TERN-601 / Terns Pharma - LARVOL DELTA

Effect of Oral Small Molecule GLP-1 Receptor Agonist TERN-601 in Healthy Participants with Obesity or Overweight—A First-in-Human Study (ADA 2025) - "Available on Friday, June 13, 2025 at 08:00am CDT."

Clinical • P1 data • Metabolic Disorders • Obesity

No Effect of Food or Proton Pump Inhibitor on the Pharmacokinetics of TERN-601, an Oral Small Molecule GLP-1 Receptor Agonist (ADA 2025) - "Available on Friday, June 13, 2025 at 08:00am CDT."

PK/PD data • Metabolic Disorders

FALCON: A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or Obesity (clinicaltrials.gov) - P2 | N=150 | Recruiting | Sponsor: Terns, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Genetic Disorders • Obesity

TERN-601: Oral, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist for obesity (GlobeNewswire) - "The FALCON Phase 2 clinical trial enrolled its first patient in March 2025, with 12-week data expected in the fourth quarter of 2025"

P2 data • Obesity

FALCON: A Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of TERN-601 in Adults with Overweight or Obesity (clinicaltrials.gov) - P2 | N=150 | Not yet recruiting | Sponsor: Terns, Inc.

New P2 trial • Genetic Disorders • Obesity

TERN-601: Oral, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist for obesity (GlobeNewswire) - "Terns announces design of the FALCON Phase 2 clinical trial, expected to initiate early in the second quarter of 2025 with 12-week data expected in the second half of 2025."

New P2 trial • Obesity

Terns Pharmaceuticals Announces First Participant Dosed in Phase 1 Clinical Trial of TERN-601 Oral GLP-1 Receptor Agonist for Treatment of Obesity (BioSpace) - "Terns Pharmaceuticals, Inc...announced that the first participant has been dosed in the Phase 1 clinical trial of TERN-601, the Company’s oral small-molecule glucagon-like peptide-1 receptor, or GLP-1R, agonist for the treatment of obesity....Top-line, proof of concept 28-day weight loss data from Part 2 (MAD) are expected in the second half of 2024."

P1 data • Trial status • Metabolic Disorders • Obesity

TERN-601, a Novel Oral GLP-1R Agonist, Suppresses Food Intake and Improves Glucose Tolerance in Transgenic Mice Expressing Human GLP-1 Receptor (ADA 2023) - "In an intraperitoneal glucose tolerance test (IPGTT) on overnight fasted hGLP-1R mice (n = 7 per group), single oral doses of TERN-601 (0.3, 1, and 3 mg/kg) administered 30 minutes prior to IP glucose injection significantly lowered blood glucose area under the curve (AUC0-120min) with comparable efficacy to liraglutide (0.3 mg/kg). In transgenic mice expressing human GLP-1R, single oral doses of TERN-601 significantly suppressed food intake and improved glucose tolerance. Together these data support the continued development of TERN-601."

Preclinical • Diabetes • Metabolic Disorders • Obesity