TMB-607 / TaiMed Biologics - LARVOL DELTA

Exploring Nanoherbal Paraboea leuserensis as a Therapeutic Agent in Traumatic Brain Injury: In Silico, and In Vivo Approaches. (PubMed, Iran J Med Sci) - "In vivo, PL100 (P<0.01), PL200 (P<0.001), and PL300 (P<0.0001) significantly enhanced SOD activity and reduced MDA levels compared to the TBI control. Both in silico and in vivo findings highlight the neuroprotective potential of Paraboea leuserensis, with PL300 showing the most pronounced antioxidant effect in TBI-induced rats."

Journal • Preclinical • CNS Disorders • Vascular Neurology • CCR2

Effects of dietary lipid and phospholipid levels on growth performance, lipid metabolism, and antioxidant capacity of largemouth bass (Micropterus salmoides) larvae. (PubMed, Fish Physiol Biochem) - "PL supplementation significantly reduced liver triglyceride and total cholesterol levels, with the lowest levels observed in the L6/PL100 and L12/PL100 groups. These findings demonstrate that graded PL replacement (up to 100%) at the 6% lipid level optimized growth, reduced fat deposition, increased antioxidant capacity, and avoided the metabolic burden induced by high fat (12% lipids), enhancing LB larval health."

Journal • Metabolic Disorders • CAT

Changes in Microbial Communities in Soil Treated with Organic or Conventional N Sources. (PubMed, J Environ Qual) - "Nitrogen was supplied with ammonium sulfate at 112 kg N ha (AS100) or 224 kg N ha (AS200) or a combination of poultry litter, cover crop and blood meal at 112 kg N ha (PL100) or no N (Control)...Overall, the results indicated that AS200 changed bacterial composition and diversity, suggesting corresponding changes in soil processes related to N mineralization and nitrification. Understanding such changes in microbial communities can help us predict changes in soil processes to adopt sustainable management systems."

Journal

Evidence of TWIST1 and transforming growth factor-B1 aberrant expressions as novel therapeutic targets in modulating the severity of osteoarthritis with focus on biologic agents. (PubMed, J Physiol Pharmacol) - "Serum levels of IL-1β, MMP-1, and MMP-3 were greatly decreased when treated with PL 100 mg/kg...Our results suggested that high-dose treatment with piperlongumine was beneficial and effective. TWIST1 and TGF-β1 aberrant expressions contributed as a new transcription factor function and supported the reduction of osteoarthritis intensity with piperlongumine therapy."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology • G3PD • GAPDH • IL1B • MMP1 • MMP3 • TGFB1

Effects of Dietary Zn/Se and α-Tocopherol Supplementation on Metabolic Milieu, Haemogram and Semen Traits of Breeding Stallions. (PubMed, Biol Trace Elem Res) - "A case-control feeding trial involved 40 stallions (age: 8-21 years; body weight, BW: 510-531 kg) of one stud centre, allotted to two experimental groups (n = 20 control, CON vs. n = 20 supplemented, SUPPL100), following a matched-pairs approach based on age...Ameliorating the micromineral status showed to improve the haemogram of stallions in view of circulating levels of Cu. Semen quality appeared to be strongly dependent on animal effects."

Journal

Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS-CoV-2 main protease: a molecular docking, molecular dynamics and binding free energy simulation study. (PubMed, J Biomol Struct Dyn) - "In the present study, we have chosen two clinical trial drugs against HIV-1 protease namely, TMB607 and TMC310911 to use as the inhibitors of SARS-CoV-2 main protease (M) enzyme. This in silico study proves that the TMB607 molecule binds strongly with the SARS-CoV-2 M enzyme and it may be suitable for the drug repurposing of COVID-19 and further drug designing. Communicated by Ramaswamy H. Sarma."

Clinical • Journal • Gene Therapies • Infectious Disease • Novel Coronavirus Disease

Oxygen supplementation increases the total work and muscle damage markers but reduces the inflammatory response in COPD patients. (PubMed, Respir Physiol Neurobiol) - "O-Suppl increases exercise-tolerance, resulting in increased muscle injury markers in COPD. However, oxygen supplementation attenuates the inflammatory response, even upon increased physical exercise."

Clinical • Journal • Chronic Obstructive Pulmonary Disease

Study of the Safety, Tolerability and Pharmacokinetics of TMB-607 in HIV-Negative Volunteers (clinicaltrials.gov) - P1; N=9; Terminated; Sponsor: TaiMed Biologics Inc.; N=35 ➔ 9; Trial completion date: Dec 2019 ➔ Jul 2019; Suspended ➔ Terminated; Trial primary completion date: Dec 2019 ➔ Jul 2019; Drug development suspended by current holder of IND

Clinical • Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Gene Therapies • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease