iNeo-Vac-R01 / Hangzhou Neoantigen Therap - LARVOL DELTA

First-in-Human Study of iNeo-Vac-R01, a Personalized mRNA Neoantigen Vaccine, Combined with First-Line Chemotherapy in Advanced Pancreatic Cancer (SITC 2025) - P1 | "Written informed consent was obtained from the patients before taking part.Consent Written informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal."

Clinical • First-in-human • Late-breaking abstract • Metastases • P1 data • Tumor-specific neoantigens • Oncology • Pancreatic Cancer • Solid Tumor

A Single-Arm Clinical Trial of iNeo-Vac-R01 for Advanced Digestive System Tumors Refractory to Standard Therapy (SITC 2025) - "Written informed consent was obtained from the patients before taking part.Consent Written informed consent was obtained from the patients for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the editor of this journal."

Clinical • Metastases • Biliary Cancer • Biliary Tract Cancer • Cholangiocarcinoma • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Oncology • Pancreatic Cancer

Personalized Tumor Neoantigen mRNA Therapy for Advanced Hepatocellular Carcinoma (clinicaltrials.gov) - P1/2 | N=30 | Recruiting | Sponsor: Zhejiang University

New P1/2 trial • Hepatocellular Cancer • Oncology • Solid Tumor

Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma (clinicaltrials.gov) - P1/2 | N=30 | Recruiting | Sponsor: Zhejiang University

New P1/2 trial • Biliary Cancer • Cholangiocarcinoma • Oncology • Solid Tumor

Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer. (clinicaltrials.gov) - P1/2 | N=30 | Not yet recruiting | Sponsor: Zhejiang University

New P1/2 trial • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

Personalized Tumor Neoantigen MRNA Therapy Adjuvant Treatment for Postoperative Pancreatic Cancer. (clinicaltrials.gov) - P1/2 | N=60 | Not yet recruiting | Sponsor: Zhejiang University

New P1/2 trial • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen Alone in Subjects With Advanced Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Sir Run Run Shaw Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Metastases • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Combination With Standard First-line Treatment in Subjects With Advanced Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Sir Run Run Shaw Hospital | Not yet recruiting ➔ Recruiting

Combination therapy • Enrollment open • Metastases • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Subjects With Resected Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Sir Run Run Shaw Hospital | Not yet recruiting ➔ Recruiting

Combination therapy • Enrollment open • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Subjects With Resected Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Not yet recruiting | Sponsor: Sir Run Run Shaw Hospital

New P1 trial • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Combination With Standard First-line Treatment in Subjects With Advanced Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Not yet recruiting | Sponsor: Sir Run Run Shaw Hospital

New P1 trial • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen Alone in Subjects With Advanced Digestive System Neoplasms (clinicaltrials.gov) - P1 | N=20 | Not yet recruiting | Sponsor: Sir Run Run Shaw Hospital

Metastases • New P1 trial • Gastrointestinal Cancer • Oncology • IL10 • IL2 • IL6