flecainide / Generic mfg. - LARVOL DELTA

Tetrodotoxin-resistant NaV1.5 channels regulate excitability of lateral septum neurons and emotion behaviors of chronically stressed mice. (PubMed, Mol Psychiatry) - "Lateral septum (LS) plays crucial roles in regulating various emotional behaviors. Importantly, acute treatment with the antiarrhythmic agent flecainide can diminish the TTX-resistant currents and alleviate the anxiety- and depression-like behaviors of stressed mice. Together, our results reveal a critical role of NaV1.5 channels in governing LSN excitability and identify a potential drug target for a rapid control of emotional disorders."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Psychiatry • NAV1

Diagnosis and management of Brugada Syndrome Unmasked by Flecainide challenge in a patient with unexplained ventricular fibrillation: a case report. (PubMed, Oxf Med Case Reports) - "Recognizing Brugada syndrome and applying appropriate diagnostic and therapeutic measures are essential for preventing fatal arrhythmic events. This case underscores the importance of considering Brugada syndrome in patients with unexplained ventricular fibrillation, emphasizing the utility of the flecainide challenge test for accurate diagnosis when characteristic ECG findings are not evident.A multidisciplinary approach, including timely diagnosis, appropriate ICD implantation, and patient education, is critical in managing high-risk occupations to prevent catastrophic outcomes."

Journal • Cardiovascular • Genetic Disorders • Heart Failure

Antiarrhythmic Drug Therapy for Acute Management of Atrial Fibrillation and Atrial Flutter. (PubMed, Card Electrophysiol Clin) - "It details the efficacy, indications, and safety profiles of commonly used agents, including beta-blockers, calcium channel blockers, and antiarrhythmic drugs such as amiodarone, ibutilide, dofetilide, and flecainide. The article highlights patient-specific considerations, emerging therapies, and the need for safer, faster acting drugs as atrial fibrillation prevalence rises. Both traditional and novel approaches are discussed to guide evidence-based clinical decision-making in acute settings."

Journal • Review • Atrial Fibrillation • Cardiovascular

FLECAINIDE TOXICITY: AN UNUSUAL PRESENTATION FOR TREMOR AND VOCAL TIC (ACC 2026) - "Abstract is embargoed at this time."

Movement Disorders

PULMONARY DELIVERY OF FLECAINIDE FOR ON-DEMAND CARDIOVERSION IN ATRIAL FIBRILLATION (ACC 2026) - "Abstract is embargoed at this time."

Atrial Fibrillation • Cardiovascular

EFFECT MODIFICATION OF CORONARY ARTERY CALCIFICATION ON MAJOR ADVERSE CARDIOVASCULAR EVENTS AND ALL-CAUSE MORTALITY IN VETERANS WITH PAROXYSMAL ATRIAL FIBRILLATION ON FLECAINIDE (ACC 2026) - "Abstract is embargoed at this time."

Adverse events • Atrial Fibrillation • Cardiovascular

PACEMAKER NON-CAPTURE AS A MANIFESTATION OF FLECAINIDE TOXICITY (ACC 2026) - "Abstract is embargoed at this time."

Cardiovascular

Adverse drug events from paediatric use of extemporaneously compounded medicines in community pharmacy settings: a scoping review. (PubMed, BMJ Paediatr Open) - "This review highlights the importance of thoroughly verifying active ingredients and their concentrations when compounding paediatric formulations in community pharmacies."

Adverse events • Journal • Pediatrics

Risk Factors and Markers for Flecainide Toxicity in Clinical Practice. (PubMed, CJC Open) - "Classic contraindications, such as left ventricular dysfunction or structural heart disease, were not associated with an increased risk of toxicity. Instead, metabolic retention factors (chronic kidney disease, hepatic cirrhosis, or drug interactions) and preclinical markers of overdose (sinus bradycardia, left ventricular ejection fraction under treatment, baseline QT interval, and prolongation of QRS and QT intervals during treatment) increased the likelihood of toxicity."

Journal • Cardiovascular • Chronic Kidney Disease • Fibrosis • Heart Failure • Hepatology • Immunology • Liver Cirrhosis • Nephrology • Renal Disease

Management of Ablation-Refractory Atrial Fibrillation During Pregnancy. (PubMed, Case Rep Med) - "Two years earlier, during her previous pregnancy, she was hospitalized for AF, where she experienced labetalol-related hypotension and failed therapy with verapamil and digoxin. She was then managed with flecainide pill-in-pocket therapy until delivery...These episodes were unresponsive to her scheduled regimen, prompting an increase in her beta-blocker dose. However, the patient developed syncope and persistent palpitations prompting her presentation to the emergency department (ED)."

Journal • Atrial Fibrillation • Cardiovascular • Hypotension

Can in silico models predict drug-induced cardiac risk in vulnerable populations? (PubMed, Toxicol Rep) - "We assessed QT prolongation and arrhythmic events following administration of moxifloxacin (benchmark antibiotic) and contraindicated drugs including quinidine, bepridil, and flecainide. Contraindicated drugs markedly increased arrhythmia risk in populations with heart failure, dilated and hypertrophic cardiomyopathy, and ischaemia, frequently leading to lethal arrhythmias such as Torsades des Pointes or ventricular fibrillation, particularly in females. These findings demonstrate that computational models capture variability in drug response across pathologies and sexes, offering a predictive framework for preclinical safety evaluations and supporting safer, more personalized drug development strategies."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertrophic Cardiomyopathy • Myocardial Infarction

Orbital pain beyond the acute phase: A long-term manifestation of carotid dissection (EHF-EHC 2025) - " She was managed with clopidogrel, atorvastatin and antihypertensive therapy.Cardiology follow-up revealed frequent symptomatic ventricular extrasystoles, treated with bisoprolol and flecainide...Low-dose amitriptyline was initiated, with partial symptomatic relief... Despite vascular recanalization, symptoms persisted, suggesting possible perivascular sympathetic fibre injury or central sensitization. Multidisciplinary assessment was essential to exclude recurrence or structural complications. This case highlights the need for long-term follow-up and individualised pain management beyond radiological resolution."

Cardiovascular • Hypertension • Musculoskeletal Pain • Pain • Rheumatology

Perinatal Management of Andersen-Tawil Syndrome Using a Wearable Cardioverter-Defibrillator: A Case Report. (PubMed, J Obstet Gynaecol Res) - "At 36 weeks, atenolol and flecainide were introduced, and a wearable cardioverter-defibrillator (WCD) was applied, further reducing arrhythmias. Postpartum, arrhythmias increased again, highlighting the importance of surveillance. This case demonstrates that combined pharmacological therapy and temporary WCD use may represent a safe and effective perinatal management strategy in high-risk pregnancies complicated by ATS."

Journal • Cardiovascular • Ventricular Tachycardia

Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3. (PubMed, PNAS Nexus) - "Electrophysiological properties were analyzed using patch-clamp techniques, and pharmacological responses to flecainide, mexiletine, and ranolazine were evaluated. This study highlights the role of sustained INa in LQTS3 severity and underscores the importance of mutation-specific treatments. By tailoring treatments to the electrophysiological characteristics of each mutation, precision medicine offers a promising approach to improving patient outcomes in LQTS3."

Journal • Cardiovascular

Blocked Beats: A Case of Flecainide Toxicity (ASHP 2025) - No abstract available

Clinical

Risk of serious bleeding with concomitant use of apixaban or rivaroxaban with amiodarone compared to flecainide or sotalol in patients with atrial fibrillation (ASH 2025) - "Covariates were well balanced post-matching (standardized differences <0.1).After matching, 253 patients in the amiodarone group experienced serious bleeding (25.8 events per1,000 person-years) compared to 175 in the comparator group (16.4 events per 1,000 person-years) (HR,1.53; 95% CI, 1.26 to 1.86).CONCLUSIONIn this comparative safety study, among patients with AF treated with apixaban or rivaroxaban,concomitant use of amiodarone was associated with a higher risk of serious bleeding compared to use offlecainide or sotalol. These findings highlight the importance of considering drug-drug interactions whenmanaging anticoagulated patients with AF to promote safe prescribing and minimize the risk of seriousbleeding complications."

Clinical • Asthma • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Hepatology • Immunology • Nephrology • CYP3A4 • PER1

DRIVE-AF: Dronedarone Rhythm Intervention for Early Atrial Fibrillation (clinicaltrials.gov) - P4 | N=1898 | Not yet recruiting | Sponsor: Inha University Hospital

HEOR • New P4 trial • Atrial Fibrillation • Cardiovascular

Magnesium in Aconitine-Induced Electrical Storm-Mechanism Yes, Mandate No. (PubMed, Ann Noninvasive Electrocardiol) - "We propose a practical, evidence-based algorithm emphasizing: (1) first-line flecainide 2 mg/kg IV, (2) magnesium sulfate adjunct targeting serum levels of 1.5-2.0 mmol/L, (3) aggressive calcium repletion to > 1.00 mmol/L, (4) early high-flux hemoperfusion within 6 h, and (5) VA-ECMO for refractory cases. Verapamil, diltiazem, and β-blockers as sole agents should be explicitly avoided."

Journal • Review • Cardiovascular • Hypotension

Signature ECG: Exercise induced syncope. (PubMed, Indian Pacing Electrophysiol J) - "The genetic testing showed pathogenic heterozygous variant in CASQ2 gene. Patient was started on propranolol and flecainide and advised to avoid strenuous physical activity."

Journal • Cardiovascular • Ventricular Tachycardia

A Case of Atrial Fibrillation and Rapid Ventricular Response in a 22-Year-Old Athlete With Sickle Cell Trait. (PubMed, Cureus) - "The patient was administered intravenous (IV) diltiazem for rate control, and synchronized cardioversion was successfully performed to restore sinus rhythm. Short-term anticoagulation therapy with apixaban was prescribed, along with flecainide on an as-needed basis for rhythm management...Preventive measures for athletes with SCT should include adequate hydration, heat acclimatization, and education of players and coaching staff. This case highlights the importance of heightened awareness, adherence to guideline-based management, and the necessity for further research into the association between SCT and AF in young athletes."

Journal • Atrial Fibrillation • Cardiovascular • Genetic Disorders • Hematological Disorders • Metabolic Disorders • Sickle Cell Disease • Ventricular Tachycardia

Blocked Atrial Bigeminy as an Unusual Cause of Bradycardia: A Case Report. (PubMed, Int Med Case Rep J) - "Therapy with flecainide and amiodarone separately was not effective...The target values of blood pressure were achieved with candesartan at a dose of 32 mg...Recognition of the P wave superimposed on the ST segment or the T wave may be a clue for a correct diagnosis. Physicians should be aware of this condition to avoid unnecessary pacemaker implantation."

Journal • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension

Quadruple parametric optical mapping to measure cardiac metabolism-excitation-contraction coupling. (PubMed, Commun Biol) - "Using this technique, we demonstrate known and novel cardiac responses to nifedipine and flecainide. We determine chronological changes in MECC with FCCP and ischemia/reperfusion to understand the interplay between electrical, mechanical, and metabolic functions in the heart and mechanisms underlying arrhythmogenesis."

Journal • Cardiovascular • Reperfusion Injury

Shortening Duration of Antiarrhythmic Medication for SVT in Infants (clinicaltrials.gov) - P=N/A | N=107 | Completed | Sponsor: Tampere University Hospital | Recruiting ➔ Completed | N=70 ➔ 107

Enrollment change • Trial completion • Cardiovascular • Ventricular Tachycardia

Serum Alkalinization Affects Elimination of Flecainide in Chronic Toxicity: A Case Report. (PubMed, Case Rep Crit Care) - "Tissue redistribution as a result of serum alkalinization likely contributed to impaired elimination in a patient with chronic flecainide toxicity. Serum alkalinization from sodium bicarbonate administration has implications in the length of stay and need for adjunctive therapies in the treatment of flecainide toxicity."

Journal • Cardiovascular • Metabolic Disorders

Under Recognized Toxicity of Flecainide Overdose. (PubMed, Prehosp Emerg Care) - "The patient was also given sodium bicarbonate, lorazepam, levetiracetam, lidocaine, amiodarone, and lipid emulsion. In general, one cannot know whether a longer transfer time will result in critical decompensation. Nonetheless, one might consider certain presentations with capacity for critical illness requiring highly specialized care as an indication for direct transport."

Journal • Cardiovascular • CNS Disorders • Critical care • Epilepsy • Hypotension • Pediatrics • Ventricular Tachycardia