iNCOVACC (ChAd36-SARS-CoV-S COVID-19 vaccine (recombinant)) / Bharat Biotech, Washington University School of Medicine in St. Louis - LARVOL DELTA

Mucosal immunization with ChAd-SARS-CoV-2-S prevents sequential transmission of SARS-CoV-2 to unvaccinated hamsters. (PubMed, Sci Adv) - "In contrast, sequential transmission occurred after systemic immunization with the mRNA vaccine. Thus, immunization with a mucosal COVID-19 vaccine protects against cycles of respiratory transmission of SARS-CoV-2 and can potentially limit the community spread of the virus."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection. (PubMed, Nat Immunol) - "A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used in India (iNCOVACC)...However, depletion of memory CD8+ T cells before XBB.1.5 challenge resulted in loss of protection against upper and lower respiratory tract infection. Thus, nasally delivered vaccines stimulate mucosal immunity against emerging SARS-CoV-2 strains, and cross-reactive memory CD8+ T cells mediate protection against lung infection by antigenically distant strains in the setting of low serum levels of cross-reactive neutralizing antibodies."

Journal • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology • Respiratory Diseases • CD8

Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin). (PubMed, NPJ Vaccines) - P3 | "Both vaccines were well tolerated. Overall reported solicited reactions were 6.9% and 25.5% and unsolicited reactions were 1.2% and 3.1% in BBV154 and Covaxin participants respectively."

Journal • P3 data • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

"hopeful for #covaxin or #incovacc" (@dvmknnth)

"And hopefully @BARDA will consider supporting @Ocugen for both covaxin and Incovacc. We shouldn’t limit ourselves." (@Dfwmb123)

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @RickABright @WHCOVIDResponse #bharatbiotech #ocugen #OCU500" (@Diego48979433)

Novel Coronavirus Disease

"Let me guess, PFE or Moderna must not have a next gen nasal vaccines yet #BuyingTime Meanwhile #iNCOVACC #Covaxin are ready" (@doc_holliday50)

Clinical

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #bharatbiotech #ocugen #OCU500" (@Diego48979433)

Novel Coronavirus Disease

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #bharatbiotech #ocugen #OCU500" (@Diego48979433)

Novel Coronavirus Disease

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"#iNCOVACC and #Covaxin" (@doc_holliday50)

"#COVAXIN #INCOVACC @NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"#covaxin #incovacc" (@NathanR91334798)

"@Ocugen just pay the fee like @moderna_tx and @pfizer if not will never see covaxin or incovacc in the United States @NIH @US_FDA @CDCgov = PAY TO PLAY." (@NathanR91334798)

"@NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #covaxin #incovacc #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"Approve Covaxin and incovacc. They may be the one way out of this mess." (@Dfwmb123)

"#IchooseCOVAXIN #INCOVACC #Ocugen #BharatBiotech #IRefusemRNA" (@CraigGordon8)

"@NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #covaxin #incovacc #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"@NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @WHCOVIDResponse #covaxin #incovacc #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"@NIHDirector @HHSGov @DrCaliff_FDA @CDCDirector @AshishKJha46 @elonmusk @WHCOVIDResponse #covaxin #incovacc #bharatbiotech #ocugen" (@Diego48979433)

Novel Coronavirus Disease

"Let’s get covaxin and incovacc avail world." (@Dfwmb123)

"@US_FDA @FDA_Drug_Info @DrCaliff_FDA #COVAXIN and #INCOVACC would be great for the people @Ocugen @BharatBiotech" (@nrbarile)

Clinical

"You should really look into #COVAXIN #INCOVACC #ocugen #bharatbiotech" (@Wetsu25)

"Approve #covaxin and #incovacc" (@Gustavo74001799)