO3 Nanoflakes for the Photocatalytic Degradation of Pharmaceuticals in a Flow Reactor. (PubMed, Nanomaterials (Basel)) - "In this study, target drugs (oxazepam, OZ, 17-α-ethinylestradiol, EE2, and drospirenone, DRO), which have been extensively detected in the effluents of WWTPs over the past decades, were selected. The photocatalytic system based on solvothermal WO3 shows much better results in terms of photocurrent generation and photocatalyst stability with respect to state-of-the-art WO3 nanoparticles. Results herein obtained demonstrate that the proposed flow system is a promising prototype for enhanced contaminant degradation exploiting advanced oxidation processes."

Journal

Evaluating the toxicity of estetrol, 17α-ethinylestradiol, and their combination with drospirenone on zebrafish larvae: A behavioural and proteomic study. (PubMed, Aquat Toxicol) - "These findings suggest that E4-based combined oral contraceptives present a more favourable environmental profile than EE2-based contraceptives, particularly during the early developmental stages of fish."

Journal

Estetrol/drospirenone versus 17α-ethinylestradiol/drospirenone: An extended one generation test to evaluate the endocrine disruption potential on zebrafish (Danio rerio). (PubMed, Environ Int) - "In contrast, E4/DRSP induced only minor histopathological changes and an increase in the proportion of males, at the highest concentration tested (∼30× PEC) in the F1 generation and had no effect on hatching success of F2 generation. Overall, this study suggests that the combination E4/DRSP has a more favourable environmental profile than EE2/DRSP."

Journal

Drugs for menopausal symptoms. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal

Metabolomic Profiling of Hormonal Contraceptive Use in Young Females Using a Commercially Available LC-MS/MS Kit. (PubMed, Metabolites) - "Although only a limited number of compounds were deemed usable, these were quantified with high reliability and facilitated the identification of meaningful biological differences among the sample groups. In addition to substantiating known drug-induced variations, new hypotheses were also generated."

Journal • Cardiovascular • Hematological Disorders • Thrombosis • Venous Thromboembolism

RP-HPLC method to assay ethinylestradiol and drospirenone with 3D chromatograph model in fixed dose in rat plasma for pharmacokinetic study analysis. (PubMed, Pak J Pharm Sci) - "The advantages of the method developed include stability under different conditions and a low limit of quantification that was in micrograms. Its applicability was confirmed by the analysis of EE and DP levels in plasma samples in a designed pharmacokinetic study in rats after oral administration."

Journal • PK/PD data • Preclinical

Ultrasound-Assisted Extraction, Followed by Gas Chromatography-Mass Spectrometry for the Simultaneous Quantification of Ethinyl Estradiol and Drospirenone in Contraceptive Formulations. (PubMed, Molecules) - "No differences were observed between the measured and the declared amount of active principle per tablet, demonstrating the applicability of the procedure. In addition, a stability study conducted on both the standards and sample extracts demonstrated that they can be stored at room temperature for a minimum period of seven days."

Journal

High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro. (PubMed, PLoS One) - "The OC hormones EE and drospirenone do not directly enhance thrombin generation potential of primary ECs in vitro."

Journal • Preclinical • Cardiovascular • Hematological Disorders • Venous Thromboembolism • CD61 • ER • SERPINE1