Timcynis (ticarcillin and clavulanic acid) / Emcure - LARVOL DELTA

Antibiogram and molecular profiling of non-respiratory isolates of Pseudomonas aeruginosa using ERIC-PCR in a tertiary care hospital. (PubMed, Iran J Microbiol) - "The highest resistance rate was observed against ticarcillin/clavulanic acid, followed by ceftazidime, whereas no resistance was detected against colistin sulphate. Notably, the findings suggest a comparatively higher rate of cross-infection among burn patients. These observations underscore the urgent need for stringent infection prevention and control measures, particularly in burn units, to limit the spread of MDR P. aeruginosa."

Journal • Infectious Disease

Differences and trends in pathogens between ventilator-associated pneumonia and non-ventilator-associated pneumonia: data from 61 hospitals in Suzhou, China, 2020-2024. (PubMed, BMJ Open) - "The two groups differed in the distribution and antimicrobial resistance of the pathogens and MDROs, and these profiles fluctuated over time. Patients with VAP have a higher percentage of drug-resistant bacteria, requiring special attention to CRAB and CRPA. Local microbiological epidemiological surveillance should be strengthened to improve infection prevention, control strategies and guide empirical antibiotic therapy."

Journal • Observational data • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Urinary tract infections among children under age 3: distribution of pathogens, evolution of antimicrobial resistance, and clinical implications. (PubMed, Am J Transl Res) - "The primary clinical symptom of UTIs in children aged 3 years and younger is fever, and the main causative pathogens are Gram-negative bacteria. Multidrug-resistant strains are primarily Enterobacteriaceae that produce extended-spectrum β-lactamases."

Journal • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Extensively drug-resistant and extended spectrum β-lactamase-producing Raoultella terrigena from the reproductive tract of a mare in Australia. (PubMed, Sci Rep) - "Phenotypic resistance was detected to cefazolin, ceftiofur, cefotaxime, ticarcillin/clavulanic acid, tetracycline, doxycycline, gentamicin, sulfamethoxazole/trimethoprim and chloramphenicol. Phylogenetic analysis of the combined dataset, including the isolate in this study and publicly available genomes, revealed two distinct clades, with equine isolates clustering together with other animal-derived isolates. The emergence of antimicrobial resistance in rare opportunistic pathogens underlines the importance of continuous monitoring of such bacteria and emphasizing the need for developing antimicrobial stewardship programs in veterinary settings."

Journal

Genomic characterization and niche adaptive analysis of Pseudomonas promysalinigenes W2469: the first clinical isolate from a human bile specimen. (PubMed, Front Cell Infect Microbiol) - "The strain exhibited a narrow-spectrum resistance phenotype, with resistance to aztreonam and ticarcillin/clavulanic acid, intermediate susceptibility to meropenem, and susceptibility to most clinically used antibiotics. Importantly, the strain exhibits clear adaptive phenotypes despite low sequence identity to known functional elements, highlighting profound knowledge gaps in the genomic diversity and uncharacterized adaptive mechanisms of this rare Pseudomonas species. This work provides a foundational genomic resource for future investigations into this emerging opportunistic pathogen."

Journal • Gastroenterology • Hepatology • Infectious Disease

Antibiotic-associated encephalopathy: A retrospective pharmacovigilance study based on 21 years of data from the US FDA Adverse Event Reporting System. (PubMed, Medicine (Baltimore)) - "The 5 most frequently reported antibiotics were metronidazole (1464 cases), levofloxacin (1447), ciprofloxacin (1290), ertapenem (825), and imipenem/cilastatin (788)...Most AAE cases occurred within 10 days of antibiotic exposure, except for several agents, including meropenem/vaborbactam and ticarcillin/clavulanic acid (type 1), and isoniazid, pyrazinamide, rifampicin, and paromomycin (type 3), which exhibited delayed onset...Most antibiotics trigger early-onset AAE, and older patients demonstrate greater susceptibility. These findings expand our understanding of AAE and inform safer antibiotic use."

Adverse events • Journal • Retrospective data • CNS Disorders

High virulence and genetic heterogeneity in Pseudomonas aeruginosa isolates from lower respiratory tract infections in neutropenic patients. (PubMed, Rev Argent Microbiol) - "High to moderate resistance rates were observed for ticarcillin, ticarcillin-clavulanic acid, piperacillin-tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin, and fosfomycin. ERIC-PCR showed high genetic heterogeneity. These findings highlight the high genetic heterogeneity of P. aeruginosa isolates in these neutropenic patients, as well as their remarkable pathogenic power, raising significant concern."

Heterogeneity • Journal • Bone Marrow Transplantation • Infectious Disease • Respiratory Diseases • Transplantation

Prevalence and Resistance Patterns of Pseudomonas aeruginosa in a Tunisian Intensive Care Unit. (PubMed, Am J Trop Med Hyg) - "The prevalence of resistance rates was highest for ticarcillin (48.3%) and ticarcillin-clavulanic acid (48.6%)...The prevalence of resistance of P. aeruginosa was 29.8% and 26.2% to ceftazidime-avibactam (CAV) and ceftolozane-tazobactam (C/T), respectively. The prevalence of resistance to amikacin and ciprofloxacin was 36.2% and 37.9%, respectively...None of the tested MDR-PA strains showed resistance to colistin. This study highlights a high prevalence of MDR strains of P. aeruginosa in our ICU, with increasing resistance over recent years. Prevention is highly warranted."

Journal • Critical care • Infectious Disease

Antimicrobial resistance dynamics in Mycobacterium tuberculosis coinfection systems: A spatiotemporal strain analysis. (PubMed, Biochem Biophys Rep) - "The drug sensitivity tests results over different years showed that K. pneumoniae exhibited significant resistance rates against doxycycline, ceftazidime, cefepime, cefuroxime, cefazolin, cefotaxime, levofloxacin, ticarcillin/clavulanate, amikacin, and norfloxacin (P < 0.05). The resistance rates of P. aeruginosa to cefazolin and ciprofloxacin were also statistically significant (P < 0.05). The drug sensitivity test results across different regions showed that the resistance rate of K. pneumoniae to minocycline in urban patients was statistically significant (P = 0.012), while the resistance rates of P. aeruginosa to tobramycin and ciprofloxacin in rural patients were statistically significant (P < 0.05)...The rise of new carbapenem-resistant K. pneumoniae strains in 2023 should be monitored. This study provides strong data support to formulate antibiotic treatment plans for patients with tuberculosis and respiratory infections, reduce the risk of resistant..."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Functional characterization of a novel class A carbapenemase CAE-1 in carbapenem-resistant Pseudomonas aeruginosa clinical isolates. (PubMed, Antimicrob Agents Chemother) - "The blaCAE-1-carrying PAO1 transformant also tested positive using the modified carbapenem inactivation method and was resistant to piperacillin-tazobactam, ticarcillin-clavulanate, and cefoperazone-sulbactam, but susceptible to ceftazidime-avibactam. Expression of blaCAE-1 in P. aeruginosa PAO1 elicited a 64- to 128-fold increase in MICs for piperacillin, ceftazidime, cefepime, and aztreonam, and an eightfold increase for meropenem, exhibiting a broader resistance profile than in E. coli DH5α...The class A β-lactamase CAE-1 is a carbapenemase posing a high risk for horizontal dissemination. Enhanced surveillance for blaCAE-1-harboring isolates is needed."

Journal

The Apparent pH Stability of Antibiotic Preparations Used for Uterine Infusions in Mares. (PubMed, Animals (Basel)) - "In experiment 1, amikacin, ampicillin, ceftiofur, ciprofloxacin, gentamicin, penicillin G potassium, penicillin G procaine, and ticarcillin clavulanate were diluted in saline and lactated Ringer' s solution and stored at 5 ° C, 21 ° C, and 37 ° C for 24 h. Solutions were evaluated for pH and physical characteristics at 0, 1, 3, 6, and 24 h after storage. In conclusion, the pH stability of uterine infusions is affected by various storage conditions and vehicles, underscoring the importance of evaluating antibiotic treatments for quality control. While pH changes were observed, the potential impact on the overall stability or antimicrobial activity of the solutions requires further investigation."

Journal • Endometriosis • Infertility

A Ten-Year Study of the Epidemiology and Antimicrobial Resistance of Bacterial Pathogens Associated with Otitis in Crete, Greece. (PubMed, Clin Lab) - "P. aeruginosa, S. aureus, and the Enterobacterales are the predominant bacterial pathogens causing otitis in our area. Regarding Gram-negatives, although resistance rates to commonly-used antibiotics are low, they are increasing over time. Continued surveillance of the prevalence and antimicrobial susceptibility of bacterial pathogens causing otitis is necessary to reassess updated antimicrobial policies and develop appropriate guidelines."

Journal • Infectious Disease • Otorhinolaryngology

Resistome, virulome and mobilome of clinical carbapenemase-producing Acinetobacter baumannii strains isolated in Togo. (PubMed, Int J Med Microbiol) - "All isolates exhibited resistance to imipenem, ticarcillin, clavulanic acid, cefotaxime, and ciprofloxacin, but remained susceptible to colistin, tigecycline, and rifampicin. Furthermore, several multidrug resistance plasmids and one virulence and AMR hybrid plasmid (accession number JBFMWK020002174.1) were identified. This study provides valuable insights into clinical A. baumannii in Togo, underscoring the need for more frequent genomic studies in sub-Saharan countries to effectively monitor and combat AMR in Africa."

Journal

A retrospective assessment of antimicrobial resistance patterns in WHO-access, watch, and reserve-classified antibiotics across two large hospitals in a resource-limited setting. (PubMed, Sci Rep) - "For the Access category, highest resistance was reported for Doxycycline at 100% resistance while the lowest resistance was reported for Amikacin at 24.63%. For the Watch category, the highest resistance was reported for Cefuroxime at 85.71% while the lowest resistance was reported for ticarcillin/clavulanic acid and Netilmicin, both with 0% resistance...More than 70% of multi-drug resistance was observed in frequently used antibiotics such as Cefuroxime, Ceftazidime, and Meropenem. Additionally, over 60% resistance was found in antibiotics like Ertapenem, Aztreonam, and Teicoplanin even though they are not readily available in Nigeria...Across gender, positive isolates were found more in women than men across almost all the microbes identified. These results, based on real patient data, highlight the urgent need for an institutionalized AWaRe Antibiotics framework across healthcare facilities in addition to broader strategies of antimicrobial stewardship, pharmaceutical..."

Journal • Retrospective data

Genetic Analysis of Virulence and β-Lactamase Determinants Related to β-Lactamase Inhibitors in Pseudomonas aeruginosa Strains from Nosocomial Infections. (PubMed, Antibiotics (Basel)) - "The MIC determination of ticarcillin/clavulanic acid and piperacillin/tazobactam was performed using the MIC test strip for antimicrobial susceptibility testing...In total, 100% (124/124) and 99.1% (123/124) of the strains isolated from patients with healthcare-associated and community-acquired infections were resistant to the β-lactamase inhibitor antibiotics, amoxicillin/clavulanic acid and ampicillin/sulbactam, respectively, while 54% (67/124) of the strains were resistant to piperacillin/tazobactam... We demonstrated different association profiles of virulence genotype related to the β-lactamase genotype, the β-lactamase inhibitor resistome, phylogroups, and clinical origin of the strains. Therefore, medical treatment regimens against infections caused by P. aeruginosa should be improved."

Journal • Infectious Disease

Motility, biofilm, and endotoxin in Ralstonia pickettii isolates obtained from purified and ultrapure pharmaceutical water systems. (PubMed, Acta Pharm) - "Antibiotic susceptibility testing revealed consistent resistance to colistin, as well as significant resistance rates to β-lactam antibiotics, ertapenem, amoxicillin/clavulanic acid, ticarcillin and ampicillin. High susceptibility to first-generation cephalosporins, cephalexin, cefoxitin and chloramphenicol was observed. All isolates were susceptible to tigecycline and tetracycline...The study highlights R. pickettii's adaptability in pharmaceutical water systems, marked by its motility, biofilm-forming capabilities, and multidrug resistance. These results emphasise the importance of rigorous monitoring of water systems to reduce transmission risks and prevent the emergence of resistant strains in clinical environments."

Journal

Molecular Characterization of Carbapenem and Colistin Resistance in Isolates Causing Urinary Tract Infections at an Outpatient Setting of a Tertiary Care Hospital. (PubMed, Cureus) - "Comparison of resistance patterns of other antibiotics in CRE and carbapenem-sensitive Enterobacterales (CSE) group shows that fosfomycin, ticarcillin-clavulanate and tetracycline had higher sensitivity in the CRE group. Colistin resistance in an outpatient setting is alarming. Early detection of these resistance-determinant genes by molecular methods is essential in limiting the spread of infection due to these organisms."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pneumonia

Occurrence of Virulence and Antibiotic Resistance in Pseudomonas aeruginosa Isolated from the Environmental Water from Tamaulipas, Mexico. (PubMed, Antibiotics (Basel)) - "In total, 100% (109/109) were susceptible to ceftazidime (CAZ), gentamicin (GM), amikacin (AN), netilmicin (NET), tobramycin (NN) and norfloxacin (NOR), and 65.7% were resistant to ticarcillin/clavulanic acid and 53.5% to ticarcillin; the resistance to the remaining antibiotics was between 19.4% and 0.9%. aeruginosa in environmental waters of Tamaulipas showed potential to cause infections and low rates of resistance to most of the antibiotics tested. However, 20% were resistant to one of the most common treatments, which could pose a risk to public health."

Journal • Infectious Disease

Insights into antibiotic resistance and prevalence of Stenotrophomonas maltophilia isolated from clinical samples in Iran: A systematic review. (PubMed, New Microbes New Infect) - "Most isolates showed high susceptibility to ticarcillin/clavulanic acid and minocycline (98.5 % and 98.2 %, respectively)...Given the low resistance rates to levofloxacin and minocycline, these antibiotics may be considered as potentially effective options for treating S. maltophilia infections in Iran. Trimethoprim-sulfamethoxazole showed comparatively higher resistance rates, suggesting that its clinical efficacy may be declining. The rising isolation of S. maltophilia from clinical specimens in recent years, compared to the previous decade, is of both epidemiological and clinical concern, highlighting the need for ongoing surveillance and prudent antibiotic use."

Journal • Review • Infectious Disease

Revitalizing cephalosporins: The promise of β-lactamase inhibitor combinations. (PubMed, GMS Hyg Infect Control) - "It examines β-lactam resistance mechanisms, established combinations (e.g., ticarcillin/clavulanic acid, piperacillin/tazobactam), and the clinical efficacy of newer therapies like ceftazidime/avibactam (CAZ-AVI) for carbapenem-resistant Klebsiella pneumoniae (CRKP) and ceftolozane/tazobactam (TOL-TAZ) for MDR Pseudomonas aeruginosa. Additionally, novel combinations (e.g., cefepime-enmetazobactam, cefepime-taniborbactam) are discussed for tackling extensively drug-resistant (XDR) bacteria. Through comparative analyses, this review provides key insights into efficacy, resistance, pharmacokinetics, and safety, guiding researchers in optimizing antimicrobial strategies and clinicians in managing MDR infections, while supporting antibiotic management and future research."

Journal • Infectious Disease • Pneumonia

First Report of New Delhi Metallo-β-Lactamase-6 (blaNDM-6) gene in Africa identified in a Carbapenem-Resistant Acinetobacter baumannii Clinical Isolate. (PubMed, Int J Infect Dis) - "This study presents the first report of blaNDM-6 in Africa. The detection in a rare lineage suggests an independent acquisition via plasmids. Further, it highlights an ongoing evolution of historically susceptible A. baumannii lineages into multidrug-resistant threats. This emphasizes the need for enhanced genomic surveillance in LMICs to monitor the emergence and dissemination of resistance determinants."

Journal

Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections. (PubMed, Front Vet Sci) - "exhibited extensive drug resistance (XDR) with complete resistance to amoxicillin-clavulanic acid, amikacin, kanamycin, streptomycin, and cefotaxime...Staphylococci isolates were highly resistant to fusidic acid, β-lactams, and tetracyclines. Amoxicillin-clavulanic acid, fosfomycin, and cephalosporines were ineffective against Enterobacteriaceae isolates. Ticarcillin, clavulanic acid, and colistin were ineffective against P. aeruginosa and Acinetobacter baumannii...There were significant differences (p < 0.05) in the wound closure % among the gentamicin group and phage cocktaoil+gentamicin groups on days 3, 5, 7, 10, and 14. This study highlights the widespread antibiotic resistance in bacteria infecting Arabian horses and posing significant challenges to equine infection management. Bacteriophage therapy shows promise as a potential treatment for wound infections."

Journal • Infectious Disease • Ocular Infections • Ophthalmology • Pneumonia • Respiratory Diseases

Neisseria sicca Bloodstream Infection in a Patient with Aortic Valve Replacement: Case Report and Genomic Analysis. (PubMed, Infect Drug Resist) - "Appropriate antibiotic therapy with ticarcillin-clavulanate led to a significant clinical improvement...Virulence gene analysis revealed that the pathogenicity of N. sicca was associated with mntB, mntC, farA, farB, mtrD, mtrE, msrA/B (pilB), rfaF, rfaC, hpuB, pilT, and recN. This case underscores the potential of N. sicca to act as an opportunistic pathogen in bloodstream infections (BSIs)."

Journal • Infectious Disease

Microbial Profiles and Antibiotic Resistance in Chronic Otorrhea: An Evaluation of Operated and Non-operated Patients. (PubMed, Indian J Otolaryngol Head Neck Surg) - "Antibiotic resistance to Ciprofloxacin, Ceftazidime, and Ticarcillin-Clavulanate was high for Pseudomonas aeruginosa in both groups, with no significant differences. Escherichia coli displayed significantly higher resistance to Ampicillin-Sulbactam in the operated group (75.0% vs. 0%, p < 0.05)...Surgical interventions influence resistance development, particularly in Escherichia coli and Staphylococcus aureus. These findings underscore the importance of routine susceptibility testing to guide effective, individualized treatment and address multidrug-resistant pathogens."

Journal • Otorhinolaryngology

Canine Pyoderma and Otitis Externa: A Retrospective Analysis of Multidrug-Resistant Bacterial Carriage in Hong Kong. (PubMed, Antibiotics (Basel)) - "High resistance rates were observed for orbifloxacin (61.3% in pyoderma; 76.7% in otitis externa), doxycycline (59.3%; 69.2%), clindamycin (62%; 68.9%), and enrofloxacin (50%; 55.5%). Most isolates were sensitive to ofloxacin, ticarcillin-clavulanate, tobramycin, ciprofloxacin, cefpodoxime, cefuroxime, and cefixime...A higher focus should be placed on topical antiseptic therapy, with oral antibiotics used only in exceptional cases and after susceptibility testing. From a One Health perspective, the potential transmission of MDR bacteria between companion animals and humans underscores the importance of a coordinated approach to antimicrobial stewardship across both veterinary and human medicine."

Journal • Retrospective data • Dermatology • Infectious Disease • Otorhinolaryngology