DLL3xCD3xCD2 TsAb / Probio - LARVOL DELTA

DLL3/CD3/CD2 trispecific T-cell engager enhances CD2 costimulation and anti-tumor immunity in small cell lung cancer (ESMO 2026) - No abstract available

Trispecific • Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • DLL3

A novel DLL3 trispecific T cell engager antibody integrating the CD2/CD58 co-stimulatory pathway demonstrates superior antitumor efficacy and balanced safety profile (AACR 2026) - "These challenges contribute to the narrow therapeutic window of TCEs in treating solid tumors and partially explain why no solid tumor-targeting TCE received regulatory approval until the DLL3-targeting tarlatamab became the first (and only to date) in 2024. In summary, the incorporation of a CD2 co-stimulatory moiety into a DLL3-targeting TCE leads to a novel, next-generation TCE with improved efficacy and safety profiles in preclinical studies. IND-enabling studies are ongoing with the potential to advance it to clinical studies in the near future."

Clinical • Trispecific • Hematological Malignancies • Oncology • Solid Tumor • CD2 • CD58 • DLL3 • TNFA

DLL3 TriTCE Co-Stim: A next generation trispecific T cell engager with integrated CD28 costimulation for the treatment of DLL3-expressing cancers (AACR 2024) - "A panel of DLL3xCD3xCD28 trispecific antibodies (Abs) was engineered with a conventional anti-CD28 agonist paratope in a variety of Ab formats, geometries, paratope affinities and specificities...In summary, we have identified multiple TriTCE Co-Stim Ab formats with improved DLL3-dependent cytotoxicity and T cell activation over competitor bispecific TCEs across multiple DLL3-expressing tumors. By screening various Ab formats, geometries and paratope affinities, we have selected lead DLL3 TriTCE Co-stim Abs displaying target-dependent activation of T cells with potent anti-tumor activity which may translate to improved and more durable antitumor responses in the treatment DLL3-expressing cancers."

Trispecific • Endocrine Cancer • Lung Cancer • Neuroendocrine Tumor • Oncology • Small Cell Lung Cancer • Solid Tumor • DLL3