adapalene/benzoyl peroxide / Generic mfg. - LARVOL DELTA

Investigating the Use of 0.3% Adapalene/2.5% Benzoyl Peroxide Gel for the Management of Moderate-to-Severe Acne in Indian Patients: A Phase 4 Study Assessing Safety and Efficacy. (PubMed, Cureus) - "Treatment satisfaction was rated as 91% by the patients. Conclusions The A0.3%+BPO2.5% gel effectively reduced the inflammatory and noninflammatory lesions and was found to be safe and well tolerated in Indians with moderate‑to‑severe acne vulgaris."

Journal • P4 data • Acne Vulgaris • Dermatology • Inflammation

New Topical Combination Formulas in Dermatology (INDERCOS 2024) - "In a clinical study including 60 patients with mild-moderate facial acne the efficacy and safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel was examined...In markets, Epiduo fort gel including 0.3% adapalene and 2.5% BPO is also available for mild-moderate acne vulgaris...Besides, Twyneo (a fixed dose comb...For the use of accompanying disorders with acne vulgaris such as acne and melasma the triple combination including Retinoic acid 0.025, Clindamycin 2%, Hydroquinone 4%; for acne and hirsutism double combination of Clindamycin 2% and Eflornithine 11.5%; for acne and seborrheic dermatitis Clotrimazole 1% and Erythromycin 2% are all available...Numerous products such as thermal waters and a variety of creams pharmaceutical compounding offers the advantage of combining with metronidazole or topical antiirritants (e.g., enoxolone, alpha bisabolol) and venotonic agents to prevent disease progression.For sensitive skin and..."

Acne Vulgaris • Alopecia • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Obesity • Psoriasis • Rosacea • Seborrheic Dermatitis

Cabtreo: A three-drug gel for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Drugs for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Adapalene/benzoyl peroxide gel 0.3%/2.5% for acne vulgaris (PubMed, Eur J Dermatol) - "While some patients experience issues with transient tolerability during retinoid and BPO therapy, it is our clinical experience that good patient education to set expectations and provide strategies to minimize irritation can overcome the majority of issues. This article reviews the data supporting the use of adapalene 0.3%/2.5% in practice, including the complementary mechanism of action of adapalene and BPO, clinical data from a range of settings, and key aspects of patient education."

Journal • Acne Vulgaris • Dermatology

Tretinoin/benzoyl peroxide cream (Twyneo) for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Clascoterone cream (Winlevi) for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

This is a clinical study to evaluate the safety and efficacy of IDP-126 Gel (study product), compared to Epiduo® Forte Gel (prescription medication) in subjects with acne (clinicaltrialsregister.eu) - P2; N=628; Sponsor: Bausch Health Americas, Inc.

Clinical • New P2 trial • Acne Vulgaris • Dermatology • Rheumatology

"$TEVA Teva Announces Launch of an Authorized Generic of Epiduo® Forte Gel (adapalene and benzoyl peroxide gel 0.3%/2.5%), in the U.S. https://t.co/wyoc4ut9Sx" (@stock_titan)

Generic launch

Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients (clinicaltrials.gov) - P4; N=23; Completed; Sponsor: East Avenue Medical Center, Philippines

Clinical • New P4 trial • Acne Vulgaris • Dermatology

Anti-acne Efficacy of a Dermo-cosmetic Product Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer in Male and Female Subjects Presenting With Mild to Moderate Acne (clinicaltrials.gov) - P4; N=200; Completed; Sponsor: Vichy Laboratoires; Not yet recruiting ➔ Completed

Clinical • Trial completion • Acne Vulgaris • Dermatology

Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (clinicaltrials.gov) - P2; N=660; Recruiting; Sponsor: Bausch Health Americas, Inc.; Not yet recruiting ➔ Recruiting

Enrollment open • Acne Vulgaris • Dermatology

Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (clinicaltrials.gov) - P2; N=660; Not yet recruiting; Sponsor: Bausch Health Americas, Inc.

Clinical • New P2 trial • Acne Vulgaris • Dermatology

Current Insights for the Management of Acne in the Modern era. (PubMed, Recent Pat Antiinfect Drug Discov) - "Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of antiacne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidences regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields patents are filed against various agents like Galderma Research & Development have filed for adapalene and benzoyl peroxide for the management of acne vulgaris. The current review highlights the potential of various novel drug delivery approaches like liposomes, niosomes, ethosomes, transfersomes etc. in enhancing the topical delivery of antiacne agents."

Journal • Acne Vulgaris • CNS Disorders • Depression • Dermatology • Dermatopathology

PUMP-it: Application of Epiduo(R) PUMP in Daily Practice in Patients With Inflammatory Acne (clinicaltrials.gov) - P=N/A; N=1388; Completed; Sponsor: Galderma Laboratorium GmbH; Enrolling by invitation ➔ Completed; N=2000 ➔ 1388

Enrollment change • Trial completion • Biosimilar • Immunology

Oral antibiotic and topical gel combo for severe acne: JDD Study (Speciality Medical Dialogues) - "The study by Leon H. Kircik...assessed the effects of combination treatment using anti-inflammatory dose doxycycline plus adapalene 0.3% and benzoyl peroxide 2.5% gel on IGA scores as well as an inflammatory lesion, non-inflammatory lesion, and nodule counts....'Combination treatment with anti-inflammatory dose doxycycline plus combination adapalene 0.3% and benzoyl peroxide 2.5% gel is safe and effective for the management of severe acne,' the investigator concluded."

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Cystic acne market ready to cross highest growth rate at 10% CAGR till 2023 - "Rising prevalence of this conditions both in developed and developing countries is driving the cystic acne market growth. The skin care industry and research laboratories are involved in research and development to provide the better treatment. According to Leon H. Kircik, M.D...recent research on severe and moderate acne patients with inflammatory acne helps to confirm the strength and efficacy of fixed-dose combination gel adapalene/benzoyl peroxide 0.3%/2.5%."

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Sol-Gel’s Twin for acne and Epsolay for rosacea face tough competition, even if approved - "It is unclear if using both active ingredients together could potentially ease tolerability, as both cause skin irritation, Feldman said....However, benzoyl peroxide is still a strong oxidant and it could perform differently in the skin, so the same irritation levels could be present, Feldman added."

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