meropenem / Generic mfg. - LARVOL DELTA

Valproic Acid and Famotidine Drug-Drug Interaction: Report of a Pediatric Case. (PubMed, Cureus) - "He was ultimately treated with L-carnitine, lactulose, and meropenem as well as admitted to the pediatric intensive care unit (PICU) with normalization of lab values and complete resolution of his neurologic symptoms after 29 hours. This case describes an extremely rare drug-to-drug interaction of valproic acid and famotidine leading to acute altered mental status in a pediatric patient. While causality cannot be established from a single case, clinicians should consider this potential interaction when new medications are added to a stable valproic acid regimen, as these two medications are commonly prescribed in both adults and children."

Journal • Bipolar Disorder • CNS Disorders • Critical care • Endocrine Disorders • Epilepsy • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Mental Retardation • Migraine • Mood Disorders • Pain • Pediatrics • Peptic Ulcer • Post-traumatic Stress Disorder • Psychiatry • Schizophrenia

Postspinal Surgery Hydrocephalus, Intraventricular Hemorrhage, and Multidrug-Resistant Ventriculitis: A Fatal Cascade. (PubMed, J Neurol Surg Rep) - "Treatment with intravenous meropenem, vancomycin, and escalation to intrathecal colistin and tigecycline achieved microbiological clearance. Despite this, neurological recovery was poor, and the patient succumbed 27 days after readmission. This report emphasizes the interplay of mechanical and infectious complications after spinal surgery, highlighting the need for early recognition, aggressive combined therapy, and preventive strategies to improve outcomes."

Journal • CNS Disorders • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Ventriculomegaly

SEVERE DISSEMINATED COCCIDIOIDOMYCOSIS WITH VERTEBRAL INVOLVEMENT PRESENTING WITH SUPERIMPOSED BACTEREMIA AND LONGSTANDING ICHTHYOSIS LIKE SKIN DISEASE (WRMC 2026) - "Cavity fluid grew pseudomonas aeruginosa and repeat blood cultures grew Capnocytophaga Sputigena. He is being treated with isavuconazonium, vancomycin, meropenem, and IV Amphotericin B liposomal and Niacin and thiamine supplementation."

Atopic Dermatitis • Cachexia • CNS Disorders • Dermatology • Hematological Disorders • Hepatitis C • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock • Vitiligo

PURPLE URINE BAG SYNDROME: A UNIQUE PRESENTATION OF A COMMON DIAGNOSIS (WRMC 2026) - "The Foley was replaced, and empiric meropenem was started based on prior sensitivities...This in turn is excreted into the urine and is converted by Indoxyl Sulfatase (produced by some bacteria) into Indigo and Indirubin, giving the urine its purple hue. In our patient, the presence of gastrointestinal bacterial overgrowth due to constipation and the presence of the urinary tract infection with Indoxyl Sulfatase-producing bacteria (i.e Klebsiella pneumonia) caused the production of the red and blue dyes in the urine, giving it the purple appearance."

Alzheimer's Disease • Benign Prostatic Hyperplasia • Cardiovascular • CNS Disorders • Constipation • Dementia • Gastroenterology • Gastrointestinal Disorder • Nephrology • Pneumonia • Respiratory Diseases

Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene. (PubMed, Trop Med Health) - "We revealed that the widespread nonsusceptibility to multiple beta-lactams among SP isolates circulating in central Vietnam was primarily driven by the dynamics of the pbp2x gene. However, the nonsusceptible pbp2x allele had little effect on clinical outcome."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Autoaggregation-associated carbapenem tolerance mediated by mrkH inactivation identified from a cohort of Klebsiella pneumoniae species complex clinical isolates. (PubMed, J Antimicrob Chemother) - "This study identified mrkH-linked autoaggregation as a novel mechanism of carbapenem tolerance in Klebsiella isolates. Overall, the findings underscore the role of multicellular behaviours in antibiotic resilience and highlight the potential clinical relevance of non-carbapenemase-mediated tolerance mechanisms."

Journal • Infectious Disease • Pneumonia • GDF15

Salmonella enteritidis: a rare pathogen in a polymicrobial acute prosthetic joint infection following total hip arthroplasty treated with double debridement, antibiotics, and implant retention (DAIR). (PubMed, J Surg Case Rep) - "She received a 3-month course of antibiotics including per os (PO) azithromycin and intravenous (IV) ceftriaxone that was switched to IV meropenem. Salmonella organism is an atypical isolate in PJI. In the absence of a primary cause and in the context of acute infection, double DAIR is a viable option to salvage the prosthesis when a dual approach of aggressive intraoperative debridement and postoperative antibiotics coverage is employed."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Comparison of in vitro antimicrobial activity of tebipenem, sulopenem, meropenem, and ertapenem against cefotaxime-resistant Enterobacterales (ESCMID Global 2026) - No abstract available

Preclinical

Phage Resistance Bidirectionally Altered Antibiotic Susceptibility in Klebsiella pneumoniae via galE mutation. (PubMed, Int J Antimicrob Agents) - "Interestingly, phage resistance imposed a fitness trade-off associated with galE disruption, resulting in collateral antibiotic effects, namely increased susceptibility to aminoglycosides, chloramphenicol and polymyxin, alongside reduced susceptibility to tetracycline and meropenem. This study demonstrates for the first time that galE mutation in K. pneumoniae diminishes phage adsorption by causing truncation of the LPS. The trade-off leads to increased susceptibility to several antibiotics, offering a potential therapeutic advantage in treating MDR infections."

Journal • Infectious Disease • Pneumonia

Phylogenomic and phenotypic profiling of carbapenem-resistant Pseudomonas aeruginosa clinical isolates reveals lineage-specific resistance mechanisms and adaptive responses. (PubMed, Microb Genom) - "A total of 136 CRPA clinical isolates collected from 28 healthcare centres across Mexico were analysed through core genome phylogeny, sequence type (ST) assignment, resistome profiling, oprD variant analysis, bacterial growth kinetics under imipenem and meropenem exposure and qRT-PCR-based expression of oprD, mexA, mexC, mexE and mexY genes...In 36% (49/146) of the isolates, β-lactamases (bla VIM 16%, bla GES11% and bla IMP 11%) were identified with carbapenemase activity previously reported...Carbapenem resistance in P. aeruginosa is shaped by both phylogenetic background and antibiotic-driven stress responses. This study provides an integrated analysis of resistance mechanisms - including gene expression and physiological adaptation - across major phylogenetic lineages in clinical isolates recovered in Mexico, underscoring the importance of considering non-carbapenemase resistance pathways in surveillance and treatment strategies."

Journal

Anorectal Complications in Acute Leukaemia: A retrospective analysis of clinical characteristics, management and outcomes in a tertiary care setting in Oman. (PubMed, Sultan Qaboos Univ Med J) - "The majority of patients were treated with meropenem (n = 44/176) and metronidazole (n = 39/176)...Fissures were the most frequently observed complication, while abscesses posed the most significant management challenge, requiring collaboration between Surgery and Infectious Diseases teams. Close monitoring of patients can facilitate early detection and intervention of these complications."

Journal • Retrospective data • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • B Acute Lymphoblastic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology

Intensive care units-acquired urinary tract infections: a 5-year multicenter retrospective study in Istanbul. (PubMed, J Infect Dev Ctries) - "Universal recommendations on the use of catheters should be carefully applied to prevent the development of the infection. Patients who are infected by multidrug resistant (MDR) microorganisms should be followed carefully. Both centers should develop their own policies on this issue."

Journal • Retrospective data • Critical care • Infectious Disease • Nephrology • Pneumonia

Real-world study of adverse events associated with ceftazidime/avibactam based on the U.S. Food and Drug Administration adverse event reporting system database. (PubMed, Front Cell Infect Microbiol) - "Ceftazidime/avibactam (CZA), a combination of the third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase inhibitor avibactam, was widely used in the treatment of multidrug-resistant (MDR) Gram-negative bacterial pathogens. The present study identified significant and novel AEs signals for CZA. Notably, the specific association between the CZA-meropenem combination and respiratory failure warrants vigilant clinical monitoring, distinct from general disease progression risks."

Adverse events • Journal • Real-world evidence • Acute Kidney Injury • Hepatology • Infectious Disease • Nephrology • Renal Disease • Respiratory Diseases

Differences in β-lactamase activity and carbapenem resistance among the Bacillus cereus group. (PubMed, Antimicrob Agents Chemother) - "Although all B. luti isolates lacked carbapenemase genes, they exhibited higher minimum inhibitory concentration (MIC) ranges for ampicillin and meropenem...All B. luti isolates and some B. mosaicus and B. cereus s.s. isolates displayed constitutive enzyme activity for penicillin G, whereas most B. mosaicus and B. cereus s.s. isolates displayed inducible activity, and five displayed silent activity...This is the first study to demonstrate interspecies variability within the B. cereus group regarding the presence of carbapenemase genes and β-lactam resistance profiles. These findings provide crucial insights into β-lactam resistance mechanisms in this bacterial group and provide a foundation for further research."

Journal • Infectious Disease

Catastrophic Consequences of Bacillus Cereus–Contaminated Hematopoietic Stem Cells: Hemolytic Transfusion Reaction, Septic Shock, and Adaptive GVHD Prophylaxis in a Pediatric Allogeneic Transplant (TCT-ASTCT-CIBMTR 2026) - " An 18-year-old female with severe aplastic anemia underwent conditioning with fludarabine, cyclophosphamide, total-body irradiation, and rATG before matched unrelated donor HCT...Empiric vancomycin and ceftazidime were escalated to meropenem for 14 days. Methotrexate was withheld due to AKI, and mycophenolate mofetil (MMF) was substituted from day +2 to +45... B. cereus contamination of HCT products constitutes a medical emergency with life-threatening consequences. Prompt recognition, aggressive supportive care, and predefined institutional protocols are essential to improve outcomes. This case illustrates the feasibility of tailoring GVHD prophylaxis when standard agents are contraindicated by organ dysfunction and underscores the importance of coordinated multidisciplinary management in these rare but catastrophic scenarios."

Clinical • Acute Graft versus Host Disease • Acute Kidney Injury • Aplastic Anemia • Graft versus Host Disease • Hematological Disorders • Immunology • Nephrology • Pediatrics • Septic Shock • Transplantation

The Gut Microbiome As the Link between Antibiotic Exposures and Cytomegalovirus Viremia after Hematopoietic Cell Transplantation in Children (TCT-ASTCT-CIBMTR 2026) - "Antibiotic exposures for cefepime, vancomycin, and anaerobic antibiotics (e.g., metronidazole, piperacillin-tazobactam, and meropenem) were assessed. We identified B. uniformis as a potential microbiome marker of CMV risk after HCT in children. The judicious use of broad-spectrum antibiotics should be exercised to limit microbiome perturbation, and the microbiome may serve as a modifiable target for novel CMV preventive strategies. Further work is needed to validate these findings in other pediatric cohorts."

Clinical • Cytomegalovirus Infection • Graft versus Host Disease • Immunology • Transplantation

Antibiotics modulate Escherichia coli-derived bacterial extracellular vesicle production and their upregulation of ICAM-1 in human endothelial cells. (PubMed, Biol Open) - "In this study, we examined how the clinically-relevant antibiotics meropenem, tobramycin, and ciprofloxacin impacted BEV production from a urinary tract infection-associated Escherichia coli strain (CFT073 [WAM2267]) and a meningitis-associated strain (K1 RS218). To our knowledge, this is the first study examining the interplay between antibiotic treatment and the effects of the resulting BEVs on endothelial ICAM-1 expression. Our results indicate treatment risks of certain antibiotics against specific strains of E. coli and could help identify therapeutic targets to reduce BEV-mediated endothelial stimulation during infection."

IO biomarker • Journal • CNS Disorders • Infectious Disease • Inflammation • Nephrology • ICAM1 • TERC • TLR4

ANTIBIOTIC TIMING AND IMPACT ON SURVIVAL OUTCOMES IN ANTI-CD19 AND ANTI-BCMA CAR-T CELL THERAPY (EBMT 2026) - "Particularly, PIM (piperacillin-tazobactam, imipenem, meropenem) are implicated with poor outcomes...CD19 products included lisocabtagene maraleucel, tisagenlecleucel, brexucabtagene autoleucel, and axicabtagene ciloleucel. BCMA products included idecabtagene vicleucel and ciltacabtagene autoleucel...Post CAR-T antibiotics were largely fourth generation cephalosporins such as cefepime, with vancomycin... Exposure to antibiotics in 30 days pre-CAR-T is associated with worse OS, even when adjusted for age, prior lines of therapy, and infection rate. Post-CAR-T antibiotics did not have an effect on PFS, OS or progression at first PET-CT scan. Clinicians should be judicious with antibiotic exposure in the 30 days prior to CAR-T therapy."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma

Clinical epidemiology, genospecies distribution, and in vitro susceptibility to novel agents among Burkholderia cepacia complex bloodstream infections in Taiwan. (PubMed, Infection) - "Burkholderia cepacia complex (BCC) showed increased resistance to recommended therapeutic agents, including levofloxacin, ceftazidime, meropenem and trimethoprim/sulfamethoxazole (TMP/SMX)...Aztreonam/avibactam and ceftolozane/tazobactam showed similar and even lower activity compared to ceftazidime and meropenem...Neither regimens of antibiotic therapy nor genospecies was associated with 14-day survival The study highlighted the survival benefit of source control, instead of therapeutic regimens. Further, in vitro potency of cefiderocol and ceftazidime/avibactam may have a potential role to improve outcomes among patients with BCC BSIs."

Journal • Preclinical • Infectious Disease

MANAGEMENT OF BLOODSTREAM INFECTION SECONDARY TO BACTERIAL TRANSLOCATION DURING THE NEUTROPENIC PHASE OF STEM CELL TRANSPLANT. A NO–CENTRAL LINE REMOVAL STRATEGY IN 73 EPISODES (EBMT 2026) - "In each episode of fever and neutropenia, a set of blood cultures was obtained, and empiric antibiotic (meropenem or ceftazidime/avibactam) was initiated within the first hour. Later, the therapy was de-escalated to cefepime according to the results and evolution... 1-More than 50% of bacteremia occurring during the neutropenic phase of SCT meet the CDC criteria of MBI-LCBI.2- Given that the central line (CL) is not the source of the infection, a strategy involving early initiation of antibiotics and salvage of the catheter is feasible and seems safe.3- This strategy saves resources and avoids invasive procedures in patients at risk of complicationsReference: (1) CDC. NHSN Patient Safety Component Manual: CLABSI. https://www.cdc.gov/nhsn/pdfs/pscmanual/4psc_clabscurrent.pdf"

Cardiovascular • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Neutropenia • Thrombosis • Transplantation

PERSISTING FEVER AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A CASE REPORT OF A RARE INFECTION WITH LOMENTOSPORA PROLIFICANS (EBMT 2026) - "Cytoreductive therapy with hydroxyurea was initiated immediately after diagnosis, with no other prior antineoplastic treatment administered. Conditioning with fludarabine, thiotepa, and melphalan was started 7 months after the initial diagnosis...The patient received an HLA-identical unrelated male donor peripheral blood stem cell graft, with graft-versus-host disease prophylaxis comprising cyclosporine, mycophenolate mofetil, and anti-thymocyte globulin (ATG)...On day −3, the patient developed febrile neutropenia and broad-spectrum antibiotic treatment (piperacillin/tazobactam) was initiated. Recurrent fever on day +1 led to escalation to meropenem and a switch from fluconazole to posaconazole; blood cultures remained negative.Under these measures, the fever persisted...On day +11, increasing somnolence, pathological breathing pattern, and new oxygen requirement prompted sampling of peripheral and central blood cultures and empiric addition of linezolid and..."

Case report • Clinical • Bone Marrow Transplantation • Chronic Myelomonocytic Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Respiratory Diseases • Septic Shock • Transplantation • ASXL1 • NRAS • RUNX1 • SETBP1 • SRSF2

METAGENOMIC NEXT-GENERATION SEQUENCING AS A DIAGNOSTIC TOOL TO DETECT PATHOGENS IN IMMUNOCOMPROMISED PATIENTS WITH PULMONARY INFECTIONS - A SINGLE CENTER PROSPECTIVE STUDY (EBMT 2026) - "In 1 of 8 patients with mNGS-detected pathogens, mNGS lead to modification of anti-infective therapy (escalation to meropenem and linezolid after detection of Nocardia elegans in BAL and blood), concordant with later SOC culture findings in pleural fluid... In this prospective single-centre cohort of high-risk hematologic patients mNGS findings influenced anti-infective management in selected cases, underlining its potential therapeutic relevance. Careful clinical adjudication remains essential, and larger controlled studies are needed to learn more about and define the role of BAL- and blood-based mNGS-diagnostic tools in immunocompromised hosts. mNGS from BAL and blood provided plausible results with a small but clinically meaningful additive diagnostic yield."

Biomarker • Clinical • Next-generation sequencing • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Respiratory Diseases • IL6

FEASIBILITY AND IMPACT SIGNALS OF AN ANC-TRIGGERED PROPHYLACTIC/PRE-EMPTIVE GRANULOCYTE TRANSFUSION PROGRAM IN T-CELL REPLETE PARTIALLY MATCHED RELATED DONOR HSCT FOR HEMATOLOGICAL MALIGNANCIES: A SINGLE-CENTRE EXPERIENCE (EBMT 2026) - "Second-line escalation most commonly included meropenem (n=9), glycopeptide (teicoplanin/vancomycin; n=6), and polymyxin/colistin (n=8); one patient required escalation to ceftazidime–avibactam plus aztreonam as third-line therapy. A universal ANC-triggered prophylactic/pre-emptive granulocyte transfusion program was operationally feasible in this real-world T-cell replete PMRD HSCT cohort and was associated with zero early infection-related mortality by day +90 despite a high-risk population and frequent need for second line antibiotic escalation. This timing-focused strategy (ANC <100/µL; pre-fever/first spike) is hypothesis-generating and warrants evaluation against matched or historical controls using standardized bacteremia/AMR and infection-severity endpoints. Third line escalation was probably minimized as only 1 patient required such escalation in this limited cohort."

Clinical • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Myelofibrosis • Oncology

RISK OF BACTEREMIA IN LEVOFLOXACIN-RESISTANT EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING ENTEROBACTERALES COLONIZED RECIPIENTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT (EBMT 2026) - "ESBL-colonized patients with neutropenic fever received empirical meropenem. Despite high rectal colonization rates (64%) with CTX-M ESBL and fluoroquinolone-resistant Enterobacterales, ESBL-E BSI incidence was low (5%) after allogeneic HSCT in patients who did not receive fluoroquinolone prophylaxis. Acute GVHD and mucositis, beyond colonization alone, probably contributes to dysbiosis and ESBL-E BSI risk."

Acute Graft versus Host Disease • Bone Marrow Transplantation • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Mucositis • Neutropenia • Transplantation

DECOLONIZATION OF MULTIDRUG-RESISTANT BACTERIA BY FECAL MICROBIOTA TRANSPLANTATION IN A PATIENT BEFORE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (EBMT 2026) - "His course was complicated by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae bacteremia that was effectively treated with colistin...He was successfully treated with cefiderocol and high-dose extended infusion of meropenem in conjunction with debridement of right femoral osteomyelitis/abscess...Six weeks post-FMT, he underwent matched unrelated donor allogeneic HSCT using total marrow and lymphoid irradiation and cyclophosphamide conditioning and tacrolimus for graft-versus-host-disease (GvHD) prophylaxis... FMT for MDRO-decolonization pre-HSCT was successful, safe, and effective in this patient with one of the longest follow-up periods reported. Given limited therapeutic options to combat MDRO infections, safety and efficacy of gut microbial restoration with FMT in patients undergoing HSCT needs to be actively explored."

Clinical • Acute Graft versus Host Disease • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Febrile Neutropenia • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Myositis • Pneumonia • Transplantation