tramadol/acetaminophen / Generic mfg. - LARVOL DELTA

RECHMPL23_0409: ESP-BACK : Erector Spinae Plane Block for acute low back pain (clinicaltrialsregister.eu) - P4 | N=300 | Not yet recruiting | Sponsor: Centre Hospitalier Universitaire De Montpellier

New P4 trial • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

TRAMPA: Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (clinicaltrials.gov) - P4 | N=300 | Recruiting | Sponsor: Universidad Nacional Autonoma de Honduras

New P4 trial • Obstetrics • Pain

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow (clinicaltrials.gov) - P4 | N=92 | Recruiting | Sponsor: The Cleveland Clinic | Trial completion date: Dec 2025 ➔ Jun 2026 | Trial primary completion date: Dec 2025 ➔ Jun 2026

Trial completion date • Trial primary completion date • Musculoskeletal Pain • Pain

Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour. (clinicaltrials.gov) - P=N/A | N=189 | Completed | Sponsor: Federal Teaching Hospital Abakaliki

New trial

Opioid Prescribing Patterns of Board-Certified Emergency Physicians Compared With Other Physicians Practicing Emergency Medicine Among Medicare Part-D Beneficiaries Between 2018 and 2020 in the United States. (PubMed, J Am Coll Emerg Physicians Open) - "The average total day supply (TDS) of opioids per beneficiary for the 4 most common opioids (acetaminophen/codeine, hydrocodone/acetaminophen, oxycodone/acetaminophen, tramadol) was estimated using generalized linear models with Poisson distribution, log-link, and individual clustering and compared by board certification in EM status. Board certification in EM was associated with lower opioid prescribing rates. The average TDS of opioids per Medicare beneficiary was lower for board-certified EM physicians compared to non-EM board-certified physicians staffing EDs between 2018 and 2020."

Journal • Medicare • Reimbursement • US reimbursement • Pain

Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort (clinicaltrials.gov) - P3 | N=60 | Recruiting | Sponsor: Al-Azhar University | Trial completion date: Nov 2024 ➔ Sep 2026 | Trial primary completion date: Nov 2024 ➔ Aug 2026

Trial completion date • Trial primary completion date • Renal Calculi

Deep learning, deeper relief: pipeline toward tailored analgesia for experimental animal models. (PubMed, Front Immunol) - "Our findings indicate that commonly used analgesics, such as tramadol and acetaminophen, not only interfere with immune cell recruitment and NF-κB activation but also skew the differentiation of epithelial stem cells into goblet cells, affecting epithelial functions even after short exposures. We then predicted and identified the signaling pathways that are impacted by amantadine treatment. In summary, our proposed pipeline facilitates a shift from one-size-fits-all analgesics to a precision medicine approach that considers the unique molecular interactions associated with each model."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Pain

Hypoglycaemia after post-operative oral analgesics administration: A case series. (PubMed, J Pak Med Assoc) - "Analgesics prescribed on discharge were Acetaminophen, Tramadol-Acetaminophen, Pregabalin, Celecoxib, etoricoxib, Diclofenac-Misoprostol, Tapentadol, and Ketorolac Tromethamine. Patients were treated with dextrose, sugar, etc., and after adjustment of analgesics dose were directed to an endocrinologist. It seems that certain analgesics increase the risk of hypoglycaemia in elderly hypertensive and diabetic fracture patients which might be a combinatory effect of analgesics, anti-hypertensive, and/or anti-diabetic agents."

Journal • Diabetes • Hypoglycemia • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Shoulder1: Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery (clinicaltrials.gov) - P4 | N=92 | Completed | Sponsor: Centre Hospitalier Universitaire de Nīmes | Unknown status ➔ Completed | N=200 ➔ 92

Enrollment change • Trial completion

Monotherapy vs. combination paracetamol and tramadol for cancer-related pain in the emergency department: a comparative study. (PubMed, Support Care Cancer) - "The co-administration of paracetamol and tramadol intravenously resulted in superior and sustained analgesia when compared with monotherapy, without an increase in adverse effects. These findings provide support for the utilization of this combination as a safe and effective multimodal strategy in the acute management of cancer-related pain in the emergency department."

Clinical • Journal • Monotherapy • Genito-urinary Cancer • Hypotension • Oncology • Pain

Presumed Envenoming by the Striped Eel-Tailed Catfish Plotosus lineatus in the Mascarene Islands: Experience of the Marseille Poison Control Center and the Indian Ocean Toxicovigilance Department. (PubMed, Wilderness Environ Med) - "The main treatment involved the use of analgesics (ie, paracetamol, tramadol, or morphine), exposure to hot water or alternating cycle of exposure to hot and cold sources, and local anesthetics. For 10 patients (33%) for whom information was available, there was full recovery within 24 h in most cases (after 7 d in 1 patient) without sequelae.ConclusionThese findings show that stings by P lineatus may occur in the Mascarene Islands and that fishermen are the most likely to be stung because of handling P lineatus."

Journal • Anesthesia • Musculoskeletal Pain • Pain

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects (clinicaltrials.gov) - P=N/A | N=140 | Recruiting | Sponsor: Zohar Nachum

Adverse events • New trial • Pain

Betamethasone and Triamcinolone Acetonide Have Comparable Efficacy as Single Intra-Articular Injections in Knee Osteoarthritis: A Double-Blinded, Randomized Controlled Trial. (PubMed, J Bone Joint Surg Am) - "No significant differences were observed between IA betamethasone and triamcinolone acetonide with respect to VAS pain, functional scores, or performance-based outcomes at 6 months."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Perioperative Opioid Prescriptions in Patients on Oral Anticoagulants Undergoing Elective Soft Tissue Hand Surgery. (PubMed, J Hand Surg Am) - "Preoperative oral anticoagulant use was associated with an increased incidence of perioperative opioid prescriptions in patients undergoing elective soft tissue hand surgery."

Journal • Pain

Ultrasound-guided caudal epidural steroid injection versus tramadol-based therapy in borderline surgical lumbar spinal stenosis: A retrospective cohort study. (PubMed, Medicine (Baltimore)) - "Two contemporaneous cohorts were analyzed: one treated with ultrasound-guided caudal ESI (dexamethasone 12 mg + 0.25% bupivacaine, 8 mL), the other with standardized tramadol/paracetamol (37.5/325 mg TID). Pain benefit attenuates by 6 months, but functional gains persist. ESI may serve as an effective interim option to enhance mobility and quality of life in carefully selected patients."

Clinical • Journal • Observational data • Retrospective data • Musculoskeletal Diseases • Orthopedics • Pain

Using Metabolomics to Identify Predictive Biomarkers for Thrombotic Complications in Patients with Left Ventricular Assist Devices (AHA 2025) - "Drug metabolites like caffeine, tramadol, and acetaminophen on day 7 influenced TC risk for up to 140 days. Increased glucuronide levels in TC patients were correlated with subtherapeutic INR, suggesting that overactive glucuronidases may be metabolizing warfarin and predisposing to thrombosis. Further metabolic studies may help to personalize thrombosis prevention in LVAD patients."

Biomarker • Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Ischemic stroke • Venous Thromboembolism

Use of intravenous lidocaine in severe cancer pain with a facial neuropathic component in a patient with 2 primary cancers (NeuPSIG 2025) - "The addition of severe neuropathic pain due to a new injury surrounding the trigemino nerve, adds a therapeutic challenge in this context. Clinical case report. Patient who presents with severe abdominal pain dependent on pancreatic injury and edema with severe orofacial pain as well, with a quality of life and functionality affected mainly by the pain.The management with which he was involved was insufficient (tramadol + acetaminophen) so a total change was made.The pain responds to subcutaneous morphine, which is titrated for several days and we ended up using a continuous elastomeric pump, achieving a decrease from a VAS 10 to 1 with this treatment (with a minimal reduction in facial pain VAS 10 to 8, but with continuous irruptions)Neuropathic pain responds partially to oral neuromodulators, although it presents adverse events, intervention is not possible depending on the type of tumor, which is why intravenous lidocaine is used.Lidocaine is administered in an..."

Clinical • CNS Disorders • Musculoskeletal Pain • Neuralgia • Pain • Peripheral Neuropathic Pain • Psychiatry

Pharmacokinetic parameters of acetaminophen computed by a traditional software program in comparison to those calculated by an artificial intelligence tool (NeuPSIG 2025) - "However, concomitant use of acetaminophen with tramadol, an opioid analgesic, is suggested to be potentially effective in reducing pain caused by diabetic neuropathy... Our results indicate that ChatGPT can efficiently perform pharmacokinetic analysis. However, larger datasets are needed to further evaluate AI tools' pharmacokinetic analysis capabilities.Reference(s):1. J Grzegorzewski et al."

PK/PD data • CNS Disorders • Neuralgia

Evaluating the capabilities of an artificial intelligence tool in calculating pharmacokinetic parameters of acetaminophen (NeuPSIG 2025) - "Although information on using acetaminophen for neuropathic pain syndromes is absent, it has been suggested that a combination of acetaminophen with tramadol might be more effective than placebo for the management of diabetic neuropathic pain [1]... ChatGPT is capable of performing pharmacokinetic parameter calculations, but it has some limitations. Larger datasets and more studies are needed to thoroughly assess the ability of AI tools to accurately carry out pharmacokinetic calculations."

PK/PD data • Back Pain • CNS Disorders • Musculoskeletal Pain • Neuralgia

Transversus Abdominis Plane Block for Postoperative Analgesia after Laparoscopic Colorectal Surgery. (PubMed, Chirurgia (Bucur)) - "The TAP block was performed under ultrasound guidance, utilizing 0.25% ropivacaine administered bilaterally...Analgesic consumption was meticulously recorded, focusing on opioids, paracetamol, tramadol, and Neodolpasse...Integrating regional anesthesia techniques into standard surgical protocols is essential for optimizing patient outcomes. Future randomized controlled trials are warranted to further validate these findings and elucidate the underlying mechanisms involved."

Journal • Observational data • Anesthesia • Colorectal Cancer • Oncology • Pain • Solid Tumor

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow (clinicaltrials.gov) - P4 | N=92 | Recruiting | Sponsor: The Cleveland Clinic | Trial primary completion date: Jul 2025 ➔ Dec 2025

Trial primary completion date • Musculoskeletal Pain • Pain

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. (PubMed, J Evid Based Dent Pract) - "Based on these results, both Cc and T/A appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects."

Clinical • Journal • Pain

Trends in opioid prescribing in Scandinavian countries from 2010 to 2023: Insights from multi-metric evaluation. (PubMed, Br J Clin Pharmacol) - "This study found major differences in total opioid use and substance-specific prescribing patterns, reflecting diverse pain management strategies across Scandinavia. Changing use patterns suggest evolving prescribing strategies and possible shifts in the target group for opioid pain therapy. In addition, metric-dependent variation underscores the need for using multiple complementary metrics to accurately interpret opioid utilization trends."

Journal • Addiction (Opioid and Alcohol) • Pain

Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study. (PubMed, Reumatismo) - "While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research."

Journal • Observational data • Retrospective data • Immunology • Osteoarthritis • Pain • Rheumatology