Luzu (luliconazole) / Bausch Health - LARVOL DELTA

Development and In Vivo Evaluation of QbD-Assisted Squalene-based Luliconazole Entrapped Ethosomal Gel for the Skin Fungal Infection. (PubMed, AAPS PharmSciTech) - "Histopathology studies further supported the efficacy of the optimized ETs-gel formulation. Overall, squalene-based ethosomes emerge as promising carriers for enhancing the topical delivery and localized effectiveness of Luliconazole."

Journal • Preclinical • Infectious Disease

The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism. (PubMed, Mycoses) - "Drug-resistant T. rubrum has emerged in China, indicating the possibly increasing severity of antifungal resistance. The complex mechanism of multidrug-resistant dermophytes poses challenges to clinical treatment, needing more attention."

Journal • Dermatology • Infectious Disease

Human-like Biofilm Models to Study the Activity of Antifungals Against Aspergillus fumigatus. (PubMed, Microorganisms) - "Here, two human-like models, precision cut lung slices (PCLS) and a biofilm co-culture model, have been developed to test the anti-biofilm activity of voriconazole, amphotericin B, as well as luliconazole against A. fumigatus. In the PCLS assay, amphotericin B showed the strongest inhibition after 24 h. In conclusion, the applied PCLS ex vivo model can be used to study the property and activity of certain antifungal compounds against Aspergillus biofilm. With its close resemblance to human conditions, the PCLS model has the potential for improving the current understanding of biofilm treatments in laboratory settings."

Journal • Pulmonary Disease • Respiratory Diseases

Beyond the surface: Unlocking enhanced antifungal efficacy through comparison between luliconazole alone and luliconazole with salicylic acid peel synergy in dermatophytosis. (EADV 2025) - "This study reveals compelling evidence for the superior efficacy of combining 30% salicylic acid peel with luliconazole 1% cream in treating superficial dermatophytosis, demonstrating significant advantages in several key areas: Lesion reduction, safety profile, pruritus relief, accelerated recovery, providng important clinical implications, potentially reshaping treatment protocols for superficial dermatophytosis. **"

Clinical • Aesthetic Medicine • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus

Comparing emollient use with topical luliconazole (azole) in the maintenance of remission of chronic and recurrent dermatophytosis. An open-label, randomized prospective active-controlled non-inferiority study (EADV 2025) - "The present study concluded that the efficacy of emollient was not inferior to topical luliconazole for maintaining remission in chronic and recurrent dermatophytosis"

Clinical • Head-to-Head • Dermatology

The Potential of Luliconazole as an Adjuvant Therapy for Terbinafine-Resistant Trichophyton Species (EADV 2025) - "Clinical outcomes varied; several cases reported complete resolution with luliconazole monotherapy, while others required adjunctive treatment with systemic antifungals such as itraconazole or fosravuconazole. Luliconazole shows promise as a therapeutic option for terbinafine-resistant dermatophytosis, particularly when used adjunctively. Its high potency, favorable safety profile, and efficacy across various Trichophyton species support its potential role in clinical management. However, current evidence is limited to small-scale studies and case reports."

Clinical • Dermatology • Infectious Disease

The prevalence of pediatric nosocomial fungal infections. (PubMed, Iran J Microbiol) - "Caspofungin and luliconazole were effective antifungal agents for isolated fungi. The rate of mortality in infected patients suffering from proven and probable infections was 15.4% (6/39 cases). Due to the high mortality rates of fungal infections in pediatrics, it is essential to identify modifiable risk factors, and implement control measures along with early detection techniques in pediatric populations."

Journal • Infectious Disease • Oncology • Pediatrics

The efficacy of luliconazole and caspofungin on planktonic and biofilm of Candida albicans from different sources. (PubMed, Iran J Microbiol) - "The MICs of biofilms were 15.6, and 171.3 higher than that of planktonic cells for caspofungin and luliconazole, respectively. Moreover, paradoxical and trailing effects occurred at 4 and 32 μg/mL of caspofungin and luliconazole, respectively."

Journal • Candidiasis • Gastrointestinal Disorder • Gynecology • Solid Tumor • Vaginitis

Topical Luliconazole Treatment for Hyperkeratotic Tinea Pedis. (PubMed, Mycopathologia) - "The resistant case showed a partial improvement with topical luliconazole and was successfully treated with oral fosravuconazole. These findings suggest that 1% topical luliconazole is effective for treating hyperkeratotic tinea pedis."

Journal • Dermatology • Infectious Disease

Primary Cutaneous Adiaspiromycosis: A Case Report and Review of the Literature. (PubMed, Turk Patoloji Derg) - "Adiaspiromycosis is a rare fungal infection and primary cutaneous involvement is a rare distinct entity. Detailed morphological assessment in histopathology is essential for its identification as the organisms are difficult to isolate in fungal culture from human clinical material."

Journal • Human Immunodeficiency Virus • Infectious Disease • Inflammation

Luliconazole bilosomal gel for treating fungal infection: development, optimization and antifungal activity. (PubMed, Ther Deliv) - "Antifungal study for LZBS gel demonstrated superior activity against Candida albicans as compared to marketed and pure drug. Thus, luliconazole-loaded bilosome gel proved to be effective against fungal infections."

Journal • Infectious Disease

In vitro susceptibility profiles of 16 antifungal drugs against Trichophyton indotineae. (PubMed, Microbiol Spectr) - "Luliconazole and amorolfine exhibited low MICs, while itraconazole showed moderately decreased susceptibility, making them preferred treatment options...In contrast, terbinafine, fluconazole, griseofulvin, oteseconazole, isavuconazole, ravuconazole, and amphotericin B exhibited elevated MICs for many strains, with strong correlations between certain azoles, indicating potential cross-resistance. A difference in the susceptibility to terbinafine and voriconazole between Chinese and Indian isolates was observed...Its resistance to first-line antifungal agents, particularly terbinafine and fluconazole, has significantly limited treatment options, emphasizing the urgent need for alternative therapies. This study provides comprehensive antifungal susceptibility data for 16 available antifungal agents, offering valuable insights into potential treatment strategies."

Journal • Preclinical • Dermatology • Infectious Disease

Dermatophytosis in a Healthy Adolescent: A Report of Terbinafine-Resistant Trichophyton indotineae Infection in Kuwait. (PubMed, Cureus) - "The patient was subsequently treated with topical clotrimazole 1% twice daily and luliconazole 1% cream at night, which led to the significant clinical improvement and complete resolution of the rash within two weeks. This case highlights the growing concern of antifungal resistance in dermatophyte infections, particularly against terbinafine, one of the most commonly prescribed treatments. The increasing prevalence of resistant Trichophyton strains underscores the need for antifungal susceptibility testing in refractory cases and the consideration of alternative treatment strategies."

Journal • Dermatology • Infectious Disease

Concurrent chromoblastomycosis and subcutaneous phaeohyphomycosis by different pathogens in a renal transplant recipient. (PubMed, Diagn Microbiol Infect Dis) - "Oral itraconazole and topical luliconazole led to healing of both lesions within six months of therapy. This case highlights the emergence of rare opportunistic fungal pathogens causing concurrent skin infections in an immunocompromised patient. This warrants investigation of their epidemiology and virulence to implement preventive measures in renal transplant recipients."

Journal • Dermatology • Infectious Disease • Pain • Transplantation

Comparative Analysis of In vitro Susceptibility Profile of Dermatophytes Against 8 Antifungal Agents: A Cross-Sectional Study. (PubMed, Indian J Dermatol) - "Antifungal susceptibility test was performed for dermatophytes against eight antifungal agents (terbinafine, griseofulvin, itraconazole, fluconazole, voriconazole, ketoconazole, luliconazole, and posaconazole) using the Clinical and Laboratory Standards Institute broth microdilution method (M38-3rd edition). It was observed that the commonly used antifungals such as fluconazole, griseofulvin, and terbinafine showed high MIC values compared to newer drugs such as luliconazole, posaconazole and voriconazole. More studies based on species distribution and antifungal susceptibility testing (AFST) should be performed to understand the changing epidemiology of dermatophytosis."

Journal • Observational data • Preclinical • Dermatology

Emerging Antifungal-Resistant Onychomycosis in a Dermatology Clinic in Kumamoto, Japan. (PubMed, Med Mycol J) - "These strains were highly sensitive to ravuconazole, efinaconazole, and luliconazole. Fosravuconazole (n = 13) and topical efinaconazole (n = 4) could cure the disease...Non-albicans Candida isolates showed low sensitivity to itraconazole and fluconazole. Trichosporon species (n = 2) were isolated from fingernail onychomycosis."

Journal • Dermatology • Infectious Disease

Evaluation of the efficacy of novel topical antifungal agents against dermatophytes in North India: A prospective study. (PubMed, Curr Med Mycol) - "This study aimed to investigate the antifungal susceptibility of efinaconazole, tavaborole, luliconazole, and sertaconazole against dermatophytes isolated from cases of dermatophytosis. Tavaborole ECVs for T. mentagrophytes/interdigitale, T. tonsurans, T. rubrum, and E. floccosum were 0.5, 0.5, 0.25, and 0.016 µg/ml, respectively. The results from the present study on the in vitro performance of newer topical antifungals suggested that they hold significant promise as prospective candidates for advancing the development of new antifungal treatments for dermatophytosis."

Journal • Dermatology • Infectious Disease

Widespread Majocchi's Granuloma Caused by Multidrug-Resistant Trichophyton rubrum Successfully Treated With Amphotericin B and Posaconazole. (PubMed, J Dermatol) - "Oral fosravuconazole and topical luliconazole were administered for 18 months, resulting in invasive dermatophytosis with a high β-d-glucan level of 7320 pg/mL. The MICs of amphotericin B, posaconazole, griseofulvin, itraconazole, voriconazole, ravuconazole, and terbinafine were 0.5, 0.5, 8, 16, 8, 16, and 32 μg/mL, respectively...Posaconazole may be a promising agent for the treatment of multidrug-resistant dermatophytes. We present the first reported case of multiazole-resistant T. rubrum resulting from prolonged fosravuconazole treatment."

Journal • Dermatology • SQLE

Antifungal Efficacy of Luliconazole-Loaded Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis. (PubMed, J Fungi (Basel)) - " Luliconazole-loaded lipid carriers enhance drug absorption and efficacy, suggesting shorter treatment durations and improved patient outcomes for resistant fungal infections. However, further studies are warranted to correlate these findings with clinical outcomes."

Journal • Preclinical • Dermatology • Infectious Disease • Inflammation

Structure-Guided Engineering of Carbonyl Reductase LbCR to Simultaneously Enhance Catalytic Activity and Thermostability toward Bulky Ketones. (PubMed, J Agric Food Chem) - "Molecular dynamics (MD) simulations and dynamic cross-correlation matrix analysis elucidated the substantial catalytic performance improvement of LbCRM4. Together, the development of LbCRM4 not only overcomes the trade-offs between catalytic activity and thermostability but also affords an efficient biocatalytic approach for the synthesis of (S)-TCPE featuring a record STY, laying a solid foundation for industrial manufacturing of luliconazole and other active pharmaceutical intermediates."

Journal

Characterization of COVID-19-Associated Candidemia Among Burn Patients. (PubMed, J Clin Lab Anal) - "Our findings indicate that colonization may act as an important prognostic factor prior to the onset of candidemia. In addition, prolonged hospitalization, catheter use, and concurrent COVID-19 infection were identified as key risk factors for candidemia in this patient group. Notably, the rising drug resistance in non-albicans Candida species is a major public health concern."

Journal • Candidiasis • Critical care • Infectious Disease • Novel Coronavirus Disease

Terbinafine-Resistant Dermatophytes Isolated in Japan. (PubMed, Med Mycol J) - "Ten strains (1 T. interdigitale strain and 9 T. rubrum strains) were found to be resistant to TBF, and susceptible to efinaconazole, itraconazole, luliconazole, and ravuconazole. We determined the sequences of the squalene epoxidase-encoding gene in 10 TBF-resistant strains, and found that all strains harbored missense and/or deletion mutations. These results indicate that the prevalence of TBF-resistant dermatophytes has increased when compared to the previous studies."

Journal • Dermatology • Infectious Disease

Luliconazole-niacinamide lipid nanocarrier laden gel for enhanced treatment of vaginal candidiasis: in vitro, ex vivo, in silico and preclinical insights. (PubMed, RSC Adv) - "In vivo antifungal activity showed that the optimized LZNMLNs-gel completely treated the infection on the 7th day of treatment in an induced rabbit model, compared to the commercial gel (Candid V gel, 10 days). Based the findings, it can be concluded that LN-laden gel is an alternative carrier for improvement of the topical delivery of drugs for the treatment of vaginal candidiasis."

Journal • Preclinical • Candidiasis • Infectious Disease • Vaginitis

Novel in vivo observations of luliconazole 5% nail solution for onychomycosis: an ultrastructural study. (PubMed, Med Mycol) - "We also examined in vivo morphological changes of dermatophytes in tinea pedis treated with ketoconazole (KCZ) to compare the morphological changes in the cell wall, plasma membrane and cytoplasm to those after application of LLCZ. Intracytoplasmic degeneration (type 1 degeneration) was observed in tinea pedis scales treated with topical KCZ. We confirmed that topical LLCZ 5% nail solution had acting points on the plasma membrane, cell wall and cytoplasm of dermatophyte hyphae and that various degrees of morphological changes in lesional nails of tinea unguium occurred during treatment with topical LLCZ 5% nail solution."

Journal • Preclinical • Dermatology • Infectious Disease

Antifungal susceptibility, clinical findings, and biofilm resistance of Fusarium species causing keratitis: a challenge for disease control. (PubMed, Braz J Microbiol) - "This study evaluated the susceptibility of planktonic cells and biofilms of FSSC (n = 7) and non-FSSC (n = 7) isolates obtained from patients with keratitis from a semi-arid tropical region to amphotericin B (AMB), natamycin (NAT), voriconazole (VRZ), efinaconazole (EFZ), and luliconazole (LCZ). This study highlights the importance of mycological diagnosis and the antifungal susceptibility testing in the clinical management of FK. The ability of Fusarium to form antifungal tolerant biofilms poses a challenge to clinicians and urges the development of new antibiofilm therapeutics."

Journal • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology • Transplantation