meropenem / Generic mfg. - LARVOL DELTA

Disseminated melioidosis presenting as pre-septal cellulitis and multifocal abscesses in an adolescent with type 1 diabetes mellitus: a case report. (PubMed, Paediatr Int Child Health) - "Patient was treated with intravenous meropenem for 4 weeks followed by oral cotrimoxazole for a planned 3‑month eradication course. Deep tissue culture remains essential for diagnosis, as superficial swabs may be misleading. Source control, coupled with dual-phase antimicrobial therapy, remain the cornerstones of effective management."

Journal • Dermatology • Diabetes • Metabolic Disorders • Ocular Infections • Pediatrics • Type 1 Diabetes Mellitus

THE RELEVANCE OF LIVER BIOPSY IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS AND CHOLESTASIS: A CASE OF HEPATIC TUBERCULOSIS MIMICKING DRUG-INDUCED LIVER INJURY (UEGW 2026) - "Suspected drug-induced liver injury (DILI) prompted a switch to amikacin, levofloxacin, ethambutol, and meropenem...The patient was discharged on levofloxacin, rifampicin, isoniazid, and ethambutol, in addition to prednisone, ART, and standard treatment for neurotoxoplasmosis.Two months later, he was readmitted with vomiting and jaundice...Microscopy for acid-fast bacilli was negative, but the Xpert MTB/RIF confirmed hepatic tuberculosis and rifampicin resistance.A multidrug-resistant tuberculosis regimen was initiated (levofloxacin, clofazimine, bedaquiline, and terizidone) leading to an 80% reduction in alkaline phosphatase and normalization of serum bilirubin within three months.This case highlights the challenge of distinguishing DILI from opportunistic infections in advanced HIV, particularly in cholestatic presentations with hepatotoxic drug exposure. Noninvasive tests may be insufficient, emphasizing the role of liver biopsy and molecular testing in management."

Biopsy • Clinical • Cholestasis • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Liver Failure • Respiratory Diseases • Septic Shock • Tuberculosis

FROM CAR-T TO COLITIS: A COMPLEX CASE OF CHRONIC SALMONELLA AND IMMUNE-MEDIATED ENTEROCOLITIS (UEGW 2026) - "Initial stool cultures isolated Group C Salmonella which is resistant to ciprofloxacin and Bactrim...Intravenous hydrocortisone was initiated following antibiotic therapy. However, he developed Group C Salmonella bacteremia requiring six weeks of intravenous meropenem and pentaglobin. Due to steroid-refractory disease, ustekinumab therapy was commenced after achieving microbiological clearance, resulting in clinical improvement (2).This case highlights that IEC represents an increasingly recognized complication following CAR-T therapy (3-4). It frequently mimics infectious enterocolitis or occurs concomitantly with true infection, creating substantial diagnostic challenges."

CAR T-Cell Therapy • Clinical • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • CRP

Pyridoxic Acid as a Novel Endogenous Biomarker for OAT-Mediated Clearance of Meropenem: A Population Pharmacokinetic Modeling and PK/PD-Response Analysis in Patients with Sepsis. (PubMed, Pharmaceutics) - " PDA is a valuable translational biomarker for OAT-mediated clearance. To achieve 100%fT > 4MIC, we recommend (i) 1 g q8h with 3 h infusion for patients with low CLcr and high PDA levels (MIC = 0.5 mg/L), and (ii) an intensified regimen of 2 g q8h with 3 h infusion for patients with normal CLcr and low PDA levels or high resistance risk (MIC ≥ 2 mg/L)."

Biomarker • Journal • PK/PD data • Infectious Disease • Septic Shock

Carbapenem-Sparing Antimicrobial Stewardship in Internal Medicine: A Prospective Quasi-Experimental Before-and-After Pilot Implementation Study. (PubMed, Antibiotics (Basel)) - "Total targeted antibiotic exposure decreased by approximately 40% (mean 5.9 vs. 10.0 Defined Daily Doses (DDD) per patient, p < 0.001), mainly driven by reduced meropenem use...No apparent short-term signal of clinical worsening was identified, although the study was not powered to establish safety, clinical non-inferiority, or equivalence. Larger multicentre studies using standardized stewardship metrics are needed."

Journal • Infectious Disease

The Evolving Clonal, Plasmid-Mediated Resistome, Virulome and Therapeutic Landscape of Carbapenem-Resistant Klebsiella pneumoniae in Oman. (PubMed, Antibiotics (Basel)) - "CRKP in Oman is characterised by convergent clonal expansion, plasmid-mediated resistance, retained virulence potential and narrowing therapeutic options. Integrated genomic surveillance with carbapenemase-directed susceptibility and synergy testing is essential to guide precision antimicrobial stewardship in high-risk healthcare settings and inform early infection prevention responses to emerging regional CRKP lineages."

Journal • Infectious Disease • Pneumonia • FOS

Isolation of Neisseria meningitidis Serogroup B from Urine in a 74-Day-Old Infant: A Case Report. (PubMed, Microorganisms) - "The patient received ceftriaxone, with temporary escalation to meropenem because of persistent fever; neuroimaging excluded intracranial complications. Complement screening (50% hemolytic complement, CH50) was normal, and the infant recovered fully. This case illustrates an unusual microbiological presentation of probable invasive meningococcal disease, and highlights the importance of promptly interpreting unexpected culture results in febrile young infants."

Journal • CNS Disorders • Infectious Disease • Meningococcal Infections • Nephrology

Antimicrobial Resistance and Associated Genetic Determinants of Aliivibrio Colonizing the Gastrointestinal Tract of Farmed Atlantic Salmon (Salmo salar L.). (PubMed, Antibiotics (Basel)) - "Based on these results, we estimated provisional epidemiological cutoff values for several antimicrobials for Aliivibrio isolates predominant in Atlantic salmon farmed in Tasmania. Furthermore, available data show no evidence that plasmid- or integron-associated ARGs are prevalent and suggest that they are, overall, uncommon in the genus Aliivibrio. The data presented provide a foundation for monitoring AMR in Atlantic salmon gut-associated commensal bacteria."

Journal • Gastrointestinal Disorder

ESBL-Producing Klebsiella pneumoniae Bacteraemia with Renal Micro-Abscesses Treated with Cefepime-Enmetazobactam in a Neutropenic Allogeneic Transplant Recipient. (PubMed, Pathogens) - "We describe a profoundly immunocompromised patient with acute myeloid leukaemia after allo-HSCT, grade III steroid-refractory gastrointestinal graft-versus-host disease, and intestinal colonization by an ESBL-producing K. pneumoniae isolate resistant to ceftolozane-tazobactam...Meropenem was rapidly de-escalated to cefepime-enmetazobactam, with temporary adjunctive fosfomycin and subsequently tigecycline...Whole-genome sequencing identified K. pneumoniae ST307 carrying blaCTX-M-15, blaTEM-1, blaSHV-28, and blaOXA-1, together with multiple resistance determinants and a large conjugative plasmid. This case describes the use of cefepime-enmetazobactam as part of a targeted carbapenem-sparing strategy for invasive ESBL-producing K. pneumoniae infection in a highly immunocompromised allo-HSCT recipient."

Journal • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Gastrointestinal Disorder • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Nephrology • Neutropenia • Oncology • Pneumonia • Transplantation

Antibiotic Utilization Patterns and Appropriateness of Antibiotic Prescribing in an Internal Medicine Service of a Secondary Care Hospital: A Retrospective Drug Utilization Study. (PubMed, Antibiotics (Basel)) - "High overall guideline alignment (73%) coexisted with substantial use of broad-spectrum antimicrobials. Stewardship prioritization should integrate quantitative utilization with qualitative prescribing assessment rather than interpret total DDD burden as avoidable exposure. These findings provide a baseline for targeted antimicrobial stewardship and clinical-pharmacy interventions in a resource-constrained secondary-care setting."

Journal • Retrospective data

Real-world effectiveness and treatment costs of ceftazidime-avibactam versus colistin-meropenem for ICU-acquired MDR gram-negative infections in liver transplant recipients. (PubMed, Eur J Clin Microbiol Infect Dis) - "When microbiologically appropriate, CAZ/AVI was associated with better clinical and microbiological outcomes and lower sepsis-related mortality than colistin-meropenem, without lower 30-day all-cause mortality. Given the observational design, incomplete treatment-appropriateness data, and limited economic scope, these associations require prospective validation before causal conclusions are drawn."

Journal • Real-world evidence • Infectious Disease • Septic Shock • Transplantation

Glutamate Potentiates Meropenem Killing of Carbapenem-Resistant Pseudomonas aeruginosa by Increasing Outer Membrane Permeability to Increase Uptake. (PubMed, ACS Omega) - "Glutamate is a nutritional amino acid, and the dose used in this study is lower than that in routine clinical use. Collectively, these findings provide an effective, convenient, and economical approach to restore meropenem killing efficacy against CR-PA."

Journal

Distribution of Non-Fermenting Gram-Negative Bacilli and Carbapenem Resistance Profiles in Intensive Care Units of a Foundation University Hospital: A 2023-2025 Retrospective Analysis. (PubMed, Medicina (Kaunas)) - "Identification and susceptibility testing used the BD Phoenix M50 system with year-specific EUCAST breakpoints (v13.0-v15.0); colistin MICs were determined by broth microdilution...Ceftazidime-avibactam resistance in P. aeruginosa was 24.3%. Of the S. maltophilia isolates, 85.8% were categorised as susceptible-increased exposure to trimethoprim-sulfamethoxazole...but rising for meropenem in P. aeruginosa. These data do not distinguish colonisation from infection and cannot be linked to clinical outcomes. They should therefore be used to inform local empirical-treatment policy alongside clinical assessment, rather than as evidence of treatment failure."

Journal • Retrospective data • Critical care • Infectious Disease

A case report on the management of sepsis complicated by eroded mixed hemorrhoids following breast cancer chemotherapy. (PubMed, Medicine (Baltimore)) - "This case demonstrates that in severely neutropenic and thrombocytopenic patients, a conservative, integrated approach combining systemic anti-infective therapy with advanced local wound care and traditional Chinese medicine can successfully manage life-threatening sepsis originating from eroded hemorrhoids. It underscores the critical importance of perianal hygiene, prompt management of chemotherapy-induced constipation and bone marrow suppression, and the potential of nonsurgical strategies in high-risk surgical candidates."

Journal • Breast Cancer • Chemotherapy-Induced Neutropenia • Constipation • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • HER2 Positive Breast Cancer • Infectious Disease • Neutropenia • Oncology • Septic Shock • Solid Tumor • Thrombocytopenia • HER-2

Antibiotic Consumption Patterns in Three Romanian Hospitals: A Five-Year Retrospective Study. (PubMed, Antibiotics (Basel)) - "Cefuroxime accounted for the highest cumulative consumption, followed by ceftriaxone, meropenem, vancomycin, ciprofloxacin, and metronidazole. Antibiotic consumption differed among the participating hospitals and study years. Monitoring antibiotic consumption provides valuable information on hospital antibiotic utilization patterns and can support evidence-based antimicrobial stewardship in hospitals."

Journal • Retrospective data

Case Report: Successful salvage therapy with sulbactam-durlobactam combined with meropenem for carbapenem-resistant Acinetobacter baumannii bloodstream infection in a child after failure of allogeneic hematopoietic stem cell transplantation. (PubMed, Front Pediatr) - "The phase III ATTACK trial demonstrates that sulbactam-durlobactam (SUL-DUR), a novel β-lactam-β-lactamase inhibitor combination is non-inferior to colistin and is associated with fewer adverse events in adults. However, evidence for SUL-DUR use in post-transplant pediatric patients remains extremely limited. This article reports the first global case of a pediatric patient who experienced two successive HSCT failures and was successfully salvaged with SUL-DUR combined with meropenem for CRAB associated BSI after failing to respond to high-dose sulbactam (150 mg/kg/day) and tigecycline during persistent severe neutropenia, providing a novel strategy for managing resistant bacterial infections in high-risk transplant populations."

Journal • Bone Marrow Transplantation • Hematological Disorders • Infectious Disease • Neutropenia • Pediatrics • Transplantation

Urban wastewater and sewage sludge as environmental sources of antimicrobial resistance, potential pathogens, and selective agents: insights from three European wastewater treatment plants. (PubMed, Front Cell Infect Microbiol) - "Of 21 antibiotics analyzed, 13 were detected in at least one sample, with ciprofloxacin, cefotaxime, and meropenem occasionally exceeding predicted no-effect concentrations. Antibiotic susceptibility testing revealed reduced susceptibility to all tested antibiotics, including 3rd generation cephalosporins, meropenem, and last-resort antibiotics, although enumeration and susceptibility testing of environmental indicator bacteria was limited by methodological constraints. These findings demonstrate that WWTPs can contribute to the environmental dissemination of ARB and ARG in both high and low antibiotic consumption and clinical AMR regions, highlighting the need for effective wastewater treatment, improved environmental surveillance and integrated One Health approaches linking human and environmental AMR compartments."

Journal • CNS Disorders • Psychiatry

Challenges in establishing epidemiological cut-off values for the Burkholderia cepacia complex. (PubMed, J Clin Microbiol) - "Here, we present an analysis of BCC ECVs for ceftazidime (CAZ), levofloxacin (LVX), meropenem (MEM), minocycline (MIN), and trimethoprim-sulfamethoxazole (TMP-SMX). Additionally, we encountered significant challenges in our analyses, including data limitations for these organisms and high ECVs that are not clinically useful. These challenges limit the practical use of these ECVs in helping guide treatment and support the removal of ECVs from the CLSI M100 standards document."

Journal • Infectious Disease

Beyond the Cumulative Antibiogram: A Weighted-Incidence Syndromic Combination Antibiogram to Guide Empirical Therapy of Bloodstream Infections in the Emergency Department. (PubMed, Infect Dis Ther) - "WISCA complements the cAST by providing regimen-level, syndrome- and subgroup-specific coverage estimates, capturing pathogen diversity missed by species-threshold cAST reporting. Integrating WISCA into local antimicrobial-stewardship programs may refine empirical treatment choices for ED bacteremia, especially according to the BSI source and patient-specific characteristics, while supporting judicious use of broad-spectrum agents."

Journal • Infectious Disease • Nephrology

Portal Venous Gas and Emphysematous Gastritis: An Uncommon Consequence of Upper Endoscopy (ACG 2026) - "She received bowel rest, total parenteral nutrition, PPI therapy, and broad-spectrum antimicrobials (meropenem, vancomycin, fluconazole)...She was discharged on amoxicillin-clavulanate, with complete endoscopic resolution seen at three month follow up...Surgical intervention should be reserved for clinical deterioration, perforation, or confirmed necrosis. Figure: CT images showing emphysematous gastritis (blue arrow) and portal venous gas (orange arrow) Figure: Endoscopic appearance of stomach on presentation, day 3, and at 3 months"

Cardiovascular • Dyspepsia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hypertension • Hypotension • Pulmonary Disease • Respiratory Diseases

Donor-Derived Disseminated Toxoplasmosis After Liver Transplant (ACG 2026) - "He was empirically treated with meropenem and micafungin...Atovaquone should be considered as a second line option for patients at risk of toxoplasmosis who cannot tolerate TMP-SMX due to its activity against both Toxoplasma and Pneumocystis . Figure: Table 1: Infection status of donor and recipient prior to transplant. Figure: Table 2: Results of initial infectious laboratory workup."

Cholestasis • Fibrosis • Hepatology • Immunology • Infectious Disease • Liver Failure • Nephrology • Renal Disease • Septic Shock • Transplantation

Refractory Pyogenic Liver Abscess Due to Achromobacter xylosoxidans Requiring Right Hepatectomy (ACG 2026) - "Blood cultures grew A. xylosoxidans , resistant to multiple agents and susceptible only to meropenem...(B) Confluent necrotizing granulomas with central acellular necrosis (H&E, 40Ã). (C) Palisading epithelioid histiocytes with mixed inflammatory infiltrate (H&E, 400Ã)."

Genetic Disorders • Hepatology • Infectious Disease • Inflammation • Obesity

"Hole" New Problem: Iatrogenic Tracheoesophageal Fistula From Esophageal Stent Erosion (ACG 2026) - "The patient was treated with a 7-day course of meropenem...Transverse and Sagittal views of CT Esophagram demonstrating TEF fistula (arrows)â Figure: Figure 2. Image taken during bronchoscopy (left) and endoscopy (right) showing erosion of stent into bronchusâ."

Cough • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Respiratory Diseases

Acute Necrotizing Gastritis Secondary to Vancomycin-Resistant Enterococcus faecium : A Non-Surgical Approach (ACG 2026) - "The patient was treated with intravenous (IV) fluconazole, meropenem, vancomycin, and acyclovir...The patient completed a two-week course of IV linezolid with continued clinical improvement and was discharged with outpatient gastroenterology follow-up...Multiple Forrest III ulcers with gastric erosions noted throughout the stomach. Abundant food material was noted."

Diabetes • Gastrointestinal Disorder • Hypotension • Infectious Disease • Metabolic Disorders • Pancreatitis • Peptic Ulcer • Pneumonia • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

From Gut to Heart: A Rare Case of Colovesical Fistula Leading to Infective Endocarditis (ACG 2026) - "Blood cultures grew vancomycin-resistant Enterococcus faecium (VRE), and daptomycin was initiated...Antimicrobial therapy was broadened to meropenem, and VRE coverage was transitioned from daptomycin to linezolid...Figure: Contrast-enhanced CT demonstrating the fistulous connection and interval enlargement of the extramural abscess to 3.5 cm, with reactive bladder wall thickening. Figure: Transesophageal echocardiogram identified a 0.21 cm mobile vegetation on the posterior mitral leaflet and a 0.46 x 0.13 cm filamentous vegetation on the noncoronary cusp of the aortic valve."

Clinical • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Diabetes • Gastrointestinal Disorder • Heart Failure • Immunology • Inflammation • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Type 2 Diabetes Mellitus