tramadol/acetaminophen / Generic mfg. - LARVOL DELTA

Monotherapy vs. combination paracetamol and tramadol for cancer-related pain in the emergency department: a comparative study. (PubMed, Support Care Cancer) - "The co-administration of paracetamol and tramadol intravenously resulted in superior and sustained analgesia when compared with monotherapy, without an increase in adverse effects. These findings provide support for the utilization of this combination as a safe and effective multimodal strategy in the acute management of cancer-related pain in the emergency department."

Clinical • Journal • Monotherapy • Genito-urinary Cancer • Hypotension • Oncology • Pain

Presumed Envenoming by the Striped Eel-Tailed Catfish Plotosus lineatus in the Mascarene Islands: Experience of the Marseille Poison Control Center and the Indian Ocean Toxicovigilance Department. (PubMed, Wilderness Environ Med) - "The main treatment involved the use of analgesics (ie, paracetamol, tramadol, or morphine), exposure to hot water or alternating cycle of exposure to hot and cold sources, and local anesthetics. For 10 patients (33%) for whom information was available, there was full recovery within 24 h in most cases (after 7 d in 1 patient) without sequelae.ConclusionThese findings show that stings by P lineatus may occur in the Mascarene Islands and that fishermen are the most likely to be stung because of handling P lineatus."

Journal • Anesthesia • Musculoskeletal Pain • Pain

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects (clinicaltrials.gov) - P=N/A | N=140 | Recruiting | Sponsor: Zohar Nachum

Adverse events • New trial • Pain

Betamethasone and Triamcinolone Acetonide Have Comparable Efficacy as Single Intra-Articular Injections in Knee Osteoarthritis: A Double-Blinded, Randomized Controlled Trial. (PubMed, J Bone Joint Surg Am) - "No significant differences were observed between IA betamethasone and triamcinolone acetonide with respect to VAS pain, functional scores, or performance-based outcomes at 6 months."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Perioperative Opioid Prescriptions in Patients on Oral Anticoagulants Undergoing Elective Soft Tissue Hand Surgery. (PubMed, J Hand Surg Am) - "Preoperative oral anticoagulant use was associated with an increased incidence of perioperative opioid prescriptions in patients undergoing elective soft tissue hand surgery."

Journal • Pain

Ultrasound-guided caudal epidural steroid injection versus tramadol-based therapy in borderline surgical lumbar spinal stenosis: A retrospective cohort study. (PubMed, Medicine (Baltimore)) - "Two contemporaneous cohorts were analyzed: one treated with ultrasound-guided caudal ESI (dexamethasone 12 mg + 0.25% bupivacaine, 8 mL), the other with standardized tramadol/paracetamol (37.5/325 mg TID). Pain benefit attenuates by 6 months, but functional gains persist. ESI may serve as an effective interim option to enhance mobility and quality of life in carefully selected patients."

Clinical • Journal • Observational data • Retrospective data • Musculoskeletal Diseases • Orthopedics • Pain

Using Metabolomics to Identify Predictive Biomarkers for Thrombotic Complications in Patients with Left Ventricular Assist Devices (AHA 2025) - "Drug metabolites like caffeine, tramadol, and acetaminophen on day 7 influenced TC risk for up to 140 days. Increased glucuronide levels in TC patients were correlated with subtherapeutic INR, suggesting that overactive glucuronidases may be metabolizing warfarin and predisposing to thrombosis. Further metabolic studies may help to personalize thrombosis prevention in LVAD patients."

Biomarker • Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Ischemic stroke • Venous Thromboembolism

Use of intravenous lidocaine in severe cancer pain with a facial neuropathic component in a patient with 2 primary cancers (NeuPSIG 2025) - "The addition of severe neuropathic pain due to a new injury surrounding the trigemino nerve, adds a therapeutic challenge in this context. Clinical case report. Patient who presents with severe abdominal pain dependent on pancreatic injury and edema with severe orofacial pain as well, with a quality of life and functionality affected mainly by the pain.The management with which he was involved was insufficient (tramadol + acetaminophen) so a total change was made.The pain responds to subcutaneous morphine, which is titrated for several days and we ended up using a continuous elastomeric pump, achieving a decrease from a VAS 10 to 1 with this treatment (with a minimal reduction in facial pain VAS 10 to 8, but with continuous irruptions)Neuropathic pain responds partially to oral neuromodulators, although it presents adverse events, intervention is not possible depending on the type of tumor, which is why intravenous lidocaine is used.Lidocaine is administered in an..."

Clinical • CNS Disorders • Musculoskeletal Pain • Neuralgia • Pain • Peripheral Neuropathic Pain • Psychiatry

Pharmacokinetic parameters of acetaminophen computed by a traditional software program in comparison to those calculated by an artificial intelligence tool (NeuPSIG 2025) - "However, concomitant use of acetaminophen with tramadol, an opioid analgesic, is suggested to be potentially effective in reducing pain caused by diabetic neuropathy... Our results indicate that ChatGPT can efficiently perform pharmacokinetic analysis. However, larger datasets are needed to further evaluate AI tools' pharmacokinetic analysis capabilities.Reference(s):1. J Grzegorzewski et al."

PK/PD data • CNS Disorders • Neuralgia

Evaluating the capabilities of an artificial intelligence tool in calculating pharmacokinetic parameters of acetaminophen (NeuPSIG 2025) - "Although information on using acetaminophen for neuropathic pain syndromes is absent, it has been suggested that a combination of acetaminophen with tramadol might be more effective than placebo for the management of diabetic neuropathic pain [1]... ChatGPT is capable of performing pharmacokinetic parameter calculations, but it has some limitations. Larger datasets and more studies are needed to thoroughly assess the ability of AI tools to accurately carry out pharmacokinetic calculations."

PK/PD data • Back Pain • CNS Disorders • Musculoskeletal Pain • Neuralgia

Transversus Abdominis Plane Block for Postoperative Analgesia after Laparoscopic Colorectal Surgery. (PubMed, Chirurgia (Bucur)) - "The TAP block was performed under ultrasound guidance, utilizing 0.25% ropivacaine administered bilaterally...Analgesic consumption was meticulously recorded, focusing on opioids, paracetamol, tramadol, and Neodolpasse...Integrating regional anesthesia techniques into standard surgical protocols is essential for optimizing patient outcomes. Future randomized controlled trials are warranted to further validate these findings and elucidate the underlying mechanisms involved."

Journal • Observational data • Anesthesia • Colorectal Cancer • Oncology • Pain • Solid Tumor

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow (clinicaltrials.gov) - P4 | N=92 | Recruiting | Sponsor: The Cleveland Clinic | Trial primary completion date: Jul 2025 ➔ Dec 2025

Trial primary completion date • Musculoskeletal Pain • Pain

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. (PubMed, J Evid Based Dent Pract) - "Based on these results, both Cc and T/A appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects."

Clinical • Journal • Pain

Trends in opioid prescribing in Scandinavian countries from 2010 to 2023: Insights from multi-metric evaluation. (PubMed, Br J Clin Pharmacol) - "This study found major differences in total opioid use and substance-specific prescribing patterns, reflecting diverse pain management strategies across Scandinavia. Changing use patterns suggest evolving prescribing strategies and possible shifts in the target group for opioid pain therapy. In addition, metric-dependent variation underscores the need for using multiple complementary metrics to accurately interpret opioid utilization trends."

Journal • Addiction (Opioid and Alcohol) • Pain

Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study. (PubMed, Reumatismo) - "While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research."

Journal • Observational data • Retrospective data • Immunology • Osteoarthritis • Pain • Rheumatology

Multidisciplinary approach for a patient with morbid obesity and psychological issues led from the pharmacy office (PubMed, Farm Comunitarios) - "Take metformin, rosuvastatin, and anastrozole...In the emergency department, he undergoes an ultrasound and intravenous analgesics that relieve the pain, diagnoses nephritic colic and prescribes metamizole and tramadol/paracetamol...The pharmacist makes a second referral to the doctor, with a written communication of suspicion of Herpes Zoster, the doctor accepts the intervention and changes the treatment by putting Valacyclovir, paracetamol/codeine and capsaicin cream. The patient returns to the pharmacy reporting that the doctor was surprised that it was a pharmacist who gave the correct diagnosis."

Journal • Breast Cancer • Diabetes • Dyslipidemia • Genetic Disorders • Herpes Zoster • Metabolic Disorders • Obesity • Oncology • Pain • Solid Tumor • Varicella Zoster

Comparative efficacy of paracetamol and tramadol for pain management in acute pancreatitis: A double-blinded randomized study. (PubMed, Pancreatology) - No abstract available

Journal • Pain • Pancreatitis

Long-acting lipegfilgrastim and antimicrobials as vigorous primary prophylaxis in bendamustine-treated patients with indolent B cell non-Hodgkin lymphoma: a multicentric real-life experience. (PubMed, Support Care Cancer) - "Febrile neutropenia (FN) is one of the most important clinical signs of infection, especially for older patients with indolent B cell non-Hodgkin lymphomas (iBC-NHLs) receiving frontline immune-chemotherapy with bendamustine-rituximab (BR). Data on the optimal strategy for infection prophylaxis from the start of chemotherapy until 1 month after the last cycle is scanty in this setting of patients, and for this reason, we carried out a multicentric retrospective study on vigorous primary anti-infectious prophylaxis consisting of lipegfilgrastim, trimethoprim-sulfamethoxazole, and acyclovir...Prophylaxis was well tolerated with grade 3 toxicity (bone pain) in only 10% of patients and was successfully managed with paracetamol or tramadol. Systematic, prompt, and sustained use of vigorous primary anti-infectious prophylaxis was able to reduce the rate of fever episodes, thus averting parenteral antimicrobial administrations, hospitalizations, and immune-chemotherapy..."

Journal • Retrospective data • B Cell Non-Hodgkin Lymphoma • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Indolent Lymphoma • Infectious Disease • Lymphoma • Musculoskeletal Pain • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Pain

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease: Drug-Wide Trial Emulation. (PubMed, Neurology) - "Our study identified several drugs with potential disease-modifying properties that could be candidates for future clinical trials. It highlights the potential of repurposing existing medications to advance drug development. While these findings are exploratory and, therefore, insufficient to justify immediate clinical application, they warrant further investigation and potential inclusion in clinical trials."

Journal • Observational data • CNS Disorders • Cough • Erectile Dysfunction • Infectious Disease • Movement Disorders • Ophthalmology • Pain • Parkinson's Disease • Respiratory Diseases

PATTERNS AND IMPLICATIONS OF OPIOID USE IN PATIENTS WITH RHEUMATIC DISEASES (EULAR 2025) - "Finally, as third-line therapy, codeine-paracetamol combination was the most prescribed (60%), followed by tramadol-paracetamol (20%) and morphine (20%). Our study showed the high level of misusage of opioids among patients with RD. Factors associated with high use are the frequency of prescription over the last year, duration of prescription and diabetes. Early identification of misuse risk factors and prioritizing alternatives are crucial."

Clinical • Addiction (Opioid and Alcohol) • Ankylosing Spondylitis • Diabetes • Fatigue • Immunology • Inflammatory Arthritis • Metabolic Disorders • Musculoskeletal Pain • Pain • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis • Xerostomia

Evaluation of pharmacotherapy in sickle cell disease in an Afro- Colombian community: A cross-sectional analytical study in San Basilio de Palenque, Bolívar. (PubMed, Intractable Rare Dis Res) - "The most commonly used medications included folic acid, analgesics (paracetamol, tramadol, naproxen, codeine, ibuprofen, morphine), L-glutamine, and enalapril...Notably, 62% of homozygous patients were not receiving baseline treatment with hydroxycarbamide, increasing their risk of complications...In conclusion, this research highlights the need for a multidisciplinary approach to optimize treatment and improve the quality of life of affected patients. Given its genetic significance, San Basilio de Palenque represents a unique setting for further studies on SCD."

Journal • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Perioperative management of myotonic dystrophy: tailored approaches to general anaesthesia – a case report (Euroanaesthesia 2025) - "Anesthesia induction was performed with 2mg midazolam, 100mcg fentanyl, 200mg propofol, and 50mg rocuronium, followed by orotracheal intubation...Analgesia included 1g paracetamol, 100mg tramadol, and 30mg ketorolac...At the procedure's end, 400mg sugammadex were administered, achieving a TOF ratio >0.9...Hypersensitivity to sedatives and paralytics increases risks of ventilatory dysfunction, delayed muscle recovery, pharyngeal dysfunction, and aspiration. To mitigate these, short-acting drugs are recommended to allow rapid recovery of consciousness and muscle strength.2"

Case report • Clinical • Anesthesia • Cardiovascular • Cataract • Dysphonia • Gastrointestinal Disorder • Genetic Disorders • Immunology • Muscular Dystrophy • Myositis • Myotonic Dystrophy • Ophthalmology • Otorhinolaryngology • Pain • Pulmonary Disease

Postoperative neuropathic pain after knee arthroplasty: The role of transitional pain medicine (Euroanaesthesia 2025) - "He was prescribed gabapentin, alpha-lipoic acid supplement, tapentadol, tramadol+paracetamol combination, duloxetine, and metamizole, and referred to the Transition Pain Clinic. The patient was followed for 7 months, gradually reduced pain medication, and initiated physical therapy. Neuropathic pain symptoms were resolved at discharge. This case highlights the importance of early intervention and specialized care in managing postoperative neuropathic pain.2 This comprehensive approach led to a favorable outcome, emphasizing the tole of Transition Pain Medicine in contemporary pain management."

Anesthesia • Musculoskeletal Pain • Neuralgia • Orthopedics • Pain

Complex hernia repair with the Fasciotens® system under combined anesthesia (Euroanaesthesia 2025) - "A cephalically-oriented epidural catheter was inserted at the T11-T12 level, followed by rapid sequence intubation with Propofol 2mg/kg, Fentanyl 2µg/kg and Rocuronium 1.2mg/kg. The maintenance agent was Sevoflurane...Analgesia included Ketamine 20mg, Paracetamol 1g, Tramadol 100mg and 1mg Epidural Morphine...A switch from Ropivacaine to fixed Epidural Morphine 2.5mg 2x/d was conducted on day 2 due to hypotension...Postoperative pain can compromise the patient's respiratory function and rehabilitation, making locoregional techniques beneficial.Learning points: The Fasciotens® system can aid surgeons in correcting large hernias. The anaesthesiologist must be familiar with these tools in order to better adapt the perioperative anaesthetic plan for each patient."

Anesthesia • Gastroenterology • Hypotension • Pain