SC-CAR4BRAIN / Seattle Children's Hospital - LARVOL DELTA

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors (clinicaltrials.gov) - P1 | N=72 | Active, not recruiting | Sponsor: Seattle Children's Hospital | Recruiting ➔ Active, not recruiting

Enrollment closed • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Diffuse Midline Glioma • Glioma • Oncology • Pediatrics • Solid Tumor

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors (clinicaltrials.gov) - P1 | N=72 | Recruiting | Sponsor: Seattle Children's Hospital | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Diffuse Midline Glioma • Glioma • Oncology • Pediatrics • Solid Tumor

Seattle Children’s Launches Pioneering Immunotherapy Clinical Trial Targeting Four Antigens at the Same Time to Combat Pediatric Brain and Spinal Cord Tumors (Seattle Children's Hospital) - "Seattle Children’s Therapeutics has launched BrainChild-04, a first-in-human phase 1 clinical trial that will be our first chimeric antigen receptor (CAR) T-cell clinical trial that targets four antigens at the same time, by delivering CAR T cells directly to the brain. The trial is for children, teens, and young adults with diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG), and other recurrent or refractory brain and spinal cord tumors."

Trial status • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors (clinicaltrials.gov) - P1 | N=72 | Not yet recruiting | Sponsor: Seattle Children's Hospital

CAR T-Cell Therapy • New P1 trial • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Diffuse Midline Glioma • Glioma • Oncology • Pediatrics • Solid Tumor