Betnovate (betamethasone valerate) / GSK - LARVOL DELTA

Chemoinformatic Approaches to Identify Bioactive Inhibitors Against Type I Dehydroquinase (DHQ1) Enzyme of Typhoidal Salmonella. (PubMed, Bioinform Biol Insights) - "A total of 10 ligands were selected with the highest binding affinities ranging from -9.8 to -9.1 (kcal/mol), ie, Cabotegravir, Imatinib, Prulifloxacin, Limonin, Silibinin, Atovaquone, Betamethasone Valerate, GSK1324726A, Isavuconazole, and Raltegravir. Molecular dynamic simulations were used to verify the stability of the protein "DHQ1" docked with 3 hit ligands Cabotegravir, Limonin, and Silibinin by calculating root mean square fluctuation (RMSF), root mean square deviation (RMSD), radius of gyration (Rg), H-bond interaction, and molecular mechanics/generalized Born surface area (MM/GBSA) scores. Based on molecular dynamic (MD) simulations, it is reported that Cabotegravir and Limonin showed the optimal binding features with bacterial DHQ1 enzyme and can be deemed as a repurposed drug candidate as compared to Silibinin, which did not show favorable interactions with DHQ1 and needs to be explored further against typhoidal Salmonella."

Journal • Infectious Disease

Efficacy of Topical Betamethasone Valerate and Olive Oil in Preventing Acute Radiation Dermatitis in Breast Cancer: A Randomized Double-Blind Placebo-Controlled Study. (PubMed, Clin Breast Cancer) - P4 | "Olive oil cream is as effective as betamethasone in alleviating RID in patients treated with adjuvant radiotherapy for breast cancer."

Journal • Breast Cancer • Dermatitis • Dermatology • Immunology • Oncology • Solid Tumor

A head-to-head comparison of two topical anti-inflammatory treatments, crisaborole and betamethasone valerate, reveals marked differences in their effects on the microstructure of the skin (WCD 2023) - P2 | "BMV treatment, compared to CRB, was associated with broad changes to the superficial dermal vasculature and collagen matrix that may foreshow the development of clinical adverse effects including striae and telangiectasia. Crisaborole may therefore be more suitable for longer-term and proactive-based treatment strategies where the risks of TCS-induced adverse effects are greatest"

Head-to-Head • Atopic Dermatitis • Dermatitis • Dermatology • Immunology