meropenem / Generic mfg. - LARVOL DELTA

Molecular Profiles and Antimicrobial Resistance Genes in Bacterial Isolates from Chronic Rhinosinusitis Patients. (PubMed, Pathogens) - "Significant phenotype-genotype correlations were observed for mecA-oxacillin, sul1-TMP-SMX, KPC-meropenem, and tem-β-lactams (p < 0.01). Gene burden increased progressively across clinical risk categories (p < 0.001), with MDR/XDR isolates concentrated in patients with repeated antibiotic exposure. Molecular and phenotypic analyses demonstrated high concordance for selected gene-antibiotic pairs, supporting targeted molecular screening as an adjunct to culture-based diagnostics in refractory CRS."

Journal • Observational data • Infectious Disease • Inflammation • Otorhinolaryngology • Pneumonia • Respiratory Diseases • Sinusitis

Comparative Stability and Quality Assessment of Powder-Liquid Double-Chamber Bag Versus Traditional Meropenem Infusions: Implications for Critical Care and Individualized Dosing. (PubMed, Pharmaceutics) - "Its stability is more sensitive to storage temperature, requiring strict adherence to refrigeration conditions. When stored under standardized conditions, the dual-chamber bag can better ensure drug efficacy stability and medication safety, making it particularly suitable for clinical emergency use and standardized workflow management."

Journal • Critical care

Genomic Features and Antimicrobial Susceptibility of Listeria innocua Isolated from Raw Drinking Milk in Poland. (PubMed, Foods) - "All isolates were phenotypically susceptible to benzylpenicillin, ampicillin, meropenem, erythromycin, and trimethoprim-sulfamethoxazole. These findings underscore the importance of ongoing genomic surveillance of L. innocua in food environments and highlight the need to assess the potential risk posed by specific lineages, such as ST492, to food safety."

Journal • Immune Modulation • Immunology

Analysis of Antibiotic Consumption Trends and Pathogens' Epidemiological Profile Within a Multidisciplinary Clinical Hospital from Romania. (PubMed, Antibiotics (Basel)) - "For Reserve antibiotics, only slight annual fluctuations were observed, but there was an important reduction in colistin consumption. The most used were cephalosporins (cefazolin, cefuroxime and ceftriaxone), carbapenems (meropenem and ertapenem), vancomycin and linezolid... The analysis was carried out using tools recommended by the World Health Organisation (Access Watch Reserve antibiotics classification (AWaRe); Bacterial Priority Pathogen List (BBPL); Defined Daily Dose (DDD)), Average Annual Percent Change (AAPC) calculation and ESKAPE classification (bacteria group: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.). Relatively stable trends in bacterial isolates and resistant strains over five years (2020-2024) are consistent with effective antimicrobial stewardship practices."

Journal • Infectious Disease • Pneumonia

Imipenem-Induced Transcriptional Responses of Porin, Efflux Pumps, and Carbapenemase Genes in Clinical Carbapenem-Resistant Acinetobacter baumannii. (PubMed, Antibiotics (Basel)) - "Antimicrobial susceptibility to imipenem and meropenem was assessed, followed by polymerase chain reaction (PCR) detection of Ade efflux pump, outer membrane porin, and OXA-type carbapenemase genes...Clonal analysis identified nine distinct genotypes, indicating genetic diversity and the absence of clonal dominance. These findings highlight the multifactorial and heterogeneous nature of carbapenem resistance in A. baumannii, emphasizing the interplay between regulatory efflux mechanisms, porin modulation, and carbapenemase carriage."

Journal

Towards precision antibiotic therapy: predictors and outcomes of meropenem target attainment. (PubMed, Eur J Hosp Pharm) - "Three-quarters of the measurements achieved the PK/PD target of 100% fT>MIC, while half achieved the more stringent target of 100% fT>4×MIC, highlighting the need for optimised dosing strategies. Target achievement rates can be improved with therapeutic drug monitoring and personalised dosing approaches are needed."

Biomarker • Journal

In Vitro Activity of Cefiderocol, Eravacycline, and Imipenem-Relebactam Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates. (PubMed, Antibiotics (Basel)) - " All isolates were resistant to imipenem and meropenem. Cefiderocol and eravacycline demonstrated promising in vitro activity against MDR A. baumannii, including colistin-resistant isolates, whereas imipenem-relebactam showed no activity. These findings support the potential role of cefiderocol and eravacycline as alternative treatment options for CRAB infections and highlight the multifactorial nature of cefiderocol resistance beyond OXA-type carbapenemase production."

Journal • Preclinical • Infectious Disease

Disulfiram Attenuates Acinetobacter baumannii-Induced Hyperinflammation by Regulating Inflammatory Pathways: Insights from RNA Sequencing. (PubMed, ACS Infect Dis) - "Recent studies have reported that disulfiram (DSF) exhibits antibacterial activity and potentiates meropenem activity against resistant A. baumannii (A. The transcriptomic data analysis revealed downregulation of genes involved in inflammatory pathways, including the NF-κB signaling pathway, toll-like receptor signaling pathway, and cytokine-cytokine receptor interaction pathway, in DSF-treated cells, which indicates its anti-inflammatory effects in suppressing A. baumannii-induced inflammation. Collectively, our findings demonstrate that DSF is a promising candidate for modulating inflammatory responses during CRAB infection; however, further validation through in vivo and clinical studies is necessary."

IO biomarker • Journal • Infectious Disease • Inflammation • Septic Shock • IL1B • IL6 • NLRP3 • TNFA

Effects of the COVID-19 pandemic on antibiotic use and resistance in French hospitals, 2019-22: a retrospective ecological analysis of national surveillance data. (PubMed, Lancet Digit Health) - "Our results highlight alterations in antibiotic use and pathogen-specific effects of the pandemic on antibiotic resistance in hospitals. Although the biological mechanisms underlying between-species differences remain unclear, these results provide insights into the potential effects of a viral pandemic on antibiotic resistance and support the need for pandemic preparedness in health-care facilities."

Journal • Retrospective data • Critical care • Infectious Disease • Novel Coronavirus Disease • Pneumonia

Community-acquired pulmonary infection caused by Bordetella hinzii: An under-recognized pathogen. (PubMed, Diagn Microbiol Infect Dis) - "This case highlights the under-recognition of B. hinzii in clinical laboratories and the importance of advanced diagnostic methods and surveillance in vulnerable populations."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

A One Health assessment of antimicrobial-resistant Enterobacterales in migratory little stints (Calidris minuta) and aquatic ecosystems in the Kenyan Rift Valley. (PubMed, PLoS One) - "Isolates were recovered from fecal samples of C. minuta foraging at the shores of Lakes Bogoria (low anthropogenic activities) and Magadi (high anthropogenic activities), as well as from peripheral freshwater sources shared by birds, humans, livestock and wildlife...Resistance was highest for ampicillin (50%) and lowest for meropenem (1.0%). The predominant MDR phenotype was a combination of resistances to ampicillin, tetracycline, and sulfamethoxazole-trimethoprim...This is the first study to link C. minuta to the antimicrobial resistance (AMR) epidemiological circuit. Our findings underscore the need to include migratory wild birds in AMR surveillance and utilizing whole-genome sequencing to accurately trace the origin and dissemination pathways of AMR strains."

Journal

Antimicrobial Susceptibility Patterns and Outcomes of Neonatal Early-Onset Sepsis over a Decade: Implications for Empirical Therapy in a Tertiary NICU. (PubMed, J Clin Med) - "All GBS isolates (n = 7) were susceptible to benzylpenicillin and vancomycin. Although 90% of E. coli were ampicillin-resistant, 90-95% remained susceptible to third-generation cephalosporins, piperacillin-tazobactam, and aminoglycosides...However, the widespread ampicillin resistance, particularly among E. coli strains, supports consideration of cephalosporin-aminoglycoside combinations or meropenem monotherapy when rapid beta-lactam bactericidal activity is clinically essential. Mortality was higher in E. coli EOS, though not statistically significant, and unrelated to ampicillin resistance."

Journal • Critical care • Infectious Disease • Septic Shock

Subperiosteal Orbital Abscess Complicated by Haemophilus influenzae Type c Bacteremia in a Fully Immunized Toddler: A Brief Clinical Study. (PubMed, J Craniofac Surg) - "Empirical meropenem and vancomycin were de-escalated to cefazolin and then oral amoxicillin for a total of 28 days after blood cultures yielded Hic. Eyelid swelling resolved, extraocular movements fully recovered, and no recurrence was observed."

Journal • Infectious Disease • Influenza • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance. (PubMed, bioRxiv) - "Notably, M. tuberculosis lacking LdtB displayed heightened sensitivity to meropenem within macrophages, suggesting that targeting this enzyme could potentiate β-lactam efficacy during infection. These findings establish LdtB as a key mediator linking peptidoglycan homeostasis to acid stress resistance and underscores the importance of in vitro culture models that recapitulate the host microenvironment for uncovering new in vivo active therapeutic targets. Disabling a key peptidoglycan cross-linking enzyme compromises M. tuberculosis survival under acidic stress and antibiotic exposure."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Urinary tract infections, risk factors and antimicrobial resistance patterns in heart failure patients on sodium-glucose transporter 2 inhibitors: Evidence from Jakaya Kikwete Cardiac Institute in Tanzania. (PubMed, PLoS One) - "UTIs are common among HF patients on SGLT2 inhibitors, with E. coli as the predominant pathogen and a concerning resistance to commonly used antibiotics. These findings underscore the need for routine urine culture and sensitivity testing to guide appropriate therapy and promote antimicrobial stewardship, particularly in resource-constrained settings."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Nephrology • Pneumonia

ANTIBIOTIC TIMING AND IMPACT ON SURVIVAL OUTCOMES IN ANTI-CD19 AND ANTI-BCMA CAR-T CELL THERAPY (EBMT 2026) - "Particularly, PIM (piperacillin-tazobactam, imipenem, meropenem) are implicated with poor outcomes...CD19 products included lisocabtagene maraleucel, tisagenlecleucel, brexucabtagene autoleucel, and axicabtagene ciloleucel. BCMA products included idecabtagene vicleucel and ciltacabtagene autoleucel...Post CAR-T antibiotics were largely fourth generation cephalosporins such as cefepime, with vancomycin... Exposure to antibiotics in 30 days pre-CAR-T is associated with worse OS, even when adjusted for age, prior lines of therapy, and infection rate. Post-CAR-T antibiotics did not have an effect on PFS, OS or progression at first PET-CT scan. Clinicians should be judicious with antibiotic exposure in the 30 days prior to CAR-T therapy."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma

METAGENOMIC NEXT-GENERATION SEQUENCING AS A DIAGNOSTIC TOOL TO DETECT PATHOGENS IN IMMUNOCOMPROMISED PATIENTS WITH PULMONARY INFECTIONS - A SINGLE CENTER PROSPECTIVE STUDY (EBMT 2026) - "In 1 of 8 patients with mNGS-detected pathogens, mNGS lead to modification of anti-infective therapy (escalation to meropenem and linezolid after detection of Nocardia elegans in BAL and blood), concordant with later SOC culture findings in pleural fluid... In this prospective single-centre cohort of high-risk hematologic patients mNGS findings influenced anti-infective management in selected cases, underlining its potential therapeutic relevance. Careful clinical adjudication remains essential, and larger controlled studies are needed to learn more about and define the role of BAL- and blood-based mNGS-diagnostic tools in immunocompromised hosts. mNGS from BAL and blood provided plausible results with a small but clinically meaningful additive diagnostic yield."

Biomarker • Clinical • Next-generation sequencing • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Respiratory Diseases • IL6

RISK OF BACTEREMIA IN LEVOFLOXACIN-RESISTANT EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING ENTEROBACTERALES COLONIZED RECIPIENTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT (EBMT 2026) - "ESBL-colonized patients with neutropenic fever received empirical meropenem. Despite high rectal colonization rates (64%) with CTX-M ESBL and fluoroquinolone-resistant Enterobacterales, ESBL-E BSI incidence was low (5%) after allogeneic HSCT in patients who did not receive fluoroquinolone prophylaxis. Acute GVHD and mucositis, beyond colonization alone, probably contributes to dysbiosis and ESBL-E BSI risk."

Acute Graft versus Host Disease • Bone Marrow Transplantation • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Mucositis • Neutropenia • Transplantation

MANAGEMENT OF BLOODSTREAM INFECTION SECONDARY TO BACTERIAL TRANSLOCATION DURING THE NEUTROPENIC PHASE OF STEM CELL TRANSPLANT. A NO–CENTRAL LINE REMOVAL STRATEGY IN 73 EPISODES (EBMT 2026) - "We assessed: 1) resolution of infection after 7 days of treatment, 2) ICU transfer, 3) recurrence of BSI with the same organism, 4) overall mortality at 30 days, and 5) the percentage of CL that was finally removed.In each episode of fever and neutropenia, a set of blood cultures was obtained, and empiric antibiotic (meropenem or ceftazidime/avibactam) was initiated within the first hour. Later, the therapy was de-escalated to cefepime according to the results and evolution... 1-More than 50% of bacteremia occurring during the neutropenic phase of SCT meet the CDC criteria of MBI-LCBI.2- Given that the central line (CL) is not the source of the infection, a strategy involving early initiation of antibiotics and salvage of the catheter is feasible and seems safe.3- This strategy saves resources and avoids invasive procedures in patients at risk of complications."

Cardiovascular • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Neutropenia • Thrombosis • Transplantation

PERSISTING FEVER AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A CASE REPORT OF A RARE INFECTION WITH LOMENTOSPORA PROLIFICANS (EBMT 2026) - "Cytoreductive therapy with hydroxyurea was initiated immediately after diagnosis, with no other prior antineoplastic treatment administered. Conditioning with fludarabine, thiotepa, and melphalan was started 7 months after the initial diagnosis...The patient received an HLA-identical unrelated male donor peripheral blood stem cell graft, with graft-versus-host disease prophylaxis comprising cyclosporine, mycophenolate mofetil, and anti-thymocyte globulin (ATG)...On day −3, the patient developed febrile neutropenia and broad-spectrum antibiotic treatment (piperacillin/tazobactam) was initiated. Recurrent fever on day +1 led to escalation to meropenem and a switch from fluconazole to posaconazole; blood cultures remained negative.Under these measures, the fever persisted...On day +11, increasing somnolence, pathological breathing pattern, and new oxygen requirement prompted sampling of peripheral and central blood cultures and empiric addition of linezolid and..."

Case report • Clinical • Bone Marrow Transplantation • Chronic Myelomonocytic Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Respiratory Diseases • Septic Shock • Transplantation • ASXL1 • NRAS • RUNX1 • SETBP1 • SRSF2

DECOLONIZATION OF MULTIDRUG-RESISTANT BACTERIA BY FECAL MICROBIOTA TRANSPLANTATION IN A PATIENT BEFORE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (EBMT 2026) - "His course was complicated by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae bacteremia that was effectively treated with colistin...He was successfully treated with cefiderocol and high-dose extended infusion of meropenem in conjunction with debridement of right femoral osteomyelitis/abscess...Six weeks post-FMT, he underwent matched unrelated donor allogeneic HSCT using total marrow and lymphoid irradiation and cyclophosphamide conditioning and tacrolimus for graft-versus-host-disease (GvHD) prophylaxis... FMT for MDRO-decolonization pre-HSCT was successful, safe, and effective in this patient with one of the longest follow-up periods reported. Given limited therapeutic options to combat MDRO infections, safety and efficacy of gut microbial restoration with FMT in patients undergoing HSCT needs to be actively explored."

Clinical • Acute Graft versus Host Disease • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Febrile Neutropenia • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Myositis • Pneumonia • Transplantation

METAGENOMIC NEXT-GENERATION SEQUENCING AS A DIAGNOSTIC TOOL TO DETECT PATHOGENS IN IMMUNOCOMPROMISED PATIENTS WITH PULMONARY INFECTIONS - A SINGLE CENTER PROSPECTIVE STUDY (EBMT 2026) - "In 1 of 8 patients with mNGS-detected pathogens, mNGS lead to modification of anti-infective therapy (escalation to meropenem and linezolid after detection of Nocardia elegans in BAL and blood), concordant with later SOC culture findings in pleural fluid... In this prospective single-centre cohort of high-risk hematologic patients mNGS findings influenced anti-infective management in selected cases, underlining its potential therapeutic relevance. Careful clinical adjudication remains essential, and larger controlled studies are needed to learn more about and define the role of BAL- and blood-based mNGS-diagnostic tools in immunocompromised hosts. mNGS from BAL and blood provided plausible results with a small but clinically meaningful additive diagnostic yield."

Biomarker • Clinical • Next-generation sequencing • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Respiratory Diseases • IL6

RISK OF BACTEREMIA IN LEVOFLOXACIN-RESISTANT EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING ENTEROBACTERALES COLONIZED RECIPIENTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT (EBMT 2026) - "ESBL-colonized patients with neutropenic fever received empirical meropenem. Despite high rectal colonization rates (64%) with CTX-M ESBL and fluoroquinolone-resistant Enterobacterales, ESBL-E BSI incidence was low (5%) after allogeneic HSCT in patients who did not receive fluoroquinolone prophylaxis. Acute GVHD and mucositis, beyond colonization alone, probably contributes to dysbiosis and ESBL-E BSI risk."

Acute Graft versus Host Disease • Bone Marrow Transplantation • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Mucositis • Neutropenia • Transplantation

ANTIBIOTIC TIMING AND IMPACT ON SURVIVAL OUTCOMES IN ANTI-CD19 AND ANTI-BCMA CAR-T CELL THERAPY (EBMT 2026) - "Particularly, PIM (piperacillin-tazobactam, imipenem, meropenem) are implicated with poor outcomes...CD19 products included lisocabtagene maraleucel, tisagenlecleucel, brexucabtagene autoleucel, and axicabtagene ciloleucel. BCMA products included idecabtagene vicleucel and ciltacabtagene autoleucel...Post CAR-T antibiotics were largely fourth generation cephalosporins such as cefepime, with vancomycin... Exposure to antibiotics in 30 days pre-CAR-T is associated with worse OS, even when adjusted for age, prior lines of therapy, and infection rate. Post-CAR-T antibiotics did not have an effect on PFS, OS or progression at first PET-CT scan. Clinicians should be judicious with antibiotic exposure in the 30 days prior to CAR-T therapy."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma

ANTICIPATION OF PHARMACOTHERAPEUTIC PROBLEMS PRIOR TO ALLO HEMATOPOÏETIC CELL TRANSPLANTATION IN PATIENTS WITH CO-MORBIDITIES: A TWO YEARS EXPERIENCE REVIEW (EBMT 2026) - "Most PIs concern drug stop (29.9%, e.g. hypolipemiants, oral antidiabetics or platelets antiaggregating agents); drug maintenance (23.1%, e.g. sartans, betablockers) and prevention of drug iatrogeny (14.6%, e.g. preventing drug-drug interactions with antiepileptics such as valproate and meropenem)... Some drugs are inappropriate for allogeneic transplant patients. Physicians and clinical pharmacists must remain vigilant about the risk of complications during allo-HCT procedures due to co-morbidities medications.Recommendations were recently published by the French bone marrow and cell therapy society (i.e. SFGM-TC) [2]."

Clinical • Review • Bone Marrow Transplantation • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Transplantation