estradiol intranasal / University of Illinois - LARVOL DELTA

Intranasal 15d-PGJ2 inhibits the growth of rat lactotroph pituitary neuroendocrine tumors by inducing PPARγ-dependent apoptotic and autophagic cell death. (PubMed, Front Neurosci) - "In conclusion, intranasal 15d-PGJ2 suppressed the growth of rat lactotroph PitNETs by inducing PPARγ-dependent apoptotic and autophagic cell death. Therefore, 15d-PGJ2 may be a potential new drug for lactotroph PitNETs."

Journal • Preclinical • Endocrine Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor • CASP3 • ER • IL1B • IL6 • LAMP1 • PPARG • PRL • SQSTM1 • TNFA

Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity during the encoding of episodic memories. (PubMed, Neuroimage) - "transdermal estradiol and intranasal placebo, 4...Collectively, the results suggest that both hormones play a crucial role in modulating sex differences in episodic memory. Furthermore, possible antagonistic interactions between estradiol and oxytocin could explain previously observed opposing hormonal effects in women and men."

Journal

Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause. (PubMed, Pharmaceutics) - "Both E2 formulations increased uterine horn weights relative to controls, with E2-cyclodextrin resulting in the greatest uterine horn weight, suggesting increased uterine stimulation. Thus, intranasal administration of freely solubilized E2 is a strategic delivery tool that can yield a cognitively beneficial impact of the hormone alongside decreased peripheral effects compared to intranasal administration of cyclodextrin solubilized E2."

Journal • CNS Disorders

Single intranasal administration of 17ß-estradiol loaded gelatin nanoparticles confers Neuroprotection in the post-ischemic brain. (PubMed, Nanomedicine) - "Following intranasal administration of 500ng E2-GNPs, brain E2 content rose by 5.24 fold (p<0.0001) after 30min and remained elevated by 2.5 fold at 2h (p<0.05). The 100ng dose of E2-GNPs reduced mean infarct volume by 54.3% (p<0.05, n=4) in comparison to saline treated controls, demonstrating our intranasal delivery system's efficacy."

Journal • Cardiovascular • Ischemic stroke • Reperfusion Injury