NEO-301 / Precision Biologics - LARVOL DELTA

Lipid peroxidation depends on the clock 3111T/C gene polymorphism in menopausal women with Insomnia. (PubMed, Chronobiol Int) - "Patients with insomnia carriers of the TT-genotype had a significantly higher thiobarbituric acid reactants level and glutathione peroxidase activity as compared to group with insomnia carriers of the minor 3111C-allele (p < .05)...The carriers of the minor allele with insomnia had a higher conjugated dienes levels and lower glutathione peroxidase activity as compared to control (p < .05). Thus, lipid peroxidation and antioxidant system parameters in Caucasian menopausal women with insomnia depend on the Clock 3111T/C gene polymorphism."

Clinical • Journal • CNS Disorders • Insomnia • Sleep Disorder

[VIRTUAL] Melatonin and thiobarbituric acid reactants in menopausal women with insomnia depending on the genotype of Clock 3111T/C gene polymorphism (ESRS 2020) - "Thus, highly toxic products of lipid peroxidation levels and circadian rhythms of melatonin in Caucasian menopausal women with insomnia depend on the Clock 3111T/C gene polymorphism. The minor allele 3111C may have the protective role of in the development of insomnia and oxidative stress."

Clinical • CNS Disorders • Insomnia • Sleep Disorder

Functional Studies of Five Toxin-Antitoxin Modules in Mycobacterium tuberculosis H37Rv. (PubMed) - Front Microbiol - "Accordingly, we investigated five uncharacterized TA systems (Rv2019-Rv2018, Rv3697c-Rv3697A, Rv3180c-Rv3181c, Rv0299-Rv0298, and Rv3749c-Rv3750c) of Mtb. Moreover, mRNAs appeared to be substrates of Rv2019. Therefore, we concluded that the ribonuclease activity of the Rv2019 toxin triggers the growth defect in E. coli and that the Rv2018 antitoxin inhibits the ribonuclease activity of the Rv2019 toxin."

Journal • Biosimilar

Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis. (PubMed) - Sci Rep - "Moreover the MIC of triclosan was not affected by efflux pump inhibitors that inhibit the activity of transporters similar to the one encoded by Rv1686c-Rv1687c. These results suggest that none of the two systems is directly involved in M. tuberculosis resistance to triclosan or to any of the antimicrobials tested."

Journal • Biosimilar

Two novel mutations in ADAMTS13 in a Chinese boy with congenital thrombocytopenic purpura: a case report. (PubMed, BMC Med Genet) - "We report two novel mutations in ADAMTS13 (332G > A, 3121C > T) in a Chinese boy. These two mutations may lead to early onset of cTTP and severe symptoms."

Clinical • Journal

Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia. (PubMed, Chronobiol Int) - "There were no statistically significant differences in the circadian rhythms of melatonin in the Asian women depending on the genotype of the Clock 3111T/C polymorphism. An assumption with respect to the protective role of the minor allele 3111C in the development of insomnia associated with the displacement of melatonin circadian rhythms in the representatives of the incoming population was made."

Clinical • Journal