Timcynis (ticarcillin and clavulanic acid) / Emcure - LARVOL DELTA

Revitalizing cephalosporins: The promise of β-lactamase inhibitor combinations. (PubMed, GMS Hyg Infect Control) - "It examines β-lactam resistance mechanisms, established combinations (e.g., ticarcillin/clavulanic acid, piperacillin/tazobactam), and the clinical efficacy of newer therapies like ceftazidime/avibactam (CAZ-AVI) for carbapenem-resistant Klebsiella pneumoniae (CRKP) and ceftolozane/tazobactam (TOL-TAZ) for MDR Pseudomonas aeruginosa. Additionally, novel combinations (e.g., cefepime-enmetazobactam, cefepime-taniborbactam) are discussed for tackling extensively drug-resistant (XDR) bacteria. Through comparative analyses, this review provides key insights into efficacy, resistance, pharmacokinetics, and safety, guiding researchers in optimizing antimicrobial strategies and clinicians in managing MDR infections, while supporting antibiotic management and future research."

Journal • Infectious Disease • Pneumonia

First Report of New Delhi Metallo-β-Lactamase-6 (blaNDM-6) gene in Africa identified in a Carbapenem-Resistant Acinetobacter baumannii Clinical Isolate. (PubMed, Int J Infect Dis) - "This study presents the first report of blaNDM-6 in Africa. The detection in a rare lineage suggests an independent acquisition via plasmids. Further, it highlights an ongoing evolution of historically susceptible A. baumannii lineages into multidrug-resistant threats. This emphasizes the need for enhanced genomic surveillance in LMICs to monitor the emergence and dissemination of resistance determinants."

Journal

Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections. (PubMed, Front Vet Sci) - "exhibited extensive drug resistance (XDR) with complete resistance to amoxicillin-clavulanic acid, amikacin, kanamycin, streptomycin, and cefotaxime...Staphylococci isolates were highly resistant to fusidic acid, β-lactams, and tetracyclines. Amoxicillin-clavulanic acid, fosfomycin, and cephalosporines were ineffective against Enterobacteriaceae isolates. Ticarcillin, clavulanic acid, and colistin were ineffective against P. aeruginosa and Acinetobacter baumannii...There were significant differences (p < 0.05) in the wound closure % among the gentamicin group and phage cocktaoil+gentamicin groups on days 3, 5, 7, 10, and 14. This study highlights the widespread antibiotic resistance in bacteria infecting Arabian horses and posing significant challenges to equine infection management. Bacteriophage therapy shows promise as a potential treatment for wound infections."

Journal • Infectious Disease • Ocular Infections • Ophthalmology • Pneumonia • Respiratory Diseases

Neisseria sicca Bloodstream Infection in a Patient with Aortic Valve Replacement: Case Report and Genomic Analysis. (PubMed, Infect Drug Resist) - "Appropriate antibiotic therapy with ticarcillin-clavulanate led to a significant clinical improvement...Virulence gene analysis revealed that the pathogenicity of N. sicca was associated with mntB, mntC, farA, farB, mtrD, mtrE, msrA/B (pilB), rfaF, rfaC, hpuB, pilT, and recN. This case underscores the potential of N. sicca to act as an opportunistic pathogen in bloodstream infections (BSIs)."

Journal • Infectious Disease

Microbial Profiles and Antibiotic Resistance in Chronic Otorrhea: An Evaluation of Operated and Non-operated Patients. (PubMed, Indian J Otolaryngol Head Neck Surg) - "Antibiotic resistance to Ciprofloxacin, Ceftazidime, and Ticarcillin-Clavulanate was high for Pseudomonas aeruginosa in both groups, with no significant differences. Escherichia coli displayed significantly higher resistance to Ampicillin-Sulbactam in the operated group (75.0% vs. 0%, p < 0.05)...Surgical interventions influence resistance development, particularly in Escherichia coli and Staphylococcus aureus. These findings underscore the importance of routine susceptibility testing to guide effective, individualized treatment and address multidrug-resistant pathogens."

Journal • Otorhinolaryngology

Canine Pyoderma and Otitis Externa: A Retrospective Analysis of Multidrug-Resistant Bacterial Carriage in Hong Kong. (PubMed, Antibiotics (Basel)) - "High resistance rates were observed for orbifloxacin (61.3% in pyoderma; 76.7% in otitis externa), doxycycline (59.3%; 69.2%), clindamycin (62%; 68.9%), and enrofloxacin (50%; 55.5%). Most isolates were sensitive to ofloxacin, ticarcillin-clavulanate, tobramycin, ciprofloxacin, cefpodoxime, cefuroxime, and cefixime...A higher focus should be placed on topical antiseptic therapy, with oral antibiotics used only in exceptional cases and after susceptibility testing. From a One Health perspective, the potential transmission of MDR bacteria between companion animals and humans underscores the importance of a coordinated approach to antimicrobial stewardship across both veterinary and human medicine."

Journal • Retrospective data • Dermatology • Infectious Disease • Otorhinolaryngology

Comparison of Biological and Genomic Characteristics Between Two Non-Intestinal Salmonella Enterica Serovar Enteritidis Isolates from the Same Patient. (PubMed, Microb Drug Resist) - "Drug susceptibility testing revealed significant differences: Sal D exhibited greater resistance to ticarcillin/clavulanate, piperacillin/sulbactam, and ciprofloxacin compared with Sal B. Morphologically, Sal B formed rougher and drier colonies than Sal D at 37°C. Collectively, these findings suggest that S. Enteritidis can undergo adaptive changes in response to distinct host environments, influencing drug resistance, adhesion, and acid resistance. This knowledge may inform future strategies for the treatment and prevention of Salmonella infections."

Journal • Infectious Disease

Prevalence and antimicrobial resistance pattern of Burkholderia cepacia at a tertiary care teaching hospital. (PubMed, Natl Med J India) - "cepacia antimicrobial resistance was seen more commonly to ticarcillin-clavulanate (72%) followed by levofloxacin (34%), trimethoprim- sulphamethoxazole (30%), ceftazidime (30%), minocycline (21%) and meropenem (14%). cepacia has been identified as an important pathogen in bloodstream infections. It is important to know the antimicrobial resistance pattern of B. cepacia for better management of patients."

Journal • Observational data • Retrospective data • Infectious Disease

Outbreak of Carbapenem-Resistant High-Risk Clone ST244 of Pseudomonas aeruginosa in Dogs and Cats in Algeria. (PubMed, Antibiotics (Basel)) - "Antibiotic-resistance phenotypes were observed against amoxicillin-clavulanic acid (100%); meanwhile, resistance towards ticarcillin was 40% (dogs) and 25% (cats), ticarcillin-clavulanic acid was 13.33% and 25% for dogs and cats, respectively, and imipenem was 75% (cats) and 20% (dogs). The genetic variety in antibiotic-resistance genes of resistant and virulent P. aeruginosa strains in dogs makes public health protection difficult. Continuous monitoring and research in compliance with the One Health policy are needed to solve this problem."

Journal • Infectious Disease

Antimicrobial resistance, virulence gene profiling, and genetic diversity of multidrug-resistant Pseudomonas aeruginosa isolates in Mazandaran, Iran. (PubMed, BMC Microbiol) - "The high rate of multidrug resistance combined with the widespread presence of virulence genes in P. aeruginosa isolates highlights the potential for increased infection severity, morbidity, and mortality in hospitalized patients. The substantial genetic diversity observed among isolates suggests that P. aeruginosa in this region may rapidly evolve, necessitating ongoing surveillance and more targeted antimicrobial strategies."

Journal • Infectious Disease

Ciprofloxacin-susceptible but levofloxacin-resistant Pseudomonas aeruginosa clinical strains with Vitek®2: which mechanism involved and consequences in case of fluoroquinolone treatment? (PubMed, Eur J Clin Microbiol Infect Dis) - "The phenotype detected by the automate Vitek2® is linked to a likely efflux-pump overexpression mechanism and not fluoroquinolone-target mutation. Regarding this discordant phenotype, an alert should be provided to clinicians concerning the high risk of selecting a fluoroquinolone-resistant mutant."

Journal

Agricultural Soil as a Reservoir of Pseudomonas aeruginosa with Potential Risk to Public Health. (PubMed, Microorganisms) - "The strains showed some level of resistance to only three antibiotics: 32.8% to ticarcillin, 40.8% to ticarcillin/clavulanic acid and 2.4% to aztreonam. However, copB and arsB genes were also identified in a percentage greater than 80%, and the least frequent genes were merA in 14.4% and czcA in 7.2%. Although P. aeruginosa strains showed a high percentage of factor virulence (potential ability to cause infections), their high levels of susceptibility to antibiotics lead to the assumption that infections are easily curable."

Journal • Infectious Disease

The Microbiological Quality of Raw Ovine Milk in the Banat Region of Romania with a Focus on Escherichia coli and Its Pathogenic Potential and Antimicrobial Resistance. (PubMed, Vet Sci) - "Antimicrobial susceptibility testing with the Vitek2 system of the isolated E. coli strains revealed resistance against ampicillin (45.8%), gentamicin (20.8%), ticarcillin-clavulanic acid (18.8%), cephalexin (18.8%), amoxicillin-clavulanic acid (8.3%), and trimethoprim-sulfamethoxazole (2.1%). This study's results underline hygienic sanitary deficiencies during the milking phase and indicate that raw ovine milk can be contaminated with pathogenic and multidrug-resistant E. coli strains, highlighting a potential risk to public health. Further studies are encouraged to better understand the risk posed to the consumer via the consumption of ovine milk and derived products."

Journal

Whatever Happened to Ticarcillin-clavulanate? We need to Resurrect it in the Era of Multidrug-resistant Gram-negative Bacteria. (PubMed, Clin Microbiol Infect) - No abstract available

Gram negative • Journal • Infectious Disease

Distribution of virulence genes and antimicrobial resistance of Escherichia coli isolated from hospitalized neonates: A multi-center study across China. (PubMed, Heliyon) - "Resistance to ceftazixime, sulfamethoxazole/trimethoprim, and ciprofloxacin was 75.5 %, 65.4 %, and 48.4 %, respectively. Lower rates of resistance to ceftazidime (p = 0.022), cefepime (p = 0.005), ticarcillin/clavulanic acid (p = 0.020) and aztreonam (p = 0.001) were observed in the invasive infection group compared to the non-invasive infection group...Neonatal E. coli isolates carried multiple virulence genes and were highly resistant to antibiotics. Further studies are needed to understand the molecular mechanisms underlying the association between virulence and AMR."

Journal • Infectious Disease

Investigating Urinary Pathogens and Their Antibiotic Resistance: A Cross-Sectional Urine Culture Study. (PubMed, Cureus) - "In conclusion, our research highlights a concerning trend of escalating antibiotic resistance among Pakistani patients with UTIs. Tobramycin B, ticarcillin-clavulanic acid, ampicillin, and clotrimazole exhibited the highest resistance rates, while imipenem, meropenem, nitrofurantoin, sulfonamides, and tigecycline demonstrated notable sensitivity. These findings emphasize the urgent need for the exploration of alternative treatment options to combat rising resistance levels effectively."

Journal • Infectious Disease • Nephrology

Double blaKPC-2 copies quadrupled minimum inhibitory concentration of ceftazidime-avibactam in hospital-derived Klebsiella pneumoniae. (PubMed, Microbiol Spectr) - "The Kpn_XM9 was resistant to amikacin, aztreonam, ticarcillin/clavulanic acid, piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, tobramycin, ciprofloxacin, levofloxacin, doxycycline, minocycline, tigecycline, colistin, and trimethoprim/sulfamethoxazole; it was barely susceptible to CZA with a minimum inhibitory concentration of 8/4 µg/mL, which declined to 2/4 µg/mL after a 18,555 bp nucleotide was knocked out and one copy of blaKPC-2 was sustained on p1_Kpn_XM9. The emergence of double copies of blaKPC-2 in a single plasmid from the predominant ST11 K. pneumoniae represents a new therapeutic challenge.IMPORTANCEWith the wide use of ceftazidime-avibactam against carbapenem-resistant organisms, its resistance is increasingly documented; among the corresponding resistance mechanisms, mutations of blaKPC-2 or blaKPC-3 into other subtypes are dominant to date. However, more copies of blaKPC-2 may also greatly increase the minimum inhibitory..."

Journal • Infectious Disease • Pneumonia

Frequency of Fecal Carriage of ESBL Resistance Genes in Multidrug-Resistant Pseudomonas aeruginosa Isolates from Cancer Patients at Laquintinie Hospital, Douala, Littoral Region, Cameroon. (PubMed, Int J Microbiol) - "aeruginosa showed significant resistance rates in cancer patients compared to noncancer patients to imipenem, cefotaxime, and ceftazidime, piperacillin-tazobactam, ticarcillin-clavulanic acid, and ciprofloxacin. The study revealed an alarmingly high prevalence of fecal carriage of ESBL-producing P. aeruginosa with a high rate of MDR among cancer patients. It indicates that regular monitoring and surveillance of ESBL-producing P. aeruginosa among cancer patients are needed to improve the management of patients."

Journal • Infectious Disease • Oncology

Antibiotic Resistance of Uropathogenic Escherichia coli (UPEC) among Iranian Pediatrics: A Systematic Review and Meta-Analysis. (PubMed, Iran J Public Health) - "The highest antibiotic resistance was related to doxycycline, ticarcillin-clavulanic acid, cefazolin, cefuroxime, and amoxycillin-clavulanic acid, 59%, 57%, 54%, 53%, and 52%, respectively. Meta-regression on the latitude was statistically significant for nitrofurantoin (P=0.05). Resistant uropathogenic Escherichia coli strains were observed in the majority of confirmed bacterial UTIs among Iranian children. The most effective antibiotics for uropathogens were colistin, meropenem, and imipenem."

Journal • Retrospective data • Review • Infectious Disease • Nephrology • Pediatrics

Biofilm generation and antibiotic resistant profile of extensive and multidrug resistant Pseudomonas aeruginosa from burn patients in Ahvaz: A cross-sectional study. (PubMed, Health Sci Rep) - "The resistance of P. aeruginosa to seven antibiotics and Colistin with minimum inhibitory concentration (MIC) was assessed...Among P. aeruginosa isolates, Piperacillin, Ceftazidime, Maeropenem, Gentamycin, and Gatifloacin had the highest resistance to antibiotics, while Ticarcillin-Clavulanic acid and Ceftolozane-Tazobactam showed the least resistance...Less than 50% P. aeruginosa samples generated strong biofilms. Consequently, hygienic measurements are essential to inhibit P. aeruginosa transmission to hospitalized patients."

Journal • Observational data • Infectious Disease

Mapping the risk factors, pathogens, and antibiotic of pharyngocutaneous fistula in patients after neck open surgery. (PubMed, Eur Arch Otorhinolaryngol) - "Special attention should be given to patients undergoing open neck surgery, especially those with intraoperative flap reconstruction, a history of preoperative radiotherapy, postoperative bleeding, or diabetes. Strengthening monitoring and care is crucial in preventing the occurrence of PCF. According to antibiotic usage guidelines and considering the distribution of pathogens in PCF patients, empirical antibiotic treatment with cefoperazone/sulbactam or ticarcillin/clavulanic acid is recommended prior to obtaining susceptibility test results."

Journal • Surgery • Diabetes • Head and Neck Cancer • Hypopharyngeal Cancer • Metabolic Disorders • Oncology • Otorhinolaryngology • Solid Tumor

Analysis of clinical characteristics of infections caused by shewanella species. (PubMed, Indian J Med Microbiol) - "We speculate that the Shewanella genus may exist as a specific colonizer in the human body, and under certain conditions, it may act as a pathogen, leading to biliary infections in the host."

Journal • Hepatology • Infectious Disease • Oncology • Solid Tumor • CAT

Scoping Review of Beta-Lactam Drug Dosing in Sustained Low-Efficiency Dialysis (SCCM 2024) - " Fourteen of 29 included SLED studies assessed dosing of 8 beta-lactams including cefepime, ceftazidime, penicillin G, piperacillin/tazobactam, ticarcillin/clavulanate, ertapenem, imipenem/cilastatin, and meropenem. There is a dearth of data regarding drug dosing of beta-lactam antibiotics in patients receiving SLED. Additional studies to optimize dosing in these patients are needed, especially in the absence of routinely available beta-lactam therapeutic drug monitoring assays."

Review • Growth Hormone Deficiency (Adult)

Evaluation of the French novel disc diffusion-based algorithm for the phenotypic screening of carbapenemase-producing Enterobacterales. (PubMed, Clin Microbiol Infect) - "The novel CA-SFM algorithm possess the best performances for the screening of CPE particularly in countries with high prevalence of OXA-48-like producers."

Journal • Infectious Disease

One year experience of Achromobacter bacteremia at a tertiary care hospital in Northern India. (PubMed, Access Microbiol) - "The isolates were found highly susceptible to ticarcillin-clavulanic acid (14/14, 100.0 %) followed by fluoroquinolones (12/14, 85.72 %) and trimethoprim-sulphamethoxazole (12/14, 85.72 %). Only 57.14 % (8/14, 57.14 %) of the patients were susceptible to piperacillin-tazobactam. The all-cause 40 day mortality was observed in 35.7 % (5/14, 35.7 %) with two deaths that were directly attributable to sepsis. This study provides insight into the incidence of Achromobacter bacteremia at our centre and the necessary antibiotic therapy to combat it."

Journal • Infectious Disease • Septic Shock