Vexol (rimexolone ophthalmic) / Novartis - LARVOL DELTA

Pediatric Ataxia and Emerging Treatments. (PubMed, Pediatr Neurol) - "We then provide an overview of emerging treatments and the pipeline for disease-modifying therapies. Unfortunately, the needle has not yet substantially shifted on survivorship in pediatric ataxia, so the focus remains on management of longer-term complications and emphasizing the importance of a multidisciplinary team and the role of palliative care."

Journal • Review • Ataxia • Friedreich ataxia • Gene Therapies • Immunology • Movement Disorders • Palliative care • Pediatrics • Primary Immunodeficiency

Immune cell-specific genetic architecture of Alzheimer's disease revealed by multi-omics analysis for therapeutic target discovery and prioritization. (PubMed, Transl Psychiatry) - "Among these compounds, Predicted blood-brain barrier permeability was observed only for phenoxybenzamine and rimexolone, with docking studies indicating stable interactions, such as those between NSC321521 and HLA-DQA1, phenoxybenzamine and GSTP1, and rimexolone and BIN1. This integrative approach highlights key immune‑cell‑specific genes involved in AD and proposes repurposable drugs with central nervous system potential, paving the way for more targeted immunomodulatory strategies in AD."

Journal • Alzheimer's Disease • CNS Disorders • CD8 • GSTP1 • HLA-DQA1

Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells. (PubMed, Eur J Pharmacol) - "These results confirm that the Nrf2 pathway is compromised in COPD and support selective Nrf2 activation-particularly via peptide-based approaches-as a promising therapeutic strategy to mitigate oxidative and inflammatory injury in the disease."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • CXCL8 • IL6 • KEAP1 • MMP9 • NFE2L2 • NQO1

Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications. (PubMed, BMC Genomics) - "In conclusion, the present study investigated key genes associated with PE pathogenesis that may contribute to identifying potential biomarkers, therapeutic agents and developing personalized treatment for PE."

Biomarker • Journal • Cardiovascular • Gynecology • Hypertension • Renal Disease

Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration. (PubMed, Bioengineered) - "Three small molecule candidate anticancer drugs (Pentoxyverine, Rimexolone, and Doxylamine) were identified. A four-gene signature (FAM129A, BCL2, PMAIP1, and RPS6) is significantly correlated with immune infiltration level. This study provides a promising biomarker reservoir to explore the mechanism by which microbiota regulate the ceRNA network involving the immune response, and further participate in colorectal carcinogenesis and progression."

IO biomarker • Journal • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • BCL2 • HOTAIR • KCNQ1OT1 • LIFR • PMAIP1 • RPS6

[VIRTUAL] Candida albicans keratitis complicated with endophthalmitis after penetrating keratoplasty in Cogan’s syndrome (ESCRS 2020) - "She was treated with 10mg/ml rimexolone eye drops and systemic methotrexate...Systematic culture of corneoscleral rim may provide diagnostic orientation and may have prognostic implications, as prophylactic treatment could be initiated. We consider that frequent follow up should be conducted specially in immunosuppressed patients as the case reported."

Cataract • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Long-term Outcomes on de novo Ocular Hypertensive Response to Topical Corticosteroids After Corneal Transplantation. (PubMed, Cornea) - "The use of alternate topical corticosteroids may be considered in cases of steroid-induced ocular hypertension after PKP because they offer good antiinflammatory prophylaxis with reduced hypertensive response."

Journal • Glaucoma • Graft versus Host Disease • Ocular Inflammation • Ophthalmology • Transplantation

Outcome and risk of ocular complications of managing children with chronic anterior uveitis with topical rimexolone 1. (PubMed, Int Ophthalmol) - "Rimexolone 1% ophthalmic suspension is an effective and safe topical steroid for pediatric anterior uveitis."

Clinical • Journal • Complement-mediated Rare Disorders • Glaucoma • Immunology • Ocular Inflammation • Ophthalmology • Pediatrics • Rare Diseases • Uveitis

"Echoworx Expands European Footprint With Nordic Language Support https://t.co/UaSveXOLgm" (,@NewsFromBW)

ACTIVATION OF NUCLEAR FACTOR ERYTHROID 2-RELATED (Nrf2) SYSTEM AS A NOVEL THERAPEUTIC APPROACH IN COPD (ERS 2019) - "Conclusions Bardoxolone, Omavexolone and Obacunone show a huge antioxidant response against CSE-induced COPD by Nrf2 activation. Thus, these drugs may represent a promising therapeutic option in COPD."