flecainide / Generic mfg. - LARVOL DELTA

ACUTE KIDNEY INJURY SECONDARY TO MIRROR SYNDROME: A CASE REPORT OF A RARE RENAL OBSTETRIC CONDITION (ISN-WCN 2026) - "Examples include but are not limited to the following 1.) hydrops secondary to Fetal supraventricular tachycardia which was treated with Flecainide, eventually resulting to livebirth, resolved arrhythmia, and resolution of mirror syndrome, 2.) hydrops secondary to twin to twin transfusion syndrome was treated with fetoscopic laser therapy meant to occlude placental vascular anastomoses, leading to resolution of mirror syndrome and live birth without any additional maternal intervention, and 3.) intrauterine fetal transfusion to address fetal anemia from parvovirus infection that caused hydrops fetalis eventually led to resolution of mirror syndrome and livebirth...This case further emphasizes that prompt identification and appropriate management—whether through treatment of the underlying cause of hydrops or, in idiopathic cases, termination of pregnancy—are crucial to prevent worsening maternal morbidity. Ultimately, the complete resolution of the patient's renal..."

Case report • Clinical • Acute Kidney Injury • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Cough • Diabetes • Diabetic Nephropathy • Gynecology • Heart Failure • Hematological Disorders • Hypertension • Hypotension • Immunology • Infectious Disease • Metabolic Disorders • Myocardial Infarction • Nephrology • Obstetrics • Postpartum Hemorrhage • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Rubella • Thrombocytopenia • Thrombosis • Ventricular Tachycardia • FLT1

Permanent Junctional Reciprocating Tachycardia (PJRT): A Rare Case of Refractory Neonatal SVT (SCCM 2026) - "There, he underwent six attempts of transcutaneous pacing and was started on a combination of esmolol, flecainide, and amiodarone. However, in neonates this procedure is very rarely performed. Given its resistance to pharmacologic agents, PJRT demands early recognition and a targeted approach to management in pediatric and neonatal populations."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

IT'S A NEW DAWN, IT'S A NEW DELTA WAVE - RECALCITRANT NEONATAL SVT CEASES WITH THE MANIFESTATION OF PREEXCITATION (ACC 2026) - "Therapy with amiodarone, flecainide, and propranolol finally achieved sinus rhythm with frequent AP echoes...The child remains SVT free on sotalol, propranolol and digoxin while weaning amiodarone at 1 year... Multidrug SVT therapy may create complex interactions."

Cardiovascular • Ventricular Tachycardia

VENTRICULAR TACHYCARDIA IN PREGNANCY (ACC 2026) - "Previously diagnosed with idiopathic VT from the cardiac crux and declined ablation, treated with Diltiazem 20mg and Flecainide 100mg...For recurrent VT antiarrhythmic therapy with Flecainide, Sotalol, or Mexiletine is recommended. VT is a rare but important to recognize complication of pregnancy. Arrhythmia in pregnancy should be managed with a multidisciplinary approach."

Cardiovascular • Ventricular Tachycardia

A COMPLEX CASE OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY REQUIRING MULTIPLE ABLATIONS AND HEART TRANSPLANTATION (ACC 2026) - "Management was complicated by intolerance and inefficacy of several antiarrhythmics, including sotalol, flecainide, mexiletine, and amiodarone. ARVC presents ongoing therapeutic challenges. Antiarrhythmic drugs and catheter ablation remain mainstays, though recurrence is common. A 2019 study showed an average of two ablations per patient."

Clinical • Cardiomyopathy • Cardiovascular • Fibrosis • Genetic Disorders • Immunology • Transplantation • Ventricular Tachycardia

FROM MISDIAGNOSED SEIZURES TO SUDDEN CARDIAC ARREST: UNMASKING PEDIATRIC CPVT (ACC 2026) - "She was treated by neurology with escalating doses of Levetiracetam, Oxcarbazepine, Zonisamide and rescue therapy with Intranasal Diazepam with no success...The addition of flecainide was considered but deferred since she had no recurrent syncope or ICD therapies. Early recognition of CPVT and timely initiation of medical therapy are critical to prevent recurrent ventricular tachyarrhythmias. Prompt diagnosis and treatment reduce the risk of sudden cardiac arrest and may even obviate the need for ICD implantation."

Clinical • Asthma • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure • Immunology • Pediatrics • Respiratory Diseases • Ventricular Tachycardia

UNMASKING PREEXCITATION: THYROID STORM PRECIPITATING ATRIAL FIBRILLATION IN WOLFF-PARKINSON-WHITE SYNDROME (ACC 2026) - "ECG suggested ventricular tachycardia; she was stable and initially treated with amiodarone, then transitioned to procainamide with restoration of sinus rhythm...She was discharged on flecainide, propranolol, methimazole, and apixaban with EP and endocrine follow-up... This case illustrates the interplay of thyrotoxicosis, AF, and WPW, emphasizing recognition of preexcitation for safe antiarrhythmic selection and treatment of endocrine triggers."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Endocrine Disorders • Grave’s Disease • Movement Disorders • Ventricular Tachycardia

FLECAINIDE TOXICITY: AN UNUSUAL PRESENTATION FOR TREMOR AND VOCAL TIC (ACC 2026) - "Flecainide toxicity-associated neurological symptoms are likely due to sodium channel blockade in the central nervous system cells. Clinicians should consider flecainide neurotoxicity in patients presenting with new neurologic symptoms, especially in the context of renal impairment. Early recognition may prevent progression to more severe toxicity and highlights the need for more nuanced monitoring of neurologic side effects in patients on chronic flecainide therapy."

Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Infectious Disease • Movement Disorders • Nephrology • Renal Disease

SAFETY AND EFFICACY OF CLASS IC VS AMIODARONE ANTIARRHYTHMIC AGENTS IN PATIENTS WITH CONGENITAL HEART DISEASE: A RETROSPECTIVE MULTI-CENTER STUDY (ACC 2026) - "Class IC antiarrhythmic drugs (AADs), flecainide and propafenone, are used but limited in CHD due to safety concerns in structural disease. In complex CHD without VT/VF, CAD, or ICD, class IC AADs provided comparable arrhythmia efficacy with significantly lower all-cause mortality than amiodarone."

Retrospective data • Atrial Fibrillation • Cardiovascular • Heart Failure

CONTINUATION VERSUS INTERRUPTION OF MAINTENANCE ANTIARRHYTHMIC THERAPY IN ADULT INTENSIVE CARE UNIT PATIENTS (ACC 2026) - "Background: For patients admitted to an intensive care unit (ICU), there is limited guidance regarding the management of maintenance antiarrhythmic drug (AAD) therapy such as flecainide, propafenone, dofetilide, dronedarone, and sotalol...For patients who developed unstable arrhythmias, acute treatment with direct current cardioversion (DCCV) or pharmacological therapy, such as amiodarone, beta or non-dihydropyridine calcium channel blockers, or digoxin, will be recorded... Research is currently ongoing with the objective of gaining insight to prescribing patterns and clinical outcomes."

Clinical • Cardiovascular • Critical care • Ventricular Tachycardia

PULMONARY DELIVERY OF FLECAINIDE FOR ON-DEMAND CARDIOVERSION IN ATRIAL FIBRILLATION (ACC 2026) - "Inhaled flecainide represents a safe and effective strategy for rapid cardioversion of recent-onset PAF. By combining the speed of IV therapy with the convenience of outpatient administration, this approach addresses a critical unmet need in early rhythm control. Larger randomized trials are warranted to validate efficacy, optimize dosing, and support integration into clinical practice."

Atrial Fibrillation • Cardiovascular • Cough • Respiratory Diseases

LIGHTNING STRIKES TWICE: RECURRENT REVERSE TAKOTSUBO SYNDROME (ACC 2026) - "Case: A 66-year-old woman with atrial fibrillation on rivaroxaban and flecainide, and a prior history of TCM presented with abdominal pain, nausea, and diaphoresis...During hospitalization, atrial flutter was observed, prompting discontinuation of flecainide and initiation of diltiazem... This case illustrates an unusual presentation of recurrent TCM manifesting as the reverse variant. While stressors are well-recognized precipitants, the potential role of flecainide as a rare pharmacologic trigger warrants consideration. Awareness of potential drug-related associations, including antiarrhythmic agents, may guide future management and improve patient safety."

Acute Coronary Syndrome • Atrial Fibrillation • Cardiomyopathy • Cardiovascular

EFFECT MODIFICATION OF CORONARY ARTERY CALCIFICATION ON MAJOR ADVERSE CARDIOVASCULAR EVENTS AND ALL-CAUSE MORTALITY IN VETERANS WITH PAROXYSMAL ATRIAL FIBRILLATION ON FLECAINIDE (ACC 2026) - "This retrospective cohort study suggests that CAC acts as an effect modifier, identifying individuals at elevated risk for MACE or all-cause mortality who warrant ischemia testing while continuing, or prior to starting, Class IC therapy. Prospective studies are needed to further validate the role of CAC in risk stratification for ischemia testing among patients with pAF on flecainide."

Adverse events • Atherosclerosis • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders

DUAL SUBSTRATE IN PREGNANCY: LEFT VENTRICULAR NON-COMPACTION WITH RYR2 PATHOGENIC VARIANT PRESENTING WITH VENTRICULAR FIBRILLATION STORM (ACC 2026) - "Despite sotalol, a VF storm occurred, and it was discontinued. Pregnancy with RYR2-positive left ventricular non-compaction represents a high-risk treatment environment, requiring management that integrates genetics, adrenergic stressors, and careful medication timing."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Vascular Neurology

PACEMAKER NON-CAPTURE AS A MANIFESTATION OF FLECAINIDE TOXICITY (ACC 2026) - "Flecainide's sodium channel blockade can be amplified in hyponatremia and hepatic disease, manifesting as increased pacing thresholds and non-capture. Serum sodium and liver function monitoring alongside routine device interrogation could be beneficial to minimize toxicity in chronic flecainide use."

Cardiovascular • Colorectal Adenocarcinoma • Colorectal Cancer • Heart Failure • Hepatocellular Cancer • Hepatology • Hypotension • Liver Failure • Rectal Adenocarcinoma • Solid Tumor

INITIAL MANAGEMENT OF ATRIAL FIBRILLATION WITHOUT ISCHEMIC HEART DISEASE: CLASS I OR CLASS III ANTIARRHYTHMIC THERAPY? (ACC 2026) - "Patients were categorized by first-line AAD use: Class I agents (flecainide, procainamide, propafenone) or Class III agents (amiodarone, sotalol, dofetilide). In this five-year retrospective study, class I AAD was associated with better clinical outcomes than class III AAD as first-line therapy for AF among patients without IHD."

Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Ischemic stroke

DISPARITIES IN RHYTHM AND RATE CONTROL THERAPIES AMONG AMERICAN INDIAN/ALASKA NATIVE PATIENTS WITH ATRIAL FIBRILLATION: A COMPARATIVE ANALYSIS (ACC 2026) - "Rhythm control was used by 13.6% of patients, with amiodarone (10.0%), flecainide and sotalol were <2.0%, ablation and DCCV were rare (1.0%, 0.6%). Rhythm control is underutilized in AI/AN patients with AF. Women more often rate controlled, while older patients had lower use, reflecting inequities. AG was suboptimal, and limited catheter ablation highlights barriers to advanced therapies, emphasizing the need for targeted interventions in this underserved population."

Clinical • Atrial Fibrillation • Cardiovascular

Soil accumulation and plant uptake of pharmaceutical active compounds and related metabolites from irrigation water in fennel (Foeniculum vulgare Mill.). (PubMed, Front Plant Sci) - "This study investigated the fate of three commonly occurring pharmaceutical contaminants (PhACs) (carbamazepine, climbazole, and flecainide) and their metabolites in the soil-plant system when applied through treated wastewater. Overall, fennel crop showed a restricted capacity to accumulate and translocate PhACs to bulbs, suggesting a physiological barrier that may reduce human health risks when using treated wastewater for irrigation. The results provide new insights into the environmental safety of wastewater reuse, with a specific focus on its impact on crop yield, highlighting the need for crop-specific assessments."

Journal

Neonatal narrow-complex SVT unmasking pre-excitation. (PubMed, J Electrocardiol) - No abstract available

Journal • Cardiovascular • Ventricular Tachycardia

Suicide by flecainide: a case report and review of the literature. (PubMed, Forensic Sci Med Pathol) - "This case highlights the complexities in diagnosing lethal flecainide intoxication, particularly considering postmortem concentration variability and individual metabolic differences. Integrating pharmacogenetic data enhances interpretation of toxicological findings and may guide personalized therapeutic strategies to mitigate risk. Further research is warranted to clarify genetic influences on flecainide toxicity."

Journal • Cardiovascular • CYP3A5

SubclincalAF: Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=520 | Recruiting | Sponsor: Samsung Medical Center

New trial • Atrial Fibrillation • Cardiovascular

CAAD-PVC: Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: Western Sydney Local Health District

New trial

Flecainide-Induced Cardiogenic Shock and Cardiac Arrest in an Elderly Patient on Anticoagulation (ATS 2026) - No abstract available

Clinical • Cardiovascular

Flecainide Toxicity Leading to Pacemaker Capture Failure and Cardiogenic Shock in a Patient With Sinus Node Dysfunction (ATS 2026) - No abstract available

Clinical • Cardiovascular

EAST-STROKE: Early treatment of irregular heartbeat (atrial fibrillation) to prevent a recurrent stroke (clinicaltrialsregister.eu) - P4 | N=1035 | Recruiting | Sponsor: University Medical Center Hamburg-Eppendorf

New P4 trial • Atrial Fibrillation • Cardiovascular • Ischemic stroke